公开(公告)号：US20060000715A1

公开(公告)日：2006-01-05

申请号：US11180165

申请日：2005-07-13

Applicant: Forrest Whitcher ,  Makoto Takeuchi

Inventor： Forrest Whitcher ,  Makoto Takeuchi

IPC: A61F2/06 ,  A61F2/24 ,  C25D5/00 ,  C23C14/00

CPC classification number: C23C14/34 ,  A61F2/82 ,  A61F2210/0014 ,  A61F2240/001 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00059 ,  A61F2310/00071 ,  A61F2310/00089 ,  A61F2310/00095 ,  A61F2310/00113 ,  A61F2310/00131 ,  A61F2310/00149 ,  A61F2310/00155 ,  A61L31/022 ,  C23C14/0005 ,  C23C14/562

Abstract: A method of forming a medical device, the method including the steps of providing a substrate, depositing a metallic layer on the substrate by a vapor deposition process, and removing the metallic layer from the substrate. The metallic layer thus removed is the medical device or serves as a basis for forming the medical device. In another aspect, the present invention includes a medical device formed by the process of the present invention.

公开(公告)号：US20050272753A1

公开(公告)日：2005-12-08

申请号：US10518043

申请日：2003-06-26

Applicant: Shinya Nagashima ,  Hiroshi Nagata ,  Masahiro Iwata ,  Masaki Yokota ,  Hiroyuki Moritomo ,  Eiichi Nakai ,  Sadao Kuromitsu ,  Keiko Ohga ,  Makoto Takeuchi

Inventor： Shinya Nagashima ,  Hiroshi Nagata ,  Masahiro Iwata ,  Masaki Yokota ,  Hiroyuki Moritomo ,  Eiichi Nakai ,  Sadao Kuromitsu ,  Keiko Ohga ,  Makoto Takeuchi

IPC: A61P11/00 ,  A61P11/06 ,  A61P43/00 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D451/04 ,  C07D453/02 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  A61K31/506 ,  A61K31/505 ,  C07D43/02

CPC classification number: C07D403/12 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D451/04 ,  C07D453/02 ,  C07D471/10 ,  C07D487/08

Abstract: A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

Abstract translation: 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物，特别是哮喘，慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基， 可以在5位被提供。

公开(公告)号：US20050234055A1

公开(公告)日：2005-10-20

申请号：US11154591

申请日：2005-06-17

Applicant: Hirokazu Kubota ,  Yasuhiro Yonetoku ,  Keizo Sugasawa ,  Masashi Funatsu ,  Souichirou Kawazoe ,  Akira Toyoshima ,  Yoshinori Okamoto ,  Jun Ishikawa ,  Makoto Takeuchi

Inventor： Hirokazu Kubota ,  Yasuhiro Yonetoku ,  Keizo Sugasawa ,  Masashi Funatsu ,  Souichirou Kawazoe ,  Akira Toyoshima ,  Yoshinori Okamoto ,  Jun Ishikawa ,  Makoto Takeuchi

IPC: A61K31/4155 ,  A61K31/416 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/538 ,  C07D231/12 ,  C07D231/14 ,  C07D401/12 ,  C07D403/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D417/02 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D521/00 ,  C07D43/02 ,  C07D49/02

CPC classification number: C07D231/12 ,  C07D231/14 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors containing the above compounds as the active ingredient, (in the formula, each symbol has the following meaning: B: phenylene, a nitrogen-containing, divalent, saturated ring group, or a monocyclic, divalent heteroaromatic ring group which may be substituted with Alk, X: —NR1—CR2R3—, —CR2R3—NR1—, —NR1—SO2—, —SO2—NR1— or —CR4═CR5—, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more substituents; lower alkenyl which may have one or more substituents; lower alkynyl which may have one or more substituents; or Alk which may have one or more substituents).

