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41.发明授权
公开(公告)号：US5266179A
公开(公告)日：1993-11-30
申请号：US733130
申请日：1991-07-19
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
IPC分类号： G01N27/26 , G01N27/28 , G01N27/416 , G01N27/49
CPC分类号： G01N33/48771 , G01N2035/009
摘要： A sensor 13 is inserted into a connector 14. A constant voltage required to obtain a response current is applied across the connector 14 by a voltage applying source 15 at timings required. A response current of the sensor 13 inserted into the connector 14 is converted into a voltage by a current-to-voltage converter 16, and the amount thereof is determined by a microcomputer, the analysis results being displayed onto a display unit.
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42.发明授权Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode system 失效具有包含酶的生物传感器的制备，电子接受体和亲水聚合物在电极系统上的制备
公开(公告)号：US5229282A
公开(公告)日：1993-07-20
申请号：US617886
申请日：1990-11-26
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The present invention relates to a process of preparation of a biosensor comprising forming an electrode system mainly containing carbon on an insulating base plate, treating the surface of electrode system with an organic solvent, and then arranging a reaction layer on the electrode system to give a unified element. The reaction layer contains an enzyme, electron acceptor and a hydrophilic polymer. Treatment with the organic solvent improves adhesion of the reaction layer to the electrode system. The electrode system contains a working electrode and a counter electrode. The electrode system is formed from a carbon paste containing a resin binder. Treatment is preferably carried out by wiping the surface of the electrodes with a material impregnated by the organic solvent.
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43.发明授权Sample treating kit and sample treating method using the same for analysis with a biosensor 失效样品处理试剂盒和使用该试剂处理方法的样品处理方法用于用生物传感器进行分析公开(公告)号：US06867002B2
公开(公告)日：2005-03-15
申请号：US09420719
申请日：1999-10-20
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/543
CPC分类号： C12Q1/001 , Y10S436/825 , Y10T436/11 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255
摘要： A sample solution treating instrument is provided for facilitating rapid and simplified adjustment of the condition of a sample solution proper for analysis with a biosensor before supplying the solution to the biosensor. The sample solution treating instrument includes, for example, a catalyst or an adsorbent which can remove any interfering substance in order to adjust the sample solution for measurement with a biosensor.
摘要翻译： 提供了一种样品溶液处理仪器，用于在将溶液供给生物传感器之前，利用生物传感器快速和简化调整适于分析的样品溶液的状况。 样品溶液处理仪器包括例如可以除去任何干扰物质的催化剂或吸附剂，以便通过生物传感器调节用于测量的样品溶液。
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公开(公告)号：US06821410B2
公开(公告)日：2004-11-23
申请号：US10084937
申请日：2002-03-01
IPC分类号： G01N27327
摘要： Disclosed is a highly responsive biosensor comprising a cholesterol-oxidizing enzyme and cholesterol esterase. The biosensor comprises: an electrically insulating base plate; an electrode system including a working electrode and a counter electrode formed on the base plate; a cover member joined with the base plate to define a sample supply pathway through which a sample solution is introduced from a sample supply port to the electrode system, the sample supply pathway being formed between the cover member and the base plate; and a reagent layer formed in the sample supply pathway, wherein the reagent layer contains a cholesterol-oxidizing enzyme, cholesterol esterase, an electron mediator, and a buffer having a buffering capacity in an acidic pH range.
摘要翻译： 公开了一种高反应性生物传感器，其包含胆固醇氧化酶和胆固醇酯酶。 生物传感器包括：电绝缘基板; 电极系统，包括形成在所述基板上的工作电极和对电极; 覆盖部件，其与所述基板接合，以限定样品供给路径，通过所述样品供给路径将样品溶液从样品供给口引入所述电极系统，所述样品供给路径形成在所述盖部件和所述基板之间; 以及在试样供给路径上形成的试剂层，其中，所述试剂层含有胆固醇 - 氧化酶，胆固醇酯酶，电子介体和在酸性pH范围内具有缓冲能力的缓冲液。
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公开(公告)号：US5658443A
公开(公告)日：1997-08-19
申请号：US277556
申请日：1994-07-19
CPC分类号： C12Q1/002 , C12Q1/001 , Y10S435/817
摘要： A biosensor for rapid quantification of a specific component contained in various biological samples with high accuracy has an electrically insulating base, an electrode system including a working electrode and a counter electrode formed on one face of the insulating base, and a reaction layer formed on the insulating base in close contact with the electrode system. The reaction layer contains at least a hydrophilic polymer, a buffer and an enzyme which is separated from the buffer.
