公开(公告)号：US4411892A

公开(公告)日：1983-10-25

申请号：US374223

申请日：1982-05-03

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Riichiro Shibakawa ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Riichiro Shibakawa ,  Junsuke Tone

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C12P19/62 ,  C12R1/465 ,  A61K31/71

CPC分类号： C07H17/08 ,  C12P19/62 ,  C12R1/47

摘要： An antibiotic complex, consisting of two major components, has been isolated from fermentations of a new subspecies of Streptomyces albus culture. The two major components from the complex are two new macrolide antibiotics, which are active as antibacterial agents against certain gram-positive and gram-negative microorganisms.

摘要翻译： 由两种主要成分组成的抗生素复合物已经从新亚种链霉菌培养物的发酵中分离出来。 该复合物的两个主要成分是两种新的大环内酯类抗生素，它们作为针对某些革兰氏阳性和革兰氏阴性微生物的抗菌剂是有活性的。

公开(公告)号：US4148880A

公开(公告)日：1979-04-10

申请号：US751032

申请日：1976-12-16

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Charles E. Moppett ,  John B. Routien ,  Riichiro Shibakawa ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Charles E. Moppett ,  John B. Routien ,  Riichiro Shibakawa ,  Junsuke Tone

IPC分类号： A61K35/00 ,  C07G11/00

CPC分类号： A61K35/742 ,  C07G11/00

摘要： A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.

摘要翻译： 当在受控条件下进行淹没好氧发酵时，称为Actinoplanes auranticolor ATCC 31011的一种Actinoplanes产生包含许多大环内酯和缩酚酸肽的抗生素混合物。 各种化合物显示出显着的抗生素活性。 粗制抗生素混合物或纯大环内酯和纯赖肽的组合显示明显的协同抗生素活性。 这些抗生素作为小鸡和猪的生长促进剂，对猪痢疾的治疗是有效的。

公开(公告)号：US4081532A

公开(公告)日：1978-03-28

申请号：US724869

申请日：1976-09-20

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Charles E. Moppett ,  John B. Routien ,  Mark T. Jefferson ,  Riichiro Shibakawa ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Charles E. Moppett ,  John B. Routien ,  Mark T. Jefferson ,  Riichiro Shibakawa ,  Junsuke Tone

IPC分类号： C12P7/00 ,  A23K20/195 ,  A61K35/74 ,  A61P31/04 ,  C07D493/20 ,  C07G11/00 ,  C12P1/02 ,  C12P17/18 ,  C12R1/645 ,  A61K35/00

CPC分类号： A23K20/195 ,  Y10S435/911

摘要： A new polycyclic ether antibiotic produced by three strains of a new species of Dactylosporangium under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

摘要翻译： 在浸没发酵条件下，由三种新孢子菌产生的新型多环醚抗生素可用于防治家禽中的球虫病，提高反刍动物饲料利用效率。

公开(公告)号：US4038383A

公开(公告)日：1977-07-26

申请号：US604260

申请日：1975-08-13

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Charles E. Moppet ,  John B. Routien ,  Riichiro Shibakawa ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Charles E. Moppet ,  John B. Routien ,  Riichiro Shibakawa ,  Junsuke Tone

IPC分类号： A61K35/00 ,  C07G11/00

CPC分类号： A61K36/06 ,  C07G11/00 ,  Y10S435/827

摘要： A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.

公开(公告)号：US4001397A

公开(公告)日：1977-01-04

申请号：US603366

申请日：1975-08-11

申请人： Walter D. Celmer ,  Charles E. Moppett ,  Walter P. Cullen ,  John B. Routien ,  Mark T. Jefferson ,  Riichiro Shibakawa ,  Junsuke Tone

发明人： Walter D. Celmer ,  Charles E. Moppett ,  Walter P. Cullen ,  John B. Routien ,  Mark T. Jefferson ,  Riichiro Shibakawa ,  Junsuke Tone

IPC分类号： A61K35/74 ,  C07G11/00

CPC分类号： C07G11/00 ,  A61K35/74 ,  Y10S435/827

摘要： Disclosed is a new antibiotic, Compound 41,012, which is produced by the submerged aerobic fermentation of a new species of Actinoplanes designated Actinoplanes nipponensis sp. nov. Routien, ATCC 31145. Methods for the recovery and purification of Compound 41,012 are also described as are some of its antimicrobial properties.