Abstract translation: 药物，特别是具有钙释放依赖性钙通道抑制作用的药物组合物，特别是含有上述化合物作为活性成分的钙释放依赖性钙通道抑制剂的下述通式（I）表示的吡唑衍生物， （在该式中，每个符号具有以下含义：B：亚苯基，含氮，二价饱和环基或可被Alk，X：-NR 1取代的单环，二价杂芳族环基团 其中R 1，R 2，R 3，R 3，R 3，R 3， -NR 2 - ， - SO 2 - ， - SO 2 - ， - SO 2 - ， - SO 2 - ， - SO 2 - 可以具有一个或多个取代基的一个 - 二环或三环稠合杂芳基，其可以具有一个或多个 取代基;可具有一个或多个取代基的环烷基;可具有一个或多个取代基的含氮饱和环基团 ents 可以具有一个或多个取代基的低级烯基; 可以具有一个或多个取代基的低级炔基; 或Alk，其可以具有一个或多个取代基）。

公开(公告)号：US20050096138A1

公开(公告)日：2005-05-05

申请号：US10967264

申请日：2004-10-19

Applicant: Makoto Takeuchi ,  Masaru Ebata ,  Satoshi Nakagaito

Inventor： Makoto Takeuchi ,  Masaru Ebata ,  Satoshi Nakagaito

IPC: F16F15/139 ,  F16D7/02 ,  F16F15/129 ,  F16F15/30 ,  F16H35/10

CPC classification number: F16F15/1297

Abstract: A torque fluctuation absorbing device includes a damping mechanism connected with an input shaft of a transmission. The damping mechanism has an approximately annular-shaped frictional member, which is fixed to both surfaces of a disc disposed at outer peripheral portion. The torque fluctuation absorbing device further includes a flywheel for transmitting driving force from a driving power source, a first plate rotated with the flywheel and abutting on a first surface of the frictional member, a second plate abutting on a second surface of the frictional member, a coned disk spring for biasing the second plate against the frictional member, a supporting member rotated with the first plate and supporting the coned disk spring, and a plurality of fixation members for fixing the first plate with the supporting member. The first plate includes a reinforcement portion which reinforces rigidity of the first plate at an inner circumference portion located radially inwardly relative to the frictional member.

Abstract translation: 扭矩波动吸收装置包括与变速器的输入轴连接的阻尼机构。 阻尼机构具有近似环形的摩擦构件，其固定到设置在外周部分的盘的两个表面。 扭矩波动吸收装置还包括用于从驱动动力源传递驱动力的飞轮，与飞轮一起旋转并抵靠在摩擦构件的第一表面上的第一板，抵靠在摩擦构件的第二表面上的第二板， 用于将第二板偏置抵靠摩擦构件的锥形盘弹簧，与第一板一起旋转并支撑盘形弹簧的支撑构件，以及用于将第一板与支撑构件固定的多个固定构件。 第一板包括加强部分，该加强部分在相对于摩擦构件径向向内定位的内周部分处加强第一板的刚度。

公开(公告)号：US06797706B1

公开(公告)日：2004-09-28

申请号：US10009276

申请日：2001-12-10

Applicant: Hiroyuki Hisamichi ,  Souichirou Kawazoe ,  Kazuhito Tanabe ,  Atsushi Ichikawa ,  Akiko Orita ,  Takayuki Suzuki ,  Kenichi Onda ,  Makoto Takeuchi

Inventor： Hiroyuki Hisamichi ,  Souichirou Kawazoe ,  Kazuhito Tanabe ,  Atsushi Ichikawa ,  Akiko Orita ,  Takayuki Suzuki ,  Kenichi Onda ,  Makoto Takeuchi

IPC: A61K3133

CPC classification number: C07D213/82 ,  C07D239/48 ,  C07D241/26 ,  C07D253/07

Abstract: A nitrogen-containing six-membered heterocyclic compound having substituents —X—A—R3, —N(R1)-(Ph substituted by R2), and —CONH2, a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an active ingredient. (In the formula, A: a (substituted) lower alkylene, a (substituted) arylene, or the like; X: NR4, CONR4, NR4CO, O, or S; R1, R4: H, a lower alkyl, —CO-lower alkyl, or —SO2-lower alkyl; R2: H, a (substituted) lower alkyl, —O-lower alkyl, —S-lower alkyl, —O-aryl, nitro, cyano, or the like; R3: —CO2H, —CO2-lower alkyl, -lower alkylene-CO2H, —NH2, -alkylene-NH2 or the like.

