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公开(公告)号:US20110183867A1
公开(公告)日:2011-07-28
申请号:US12672528
申请日:2008-08-07
申请人: Martyn Christopher Davies , Morgan Alexander , Paul Williams , Robert Langer , Daniel Anderson , Andrew Urquhart
发明人: Martyn Christopher Davies , Morgan Alexander , Paul Williams , Robert Langer , Daniel Anderson , Andrew Urquhart
CPC分类号: C40B50/14 , B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00691 , B01J2219/00711 , B01J2219/00716 , B01J2219/00736 , B01J2219/00743 , B82Y30/00 , C12Q1/04
摘要: This invention relates to a method of screening arrays of polymers having pre-determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation.
摘要翻译: 本发明涉及一种筛选具有预定表面能的聚合物阵列的方法。 本发明的聚合物阵列可用于筛选微生物附着。 更具体地,阵列可用于筛选特定细菌或真菌对阵列中特定聚合物的粘附。 此外,本发明涉及将原位聚合物合成与所得聚合物阵列的物理化学表征和随后的细菌或真菌粘附的生物测定相结合的方法。 这允许对细菌或真菌粘附不敏感的候选聚合物进行高通量筛选和表征,或者可以在需要这些聚合物的情况下用于支持细菌或真菌附着。 阵列也可用于筛选抑制或促进生物膜形成。
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公开(公告)号:US09981068B2
公开(公告)日:2018-05-29
申请号:US14115451
申请日:2012-05-04
申请人: Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
发明人: Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
IPC分类号: A61L29/16 , A01N37/12 , A01N37/20 , A61L29/08 , A61L31/14 , A61L31/10 , A61L27/50 , A61L27/34 , A61L29/14 , C08F220/56 , C08F220/24 , C08F220/18 , C08F220/22 , C08F222/10
CPC分类号: A61L29/16 , A01N37/12 , A01N37/20 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F220/18 , C08F220/22 , C08F220/24 , C08F220/56 , C08F222/1006 , C08L33/08 , C08L33/10 , C08L33/26 , A01N25/10 , A01N25/34
摘要: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR (I) [H2C═CR′—C(═O)—NH—]nR (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
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公开(公告)号:US20140314826A1
公开(公告)日:2014-10-23
申请号:US14115451
申请日:2012-05-04
申请人: Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
发明人: Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
CPC分类号: A61L29/16 , A01N37/12 , A01N37/20 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F220/18 , C08F220/22 , C08F220/24 , C08F220/56 , C08F222/1006 , C08L33/08 , C08L33/10 , C08L33/26 , A01N25/10 , A01N25/34
摘要: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR (I) [H2C═CR′—C(═O)—NH—]nR (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
摘要翻译: 本发明提供了抑制细菌附着于表面的方法,该方法包括由聚合物形成表面,或将聚合物施用于表面,其中聚合物是由(甲基)丙烯酸酯或(甲基)丙烯酰胺单体形成的均聚物 或由一种或多种(甲基)丙烯酸酯或(甲基)丙烯酰胺单体形成的共聚物,其中(甲基)丙烯酸酯或(甲基)丙烯酰胺单体为式(I)或(II):[H 2C≡CR'-C 其中n为1,2或3,R'独立地为H或CH 3,R为(C 1 -C 6) 总共具有2至24个碳原子的有机基团,其中有机基团包括脂族或芳族烃部分,并且其中有机基团不包括任何羟基。
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公开(公告)号:US06924338B1
公开(公告)日:2005-08-02
申请号:US10110546
申请日:2000-10-16
IPC分类号: G02C7/04 , A61L27/00 , A61L27/34 , A61L33/06 , C08J7/04 , C08L33/00 , C08L33/14 , C08L43/00 , C08L101/00 , C09D133/04 , C09D133/24 , C09D143/02 , C09D157/00 , C08L27/10 , C08L33/04 , C08L39/04 , C08L45/00
CPC分类号: A61L27/34 , A61L33/062 , C08L33/00 , C08L33/14 , A61L27/26 , C08L101/02 , C08L33/10 , C08L2666/04
摘要: A polymer blend for use in a biomedical application comprising: (A) a polymer A, bearing zwitterionic pendant groups; and (B) a hydrophobic addition polymer B, selected from the group consisting silyl(alk)acrylates, alkyl(alk)acrylamides, dialkyl(alk)acrylamides, and alkyl(alk)acrylate polymers, wherein the structure of the blend exhibits phase separation forming a micro-phase segregated structure at a surface. Articles, methods of production and liquid blend compositions are also disclosed. Preferably A is a copolymer of 15 to 30 mole % 2-methacryloyloxyethy1-2-trimethylammonium ethyl phosphate inner salt and 85 to 70 mole % of a C6-18 alkyl methacrylate, and B is a homopolymer of a C4-18 alkyl(meth)acrylate, blended in weight proportions of 1:1 to 1:50.
摘要翻译: 一种用于生物医学应用的聚合物共混物,其包含:(A)具有两性离子侧基的聚合物A; 和(B)疏水加成聚合物B,其选自甲硅烷基(alk)丙烯酸酯,烷基(alk)丙烯酰胺,二烷基(alk)丙烯酰胺和烷基(alk)丙烯酸酯聚合物,其中共混物的结构表现出相分离 在表面形成微相分离结构。 还公开了制品,生产方法和液体共混组合物。 A优选为15〜30摩尔%2-甲基丙烯酰氧基乙基)-2-三甲基铵乙基磷酸内酯盐和85〜70摩尔%甲基丙烯酸C 18-18烷基酯的共聚物,B为均聚物 (甲基)丙烯酸C 4-18烷基酯,其重量比例为1:1至1:50。
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