公开(公告)号：US06727271B2

公开(公告)日：2004-04-27

申请号：US10081075

申请日：2002-02-22

申请人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： A61K3142

CPC分类号： C07D263/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

摘要翻译： 提供具有结构的化合物，其中Q是C或N，A是O或S，Z是O或键，X是CH或N和R 1，R 2，R 2a，R 2b R 2，R 3，R 3，Y，x，m和n如本文所定义，该化合物可用作抗糖尿病，降血脂药和抗肥胖剂。

公开(公告)号：US06653314B2

公开(公告)日：2003-11-25

申请号：US10080981

申请日：2002-02-22

申请人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： A61K31505

CPC分类号： C07D263/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

摘要翻译： 提供具有结构的化合物，其中Q是C或N，A是O或S，Z是O或键，X是CH或N和R 1，R 2，R 2a，R 2b >，R 2c，R 3，Y，x，m和n如本文所定义，该化合物可用作抗糖尿病，降血脂药和抗肥胖剂。

公开(公告)号：USD410449S

公开(公告)日：1999-06-01

申请号：US88914

申请日：1998-06-03

申请人： Sean Chen

设计人： Sean Chen

公开(公告)号：US10099182B2

公开(公告)日：2018-10-16

申请号：US12842193

申请日：2010-07-23

申请人： James Huang ,  Sean Chen ,  Radium Huang ,  Jeff Han

发明人： James Huang ,  Sean Chen ,  Radium Huang ,  Jeff Han

IPC分类号： B01D69/02 ,  B01D39/16 ,  B01D61/32 ,  B01D69/10 ,  B01D71/26 ,  B01D71/36 ,  F21S4/00 ,  H05K5/03 ,  B29K105/04 ,  B29L31/00

摘要： Disclosed is a water-proof and dust-proof membrane assembly and applications thereof. The water-proof and dust-proof membrane assembly comprises a body and a supporting member. The body is of membrane and has a first surface, a second surface, and an asymmetric porous structure formed between the first surface and the second surface of the body. The asymmetric porous structure has a thickness ranging between 1 μm and 1000 μm, a first volumetric porosity ranging between 5% and 99%. The asymmetric porous structure has plural pores, and each pore has a pore diameter between 0.01 μm and 15 μm. The supporting member is of a polymeric material and has a first contacting surface, a second contacting surface, and a second volumetric porosity which is greater than the first volumetric porosity. The first contacting surface of the supporting member is adhered to the first surface of the body.

公开(公告)号：US09306446B2

公开(公告)日：2016-04-05

申请号：US13708741

申请日：2012-12-07

申请人： Hong Zhang ,  Sean Chen ,  Dilip Sangam ,  Wenbo Liang

发明人： Hong Zhang ,  Sean Chen ,  Dilip Sangam ,  Wenbo Liang

IPC分类号： H02M1/32 ,  H02M3/335 ,  H02H3/24 ,  H02H7/12 ,  H02M1/36

CPC分类号： H02M1/32 ,  H02H3/243 ,  H02H7/1213 ,  H02M1/36 ,  H02M3/335

摘要： A fault protection and correction circuit for the control of a power converter is disclosed. An example circuit generates a waveform that drives a switch on or off and controls the power converter. The controller circuit in addition to power factor correction (PFC) circuitry includes a first and a second shut down mode modules, both of them cause the switching to stop. The circuit includes a module for receiving fault events. When a fault occurs, the controller enters the second shut down mode. The controller stays in the second shut down mode if the required current for this mode can be provided by the outside circuitry. Otherwise, the controller enters the first shut down mode that requires less current and subsequently restarts the controller. By modifying the outside circuitry the controller can respond differently to fault events.

