公开(公告)号：US20110183867A1

公开(公告)日：2011-07-28

申请号：US12672528

申请日：2008-08-07

Applicant: Martyn Christopher Davies ,  Morgan Alexander ,  Paul Williams ,  Robert Langer ,  Daniel Anderson ,  Andrew Urquhart

Inventor： Martyn Christopher Davies ,  Morgan Alexander ,  Paul Williams ,  Robert Langer ,  Daniel Anderson ,  Andrew Urquhart

IPC: C40B30/00 ,  C40B30/06

CPC classification number: C40B50/14 ,  B01J19/0046 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00736 ,  B01J2219/00743 ,  B82Y30/00 ,  C12Q1/04

Abstract: This invention relates to a method of screening arrays of polymers having pre-determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation.

Abstract translation: 本发明涉及一种筛选具有预定表面能的聚合物阵列的方法。 本发明的聚合物阵列可用于筛选微生物附着。 更具体地，阵列可用于筛选特定细菌或真菌对阵列中特定聚合物的粘附。 此外，本发明涉及将原位聚合物合成与所得聚合物阵列的物理化学表征和随后的细菌或真菌粘附的生物测定相结合的方法。 这允许对细菌或真菌粘附不敏感的候选聚合物进行高通量筛选和表征，或者可以在需要这些聚合物的情况下用于支持细菌或真菌附着。 阵列也可用于筛选抑制或促进生物膜形成。

公开(公告)号：US20090074983A1

公开(公告)日：2009-03-19

申请号：US12207973

申请日：2008-09-10

Applicant: Peter Nicholas Heys ,  Andrew Kingsley ,  Fuquan Song ,  Paul Williams ,  Thomas Leese ,  Hywel Owen Davies ,  Rajesh Odedra

Inventor： Peter Nicholas Heys ,  Andrew Kingsley ,  Fuquan Song ,  Paul Williams ,  Thomas Leese ,  Hywel Owen Davies ,  Rajesh Odedra

IPC: C23C16/513 ,  C23C16/44 ,  C23C16/48

CPC classification number: C23C16/45553

Abstract: Methods of forming titanium-containing films by atomic layer deposition are provided. The methods comprise delivering at least one precursor to a substrate, wherein the at least one precursor corresponds in structure to Formula I: wherein: R is C1-C6-alkyl; n is zero, 1, 2, 3, 4 or 5; L is C1-C6-alkoxy or amino, wherein the amino is optionally independently substituted 1 or 2 times with C1-C6-alkyl.

Abstract translation: 提供了通过原子层沉积形成含钛膜的方法。 所述方法包括将至少一种前体递送至底物，其中所述至少一种前体在结构上相应于式I：其中：R是C 1 -C 6 - 烷基; n为零，1，2，3，4或5; L是C1-C6-烷氧基或氨基，其中氨基任选独立地被C 1 -C 6 - 烷基取代1或2次。

公开(公告)号：US20080282970A1

公开(公告)日：2008-11-20

申请号：US12093846

申请日：2006-06-08

Applicant: Peter Nicholas Heys ,  Paul Williams ,  Fuquan Song

Inventor： Peter Nicholas Heys ,  Paul Williams ,  Fuquan Song

IPC: C23C16/18 ,  C07F17/00 ,  C30B23/02

CPC classification number: C23C16/45525 ,  C23C16/405 ,  C23C16/45553

Abstract: Precursors suitable for chemical vapour deposition, especially ALD, of hafnium oxide or zirconium oxide, have the general formula: (R1Cp)2MR2 wherein Cp represents a cyclopentadienyl ligand, R1 is H or a substituting alkyl group, alkoxy group or amido group of the Cp ligand, R2 is an alkyl group, an alkoxy group or an amido group and M is hafnium or zirconium.

