公开(公告)号：US08706619B1

公开(公告)日：2014-04-22

申请号：US12823733

申请日：2010-06-25

申请人： Qiang Yu ,  David C. Jernberg ,  Joseph E. Magerramov

发明人： Qiang Yu ,  David C. Jernberg ,  Joseph E. Magerramov

IPC分类号： G06Q40/00 ,  G06Q10/06 ,  G06Q20/10 ,  G06F17/30 ,  G06F9/46

CPC分类号： G06Q40/12 ,  G06F9/466 ,  G06F9/526 ,  G06F17/30171 ,  G06F17/30362 ,  G06Q10/06 ,  G06Q20/10 ,  G06Q20/405 ,  G06Q40/00 ,  G06Q40/02

摘要： Disclosed are various embodiments for employing spillover tables to improve performance of data store updates. A request to update a data field is received, and if an exclusive lock on a data table cannot be obtained, the request is placed in a spillover table until the exclusive lock can be obtained. If the request causes a constraint on the data field to be violated or causes the data field to move closer to the constraint, the request is not placed in the spillover table. A spillover task can collapse entries in the spillover table into the data store when an exclusive lock can be obtained.

摘要翻译： 披露了采用溢出表来提高数据存储更新性能的各种实施例。 接收到更新数据字段的请求，如果不能获得对数据表的排他锁，则请求将被放置在溢出表中，直到可以获得排他锁。 如果请求导致对数据字段的约束被违反或导致数据字段更接近约束，则请求不会放置在溢出表中。 当可以获得排他锁时，溢出任务可以将溢出表中的条目折叠到数据存储中。

公开(公告)号：US20130210024A1

公开(公告)日：2013-08-15

申请号：US13879494

申请日：2011-10-14

申请人： Qiang Yu ,  Zhenlong Wu

发明人： Qiang Yu ,  Zhenlong Wu

IPC分类号： C12N9/00

CPC分类号： C12N9/93 ,  A61K31/122 ,  A61K31/337 ,  A61K31/36 ,  A61K31/404 ,  A61K31/475 ,  A61K31/506 ,  A61K31/517 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/713 ,  A61K33/24 ,  G01N2333/4703 ,  G01N2800/52 ,  A61K2300/00

摘要： The present technology relates to a method of treating cancer by sensitizing human tumours to DNA damaging therapies through activating FBXO32 expression. Transactivation of FBXO32 through the inhibition of EZH2, a histone methyltransferase, decreases p21 protein induction which results in the sensitization of human tumours to chemotherapy. The method further provides a prognostic method to determine if a combination treatment would be effective.

摘要翻译： 本技术涉及通过激活FBXO32表达使人肿瘤对DNA损伤疗法敏感来治疗癌症的方法。 FBXO32通过抑制组蛋白甲基转移酶EZH2的反式激活降低p21蛋白的诱导，导致人类肿瘤对化学疗法的敏化。 该方法还提供了一种预测方法来确定组合治疗是否有效。

公开(公告)号：USRE44070E1

公开(公告)日：2013-03-12

申请号：US13525252

申请日：2012-06-15

申请人： Qiang Yu ,  Weixin D. Song

发明人： Qiang Yu ,  Weixin D. Song

IPC分类号： B32B3/26 ,  B32B13/00 ,  C04B28/14

CPC分类号： C04B28/14 ,  C04B2111/0062 ,  Y02W30/97 ,  Y10T428/24479 ,  C04B14/42 ,  C04B18/24 ,  C04B22/16 ,  C04B24/226 ,  C04B24/383 ,  C04B2103/408

摘要： The invention provides a light weight composite gypsum board including a foamed low density set gypsum core, a top non-foamed (or reduced-foamed) bonding high density layer and a bottom non-foamed (or reduced-foamed) bonding high density layer, a top cover sheet bonded to the foamed low density set gypsum core by the top non-foamed (or reduced-foamed) bonding high density layer, and a bottom cover sheet bonded to the foamed low density set gypsum core by the bottom non-foamed (or reduced-foamed) bonding high density layer. The foamed low density set gypsum core is prepared having a density of less than about 30 pcf using soap foam in the gypsum-containing slurry. The combination of components provide a composite gypsum board having light weight and high strength.

