公开(公告)号：US07842735B2

公开(公告)日：2010-11-30

申请号：US11568360

申请日：2005-04-28

申请人： Paul Jacobs ,  Roger Lock ,  Neil Witten ,  Michael Werth ,  Ramin Amin-Sanayei

发明人： Paul Jacobs ,  Roger Lock ,  Neil Witten ,  Michael Werth ,  Ramin Amin-Sanayei

IPC分类号： C08J9/14

CPC分类号： C08J9/122 ,  B29C44/3453 ,  C08J3/28 ,  C08J2201/026 ,  C08J2201/032 ,  C08J2203/06 ,  C08J2327/12

摘要： Described is a process for making closed cell fluoropolymer foam, and the foam so made. The process includes subjecting a fluoropolymer resin an inert gas at a pressure higher than atmospheric to drive gas into the resin, raising the temperature of the resin to or above its softening point, and reducing the pressure while maintaining the temperature at or above the softening point of the resin, in order to expand the resin to result in closed cell fluoropolymer foam. The resin is cross-linked prior to expansion. The resulting foams can be used in various applications, such as in flotation devices and for making thermal and/or acoustic insulation.

摘要翻译： 描述了制造闭孔含氟聚合物泡沫的方法，以及如此制成的泡沫。 该方法包括使含氟聚合物树脂在高于大气压的惰性气体中进行，以将气体引入树脂中，将树脂的温度升高到其软化点以上，降低压力同时保持温度在软化点以上 的树脂，以便膨胀树脂以产生闭孔含氟聚合物泡沫。 树脂在膨胀之前是交联的。 所得泡沫可用于各种应用中，例如在浮选装置中并用于制造热和/或隔音。

公开(公告)号：US20090221446A1

公开(公告)日：2009-09-03

申请号：US12089528

申请日：2006-09-06

申请人： Wim Laureyn ,  Jan Suls ,  Paul Jacobs

发明人： Wim Laureyn ,  Jan Suls ,  Paul Jacobs

IPC分类号： C40B40/08 ,  G01N27/00 ,  H05K3/16 ,  C40B40/06 ,  C40B40/10

CPC分类号： C12Q1/001 ,  G01N27/021 ,  G01N33/5438 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T29/49155

摘要： Interdigitated electrode arrays are very promising devices for multi-parameter (bio)sensing, for example the label-free detection of nucleic acid hybridisation for diagnostic applications. The current disclosure provides an innovative method for the affordable manufacturing of polymer-based arrays of interdigitated electrodes with μm-dimensions. The method is based on a combination of an appropriate three-dimensional structure and a single and directional deposition of conductive material. The three-dimensional structure can be realized in a polymer material using a moulding step, for which the moulds are manufactured by electroplating as a reverse copy of a silicon master structure. In order to ensure sufficient electrical isolation and individual, but convenient, accessibility of the sensors in the array, the interdigitated electrode regions need to be complemented with specific features on the three-dimensional structure. Combined with the use of e.g. shadow masks in the deposition step, these features allow for the site-specific deposition of the conductive material. The technology described has the additional advantage to integrate highly miniaturized and arrayed electronics elements into polymer micro-fluidics technology, which leads to the affordable manufacturing of (bio)sensor arrays.

摘要翻译： 交叉电极阵列是用于多参数（生物）感测的非常有希望的装置，例如用于诊断应用的无标记检测核酸杂交。 本公开提供了一种创新的方法，用于可负担地制造具​​有母体尺寸的交错电极的基于聚合物的阵列。 该方法基于合适的三维结构和导电材料的单次和定向沉积的组合。 三维结构可以使用成型步骤在聚合物材料中实现，其中通过电镀制造模具作为硅主体结构的反向拷贝。 为了确保阵列中传感器的足够的电气隔离和单独但方便的可访问性，交叉电极区域需要与三维结构上的特定特征相辅相成。 结合使用例如 在沉积步骤中的阴影掩模，这些特征允许导电材料的位置特异性沉积。 所描述的技术具有将高度小型化和排列的电子元件集成到聚合物微流体技术中的额外优点，这导致（bio）传感器阵列的负担得起的制造。

公开(公告)号：US20080207782A1

公开(公告)日：2008-08-28

申请号：US11814199

申请日：2006-01-18

申请人： Paul Jacobs ,  Neil Witten

发明人： Paul Jacobs ,  Neil Witten

IPC分类号： C08J9/22 ,  C08J9/32 ,  C08G73/10

CPC分类号： C08J9/122 ,  B29C44/08 ,  B29C44/3453 ,  B29C44/348 ,  C08J9/0061 ,  C08J2201/03 ,  C08J2201/032 ,  C08J2205/052 ,  C08J2377/02 ,  C08J2423/00

摘要： Closed cell polyamide foams are prepared by subjecting a polyamide resin to inert gases at an elevated pressure and at a temperature above the softening point of the resin and reducing the pressure while the temperature is maintained above the softening point of the resin, resulting in expansion of the resin.

