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公开(公告)号：US06623700B1
公开(公告)日：2003-09-23
申请号：US09721386
申请日：2000-11-22
IPC分类号： B01L302
CPC分类号： B41J2/17566 , B41J2/1714 , Y10T436/2575
摘要： A level control mechanism is provided for a biofluid drop ejection device which ejects biofluid drops in small volumes. The biofluid drop device includes a drop ejection mechanism having a transducer which generates energy used to emit the biofluid drops. A reagent cartridge or biofluid holding area holds a biofluid, isolated from the drop ejection mechanism to avoid contamination between the biofluid drop ejection mechanism and the reagent cartridge. The reagent cartridge is connected to the drop ejection mechanism such that upon operation of the mechanism, the biofluid is emitted in controlled biofluid drops. A level sensor is positioned to sense a height of the biofluid within the cartridge. Upon sensing the height of the biofluid below a certain level, an adjustment is made to the height by providing at least one of additional biofluid to the cartridge, and raising the level of the entire reagent cartridge.
摘要翻译： 为生物流体液滴喷射装置提供液面控制机构，其以小体积喷射生物流体液滴。 生物流体液滴装置包括液滴喷射机构，其具有产生用于发射生物流体滴的能量的换能器。 试剂盒或生物流体保持区域保持与液滴喷射机构隔离的生物流体，以避免生物流体液滴喷射机构和试剂盒之间的污染。 试剂盒连接到液滴喷射机构，使得在机构操作时，生物流体在受控的生物流体滴下发射。 水平传感器被定位成感测盒内的生物流体的高度。 当感测到生物流体的高度低于一定水平时，通过向盒提供至少一种额外的生物流体，并提高整个试剂盒的水平来调节高度。
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公开(公告)号：US06525136B1
公开(公告)日：2003-02-25
申请号：US09920926
申请日：2001-08-02
申请人： Daniel A. Foucher , Jaan Noolandi , James H. Sharp
发明人： Daniel A. Foucher , Jaan Noolandi , James H. Sharp
IPC分类号： C08L5300
CPC分类号： G03G9/0926 , C08F8/30 , C08F257/02 , C08F265/04 , C08F269/00 , C08F271/02 , C08F287/00 , C08F291/00 , C08L51/003 , C08L51/006 , G03G9/0906 , C08L2666/02
摘要： Disclosed is a composition comprising a matrix which comprises particles comprising a core resin and a shell resin thereover, wherein at least one of the core resin and the shell resin contains a chelating agent and a spiropyran compound of the formula wherein n is an integer representing the number of repeat —CH2— units and R is —H or —CH═CH2, wherein the shell resin is the continuous phase of the matrix, wherein the spiropyran compound can produce changes in the optical and photoactive properties of the resin containing the spiropyran when irradiated.
摘要翻译： 公开了一种组合物，其包含基质，其包含包含芯树脂和其上的壳树脂的颗粒，其中核心树脂和壳树脂中的至少一个含有螯合剂，并且所述糠醛的螺吡喃化合物是表示数字的整数 的重复-CH 2 - 单元，并且R是-H或-CH = CH 2，其中壳树脂是基质的连续相，其中当被照射时，螺吡喃化合物可以产生含有螺吡喃的树脂的光学和光活性 。
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公开(公告)号：US06514704B2
公开(公告)日：2003-02-04
申请号：US09773804
申请日：2001-02-01
申请人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
发明人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
IPC分类号： C12Q168
CPC分类号： G01N35/10 , G01N35/00712 , G01N35/1009 , G01N2035/1037 , G06F19/00
摘要： A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.