Abstract translation: 具有取代基-XAR 3，-N（R 1） - （Ph被R 2取代的）的含氮六元杂环化合物和-CONH 2，其盐，其前药和 含有与活性成分相同的Syk抑制剂。 （式中，A：（取代的）低级亚烷基，（取代的）亚芳基等; X：NR 4，CONR 4，NR 4 CO，O或S; R 1 R 4：H，低级烷基，-CO-低级烷基或-SO 2 - 低级烷基; R 2：H，（取代的）低级烷基，-O-低级烷基，-S-低级 烷基，-O-芳基，硝基，氰基等; R 3：-CO 2 H，-CO 2 - 低级烷基， - 低级亚烷基-CO 2 H，-NH 2， - 亚烷基-NH 2等。

公开(公告)号：US06758658B2

公开(公告)日：2004-07-06

申请号：US10158058

申请日：2002-05-31

Applicant: Katsuhiro Fujita ,  Makoto Takeuchi

Inventor： Katsuhiro Fujita ,  Makoto Takeuchi

IPC: F04C1804

CPC classification number: F04C18/0276 ,  F04C18/0215

Abstract: In a scroll compressor equipped with fixed scroll member 1 and orbiting scroll member 2 having step portions 4, a convex side end of at least one step portion of each of scroll members 1 and 2 has chamfered portions 1f and 2f which are formed lower than an extrapolated line of an upper edge.

Abstract translation: 在具有固定涡旋构件1和具有台阶部4的绕动涡旋构件2的涡旋压缩机中，每个涡旋构件1和2的至少一个台阶部的凸侧端部具有倒角部1f和2f， 上边缘的外推线。

公开(公告)号：US06746224B2

公开(公告)日：2004-06-08

申请号：US10049911

申请日：2002-02-20

Applicant: Takahide Itoh ,  Makoto Takeuchi ,  Hiroshi Yamazaki ,  Yasuharu Maruiwa ,  Yukio Nagato ,  Chikako Sasakawa ,  Susumu Matsuda

Inventor： Takahide Itoh ,  Makoto Takeuchi ,  Hiroshi Yamazaki ,  Yasuharu Maruiwa ,  Yukio Nagato ,  Chikako Sasakawa ,  Susumu Matsuda

IPC: F03C200

CPC classification number: F04C29/126 ,  F04C18/0276

Abstract: In a scroll compressor furnished with a fixed scroll and an orbiting scroll, and provided with steps on end plates of the fixed scroll and the orbiting scroll, formed such that the height thereof is high at a central side and low at an outer peripheral end side in a spiral direction of the walls, and with upper rims of the walls formed in a stepped shape corresponding to the steps, gaps are respectively provided between the end plates and upper rims of the walls, and a height of the gaps at room temperature is formed higher than a height under operating conditions. Moreover, the steps are provided at positions which exceeds a pitch angle of &pgr; (rad) along the spiral direction from the outer peripheral end. Furthermore, a concavity is formed in the end plate of the fixed scroll, and a discharge valve is provided in the concavity. Moreover, a plate which is freely movable in an orbit axis direction of the orbiting scroll is arranged, and a pressing device which presses the plate is provided. In addition, a shape of connecting wall faces which connect adjacent parts on one side face of the end plates, is determined by an envelope drawn by an orbit locus of a connecting rim which connects adjacent parts of the upper rims. Furthermore, there is provided a communication passage which communicates between two compression chambers which are developed by contact of the connecting rim and the connecting wall face.