摘要翻译： 闭孔聚酰胺泡沫体是通过在高压和高于树脂软化点的温度下将聚酰胺树脂进行惰性气体制备的，并且在保持高于树脂软化点的同时降低压力，导致膨胀 树脂。

公开(公告)号：US20080027710A1

公开(公告)日：2008-01-31

申请号：US11622608

申请日：2007-01-12

申请人： Paul Jacobs ,  Andrew Dejaco

发明人： Paul Jacobs ,  Andrew Dejaco

IPC分类号： G10L19/00

CPC分类号： G10L19/005

摘要： A speech signal is decoded by a vocoder and the reconstructed speech samples are provided to a decoded frame check unit. The decoded frame check unit examines the energy of the reconstructed speech and compares the energy of the reconstructed speech to a range of acceptable energy values. If the energy is not within the range of energy values, a frame erasure is declared and the decoded frame is prevented from being to the speaker in the telephone. In the exemplary implementation, the speech is reconstructed by a vocoder which includes a postfilter which in turn includes automatic gain control. The automatic gain control element of a post filter includes a means for measuring the energy of the decoded speech data. This measured energy is used by the decoded frame check unit to decide whether to provide the decoded data to the user or to declare a frame erasure. This implementation reduces the amount of additional hardware necessary to implement the present invention.

摘要翻译： 语音信号由声码器解码，并且将重构的语音样本提供给解码帧校验单元。 解码帧检查单元检查重构语音的能量，并将重构语音的能量与可接受的能量值的范围进行比较。 如果能量不在能量值的范围内，则声明帧擦除，并且防止解码的帧被发送到电话中的扬声器。 在示例性实现中，语音由包括后置滤波器的声码器重构，后置滤波器又包括自动增益控制。 后置滤波器的自动增益控制元件包括用于测量解码语音数据的能量的装置。 被测量的能量由解码帧检查单元使用以决定是否向用户提供解码的数据或者声明帧擦除。 该实现减少了实现本发明所需的附加硬件的数量。

公开(公告)号：US20070198981A1

公开(公告)日：2007-08-23

申请号：US11676112

申请日：2007-02-16

申请人： Paul Jacobs ,  Stephen Sprigg

发明人： Paul Jacobs ,  Stephen Sprigg

IPC分类号： G06F9/46

CPC分类号： G06F9/5044 ,  G06F1/3203 ,  G06F1/3293 ,  G06F9/5094 ,  Y02D10/122 ,  Y02D10/22 ,  Y02D10/24

摘要： Described are methods and mechanisms for providing application support in a multi-processor system including receiving a request to execute an application, identifying a property specifying which processor from a plurality of processors to utilize to execute the application that is associated with the application, scheduling the application for execution on the specified processor based on the identified property, loading the application responsive to the scheduling of the application, and executing the application utilizing the specified processor.

摘要翻译： 描述了用于在多处理器系统中提供应用支持的方法和机制，包括接收执行应用的请求，识别指定从多个处理器中使用哪个处理器来执行与应用相关联的应用的属性，调度 基于所识别的属性在指定处理器上执行应用程序，响应于应用程序的调度加载应用程序，以及使用指定的处理器执行应用程序。

公开(公告)号：US07173117B2

公开(公告)日：2007-02-06

申请号：US10297563

申请日：2001-06-07

申请人： Alex Bollen ,  Paul Jacobs ,  Alain Jacquet ,  Marc Georges Francis Massaer

发明人： Alex Bollen ,  Paul Jacobs ,  Alain Jacquet ,  Marc Georges Francis Massaer

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N15/02 ,  C12P21/04 ,  G01N33/53

CPC分类号： C07K14/43531 ,  A61K38/00

摘要： The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoids dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.

摘要翻译： 本发明涉及密码子优化的多核苷酸，其在哺乳动物细胞中有效表达并编码来自皮肤螨类的昆虫蛋白质。 特别地，优化的密码子多核苷酸编码来自Dermaphagoides pteronyssinus的蛋白质，例如DerP1或proDerP1。 本发明还提供了制备包含密码子优化的多核苷酸表达的药物组合物的方法，以及包含它们的载体和转化的宿主细胞。

公开(公告)号：US20050244297A1

公开(公告)日：2005-11-03

申请号：US11093526

申请日：2005-03-30

申请人： Szu-Min Lin ,  Paul Jacobs ,  Jenn-Hann Wang ,  James Kohler ,  Richard Kendall ,  Harold Williams ,  Robert Lukasik

