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41.发明申请HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR 审中-公开人类胆固醇ACYLTRANSFERASE 2（DGAT2）家族成员及其用途公开(公告)号：US20070166748A1
公开(公告)日：2007-07-19
申请号：US11684365
申请日：2007-03-09
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection, with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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42.发明授权公开(公告)号：US07241585B2
公开(公告)日：2007-07-10
申请号：US10658904
申请日：2003-09-10
CPC分类号： C12N9/1205
摘要： The invention relates to a novel kinase nucleic acid sequence and protein. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译： 本发明涉及一种新的激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。
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公开(公告)号：US07235634B2
公开(公告)日：2007-06-26
申请号：US10767308
申请日：2004-01-29
IPC分类号： C07K14/00
CPC分类号： C12N9/48
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。
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44.发明授权Human protein kinase, phosphatase, and protease family members and uses thereof 失效人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途公开(公告)号：US07070947B2
公开(公告)日：2006-07-04
申请号：US10170789
申请日：2002-06-13
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
CPC分类号： C12N9/12 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/40 , C07K2319/00 , C12N9/1205 , C12N9/14 , C12N9/16 , C12N9/6424 , C12N9/6427 , C12N9/6437 , C12Q1/34 , C12Q1/44 , C12Y207/01001 , C12Y301/02015 , C12Y304/21004 , C12Y304/21021 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/6893 , G01N2500/00
摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, hexokinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族的分离的核酸分子，命名为2504,15977,14760,53070,15985,5042,56583,21953，m32404,14089和23436核酸分子 成员，己糖激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供了反义核酸分子，含有2504,15977,14760,53070,15985,5042,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 和非人类转基因动物，其中引入或破坏了2504,15977,14760,53070,15985,550365,26583,21953，m32404,14089或23436基因。 本发明还进一步提供分离的2504,15977,14760,53070,15985,5038,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗2504,15977,14760,53070,15985,50365， 26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07052888B2
公开(公告)日：2006-05-30
申请号：US09935290
申请日：2001-08-21
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。 本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。 本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US06703230B2
公开(公告)日：2004-03-09
申请号：US09973457
申请日：2001-10-09
IPC分类号： C12Q300
CPC分类号： C12N9/1048 , A61K38/00 , Y02A50/401
摘要： The invention provides isolated nucleic acids molecules, designated 47174 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47174 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47174 gene has been introduced or disrupted. The invention still further provides isolated 47174 proteins, fusion proteins, antigenic peptides and anti-47174 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods of modulating pain or pain related disorders utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing neurological disorders are disclosed.
摘要翻译： 本发明提供编码新的糖基转移酶家族成员的分离的核酸分子，命名为47174核酸分子。 本发明还提供了反义核酸分子，含有47174个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及47174基因导入或破坏的非人转基因动物。 本发明还进一步提供分离的47174蛋白，融合蛋白，抗原肽和抗-47174抗体。 还提供了利用本发明组合物的诊断方法。 本发明还提供利用本发明组合物调节疼痛或疼痛相关疾病的方法。 因此，公开了治疗，预防和/或诊断神经障碍的方法。
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公开(公告)号：US06607892B2
公开(公告)日：2003-08-19
申请号：US10121911
申请日：2002-04-12
IPC分类号： G01N3353
CPC分类号： C12N9/88
摘要： Novel adenylate cyclase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length adenylate cyclase proteins, the invention further provides isolated adenylate cyclase fusion proteins, antigenic peptides, and anti-adenylate cyclase antibodies. The invention also provides adenylate cyclase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an adenylate cyclase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US06444802B1
公开(公告)日：2002-09-03
申请号：US09409180
申请日：1999-09-30
IPC分类号： C07H2104
CPC分类号： C12N9/48 , A01K2217/05 , A61K38/00 , Y02A50/411 , Y10S435/81 , Y10S435/975
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。
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公开(公告)号：US06403358B1
公开(公告)日：2002-06-11
申请号：US09412210
申请日：1999-10-05
IPC分类号： C12N988
CPC分类号： C12N9/88
摘要： Novel adenylate cyclase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length adenylate cyclase proteins, the invention further provides isolated adenylate cyclase fusion proteins, antigenic peptides, and anti-adenylate cyclase antibodies. The invention also provides adenylate cyclase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an adenylate cyclase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US08399405B2
公开(公告)日：2013-03-19
申请号：US13366113
申请日：2012-02-03
申请人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
发明人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
CPC分类号： G01N33/5008 , C07K14/00 , C07K14/4705 , C07K14/4747 , C07K14/4748 , G01N2500/10
摘要： Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides; and methods of making and identifying such improved polypeptides.
摘要翻译： 具有相对于其对应的前体多肽具有改进性质的生物活性交联多肽; 以及制备和鉴定这些改良多肽的方法。
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