Abstract:
An amplifier circuit capable of reducing load of a circuit at the previous stage by providing increased input impedance producing less noises. The amplifier circuit includes a fully-differential operational amplifier composed of an inverting input terminal, a non-inverting input terminal receiving a signal different from a signal to be input to the inverting input terminal, an inverting output terminal with the same polarity of the inverting input terminal, and a non-inverting output terminal with reverse polarity; an input impedance element with one end connected to the inverting input terminal; an input impedance element with one end connected to the non-inverting input terminal; and positive feedback impedance elements, with one end of connected to the other end of the input impedance element and the other end connected to the inverting output terminal or to the non-inverting output terminal.
Abstract:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
Abstract:
Pharmaceutical compositions and methods of treatment are provided for treating amyloidosis, containing, as an active ingredient, at least one nitrogen-containing heteroaryl compound represented by the following general formula or a pharmacologically permitted salt thereof; together with nitrogen-containing heteroaryl derivatives, and pharmacologically permitted salts thereof: where, R1, R2, Z1-Z5, and A are as defined herein.
Abstract:
A compound of the formula (I): wherein R1 is a C1-C6 alkyl, an amino, a (C1-C6 alkyl)amino, a di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are the same or different and are a hydrogen or a C1-C6 alkyl; Arom is an unsubstituted or substituted aryl or an unsubstituted or substituted heteroaryl; wherein the substituted aryl is substituted at 1 to 5 positions and the substituted heteroaryl is substituted at 1 to 3 positions; wherein the heteroaryl is furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; and wherein the substituents of the substituted aryl and of the substituted heteroaryl are independently halogen, C1-C6 alkyl, halogeno C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C3 alkylenedioxy, C1-C7 alkanoyl, C2-C7 alkyloxycarbonyl, amino, C1-C7 alkanoylamino, hydroxyl, mercapto, cyano, nitro or carboxyl; A is an ethylene or propylene; Ra is a hydrogen, a C1-C6 alkyl or a C2-C6 alkenyl; E is a single bond, an oxygen, a sulfur or —NR4—, wherein R4 is a hydrogen or a C1-C7 alkanoyl; X1 and X2 are the same or different and are an oxygen or a sulfur, or a pharmacologically acceptable salt or ester thereof.
Abstract:
A compound of the formula (I): wherein R1 is C1-C6 alkyl, amino, (C1-C6 alkyl)amino, di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are hydrogen or C1-C6 alkyl; Arom is phenyl, idenyl, napthyl, phenanthrenyl, furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; A is C1-C6 alkylene; Ra is hydrogen, C1-C6 alkyl or C2-C6 alkenyl; E is a single bond, oxygen, sulfur or —NR4—, wherein R4 is hydrogen or C1-C7 alkanoyl; X1 and X2 are oxygen or sulfur; or a pharmacologically acceptable salt or ester thereof.
Abstract:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
Abstract translation:本发明涉及阿尔茨海默病的预防药物或补救剂,或淀粉样蛋白原纤维形成抑制剂,其包括作为活性成分的下列通式(I)的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药理学上允许的盐,其作为阿尔茨海默氏病的预防剂或治疗剂是有价值的,或作为淀粉样蛋白原纤维形成抑制剂:(其中R 1, 和R 2是H或烷基; Z 1和Z 2是H,烷基,烷氧基,卤代烷基或卤代; Z 3 烷氧基,SH,烷硫基,NH 2,单或二烷基氨基,OH或卤素; Z 4和Z 5 >为H或卤素; A为4,6-嘧啶-1,3-二基,1,3,5-三嗪-2,6-二基等)。
Abstract:
An isoxazole compound having the following formula: wherein R.sup.1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R.sup.2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.
Abstract:
A packaging machine has belts for clamping both side edges of a film pulled out selectably from either of two film rolls and transporting it accordingly in either direction to a packaging station. Its film supplying apparatus includes a plurality of sensors capable of detecting both presence and absence of a film. They are disposed at both ends of the belts and each sensor is adapted to output a warning signal when either the presence or absence of a film is detected thereby, depending whether it is at the downstream or upstream end of the belt with respect to the direction of film being transported thereby. A lift mechanism for such a packaging machine for lifting loaded trays of different sizes against a stretched film includes a frame, a mechanism for moving the frame selectably upward or downward, a plurality of posts standing on the frame for supporting trays thereon, some of the posts being fixed posts, which are affixed to the frame, and the others being mobile posts, which can move horizontally in a specified direction within a specified range each towards or away from an associated one of the fixed posts, a slidable member extending perpendicularly to the specified direction and capable of sliding in this direction beyond the specified range, and a controller for stopping the slidable member at a plurality of stop positions within the specified range and wait positions outside the specified range. The controller also causes the slidable member and the mobile posts to move towards or away from each other at any of the stop positions.
Abstract:
Receivable frequencies based on a predetermined instruction signal are scanned in a first direction and across a frequency range extending from a first start frequency to a first end frequency. The tuning is retraced to the first start frequency, and scanning is resumed in the opposite direction across a second frequency range extending from the first start frequency to a second end frequency. Next, tuning is retraced to the second start frequency and scanning is resumed in the first direction across a third frequency range extending from the first end frequency to a third end frequency. The scan operation is repeated until predetermined upper and lower frequency limits are reached. When one of the frequency limits are reached, scanning is performed for one or more frequency ranges in the opposite direction without retrace until the second frequency limit is reached.
Abstract:
A thrust transmitting plate 14b on a cylinder hole bottom side portion of an adjuster nut 14, a drive side cam plate 12, and a cam spring 15 for biasing the thrust transmitting plate 14b toward the drive side cam plate 12 are accommodated in a generally cylindrical housing 16. Parts of the arc face of the circumferential wall of the housing 16 are deformed inwardly to form flat portions 16d. Engaging apertures 16e are formed in the flat portions 16d such that the engaging protrusions 14d are movable only in the cylinder axis direction when they are engaged. Portions of the circumferential wall of the housing 16 are protruded outwardly in convex shapes by presswork to form plural locking parts 16g arranged in the circumferential direction. The housing 16 is configured so as to be mounted in a cylinder hole 8 by latching those locking parts 16g to a circumferential groove 8f formed in the cylinder hole 8.