摘要翻译： 公开了一种用于控制功率转换器的故障保护和校正电路。 示例电路产生驱动开关打开或关闭并控制功率转换器的波形。 除了功率因数校正（PFC）电路之外，控制器电路包括第一和第二关断模式模块，它们都导致切换停止。 该电路包括用于接收故障事件的模块。 当发生故障时，控制器进入第二个关闭模式。 如果外部电路可以提供该模式所需的电流，则控制器保持在第二关闭模式。 否则，控制器进入需要较少电流的第一关闭模式，然后重新启动控制器。 通过修改外部电路，控制器可以对故障事件做出不同的响应。

公开(公告)号：US08614332B2

公开(公告)日：2013-12-24

申请号：US13397123

申请日：2012-02-15

申请人： Denis E. Ryono ,  Peter T. W. Cheng ,  Scott A. Bolton ,  Sean Chen ,  Yan Shi ,  Wei Meng ,  Joseph A. Tino ,  Richard B. Sulsky

发明人： Denis E. Ryono ,  Peter T. W. Cheng ,  Scott A. Bolton ,  Sean Chen ,  Yan Shi ,  Wei Meng ,  Joseph A. Tino ,  Richard B. Sulsky

IPC分类号： C07D231/00

CPC分类号： C07F9/6539 ,  C07F9/58 ,  C07F9/65031 ,  C07F9/650952 ,  C07F9/6518

摘要： Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—PO(OR7)R9, —(CH2)n—Z—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

摘要翻译： 提供了膦酸酯和次膦酸酯活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且其结构是杂芳基环; R4是 - （CH2）nZ-（CH2）m-PO（OR7）（OR8）， - （CH2）nZ-（CH2）m-PO（OR7）R9， - （CH2）nZ-（CH2） （OR7）R9， - （CH2）nZ-（CH2）m-OPO（R9）（R10）或 - （CH2）nZ-（CH2）m-PO（R9）（R10） R5和R6独立地选自H，烷基和卤素; Y为R 7（CH 2）s或不存在; 并且X，n，Z，m，R 4，R 5，R 6，R 7和s如本文所定义; 或其药学上可接受的盐。 还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

公开(公告)号：US08530004B2

公开(公告)日：2013-09-10

申请号：US12732571

申请日：2010-03-26

申请人： James Huang ,  Sean Chen ,  Radium Huang

发明人： James Huang ,  Sean Chen ,  Radium Huang

IPC分类号： H05H1/00 ,  H05H1/32 ,  C08J7/18

CPC分类号： C25D5/18

摘要： Disclosed is a polymeric electret film as well as the method of manufacturing the same. The polymeric electret film comprises a polytetrafluoroethylene film and an electrode layer. The polytetrafluoroethylene film includes a porous layer, which has a porous structure. The porous structure has a pore diameter ranging between 0.01 μm and 5.0 μm and has a porosity ranging between 20% and 95%. The polytetrafluoroethylene film has a thickness ranging between 1 μm and 50 μm, and is preferably made of expanded porous polytetrafluoroethylene. The polymeric electret film has a surface potential ranging between 0.1 V and 1000 V.

摘要翻译： 公开了一种聚合物驻极体膜及其制造方法。 聚合物驻极体膜包括聚四氟乙烯膜和电极层。 聚四氟乙烯膜包括具有多孔结构的多孔层。 多孔结构的孔径在0.01μm和5.0μm之间，孔隙率在20％和95％之间。 聚四氟乙烯膜的厚度范围在1〜50μm之间，优选由膨胀的多孔聚四氟乙烯制成。 聚合物驻极体膜的表面电位范围为0.1V至1000V。

公开(公告)号：US08222285B2

公开(公告)日：2012-07-17

申请号：US12663807

申请日：2008-06-11

申请人： Sean Chen ,  Peter T. W. Cheng ,  Rebecca A. Smirk

发明人： Sean Chen ,  Peter T. W. Cheng ,  Rebecca A. Smirk

IPC分类号： A01N43/78 ,  A61K31/425

CPC分类号： C07D277/56 ,  C07D417/12 ,  C07D417/14 ,  C07F9/6539

摘要： Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R2 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or NR4; R3, R4, and R5 are as defined herein; R8 is aryl, heteroaryl, —PO(OR9)(OR10), —PO(OR9)R10 or —P(O)(R9)R10 (wherein R9 and R10 are as defined herein)/R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