摘要翻译： 本发明提供了一种重量轻的复合石膏板，其包括发泡低密度石膏芯，顶部非发泡（或还原发泡）键合高密度层和底部非发泡（或还原发泡）键合高密度层， 通过顶部非发泡（或还原发泡）键合高密度层与发泡的低密度凝固石膏芯结合的顶盖片，以及通过底部未发泡的，与发泡的低密度凝固石膏芯接合的底盖片 （或还原发泡）键合高密度层。 使用含石膏浆料中的肥皂泡沫，制备密度低于约30PCF的泡沫低密度凝固石膏芯。 组分的组合提供了重量轻且强度高的复合石膏板。

公开(公告)号：US08058258B2

公开(公告)日：2011-11-15

申请号：US12281470

申请日：2006-11-15

申请人： Qiang Yu ,  Jing Tan ,  Xiao Jing Yang

发明人： Qiang Yu ,  Jing Tan ,  Xiao Jing Yang

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： A61K31/519 ,  A61K31/52

摘要： The present invention relates to a method of inducing apoptosis in a tumour cell as well as modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of general formula (I). In general formula A is C or N. R1, R4 and R5 are, independently selected, H or aliphatic, cycloaliphatic aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0-3 heteroatoms being N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen, such as F or Cl. R3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1-8 main chain carbon atoms and 0-3 heteroatoms being N, O, S, Si, or a halogen such as Cl or F. Also provided is a pharmaceutical composition for inducing apoptosis in a tumour cell and/or modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The pharmaceutical composition comprises a compound as defined above or a pharmaceutically acceptable salt thereof and a carrier or diluent.

摘要翻译： 本发明涉及诱导肿瘤细胞凋亡的方法以及调节干细胞/祖细胞的多能性和/或自我更新特性。 该方法包括向各细胞施用通式（I）的化合物。 通式A是C或N.R 1，R 4和R 5独立地选自H或脂族，脂环族芳族，芳基脂族或芳基环脂族烃基，其包含0-3个杂原子是N，O，S或Si。 R 4和R 5可以任选连接以限定脂族烃基桥。 R2是H或卤素，例如F或Cl。 R 3是H，或包含1-8个主链碳原子和0-3个杂原子的脂族或芳基脂族烃基是N，O，S，Si或卤素如Cl或F.还提供了用于诱导 肿瘤细胞凋亡和/或调节干细胞/祖细胞的多能性和/或自我更新特性。 药物组合物包含如上所定义的化合物或其药学上可接受的盐和载体或稀释剂。

公开(公告)号：US20110237606A1

公开(公告)日：2011-09-29

申请号：US13121180

申请日：2009-09-25

申请人： Christina L. L. Chai ,  Eric K.W. Tam ,  Haiyan Yang ,  Qiang Yu ,  Tuan Minh Nguyen

发明人： Christina L. L. Chai ,  Eric K.W. Tam ,  Haiyan Yang ,  Qiang Yu ,  Tuan Minh Nguyen

IPC分类号： A61K31/52 ,  C07D473/00 ,  C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/52 ,  A61K31/7076 ,  C07D473/34 ,  C07H15/04

摘要： This invention describes the series of compounds based on the 3-deazaneplanocin A (DZNep) core structure designed to inhibit the function of Polycomb repressive complex 2 (PRC2) proteins.

