-
公开(公告)号:US20090124655A1
公开(公告)日:2009-05-14
申请号:US12269109
申请日:2008-11-12
申请人: Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Tara Leanne Hampton
发明人: Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Tara Leanne Hampton
IPC分类号: A61K31/47 , C07D217/00 , A61P25/00
CPC分类号: C07D417/14
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US07432290B2
公开(公告)日:2008-10-07
申请号:US10997810
申请日:2004-11-24
申请人: Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
发明人: Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
IPC分类号: A61K31/41 , A61K31/425 , C07D263/00 , C07D263/02
CPC分类号: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译: 本发明涉及抑制IMPDH的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性,因此可有利地用作IMPDH介导的方法的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
-
公开(公告)号:US20050148644A1
公开(公告)日:2005-07-07
申请号:US10997810
申请日:2004-11-24
申请人: Dean Stamos , Martin Trudeau , Randy Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
发明人: Dean Stamos , Martin Trudeau , Randy Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
IPC分类号: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/325 , C07D263/34
CPC分类号: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译: 本发明涉及抑制IMPDH的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性,因此可有利地用作IMPDH介导的方法的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
-
公开(公告)号:US06498178B2
公开(公告)日:2002-12-24
申请号:US09955626
申请日:2001-09-19
申请人: Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
发明人: Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
IPC分类号: A61K31277
CPC分类号: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
-
公开(公告)号:US20130030004A1
公开(公告)日:2013-01-31
申请号:US11593418
申请日:2006-11-06
申请人: Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
发明人: Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
IPC分类号: A61K31/506 , C07D403/10 , A61K31/4184 , A61P31/04 , A61K31/4439 , C07D401/14 , A61K31/4545 , C07D403/14 , C07D401/10
CPC分类号: C07D403/04 , C07D401/04 , C07D403/14
摘要: The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, that inhibit bacterial gyrase and/or TopoIV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译: 本发明涉及抑制细菌促旋酶和/或TopoIV的式I化合物或其药学上可接受的盐以及包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此,本发明还涉及用于治疗哺乳动物细菌感染的方法。
-
46.
公开(公告)号:US08163720B2
公开(公告)日:2012-04-24
申请号:US12844047
申请日:2010-07-27
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A01N51/00 , A61N31/655
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
-
公开(公告)号:US08097636B2
公开(公告)日:2012-01-17
申请号:US12269109
申请日:2008-11-12
申请人: Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Tara Leanne Hampton
发明人: Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Tara Leanne Hampton
IPC分类号: A61K31/47 , C07D217/00
CPC分类号: C07D417/14
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
-
公开(公告)号:US08076343B2
公开(公告)日:2011-12-13
申请号:US11492643
申请日:2006-07-21
申请人: Hayley Binch , Simon Everitt , Michael Mortimore , Daniel Robinson , Dean Stamos
发明人: Hayley Binch , Simon Everitt , Michael Mortimore , Daniel Robinson , Dean Stamos
IPC分类号: C07D239/42 , C07D401/04
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D487/08
摘要: The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDK1 protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作Aurora,FLT-3或PDK1蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
-
公开(公告)号:US20100004300A1
公开(公告)日:2010-01-07
申请号:US12495880
申请日:2009-07-01
申请人: Nicole Zimmermann , Peter D.J. Grootenhuis , Mehdi Michel Djamel Numa , Dean Stamos , Corey Don Anderson , Tara Whitney
发明人: Nicole Zimmermann , Peter D.J. Grootenhuis , Mehdi Michel Djamel Numa , Dean Stamos , Corey Don Anderson , Tara Whitney
IPC分类号: A61K31/427 , C07D277/38 , A61P25/00
CPC分类号: C07D417/14
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US20090325955A1
公开(公告)日:2009-12-31
申请号:US12483312
申请日:2009-06-12
申请人: PAUL Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人: PAUL Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号: A61K31/506 , A61K31/5377 , A61P31/04 , A61K31/519 , A61K31/4439 , A61K31/4184
CPC分类号: A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译: 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗,预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
-
-
-
-
-
-
-
-
-