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公开(公告)号：US06503454B1
公开(公告)日：2003-01-07
申请号：US09721389
申请日：2000-11-22
IPC分类号： B01L302
CPC分类号： B01L3/0268 , G01N2035/1039 , Y10T436/2575
摘要： A multiple-ejector system for printing arrays of biofluids include a tooling plate having a plurality of sets of tooling pins extending outward from the surface of the tooling plate. A printed circuit board is provided having pairs of power connection pins and ground return pins extending from a surface of the circuit board. A plurality of biofluid drop ejection units are provided and include alignment grooves and at least a transducer. Each of the plurality of biofluid drop ejection units are connected to a corresponding one of a set of tooling pins by connection of the tooling pins and alignment grooves. The power connection pins of the pairs are in operational connection with respective transducers and the ground return connection pins of the pairs are in operational connection with a body portion of the drop ejection units. The different drop ejection units will contain different biofluids which are to be emitted onto a substrate. Verification of drop ejection units containing biofluids, may be obtained in one embodiment through the use of an optical scanner. Detection of drops at defined locations provides a verification that validates a properly formed spot is present on a substrate, and is in the correct position.
摘要翻译： 用于打印生物流体阵列的多喷射器系统包括具有从工具板的表面向外延伸的多组工具销的工具板。 提供一个印刷电路板，其具有从电路板的表面延伸的成对的电源连接引脚和接地返回引脚。 提供多个生物流体液滴喷射单元，并且包括对准凹槽和至少一个换能器。 多个生物流体滴落喷射单元中的每一个通过工具销和对准槽的连接连接到一组加工销中的对应的一个。 成对的电源连接引脚与相应的换能器操作连接，并且对的接地返回连接引脚与液滴喷射单元的主体部分操作连接。 不同的液滴喷射单元将包含将被发射到基底上的不同生物流体。 通过使用光学扫描仪可以在一个实施例中获得包含生物流体的液滴喷射单元的验证。 在限定位置处检测液滴提供验证，验证正确形成的斑点存在于基底上，并处于正确的位置。
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公开(公告)号：US6146798A
公开(公告)日：2000-11-14
申请号：US222921
申请日：1998-12-30
CPC分类号： B41C1/1041 , B41C1/1058
摘要： The present invention is a method and system for lithographic printing by controlling the surface energy of a printing plate to affect the hydrophilic and hydrophobic properties of the printing plate. These properties enable the ink to be applied to the printing plate in an image-wise manner and provides for rapid production of images on a recording medium. The lithographic printing plate may be rewritten repeatedly between printing jobs or may even be rewritten between individual recording media.
摘要翻译： 本发明是通过控制印版的表面能来影响印版的亲水性和疏水性的方法和系统。 这些特性使油墨能够以图像方式施加到印版上，并且可以在记录介质上快速生成图像。 平版印刷版可以在打印作业之间重复重写，或者甚至可以在各个记录介质之间重写。
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公开(公告)号：US5952131A
公开(公告)日：1999-09-14
申请号：US67067
申请日：1998-04-27
申请人： Eugenia Kumacheva , Jaan Noolandi , Olga Kalinina
发明人： Eugenia Kumacheva , Jaan Noolandi , Olga Kalinina
CPC分类号： B82Y10/00 , G11B7/24044 , G11B7/244 , G11B7/245 , G11B7/26 , G11B2007/0009 , G11B7/00455 , G11B7/24 , Y10S430/163
摘要： A composition including a matrix comprised of particles comprised of a core resin and a shell resin thereover, wherein the core resin contains a covalently bonded photosensitive compound, and wherein the shell resin is the continuous phase of the matrix.