摘要翻译： 用于以高精度快速定量包含在各种生物样品中的特定成分的生物传感器具有电绝缘基底，包括形成在绝缘基底的一个面上的工作电极和对电极的电极系统，以及形成在绝缘基底上的反应层 绝缘基座与电极系统紧密接触。 反应层至少含有亲水性聚合物，缓冲液和与缓冲液分离的酶。
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公开(公告)号：US5512159A
公开(公告)日：1996-04-30
申请号：US293131
申请日：1994-08-19
申请人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
发明人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
IPC分类号： G01N27/28 , C12M1/34 , C12M1/40 , C12Q1/00 , C12Q1/54 , G01N27/327 , G01N33/483
CPC分类号： C12Q1/001
摘要： A biosensor of the present invention is provided with an insulating base plate, an electrode system mainly consisting of a working electrode and a counter electrode formed on the insulating base plate, and a reaction layer on the electrode system. The counter electrode is partially a circular arc. A manufacturing method of the biosensor of the present invention is comprised of a step to form a base by arranging leads, an electrode system, and an insulating layer on an insulating base plate, and a step to form a reaction layer mainly composed of an enzyme on the electrode system. Since the counter electrode is partially in the shape of a circular arc, the reaction layer is easily formed and prevented from delaminating, whereby the measuring accuracy, preservative properties and reliability of the biosensor are improved. The present invention enables highly efficient biosensors to be mass produced at low cost.
摘要翻译： 本发明的生物传感器设置有绝缘基板，主要由在绝缘基板上形成的工作电极和对电极组成的电极系统和电极系统上的反应层。 对电极部分是圆弧。 本发明的生物传感器的制造方法包括通过在绝缘基板上排列引线，电极系统和绝缘层形成基底的步骤，以及形成主要由酶组成的反应层的步骤 在电极系统上。 由于对电极部分为圆弧形状，反应层易于形成并防止分层，从而提高了生物传感器的测量精度，防腐性能和可靠性。 本发明能够以低成本批量生产高效生物传感器。
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公开(公告)号：US5192415A
公开(公告)日：1993-03-09
申请号：US845073
申请日：1992-03-02
申请人： Toshihiko Yoshioka , Shiro Nankai
发明人： Toshihiko Yoshioka , Shiro Nankai
IPC分类号： C12Q1/00
CPC分类号： C12Q1/004
摘要： The biosensor of the present invention quantifies a substrate contained in a sample liquid by reducing electron acceptors using electron generated in a reaction of the substrate to enzyme and then by measuring the reduced amount of the electron acceptors electrochemically. The biosensor has an electrical insulating substrate, an electrode system including at least a working electrode and a counter electrode, a reaction layer including the enzyme provided on the electrode system and a hydrogen ion concentration control layer, and the reaction layer is in contact with the electrode system. According to the present invention, the hydrogen ion concentration in the sample liquid can be made most appropriate in accordance with the type of the enzyme contained in the reaction layer, without the adjustment of the hydrogen ion concentration in the sample liquid beforehand. Thus, the specific substrate contained in the sample liquid can be easily quantified with accuracy and speed.
