摘要:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要翻译:本发明涉及阿尔茨海默病的预防药物或补救剂,或淀粉样蛋白原纤维形成抑制剂,其包括作为活性成分的下列通式(I)的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药学上允许的盐,其作为阿尔茨海默氏病的预防剂或治疗剂是有价值的,或作为淀粉样蛋白原纤维形成抑制剂:(其中,R 1和R 2为H或烷基; Z 1 Z 2是H,烷基,烷氧基,卤代烷基或卤代; Z 3是烷氧基,SH,烷硫基,NH 2,一或二烷基氨基,OH或卤素; Z 4和Z 5是H或卤素; A是4,6- -1,3-二基,1,3,5-三嗪-2,6-二基等)。
摘要:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要翻译:本发明涉及阿尔茨海默病的预防药物或补救剂,或淀粉样蛋白原纤维形成抑制剂,其包括作为活性成分的下列通式(I)的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药学上允许的盐,其作为阿尔茨海默氏病的预防剂或治疗剂是有价值的,或作为淀粉样蛋白原纤维形成抑制剂:(其中,R 1和R 2为H或烷基; Z 1 Z 2是H,烷基,烷氧基,卤代烷基或卤代; Z 3是烷氧基,SH,烷硫基,NH 2,一或二烷基氨基,OH或卤素; Z 4和Z 5是H或卤素; A是4,6- -1,3-二基,1,3,5-三嗪-2,6-二基等)。
摘要:
A compound of the formula (I): wherein R1 is a C1-C6 alkyl group, an amino group, a (C1-C6 alkyl)amino group, a di(C1-C6 alkyl)amino group or a nitrogen-containing saturated heterocyclic group; R3 is a hydrogen atom or a C1-C6 alkyl group; Arom is an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; wherein the substituted aryl group is substituted at 1 to 5 positions and the substituted heteroaryl group is substituted at 1 to 3 positions; and wherein the substituents of the aryl group and of the heteroaryl group are independently selected from the group consisting of halogen atom, C1-C6 alkyl, halogeno C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C3 alkylenedioxy, C1-C7 alkanoyl, C2-C7 alkyloxycarbonyl, amino, C1-C7 alkanoylamino, hydroxyl, mercapto, cyano, nitro and carboxyl; A is a C1-C6 alkylene group; Ra together with R2 is a C2-C3 alkylene group containing a double bond; E is a single bond, an oxygen atom, a sulfur atom or a group of the formula: —NR4—, wherein R4 is a hydrogen atom or a C1-C7 alkanoyl group; X1 and X2 are the same or different and are an oxygen atom or a sulfur atom, or a pharmacologically acceptable salt or ester thereof.
摘要:
A cast iron cylinder liner of the present invention includes a plurality of grooves formed on an outer surface of the cylinder liner. Each of the grooves extends in a circumferential direction of the cylinder liner in a ring or spiral shape, and the grooves divide the outer surface of the cylinder liner into a plurality of ring or spiral sections. The outer surfaces of the ring sections have a uniform distance from the central axis of the cylinder liner over the entire area of the outer surfaces, and the grooves being arranged symmetrically with respect to the center of the cylinder liner in an axial direction thereof. Each of the grooves has a J-shaped longitudinal cross-section including a first inclination part and a groove bottom part. The first inclination part extends from the outer surface of one of the ring sections or of one turn of the spiral sections toward the center of the cylinder liner in an axial direction thereof. The groove bottom part has a longitudinal cross-section approximately in the form of a circular arc, and extends from the first inclination part in a direction away from the center of the cylinder liner in an axial direction thereof.
摘要:
A casting C obtained by solidification of molten metal by using a pair of water cooled casting rolls 2a, 2b is subjected to temperature adjustment in a temperature zone so that an austenite structure exists in its matrix. Thereafter, the casting is rolled by an in-line rolling mill 5 at a temperature ranging from 850.degree. C. to less than 1,350.degree. C. and at a reduction of 5 to 50%. In this way, overall variance of elongation of the steel material is kept within 5% in terms of the standard deviation.
摘要:
A high-strength steel sheet suitable for deep drawing, characterized by comprising 0.04 to 0.25 mass % of C and 0.3 to 3.0 mass %, in total, of at least one of Si and Al, the steel sheet having multiple phases structure comprising ferrite as a main phase (a phase having the highest volume fraction), not less than 3 vol. % of austenite, and bainite and martensite; said steel satisfying a requirement that a value obtained by dividing volume fraction of Vg (vol. %) of austenite before working by the content of C (mass %) contained in the whole steel, Vg/C, is 40 to 140, a requirement that Vp (volume fraction of austenite at the time of plane strain tensile deformation)/Vs (volume fraction of austenite at the time of shrink flanging deformation) is not more than 0.8, and a requirement represented by the formula220
摘要:
A receiver has a random counter, which outputs a timer signal to a control circuit. A zero-cross point detection circuit generates a detection signal which is input to the control circuit. When the random counter outputs a timer signal and the zero-cross detection circuit detects a zero-cross point, a muting function is activated. Simultaneously, different frequencies are scanned for broadcasts containing the same program and having higher field strengths. If on re-checking zero-cross point detection, a zero-cross point is found or a predetermined interval has expired, then the muting function is deactivated. The frequency with the greater field strength is selected.
摘要:
Disclosed are processes for producing cold rolled steel sheets and strips having excellent press formability and ageing property by a continuous annealing method, in which specific heating cycles are adopted in combination with steel compositions with lowered phosphorus contents.
摘要:
An r value of a hot-rolled steel sheet is enhanced by: a specific composition consisting of not more than 0.015 wt % of C, from 1.0 to 2.5 wt % of Mn, from 0.005 to 0.10 wt % of Al, from 0.01 to 0.06 wt % of Nb, from 0.01 to 0.1 wt % of Ti; and, controlled rolling, characterized by in the rough rolling, imparting, in a temperature range of from 980.degree. to 1100.degree. C., a heavy reduction of not less than 20% per pass to the steel sheet; completing a finishing rolling at from Ar.sub.3 to 930.degree. C. and maintaining a total reduction at a temperature of not more than Ar.sub.3 +150.degree. C. to not less than 90%; and, coiling at a temperature of from 600.degree. to 800.degree. C.
摘要:
Merchandise discharged from a packaging machine in a lateral posture can be reliably aligned into a longitudinal posture, and the merchandise can then be sent to a labeling machine with one side of each article in sliding contact with an article-aligning member at all times, irrespective of the size of tray used. This enables the omission of the operations of correcting the posture and position of articles by an operator, and the articles can always be labeled at correct portions thereof, said turn conveyor is so formed that the height of a start end thereof can be regulated to enable the turn conveyor, alignment conveyor, weighing machine and labeling machine to be connected to a packaging machine which has an article discharge section at a height different from that of the turn conveyor or an intermediate conveyor connected to the discharge section of the packaging machine.