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58 条记录 (耗时 0.034 秒)

    TRP/HIS Exchange and Kynurenine Induced TRP Transport
    41.
    发明申请
    TRP/HIS Exchange and Kynurenine Induced TRP Transport 失效
    TRP / HIS交换和Kynurenine诱导的TRP运输

    公开(公告)号：US20080227140A1

    公开(公告)日：2008-09-18

    申请号：US12040524

    申请日：2008-02-29

    申请人： Thijs Kaper ,  Michael Platten ,  Lawrence Steinman ,  Wolf Frommer

    发明人： Thijs Kaper ,  Michael Platten ,  Lawrence Steinman ,  Wolf Frommer

    IPC分类号： C12Q1/02 ,  C12N5/06

    CPC分类号： G01N33/6872 ,  G01N33/5008 ,  G01N2333/70596 ,  G01N2800/24

    摘要： The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.

    摘要翻译： 本发明提供了用于检测细胞中色氨酸浓度变化的方法以及鉴定调节细胞色氨酸浓度的试剂的方法。 特别地，本发明提供了检测色氨酸和犬尿氨酸之间的细胞交换的方法，以及用于鉴定调节该交换的试剂的方法。 本发明还提供了在有需要的受试者中治疗与免疫抑制相关的疾病的方法。 特别地，本发明涉及一种治疗与免疫抑制相关的疾病的方法，其包括将疾病与调节细胞Trp /犬尿苷交换的药物接触。 此外，本发明提供了鉴定调节免疫抑制的药剂的方法。

    Antibody profiling for determination of patient responsiveness
    42.
    发明申请
    Antibody profiling for determination of patient responsiveness 审中-公开
    用于确定患者反应性的抗体谱

    公开(公告)号：US20080026485A1

    公开(公告)日：2008-01-31

    申请号：US11788232

    申请日：2007-04-18

    申请人： Wolfgang Hueber ,  William Robinson ,  Lawrence Steinman ,  Paul Utz ,  Mark Genovese

    发明人： Wolfgang Hueber ,  William Robinson ,  Lawrence Steinman ,  Paul Utz ,  Mark Genovese

    IPC分类号： G01N33/564

    CPC分类号： G01N33/6869 ,  G01N33/564 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2333/522 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2333/545 ,  G01N2800/102 ,  G01N2800/52

    摘要： Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of circulating blood levels of serum autoantibodies and/or cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Additionally, serum autoantibody and/or cytokine signature patterns can be utilized to monitor responses to therapy. Assessment of this signature pattern of autoantibodies and/or cytokines in a patient thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.

    摘要翻译： 提供组合物和方法用于将自身免疫性疾病患者预后分类为亚型，其中亚型对患者对治疗的需要和对感兴趣的治疗的反应性提供信息。 血清自身抗体和/或细胞因子的循环血液水平的模式提供了可以识别可能受益于治疗性干预的患者的签名模式，以及将具有低概率的那些对治疗具有高反应性概率的患者区分开来 的反应。 另外，可以利用血清自身抗体和/或细胞因子特征图来监测对治疗的反应。 因此，患者自身抗体和/或细胞因子的这种特征图案的评估因此允许改进的护理方法。 在本发明的一个实施方案中，自身免疫性疾病是类风湿性关节炎。

    T-cell receptor varible transcripts as disease related markers
    49.
    发明授权
    T-cell receptor varible transcripts as disease related markers 失效
    T细胞受体可变转录物作为疾病相关标志物

    公开(公告)号：US5667967A

    公开(公告)日：1997-09-16

    申请号：US66325

    申请日：1993-05-21

    申请人： Lawrence Steinman ,  Jorge Oksenberg ,  Claude Bernard

    发明人： Lawrence Steinman ,  Jorge Oksenberg ,  Claude Bernard

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  G01N2800/285

    摘要： Methods are provided for determining relations between autoimmune degenerative diseases and specific variable regions of T-cell receptors as associated with the host HLA or T-cells associated with umbatting neoprofilerative diseases. By identifying the particular T-cell receptors which cause or are the disease in mammals, various prophylactic and therapeutic techniques may be employed for inhibiting the attack of the T-cell receptors on the native protein or tissue enhance the defense. In addition, individuals may be diagnosed as to their propensity for a particular autoimmune disease or the occurrence of such a disease.

    摘要翻译： 提供了用于确定自身免疫性退行性疾病与T细胞受体的特异性可变区之间的关系的方法，所述T细胞受体与与神经调节性新生儿疾病相关的宿主HLA或T细胞相关。 通过鉴定在哺乳动物中引起或者是疾病的特定T细胞受体，可以采用各种预防和治疗技术来抑制天然蛋白质或组织上的T细胞受体的攻击增强了防御性。 此外，个体可能被诊断为其对特定自身免疫疾病的倾向或这种疾病的发生。

    Polypeptide pertussis toxin vaccine
    50.
    发明授权
    Polypeptide pertussis toxin vaccine 失效
    多肽百日咳毒素疫苗

    公开(公告)号：US5000952A

    公开(公告)日：1991-03-19

    申请号：US227372

    申请日：1988-08-02

    申请人： Lawrence Steinman ,  Jorge R. Oksenberg ,  Gary K. Schoolnik ,  Amrit K. Judd

    发明人： Lawrence Steinman ,  Jorge R. Oksenberg ,  Gary K. Schoolnik ,  Amrit K. Judd

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/10 ,  A61P37/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/195 ,  C07K14/235 ,  C07K14/41 ,  C07K16/12 ,  G01N33/50 ,  G01N33/569

    CPC分类号： C07K16/1225 ,  C07K14/235 ,  G01N33/505 ,  A61K39/00

    摘要： A novel method of defining oligopeptides is provided for determining useful immunodominant sequences for use as vaccines for pathogens. The method involves identifying sequences by particular selection procedures and using such sequences with antigen-presenting cells and T-cells to demonstrate activation of the common histocompatibility antigens DQ and DR in humans and their analogs in other animals. The oligopeptides may then be used individually or in combination to produce safe and effective vaccines, where genes may be prepared encoding the oligopeptides and used for expression of the oligopeptides or combinations of the oligopeptides or the gene transformed into the appropriate host, e.g., B. pertussis, for use as a vaccine to the intact organism.

    摘要翻译： 提供了一种定义寡肽的新方法，用于确定用作病原体疫苗的有用的免疫显性序列。 该方法包括通过特定选择程序鉴定序列，并使用具有抗原呈递细胞和T细胞的这些序列来证明人及其他动物中人类及其类似物中常见的组织相容性抗原DQ和DR的活化。 然后可以单独或组合使用寡肽以产生安全和有效的疫苗，其中可以制备编码寡肽的基因并用于表达寡肽或寡肽或转化到合适宿主例如B中的基因的组合。 百日咳，用作完整生物体的疫苗。