摘要翻译： 一种组合物，其包含由芯树脂和其上的壳树脂构成的颗粒构成的基体，其中所述芯树脂含有共价键合的感光性化合物，并且其中所述壳树脂为所述基质的连续相。
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公开(公告)号：US20110182968A1
公开(公告)日：2011-07-28
申请号：US12928818
申请日：2010-12-20
申请人： David Myung , Christopher N. Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi , Laura Hartmann
发明人： David Myung , Christopher N. Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi , Laura Hartmann
IPC分类号： A61K9/00 , A61K35/12 , A61K38/02 , A61K38/16 , A61K31/197 , A61K31/70 , A61K31/7052 , A61K39/395 , A61K38/18 , A61P27/02
CPC分类号： A61F2/142 , A61L27/26 , A61L27/3804 , A61L27/3869 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/414 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C12N2533/50 , C12N2533/54 , C12N2535/10 , C08L33/08 , C08L71/02
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylamide, PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译： 本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。 这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酰胺，PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水单体是丙烯酸类单体。 任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。 该材料设计用作角膜假体。
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公开(公告)号：US20070233240A1
公开(公告)日：2007-10-04
申请号：US11725190
申请日：2007-03-16
申请人： Curtis Frank , Christopher Ta , David Myung , Jaan Noolandi , Michael Carrasco , Won-Gun Koh
发明人： Curtis Frank , Christopher Ta , David Myung , Jaan Noolandi , Michael Carrasco , Won-Gun Koh
IPC分类号： A61F2/16
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： The present invention provides a hydrogel-based intraocular lens (IOL) implant that can covalently attach to a lens capsule on implantation into an eye. The inventive IOL has a high refractive index, high elasticity, and is of a similar size to a naturally occurring lens. In addition, the IOL can be implanted in a smaller, dehydrated state, allowing the IOL to be placed in the lens capsule with a small incision (up to about 1/10 the volume of the IOL). Exposure to fluid can then initiate rapid swelling of the dried polymer to the shape and dimensions of a natural lens, with full occupation of the lens capsule. Upon equilibrium swelling, the IOL can then make contact with the inner aspect of the lens capsule and covalently bind to it. By this attachment process, the IOL may accommodate in a manner identical to that of the natural lens.
摘要翻译： 本发明提供一种水凝胶型眼内透镜（IOL）植入物，其可以植入眼睛中共价连接到晶状体囊。 本发明的IOL具有高折射率，高弹性，并且具有与天然存在的透镜相似的尺寸。 此外，IOL可以植入较小的脱水状态，允许IOL以小切口（高达IOL体积的约1/10）放置在晶状体囊中。 然后暴露于流体可以引发干燥的聚合物快速膨胀到天然晶状体的形状和尺寸，完全占据晶状体囊。 在平衡肿胀时，IOL然后可以与镜片胶囊的内部部分接触并共价结合。 通过该附接过程，IOL可以以与天然镜片相同的方式容纳。
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公开(公告)号：US20070126982A1
公开(公告)日：2007-06-07
申请号：US11636114
申请日：2006-12-07
申请人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
发明人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
IPC分类号： G02C7/04
摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译： 本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。 水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 遥爪大分子单体的分子量优选为约575Da至约20,000Da。 也可以使用分子量的混合物。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。 该材料被设计成用作隐形眼镜。
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50.发明申请Artificial biocompatible material as a support for cells in a retinal implant 审中-公开人造生物相容性材料作为视网膜植入物中的细胞的支持物公开(公告)号：US20050214345A1
公开(公告)日：2005-09-29
申请号：US11061171
申请日：2005-02-18
IPC分类号： A61F2/14 , A61K31/716
CPC分类号： A61F2/14 , A61F9/00 , A61F9/007 , C12N5/062 , C12N2533/30
摘要： A retinal implant is provided that uses an artificial biocompatible material as a support material on which retinal pigment epithelial cells, iris pigment epithelial cells, and/or stem cells can be deposited either in situ or in vivo. The support material has a surface topology that is rough to promote cell adhesion, has surface pits to allow pigment cells to grow into, and has pores to allow for proper diffusion of materials. The support material serves as a substrate for cell growth and as a patch for damaged basement membrane (Bruch's membrane). This cell-coated membrane or pigment cell-enriched membrane is surgically positioned in the sub-retinal space to rescue or restore photoreceptor cell function that may be damaged or threatened by degenerative diseases of the eye, such as age-related macular degeneration.
摘要翻译： 提供视网膜植入物，其使用人造生物相容性材料作为支架材料，视网膜色素上皮细胞，虹膜色素上皮细胞和/或干细胞可原位或体内沉积。 支撑材料具有粗糙的表面拓扑以促进细胞粘附，具有表面凹坑以允许颜料细胞生长并具有允许材料适当扩散的孔。 支撑材料用作细胞生长的底物和用作损伤的基底膜（布鲁赫氏膜）的贴剂。 这种细胞包被的膜或色素细胞富集的膜通过外科手术放置在视网膜下部空间中以挽救或恢复可能由于退行性疾病（如年龄相关性黄斑变性）而损伤或受到威胁的感光细胞功能。
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