发明人： Szu-Min Lin ,  Paul Jacobs ,  Jenn-Hann Wang ,  James Kohler ,  Richard Kendall ,  Harold Williams ,  Robert Lukasik

IPC分类号： A61L2/20 ,  A61L2/24

CPC分类号： A61L2/24 ,  A61L2/208 ,  A61L2202/122 ,  A61L2202/14

摘要： A method of sterilizing an article includes placing the article into a chamber containing an inner atmosphere and exhausting the inner atmosphere to lower pressure in the chamber. Hydrogen peroxide vapor is present in the chamber during at least a portion of the step of exhausting the inner atmosphere. Exhaustion of the inner atmosphere is terminated and additional hydrogen peroxide is admitted into the chamber. Hydrogen peroxide vapor contacts the article for a sufficient period to effect sterilization of the article.

摘要翻译： 对物品进行灭菌的方法包括将物品放置在含有内部气氛的室中并排出内部气氛以使室内的压力降低。 在排气内部气氛的步骤的至少一部分期间，过氧化氢蒸汽存在于室中。 内部气氛的耗尽终止，另外的过氧化氢进入腔室。 过氧化氢蒸气与制品接触足够的时间以实现制品的灭菌。

公开(公告)号：US20050191209A1

公开(公告)日：2005-09-01

申请号：US11119609

申请日：2005-04-29

申请人： Szu-Min Lin ,  Paul Jacobs

发明人： Szu-Min Lin ,  Paul Jacobs

IPC分类号： A61L2/14 ,  A61L2/16 ,  A61L2/20

CPC分类号： A61L2/208 ,  A61L2/14 ,  A61L2/16 ,  A61L2202/122

摘要： A method and an apparatus for sterilizing a lumen device. A lumen and a container having an interface on a wall of the container are enclosed in a chamber. The lumen is placed across the interface so that one end of the lumen is in the container and the other end is in the chamber. Germicide is introduced into the chamber, and a pressure difference is created between the two ends of the lumen, so that the germicide flows through the lumen. The lumen may alternatively be placed across an interface which separates the chamber into two areas. Germicide is introduced into the chamber, and a pressure difference is created between the two areas of the chamber, causing the germicide to flow through the lumen.

摘要翻译： 一种用于对管腔装置进行灭菌的方法和装置。 在容器的壁上具有界面的管腔和容器被封闭在腔室中。 管腔被放置在界面上，使得内腔的一端在容器中，另一端在腔室中。 将杀菌剂引入室中，并且在管腔的两端之间产生压力差，使得杀菌剂流过管腔。 管腔可以替代地放置在将腔室分成两个区域的界面上。 将杀菌剂引入室中，并且在室的两个区域之间产生压力差，导致杀菌剂流过管腔。

公开(公告)号：US06656426B1

公开(公告)日：2003-12-02

申请号：US09474142

申请日：1999-12-29

申请人： Jenn-Hann Wang ,  Paul Jacobs ,  Szu-Min Lin

发明人： Jenn-Hann Wang ,  Paul Jacobs ,  Szu-Min Lin

IPC分类号： A61L220

CPC分类号： A61L2/208 ,  A61L2/14 ,  A61L2/16 ,  A61L2/28 ,  A61L2202/122 ,  A61L2202/24

摘要： The present invention relates to a process for sterilization of medical instruments by concentrating a sterilant such as hydrogen peroxide inside of a sterilization chamber and sterilizing articles therewith. The sterilant is concentrated by removing more water from the sterilization chamber than peroxide.

摘要翻译： 本发明涉及医疗器械的灭菌方法，该方法是通过在灭菌室内浓缩灭菌剂如过氧化氢并对其进行灭菌。 通过从灭菌室除去比过氧化物更多的水来浓缩灭菌剂。

公开(公告)号：US06627150B1

公开(公告)日：2003-09-30

申请号：US09474285

申请日：1999-12-29

申请人： Jenn-Hann Wang ,  Paul Jacobs ,  Szu-Min Lin

发明人： Jenn-Hann Wang ,  Paul Jacobs ,  Szu-Min Lin

IPC分类号： A61L220

CPC分类号： A61L2/208 ,  A61L2/14 ,  A61L2/16 ,  A61L2/28 ,  A61L2202/122 ,  A61L2202/24

摘要： The present invention relates to a process for sterilization of medical instruments by concentrating a sterilant such as hydrogen peroxide inside of a sterilizer and sterilizing articles therewith. This concentrating process is monitored by determining the concentrations of water and peroxide in the chamber.

摘要翻译： 本发明涉及一种通过将杀菌剂等灭菌剂如过氧化氢浓缩到灭菌器内并对其进行杀菌的方法来灭菌医疗器械。 通过确定室中的水和过氧化物的浓度来监测该浓缩过程。