摘要翻译： 提供作为葡糖激酶活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且具有其中在环中表示一个或两个双键的结构; R 1是烷基，芳基，芳烷基，杂芳基或杂芳基烷基; R2是烷基，芳基，芳基烷基，杂芳基或杂芳基烷基; R5如本文所定义; Z是O，S，S（O），S（O）2或NR5a; X是S，O，N，NR 3或CR 3; Y是NCR4或NR4; R3，R4和R5如本文所定义; R8是芳基，杂芳基，-PO（OR9）（OR10），-PO（OR9）R10或-P（O）（R9）R10（其中R9和R10如本文所定义）/ R6和R7独立地是H，卤素 ，或烷基; m为0或1; 和n为0至3，或其药学上可接受的盐。 还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

公开(公告)号：US08153677B2

公开(公告)日：2012-04-10

申请号：US13012351

申请日：2011-01-24

申请人： Denis E. Ryono ,  Peter T. W. Cheng ,  Scott A. Bolton ,  Sean Chen ,  Yan Shi ,  Wei Meng ,  Joseph A. Tino ,  Richard B. Sulsky

发明人： Denis E. Ryono ,  Peter T. W. Cheng ,  Scott A. Bolton ,  Sean Chen ,  Yan Shi ,  Wei Meng ,  Joseph A. Tino ,  Richard B. Sulsky

IPC分类号： A61K31/415

CPC分类号： C07F9/6539 ,  C07F9/58 ,  C07F9/65031 ,  C07F9/650952 ,  C07F9/6518

摘要： Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from hydrogen, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

摘要翻译： 提供了膦酸酯和次膦酸酯活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且其结构是杂芳基环; R4是 - （CH2）n-Z-（CH2）m-PO（OR7）（OR8）， - （CH2）nZ-（CH2）m-OPO（OR7）R9， - （CH2）nZ-（CH2） -OPO（R9）（R10）或 - （CH2）nZ-（CH2）m-PO（R9）（R10）; R5和R6独立地选自氢，烷基和卤素; Y为R 7（CH 2）s或不存在; 并且X，n，Z，m，R 4，R 5，R 6，R 7和s如本文所定义; 或其药学上可接受的盐。 还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

公开(公告)号：US07889744B2

公开(公告)日：2011-02-15

申请号：US11149631

申请日：2005-06-10

申请人： Sean Chen ,  Zesen Chen ,  Yongdong Zhao ,  Peter Chou

发明人： Sean Chen ,  Zesen Chen ,  Yongdong Zhao ,  Peter Chou

IPC分类号： H04L12/56 ,  H04L12/54

CPC分类号： H04L43/12 ,  H04L12/5601 ,  H04L2012/5626 ,  H04L2012/5636

摘要： A method and apparatus for automatic synchronization of monitoring points for a network management system (“NMS”) along a permanent virtual circuit (“PVC”) is disclosed. A NMS in an asynchronous transfer mode (“ATM”) network coupled to a plurality of ATM switches is operative to monitor each of the plurality of ATM switches storied in a monitoring service object corresponding to a PVC. The NMS receives at least one notification from at least one ATM switch of the plurality of ATM switches indicating an ATM switch has been added or removed from the PVC. In response to the at least notification, the NMS adds at least one ATM switch to the monitoring service object or removes at least one ATM switch from the monitoring service object.

摘要翻译： 公开了一种用于沿着永久虚拟电路（“PVC”）的网络管理系统（“NMS”）的监视点的自动同步的方法和装置。 耦合到多个ATM交换机的异步传输模式（“ATM”）网络中的NMS可操作以监视存储在对应于PVC的监控服务对象中的多个ATM交换机中的每一个。 NMS从多个ATM交换机中的至少一个ATM交换机接收至少一个通知，指示已经从PVC添加或移除了ATM交换机。 响应于至少通知，NMS向监控服务对象添加至少一个ATM交换机，或从监控服务对象中移除至少一个ATM交换机。