Abstract translation: 适用于化学气相沉积的前体，特别是氧化铪或氧化锆的ALD具有以下通式：<？in-line-formula description =“In-line formula”end =“lead”？>（R 1 ＆lt; / SUP＆gt; Cp）＆lt; 2＆gt;＆lt;？in-line-formula description =“In-line Formulas”end =“tail”？>其中Cp表示环戊二烯基 配体，R 1是H或Cp配体的取代烷基，烷氧基或酰氨基，R 2是烷基，烷氧基或酰氨基 M是铪或锆。

公开(公告)号：US20070262277A1

公开(公告)日：2007-11-15

申请号：US10578815

申请日：2004-10-27

Applicant: Paul Williams ,  Kenneth Bibbo

Inventor： Paul Williams ,  Kenneth Bibbo

IPC: F16K7/04

CPC classification number: F16K7/123 ,  F16K7/126

Abstract: A diaphragm valve (1) comprising a valve body (2); a diaphragm (12) which is sealed to the valve body (2) to define a flow passage (9) which extends between an inlet port (7) and an outlet port (8), both defined by the valve body (2); and an operating mechanism secured to the valve body (2) for moving the diaphragm (12) into sealing engagement with a seat (11) provided on the valve body (2) in order to close the flow passage (9) to fluid flow. The valve body (2) and diaphragm (12) are formed as a disposable assembly having a relatively less flexible region which forms a valve seat (11) and a relatively more flexible region (12) which forms the diaphragm which may be forced into engagement with the valve seat (11) to close the flow passage (9) to fluid flow, and a housing (3) is provided for mechanically supporting the region of the valve body in which the seat area is defined.

Abstract translation: 一种包括阀体（2）的隔膜阀（1）; 隔膜（12），其被密封到阀体（2）以限定在由阀体（2）限定的入口（7）和出口（8）之间延伸的流动通道（9）; 以及固定到所述阀体（2）的操作机构，用于使所述隔膜（12）与设置在所述阀体（2）上的阀座（11）密封接合，以便将所述流路（9）关闭成流体流动。 阀体（2）和隔膜（12）形成为具有相对较小柔性区域的一次性组件，其形成阀座（11）和形成隔膜的相对更柔性的区域（12），该区域可能被迫接合 其中阀座（11）将流动通道（9）关闭以流体流动，并且提供壳体（3）用于机械地支撑限定了座椅区域的阀体的区域。

公开(公告)号：US20060258920A1

公开(公告)日：2006-11-16

申请号：US11460191

申请日：2006-07-26

Applicant: John Burd ,  Paul Williams

Inventor： John Burd ,  Paul Williams

IPC: A61B5/00

CPC classification number: A61B5/6887 ,  A61B5/0002 ,  A61B5/14532

Abstract: A method of using a non-invasive analyte reading device to substantially continuously measure the presence, absence, or concentration of one or more analytes in a tissue of a subject includes wearing the non-invasive analyte reading device constantly or for at least the duration of the desired measurement period; and using the non-invasive analyte reading device to non-invasively measure the presence, absence, or concentration of one or more analytes in a tissue of a subject substantially continuously.

Abstract translation: 使用非侵入性分析物读取装置基本上连续地测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括不间断佩戴非侵入性分析物读取装置或至少持续 期望的测量周期; 并且使用非侵入性分析物读取装置基本连续不间断地测量受试者组织中一种或多种分析物的存在，不存在或浓度。

公开(公告)号：US20060258918A1

公开(公告)日：2006-11-16

申请号：US11460173

申请日：2006-07-26

Applicant: John Burd ,  Paul Williams

Inventor： John Burd ,  Paul Williams

IPC: A61B5/00

CPC classification number: A61B5/6887 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1455

Abstract: A combination non-invasive analyte reading and sample analyte reading device for both non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject and measuring the presence, absence, or concentration of one or more analytes in a biological sample of a subject includes a device housing; one or more outputs carried by the device housing; one or more inputs carried by the device housing to control operation of the device; a non-invasive analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a tissue of a subject; and a sample analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a biological sample of a subject.