Abstract translation: 在具有固定涡旋件和绕动涡旋件的涡旋式压缩机中，在固定涡旋盘和绕动涡旋盘的端板上设置台阶，使其高度在中心侧高，而在外周端侧低 在壁的螺旋方向上，并且壁的上边缘形成为对应于台阶的阶梯形状，在端板和壁的上边缘之间分别设置有间隙，并且室温下间隙的高度为 形成高于运行条件下的高度。 此外，在从外周端沿着螺旋方向超过间隔角pi（rad）的位置设置台阶。 此外，在固定涡旋盘的端板中形成凹部，在凹部设置有排出阀。 此外，可以在绕动涡旋盘的轨道轴线方向上自由移动的板，并且设置有压板的加压装置。 此外，连接壁面的形状连接端板的一个侧面上的相邻部分，由连接边缘的轨道轨迹拉出的外壳确定，该连接边缘连接着上边缘的相邻部分。 此外，设置有通过连接边缘和连接壁面的接触而展开的两个压缩室之间连通的连通通道。

公开(公告)号：US06695598B2

公开(公告)日：2004-02-24

申请号：US10040631

申请日：2002-01-09

Applicant: Katsuhiro Fujita ,  Takahide Itoh ,  Makoto Takeuchi ,  Tetsuzou Ukai ,  Hiroshi Ogawa ,  Shigeki Miura ,  Yasuhiro Wada ,  Yasuharu Maruiwa ,  Kou Tanaka

Inventor： Katsuhiro Fujita ,  Takahide Itoh ,  Makoto Takeuchi ,  Tetsuzou Ukai ,  Hiroshi Ogawa ,  Shigeki Miura ,  Yasuhiro Wada ,  Yasuharu Maruiwa ,  Kou Tanaka

IPC: F04C1800

CPC classification number: F04C18/0276

Abstract: A scroll compressor comprises a fixed scroll member and a revolving scroll member that engage with each other with their centrifugal walls, wherein the revolving scroll member is supported to revolve with respect to the fixed scroll member, but to avoid self-rotation thereof. The spiral-starting portion of the centrifugal wall comprises non-stepped portions formed along curves of &bgr;1-&bgr;1′ and &bgr;2-&bgr;2′ respectively, and a stepped portion formed along a curve &bgr;1′-&bgr;2′ that provides a thickness increase area encompassed by its upper-side curved surface and its lower-side curved surface. The discharge port is located on the end board of the fixed scroll member to partly overlap with the thickness increase area by partly hollowing the lower side of the stepped portion with the prescribed height.

Abstract translation: 涡旋压缩机包括固定涡旋构件和与其离心壁相互接合的回转涡旋构件，其中旋转涡旋构件被支撑成相对于固定涡旋构件旋转，但是为了避免其自身旋转。 离心壁的螺旋起始部分分别包括沿着β1-β1'和β2-β2'的曲线形成的非阶梯部分，并且沿着曲线β1'-β2'形成的阶梯部分，其提供包围在其中的厚度增加区域 其上侧曲面及其下侧曲面。 排出口位于固定涡旋构件的端板上，通过以规定的高度部分地将台阶部分的下侧部分地中空，而与厚度增加区域重叠。

公开(公告)号：US06659745B2

公开(公告)日：2003-12-09

申请号：US10198992

申请日：2002-07-22

Applicant: Katsuhiro Fujita ,  Makoto Takeuchi

Inventor： Katsuhiro Fujita ,  Makoto Takeuchi

IPC: F04C1804

CPC classification number: F04C18/0276

Abstract: An object of the present invention is to provide a scroll compressor which can improve the decrease in the compression ratio due to the leakage of compressed gas via a tip clearance between adjacent compression chambers, which can be assembled with fewer processes, and which can be manufactured at a low cost. In order to achieve the object, the present invention provides: a scroll compressor comprising a fixed scroll member which is fixed in position and has a spiral wall body provided on one surface of an end plate; an orbiting scroll member which has a spiral wall body provided on one surface of an end plate, being supported by engaging the spiral wall bodies so as to orbit and revolve around the fixed scroll member without rotation; the spiral wall bodies of the fixed scroll member and the orbiting scroll member each comprise a step portion which divides a top edge of the spiral wall body into plural parts forming a low top edge at the center and a high top edge at the outer end of the spiral wall body; and the end plates of the fixed scroll member and the orbiting scroll member each comprise a step portion which divides the end plate into a high part at the center and a low part at the outer end of the end plate; wherein at least one of a clearance between the high part of the end plate of the fixed scroll member and the low top edge of the spiral wall body of the orbiting scroll member, and a clearance between the high part of the end plate of the orbiting scroll member and the low top edge of the spiral wall body of the fixed scroll member is a fixed value.

