公开(公告)号：US20100240974A1

公开(公告)日：2010-09-23

申请号：US12793665

申请日：2010-06-03

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20100223021A1

公开(公告)日：2010-09-02

申请号：US12779941

申请日：2010-05-13

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： G06F19/00

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20100204554A1

公开(公告)日：2010-08-12

申请号：US12761381

申请日：2010-04-15

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

IPC分类号： A61B5/1468

CPC分类号： A61B5/14532 ,  A61B5/01 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  C12Q1/001 ,  C12Q1/006

摘要： An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.

公开(公告)号：US20100198188A1

公开(公告)日：2010-08-05

申请号：US12699258

申请日：2010-02-03

申请人： Adam Heller

发明人： Adam Heller

IPC分类号： A61M37/00

CPC分类号： A61M5/14276 ,  A61M5/14 ,  A61M5/14212 ,  A61M5/14244 ,  A61M5/1723 ,  A61M25/00 ,  A61M25/02 ,  A61M2205/3317 ,  A61M2205/3334 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/3592

摘要： Embodiments of the present disclosure relate to devices for delivering a predetermined amount of an active agent to a subject by inclusion of a detector configured to detect the number of insoluble active agent particles in a fluid flowing by the detector. A controller is operably connected to the detector and configured to determine the amount of the active agent to be delivered to the subject based on the number of insoluble active agent particles flowing by the detector. Also provided are methods of using the subject devices for delivering a predetermined amount of an active agent to a subject.

摘要翻译： 本公开的实施例涉及用于通过包括检测器，其被配置为检测由检测器流动的流体中的不溶性活性剂颗粒的数量来将预定量的活性剂递送给受试者。 控制器可操作地连接到检测器并且被配置为基于由检测器流动的不溶性活性剂颗粒的数量来确定要递送到受试者的活性剂的量。 还提供了使用本发明装置将预定量的活性剂递送到受试者的方法。

公开(公告)号：US20100170793A1

公开(公告)日：2010-07-08

申请号：US12723169

申请日：2010-03-12

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N27/26

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

公开(公告)号：US07699964B2

公开(公告)日：2010-04-20

申请号：US10819498

申请日：2004-04-06

申请人： Benjamin Feldman ,  Zenghe Liu ,  Fei Mao ,  Adam Heller

发明人： Benjamin Feldman ,  Zenghe Liu ,  Fei Mao ,  Adam Heller

IPC分类号： G01N27/40 ,  G01N27/327

CPC分类号： C12Q1/005

摘要： A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating/catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and/or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.

摘要翻译： 提供多功能膜。 多功能膜适用于分析物传感器。 在特定应用中，多功能膜可以与电流计生物传感器（例如经皮电流生物传感器）结合使用。 膜的一些功能与膜本身的性质相关，膜本身由包含杂环氮基团的交联聚合物组成。 例如，膜由于其聚合物组合物可以将分析物的通量调节到传感器。 这种调节通常改善传感器在宽范围的分析物浓度下的动力学性能。 膜的其它功能与可以结合到由膜提供的支架结合的酶或酶模拟物的形式的功能组分如超氧化物歧化/过氧化氢酶催化剂相关联。 任何此类酶或酶模拟物的作用是降低生物传感器感应层附近代谢物如超氧化物和/或过氧化氢的浓度。 降低通常对传感器功能有害的代谢物的浓度通常保护或增强生物传感器的完整性和性能。 因此，膜是分析物传感器，电流传感器，生物传感器，特别是经皮生物传感器的重要工具。 还提供了膜覆盖传感器及其制造方法。

公开(公告)号：US20100059372A1

公开(公告)日：2010-03-11

申请号：US12551497

申请日：2009-08-31

申请人： Adam Heller ,  Michael V. Pishko

发明人： Adam Heller ,  Michael V. Pishko

IPC分类号： G01N27/26

CPC分类号： C12Q1/54 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S435/917 ,  Y10S435/962

摘要： A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

摘要翻译： 描述了设计用于皮下体内电导率监测葡萄糖的小直径柔性电极。 电极被设计成允许“一点”体内校准，即即使在血清或血液的其它电反应物质的存在下也能在零葡萄糖浓度下具有零输出电流。 电极优选为三层或四层，其中层叠在聚酰胺绝缘金线的尖端上的凹槽内。 第一葡萄糖浓度 - 电流转导层用电绝缘和葡萄糖通量限制层（第二层）涂覆，其上任选地沉积固定的干扰消除辣根过氧化物酶基膜（第三层）。 外（第四）层是生物相容的。

公开(公告)号：US20100059370A1

公开(公告)日：2010-03-11

申请号：US12551480

申请日：2009-08-31

申请人： Adam Heller ,  Michael V. Pishko

发明人： Adam Heller ,  Michael V. Pishko

IPC分类号： C12Q1/00

CPC分类号： C12Q1/54 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S435/917 ,  Y10S435/962

摘要： A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

公开(公告)号：US07666284B2

公开(公告)日：2010-02-23

申请号：US10862932

申请日：2004-06-07

申请人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

IPC分类号： G01N27/327

CPC分类号： G01N27/3271

摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。

公开(公告)号：US20100032317A1

公开(公告)日：2010-02-11

申请号：US12569310

申请日：2009-09-29

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N33/50 ,  G01N27/26

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。