Abstract translation: 非侵入性分析物读数和样品分析物读取装置的组合，用于非侵入性地测量受试者组织中一种或多种分析物的存在，不存在或浓度，并测量一种或多种分析物的存在，不存在或浓度 在受试者的生物样品中包括装置壳体; 由设备外壳承载的一个或多个输出; 由设备外壳承载的一个或多个输入以控制设备的操作; 一种非侵入式分析物读取器，由该装置壳体承载并被配置成测量受试者的组织中一种或多种分析物的存在，不存在或集中; 以及由所述装置容纳并被配置为测量受试者的生物样品中一种或多种分析物的存在，不存在或浓缩的样品分析物读取器。

公开(公告)号：US20060258917A1

公开(公告)日：2006-11-16

申请号：US11460162

申请日：2006-07-26

Applicant: John Burd ,  Paul Williams ,  William Sell

Inventor： John Burd ,  Paul Williams ,  William Sell

IPC: A61B5/00 ,  G06Q99/00 ,  G06F17/00

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/6887

Abstract: An apparatus and method of use for enabling a NAM device are provided. The NAM device is configured to authenticate its use each time a measurement is requested. The operation of the NAM device is governed by a refillable media card that tracks a predetermined number of authorized uses. The NAM device confirms that remaining authorized uses are available on the refillable media card. In addition to tracking the number of authorized uses of the NAM device, the media card may also store the results of the measurements for tracking by a tracking server. When the number of authorized uses on the media card is depleted, the media card may be refilled by completing a refill transaction over a wired or wireless communication network. Alternatively, the media card may be refilled at a kiosk station or a new media card may be obtained for use with the NAM device.

Abstract translation: 提供了一种用于启用NAM设备的设备和方法。 NAM设备被配置为在每次请求测量时验证其使用。 NAM设备的操作由跟踪预定数量的授权用途的可再填充媒体卡控制。 NAM设备确认剩余的授权用途在可再充装的媒体卡上可用。 除了跟踪NAM设备的授权使用的数量之外，媒体卡还可以存储跟踪服务器进行跟踪的测量结果。 当媒体卡上的授权用途数量被耗尽时，可以通过在有线或无线通信网络上完成再填充交易来重新填充媒体卡。 或者，媒体卡可以在报亭站重新填充，或者可以获得与NAM设备一起使用的新媒体卡。

公开(公告)号：US20060006188A1

公开(公告)日：2006-01-12

申请号：US10886441

申请日：2004-07-06

Applicant: Paul Williams

Inventor： Paul Williams

IPC: B65D51/04

CPC classification number: B65F1/16 ,  Y10S220/908

Abstract: A removable cover assembly for a refuse container has a frame with pivotable plastic covers and retractable hoisting pins, which can be utilized using the same hoisting apparatus as is used for the refuse container.

Abstract translation: 用于垃圾容器的可拆卸盖组件具有带有可枢转的塑料盖和可收回的提升销的框架，其可以使用与用于垃圾容器的相同的提升装置来使用。

公开(公告)号：US20050175979A1

公开(公告)日：2005-08-11

申请号：US10504036

申请日：2003-02-26

Applicant: Paul Williams

Inventor： Paul Williams

IPC: C12Q1/00 ,  G01N15/14 ,  G01N33/50

CPC classification number: G01N15/1459 ,  G01N33/5005 ,  G01N33/5094 ,  G01N2015/1486 ,  G01N2015/149

Abstract: The invention concerns a method for determining the absolute cell count of an identifiable cell sub-population contained in a sample by introducing into an aliquot of said biological sample a pre-determined amount of a fluid reagent comprising a known concentration of fixed and labelled cells; then using flow cytometry to determine an absolute cell count of said cell sub-population.

Abstract translation: 本发明涉及一种用于通过将包含已知浓度的固定和标记细胞的预定量的流体试剂引入到所述生物样品的等分试样中来确定样品中包含的可鉴定细胞亚群的绝对细胞计数的方法; 然后使用流式细胞术来确定所述细胞亚群的绝对细胞计数。

公开(公告)号：US06521263B1

公开(公告)日：2003-02-18

申请号：US09830738

申请日：2001-06-25

Applicant: David Idris Pritchard ,  Paul Williams

Inventor： David Idris Pritchard ,  Paul Williams

IPC: A61K3556

CPC classification number: A61K35/62

Abstract: An immunosuppressive agent, obtainable from the nematode Heligmosomoides polygyrus, characterised in that the agent has a molecular weight of less than 12 kDa, is resistant to proteinase K and is not bound to a polypeptide.

Abstract translation: 可从线虫Heligmosomoides polygyrus获得的免疫抑制剂，其特征在于该试剂的分子量小于12kDa，对蛋白酶K具有抗性，并且不与多肽结合。