摘要翻译： 本发明的生物传感器通过使用在基板与酶的反应中产生的电子，然后通过电化学测量电子受体的量减少电子受体来量化包含在样品液体中的基板。 生物传感器具有电绝缘基板，至少包括工作电极和对电极的电极系，包含设置在电极系上的酶的反应层和氢离子浓度控制层，反应层与 电极系统。 根据本发明，不需要事先调整样品液中的氢离子浓度，可以根据反应层中所含的酶的种类，使样品液中的氢离子浓度最适合。 因此，可以容易地以准确度和速度量化包含在样品液体中的特定基质。
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公开(公告)号：US06969450B2
公开(公告)日：2005-11-29
申请号：US10616305
申请日：2003-07-10
IPC分类号： A61B5/00 , G01N27/30 , G01N33/487 , C12M1/00
CPC分类号： G01N33/4875 , A61B5/1486 , A61B2562/0295
摘要： In biosensor system 1, biosensor 2 is mounted in measuring apparatus 3 for quantifying or detecting existence of a targeted substrate in a sample solution. Mounting end portion 20 of biosensor 2 to be mounted in measuring apparatus 3 has an extension of one base plate in the length direction, and further extensions of the other base plate in the width direction. Sensor mounting portion 30 of measuring apparatus 3 has a shape matching up with the shape of mounting end portion 20. Thereby wrong insertion of biosensor 2 in measuring apparatus 3 can be prevented.Further, varying shapes of plural biosensors 5 and 6 to have a common part and a non-common part, such biosensors can be handily measured by one measuring apparatus 7.
摘要翻译： 在生物传感器系统1中，将生物传感器2安装在用于定量或检测样品溶液中目标基板的存在的测量装置3中。 安装在测量装置3中的生物传感器2的安装端部20在长度方向上具有一个基板的延伸部，另一个底板在宽度方向上延伸。 测量装置3的传感器安装部30具有与安装端部20的形状相匹配的形状。 从而可以防止生物传感器2在测量装置3中错误插入。 此外，多个生物传感器5和6的不同形状具有公共部分和非共同部分，可以通过一个测量装置7轻松测量这样的生物传感器。
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公开(公告)号：US20050175509A1
公开(公告)日：2005-08-11
申请号：US10515602
申请日：2003-12-19
CPC分类号： C12Q1/006 , C12Q1/004 , G01N2333/904
摘要： The present invention relates to a biosensor which comprises an electrode system including at least one pair of electrodes, at least one insulating base plate for supporting the electrode system, a first reaction layer provided at least on a working electrode of the electrode system, including an organic compound having a functional group capable of bonding or being adsorbed to an electrode and a hydrophobic hydrocarbon group, a second reaction layer provided on the first reaction layer, including an amphiphilic lipid capable of bonding or being adsorbed to a hydrophobic portion of the first reaction layer, and a reagent system carried in a two-component membrane composed of the first and second reaction layers, including at least membrane-binding type pyrroquinoline quinone-dependent glucose dehydrogenase and an electron mediator.
摘要翻译： 本发明涉及一种生物传感器，其包括电极系统，该电极系统包括至少一对电极，至少一个用于支撑电极系统的绝缘基板，至少设置在电极系统的工作电极上的第一反应层， 具有能够键合或吸附到电极和疏水性烃基的官能团的有机化合物，设置在第一反应层上的第二反应层，包括能够键合或吸附到第一反应的疏水部分的两亲性脂质 以及由第一反应层和第二反应层构成的双组分膜中携载的至少包含膜结合型吡喹啉醌依赖性葡萄糖脱氢酶和电子介体的试剂系统。
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公开(公告)号：US07238160B2
公开(公告)日：2007-07-03
申请号：US10512939
申请日：2004-01-16
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： A61B5/00
CPC分类号： A61B5/6843 , A61B5/14532 , A61B5/150022 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150748 , A61B5/150954 , A61B5/15107 , A61B5/15117 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417
摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus. The puncture mechanism includes a puncture needle, and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing. The skin contact surface having an opening through which the puncture needle moves to puncture the skin, and is shaped so as to fit a surface shape of the skin to be punctured. The set includes a plurality of different caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.
摘要翻译： 生物成分测定装置技术领域本发明涉及一种生物成分测定装置，其特征在于，将生物体测定装置与被检体的皮肤刺穿用于收集血样的穿刺机构一体化。 穿刺机构包括穿刺针和与装置的主体可拆卸地接合的帽，其中，所述帽具有与皮肤接触以进行穿刺的皮肤接触表面。 皮肤接触表面具有穿刺针穿过的穿刺孔，并且被成形为适合要刺穿的皮肤的表面形状。 该集合包括多个不同的盖，每个不同的盖对应于不同的采样站点，从而可以选择多个不同的样本采集站点。
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