摘要翻译： 本发明描述了基于设计用于抑制Polycomb抑制性复合物2（PRC2）蛋白的功能的3-脱氮吡哆醛A（DZNep）核心结构的一系列化合物。

公开(公告)号：US20110196090A1

公开(公告)日：2011-08-11

申请号：US13091369

申请日：2011-04-21

申请人： Xuming Wang ,  Qingxin Liu ,  Paul Reed ,  Qiang Yu

发明人： Xuming Wang ,  Qingxin Liu ,  Paul Reed ,  Qiang Yu

IPC分类号： C04B11/00

CPC分类号： C04B28/14 ,  C04B2111/0062 ,  C04B2111/27 ,  Y02W30/92 ,  Y10T428/31663 ,  Y10T442/665 ,  C04B18/08 ,  C04B20/0048 ,  C04B22/066 ,  C04B24/383 ,  C04B24/42 ,  C04B38/02 ,  C04B40/0028 ,  C04B2103/12 ,  C04B2103/22 ,  C04B2103/408 ,  C04B2103/67

摘要： Polymerization of siloxane is improved using a gypsum-based slurry that includes stucco, Class C fly ash, magnesium oxide and an emulsion of siloxane and water. This slurry is used in a method of making water-resistant gypsum articles that includes making an emulsion of siloxane and water, then combining the slurry with a dry mixture of stucco, magnesium oxide and Class C fly ash. The slurry is then shaped as desired and the stucco is allowed to set and the siloxane polymerizes. The resulting product is useful for making a water-resistant gypsum panel having a core that includes interwoven matrices of calcium sulfate dihydrate crystals and a silicone resin, where the interwoven matrices have dispersed throughout them a catalyst comprising magnesium oxide and components from a Class C fly ash.

公开(公告)号：US20080299413A1

公开(公告)日：2008-12-04

申请号：US11807980

申请日：2007-05-31

申请人： W. David Song ,  Mark H. Englert ,  Qiang Yu ,  Martin W. Brown ,  Richard B. Stevens

发明人： W. David Song ,  Mark H. Englert ,  Qiang Yu ,  Martin W. Brown ,  Richard B. Stevens

IPC分类号： B29D7/00 ,  B32B13/00 ,  B32B37/00 ,  C04B11/00 ,  C04B14/00

CPC分类号： B28B19/0092 ,  B32B2305/30 ,  B32B2307/10 ,  B32B2315/18 ,  B32B2607/00 ,  C04B14/185 ,  C04B28/145 ,  C04B2111/0062 ,  C04B2111/52 ,  Y10T442/20 ,  Y10T442/2738 ,  Y10T442/361 ,  Y10T442/665 ,  C04B20/002 ,  C04B20/0048 ,  C04B20/0076 ,  C04B22/16 ,  C04B24/38 ,  C04B2103/408 ,  C04B20/1018

摘要： The acoustical product of the present invention comprises an acoustical product including a matrix of calcium sulfate dihydrate crystals and expanded perlite distributed throughout the matrix. The expanded perlite has a particle size distribution with at least 10% of the perlite having a particle diameter of 700 microns or more, and the amount of expanded perlite to calcium sulfate dihydrate is about 35% to about 75% by weight, based upon the dry weight of the calcium sulfate dihydrate. A dispersing agent and glass fibers having a particle length of about ¼ inch to about 1 inch are dispersed throughout the gypsum matrix.

摘要翻译： 本发明的声学产品包括包含分布在整个基质中的硫酸钙二水合物晶体和膨胀珍珠岩基质的声学产物。 膨胀珍珠岩具有粒度分布，其中至少10％的珍珠岩具有700微米或更大的粒径，并且膨胀珍珠岩与硫酸钙二水合物的量为约35重量％至约75重量％，基于 硫酸钙二水合物的干重。 具有约1/4英寸至约1英寸的颗粒长度的分散剂和玻璃纤维分散在整个石膏基质中。

公开(公告)号：US20060278133A1

公开(公告)日：2006-12-14

申请号：US11449177

申请日：2006-06-07

申请人： Qiang Yu ,  Weixin Song ,  Michael Lynn

发明人： Qiang Yu ,  Weixin Song ,  Michael Lynn

IPC分类号： C04B28/14 ,  C04B11/00

CPC分类号： C04B11/00 ,  C04B22/16 ,  C04B24/226 ,  C04B24/383 ,  C04B28/14 ,  C04B2103/0045 ,  C04B2103/408 ,  C04B2111/0062 ,  Y02W30/97 ,  Y10T428/249953 ,  Y10T428/2978 ,  Y10T428/31971 ,  Y10T428/31993 ,  Y10T442/665 ,  C04B14/42 ,  C04B18/24

