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    MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID
    49.
    发明申请
    MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID 有权
    突变体rpsA基因和生产L-氨基酸的方法

    公开(公告)号：US20130005000A1

    公开(公告)日：2013-01-03

    申请号：US13569264

    申请日：2012-08-08

    申请人： Hidetaka Doi ,  Yusuke Hagiwara ,  Yoshihiro Usuda

    发明人： Hidetaka Doi ,  Yusuke Hagiwara ,  Yoshihiro Usuda

    IPC分类号： C12P13/22 ,  C12N1/21 ,  C12N15/31 ,  C12P13/04

    CPC分类号： C12P13/04 ,  C07K14/24 ,  C07K14/245 ,  C12P13/08

    摘要： A method for efficiently producing an L-amino acid utilizing a bacterium belonging to the family Enterobacteriaceae from a fatty acid or an alcohol such as glycerol as a raw material is provided. A bacterium belonging to the family Enterobacteriaceae which is able to produce L-amino acid and harbors an RpsA protein which has a mutation such that the native aspartic acid residue at position 210 is replaced with another amino acid residue is used. This bacterium is cultured in a medium containing a carbon source selected from a fatty acid and an alcohol, and the produced L-amino acid is collected from the medium.

    摘要翻译： 提供利用脂肪酸或醇如甘油作为原料的属于肠杆菌科的细菌有效生产L-氨基酸的方法。 使用属于肠杆菌科的细菌，其能够产生L-氨基酸并且含有具有突变的RpsA蛋白，使得第210位的天然天冬氨酸残基被另一个氨基酸残基替代。 该细菌在含有选自脂肪酸和醇的碳源的培养基中培养，从培养基中收集产生的L-氨基酸。

    Bacterium capable of producing L-amino acid and method for producing L-amino acid
    50.
    发明授权
    Bacterium capable of producing L-amino acid and method for producing L-amino acid 有权
    能够产生L-氨基酸的细菌和L-氨基酸的生产方法

    公开(公告)号：US08192963B2

    公开(公告)日：2012-06-05

    申请号：US13037772

    申请日：2011-03-01

    申请人： Yousuke Nishio ,  Yoshihiro Usuda

    发明人： Yousuke Nishio ,  Yoshihiro Usuda

    IPC分类号： C12P13/14 ,  C12P13/10 ,  C12P13/08

    CPC分类号： C12P13/08 ,  C12P13/10 ,  C12P13/14

    摘要： A bacterium is described which belongs to the Enterobacteriaceae family, and has an ability to produce an L-amino acid, such as L-glutamic acid, L-arginine and L-threonine. The bacterium is modified so that the activity of a protein encoded by ydcI gene is decreased, thereby producing and accumulating the L-amino acid selected from L-glutamic acid, L-arginine, and L-threonine in the culture medium or cells of the bacterium when cultured in a culture medium. Subsequently, the L-amino acid is collected from the culture medium or the bacterium.

    摘要翻译： 描述属于肠杆菌科的细菌，并且具有产生L-氨基酸的能力，例如L-谷氨酸，L-精氨酸和L-苏氨酸。 修饰细菌使得由ydcI基因编码的蛋白质的活性降低，从而在培养基或细胞中产生并积累选自L-谷氨酸，L-精氨酸和L-苏氨酸的L-氨基酸 细菌培养在培养基中。 随后，从培养基或细菌收集L-氨基酸。