Abstract translation: 本发明的目的是提供一种涡旋式压缩机，其能够通过相邻的压缩室之间的顶端间隙而导致由于压缩气体的泄漏而导致的压缩比的降低，该压缩室可以以较少的工艺组装，并且可以被制造 以低成本。 为了达到上述目的，本发明提供一种涡旋式压缩机，其特征在于，包括：固定涡旋部件，其固定在适当的位置，并具有设置在端板的一个面上的螺旋壁体; 旋转涡旋构件，其具有设置在端板的一个表面上的螺旋壁体，其通过使螺旋壁体接合而不旋转地围绕固定涡旋构件进行轨道旋转; 固定涡旋构件和绕动涡旋构件的螺旋壁体各自包括台阶部分，该台阶部分将螺旋壁体的顶部边缘分成多个部分，形成中心处的低顶部边缘， 螺旋壁体; 并且固定涡旋构件和绕动涡旋构件的端板各自包括台阶部分，其将端板分成中心处的高部分和在端板的外端处的低部分; 其中所述固定涡旋构件的端板的高部分与所述绕动涡旋构件的螺旋壁体的低顶部之间的间隙中的至少一个以及所述旋转涡旋构件的所述端板的高部分之间的间隙 涡旋构件和固定涡旋构件的螺旋壁体的低顶部边缘是固定值。

公开(公告)号：US06585501B2

公开(公告)日：2003-07-01

申请号：US09985493

申请日：2001-11-05

Applicant: Makoto Takeuchi ,  Takahide Itoh ,  Yasuharu Maruiwa ,  Hiroshi Yamazaki ,  Takayuki Hagita ,  Tetsuzou Ukai ,  Katsuhiro Fujita

Inventor： Makoto Takeuchi ,  Takahide Itoh ,  Yasuharu Maruiwa ,  Hiroshi Yamazaki ,  Takayuki Hagita ,  Tetsuzou Ukai ,  Katsuhiro Fujita

IPC: F04C1804

CPC classification number: F04C18/0276 ,  F04C18/0269 ,  F04C27/005

Abstract: A scroll compressor including a fixed scroll having a spiral-shaped wall body, and a swiveling scroll which has a spiral-shaped wall body and revolves while linking together the two wall bodies. The wall bodies have steps, and side faces of two end plates have high and low bottom faces in correspondence with the steps. A tip seal is provided along a join edge which connects top edges on different sides of each step, and a mechanism is provided therebetween to prevent the tip seals from becoming removed from the join edges. Furthermore, in the same scroll compressor, tip seals are provided respectively in two grooves, and join paths are provided respectively between a high-pressure compression chamber, which is formed with the bottom faces as one section, and the two grooves. The pressure inside the high-pressure compression chamber is used as a pressing force for the tip seals.

Abstract translation: 一种涡旋式压缩机，包括具有螺旋状壁体的固定涡旋件和具有螺旋状壁体的旋转涡旋件，并且将两个壁体连结在一起。 壁体具有台阶，两个端板的侧面具有与台阶对应的高低底面。 沿着连接边缘设置尖端密封件，该连接边缘连接每个台阶的不同侧面的顶部边缘，并且在其间设置有机构以防止末端密封件从接合边缘移除。 此外，在同一涡旋压缩机中，末端密封件分别设置在两个槽中，并且连接路径分别设置在形成有作为一个部分的底面的高压压缩室与两个槽之间。 高压压缩室内的压力用作顶端密封件的压力。