摘要： The invention generally provides gypsum-containing slurries including stucco, naphthalenesulfonate dispersant, and pregelatinized starch. The naphthalenesulfonate dispersant is present in an amount of about 0.1%-3.0% by weight based on the weight of dry stucco. The pregelatinized starch is present in an amount of at least about 0.5% by weight up to about 10% by weight of pregelatinized starch by weight based on the weight of dry stucco in the formulation. Other slurry additives can include trimetaphosphate salts, accelerators, binders, paper fiber, glass fiber, and other known ingredients. The invention also comprises the gypsum-containing products made with such slurries, for example, gypsum wallboard, and a method of making gypsum wallboard.

摘要翻译： 本发明通常提供含石膏，萘磺酸盐分散剂和预胶化淀粉的含石膏的浆料。 基于干灰泥的重量，萘磺酸盐分散剂的存在量为约0.1重量％至3.0重量％。 基于制剂中干灰泥的重量，预胶化淀粉的存在量为预胶化淀粉的至少约0.5重量％至多约10重量％。 其它浆料添加剂可以包括三偏磷酸盐，促进剂，粘合剂，纸纤维，玻璃纤维和其它已知成分。 本发明还包括用这种浆料制成的含石膏的产品，例如石膏墙板，以及制造石膏墙板的方法。

公开(公告)号：US06387172B1

公开(公告)日：2002-05-14

申请号：US09557636

申请日：2000-04-25

申请人： Qiang Yu ,  Srinivas Veeramasuneni ,  Frederick Thomas Jones

发明人： Qiang Yu ,  Srinivas Veeramasuneni ,  Frederick Thomas Jones

IPC分类号： C04B1100

CPC分类号： C04B28/147 ,  C04B2111/00068 ,  C04B2111/00612 ,  C04B2111/0062 ,  C04B2111/34 ,  C04B22/16 ,  C04B24/2641 ,  C04B2103/40

摘要： A set gypsum composition and methods for the preparation thereof are disclosed. The set gypsum composition comprises a continuous phase of interlocking set gypsum matrix having an enhanced water voids volume and/or is prepared from a mixture (e.g., slurry) comprising an elevated ratio of water to calcined gypsum. Also disclosed is an article comprising the set gypsum composition.

摘要翻译： 公开了一套集石膏组合物及其制备方法。 集合的石膏组合物包括具有增强的水空隙体积的互锁凝结石膏基质的连续相和/或由包含水与煅烧石膏的升高比例的混合物（例如浆料）制备。 还公开了包含所设置的石膏组合物的制品。

公开(公告)号：US09840066B2

公开(公告)日：2017-12-12

申请号：US11906479

申请日：2007-10-02

申请人： Qiang Yu ,  Weixin David Song

发明人： Qiang Yu ,  Weixin David Song

IPC分类号： B32B3/00 ,  B32B13/08 ,  B32B3/26 ,  B32B5/02 ,  B32B17/02 ,  B32B29/00 ,  C04B28/14 ,  B32B13/14 ,  C04B111/00 ,  C04B111/40

CPC分类号： B32B13/08 ,  B32B3/26 ,  B32B5/02 ,  B32B13/14 ,  B32B17/02 ,  B32B29/00 ,  C04B28/14 ,  C04B2111/0062 ,  C04B2111/40 ,  Y10T428/249968 ,  C04B22/16 ,  C04B24/226 ,  C04B24/383 ,  C04B2103/408

摘要： This invention provides gypsum wallboards with a unique microstructure where the walls between voids are enhanced in thickness and strength to substantially improve the strength and handling properties of the wallboards. A method of making lightweight gypsum wallboards is also provided.