公开(公告)号：US5589366A

公开(公告)日：1996-12-31

申请号：US556245

申请日：1995-11-09

申请人： Mark A. Haxell ,  David A. Perry ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Mark A. Haxell ,  David A. Perry ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A01N43/90 ,  A01N63/02 ,  A61K31/365 ,  A61K31/37 ,  A61P33/00 ,  A61P33/10 ,  C07D493/22 ,  C07H9/02 ,  C07H19/01 ,  C12N1/20 ,  C12P17/18 ,  C12P19/44 ,  C12R1/55

CPC分类号： C07H19/01 ,  A01N43/90 ,  C12P17/181 ,  C12P19/445 ,  C12R1/55 ,  Y10S435/898

摘要： The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari, free-living nematodes and endo- and ectoparasites. This invention also relates to pharmaceutical and other compositions comprising such compounds, methods of using such compounds, the microorganism Streptomyces hygroscopicus ATCC 53718 and mutants or genetically transformed or recombinant form thereof, and processes for producing such compounds.

摘要翻译： 本发明涉及本文中称为N787-182化合物的某些抗生素化合物及其衍生物，其为抗寄生虫病，抗病虫害，螨虫，自由活生生线虫和内寄生虫和外寄生虫的抗寄生虫药物。 本发明还涉及包含这种化合物的药物和其它组合物，使用这些化合物的方法，微生物吸水链霉菌Streptomyces ATCC 53718以及其突变体或遗传转化或重组形式，以及制备这些化合物的方法。

公开(公告)号：US5573946A

公开(公告)日：1996-11-12

申请号：US553129

申请日：1995-11-07

申请人： Mark A. Haxell ,  David A. Perry ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Mark A. Haxell ,  David A. Perry ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A01N43/90 ,  A01N63/02 ,  A61K31/365 ,  A61K31/37 ,  A61P33/00 ,  A61P33/10 ,  C07D493/22 ,  C07H9/02 ,  C07H19/01 ,  C12N1/20 ,  C12P17/18 ,  C12P19/44 ,  C12R1/55 ,  A01N63/00 ,  C12N1/00 ,  C12P1/06

CPC分类号： C07H19/01 ,  A01N43/90 ,  C12P17/181 ,  C12P19/445 ,  C12R1/55 ,  Y10S435/898

摘要： The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari, free-living nematodes and endo- and ectoparasites. This invention also relates to pharmaceutical and other compositions containing such compounds, methods of using such compounds, the microorganism Streptomyces hygroscopicus ATCC 53718 and mutants or genetically transformed or recombinant form thereof, and processes for producing such compounds.

摘要翻译： 本发明涉及本文中称为N787-182化合物的某些抗生素化合物及其衍生物，其为抗寄生虫病，抗病虫害，螨虫，自由活生生线虫和内寄生虫和外寄生虫的抗寄生虫药物。 本发明还涉及含有这些化合物的药物和其它组合物，使用这些化合物的方法，微生物吸水链霉菌Streptomyces ATCC 53718及其突变体或遗传转化或重组形式，以及制备这些化合物的方法。

公开(公告)号：US5350764A

公开(公告)日：1994-09-27

申请号：US30055

申请日：1993-03-12

申请人： John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

发明人： John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K1/16 ,  A61K31/35 ,  A61P31/04 ,  A61P33/02 ,  C07D407/04 ,  C12N1/20 ,  C12P17/16 ,  C12R1/03 ,  C12R1/465 ,  C07D315/00

CPC分类号： C07D407/04 ,  C12P17/162 ,  C12R1/03

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55027. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.

摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 55027.这种新型抗生素可用作家禽中的抗球虫，预防和治疗猪痢疾以及作为牛和猪的生长促进剂。

公开(公告)号：US5155097A

公开(公告)日：1992-10-13

申请号：US527627

申请日：1990-05-23

申请人： Walter P. Cullen ,  John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter P. Cullen ,  John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： C07H15/04 ,  C07H19/01

CPC分类号： C07H15/04 ,  C07H19/01 ,  Y10S435/886

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 55028. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, as a growth promotant in cattle and swine, and as an anthelmintic in mammals, particularly in dogs, cats, sheep, cattle and swine.

摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚类抗生素是通过新型微生物Streptomyces sp。 ATCC 55028.这种新型抗生素可用作鸡中的抗球虫病，预防或治疗猪痢疾，作为牛和猪的生长促进剂，并且作为哺乳动物，特别是狗，猫，绵羊，牛和猪的驱虫剂 。

公开(公告)号：US4751317A

公开(公告)日：1988-06-14

申请号：US902353

申请日：1986-08-29

申请人： Walter P. Cullen ,  John R. Oscarson ,  Junsuke Tone ,  Hiroshi Maeda

发明人： Walter P. Cullen ,  John R. Oscarson ,  Junsuke Tone ,  Hiroshi Maeda

IPC分类号： C07D407/14 ,  C12P17/16 ,  C12P19/44 ,  C07D309/06

CPC分类号： C07D407/14 ,  C12P17/16 ,  C12P19/44

摘要： An antibiotic has been isolated from fermentation of a new Streptomyces culture. The new ionophore is active as an antibacterial and anticoccidial agent.

摘要翻译： 已经从新的链霉菌培养物的发酵中分离出抗生素。 新型离子载体作为抗菌和抗球虫剂具有活性。