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41.发明授权Substituted phenols and their use for the treatment of disorders caused by cell proliferation 失效取代的苯酚及其用于治疗由细胞增殖引起的疾病的用途
公开(公告)号：US5519018A
公开(公告)日：1996-05-21
申请号：US431794
申请日：1995-05-01
申请人： Rudolf Matusch , Manfred Hunz , Jorg Czech , Hans-Harald Sedlacek
发明人： Rudolf Matusch , Manfred Hunz , Jorg Czech , Hans-Harald Sedlacek
IPC分类号： A61K31/415 , A61K31/445 , A61K31/495 , A61P17/00 , A61P35/00 , A61P37/04 , C07C251/24 , C07C251/86 , C07D233/54 , C07D233/64 , C07D295/22 , C07D295/30 , A61K31/41 , A61K31/535
CPC分类号： C07D233/64 , C07C251/24 , C07C251/86 , C07D295/30
摘要： Substituted phenols of the formula I ##STR1## processes for their preparation and compositions containing substituted phenols of the formulae I and II ##STR2## for the treatment of disorders caused by cell proliferation, such as psoriasis, tumor disorders and immunological disorders, are described.
摘要翻译： 式I的取代的酚I制备及其含有式I和II的取代的酚的组合物用于治疗由细胞增殖引起的疾病，例如牛皮癣，肿瘤病症和免疫学障碍的组合物 描述。
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公开(公告)号：US4762848A
公开(公告)日：1988-08-09
申请号：US837700
申请日：1986-03-10
申请人： Karl-Heinz Scheunemann , Walter Durckheimer , Jurgen Blumbach , Michael Limbert , Hans-Ulrich Schorlemmer , Gerhard Dickneite , Hans-Harald Sedlacek
发明人： Karl-Heinz Scheunemann , Walter Durckheimer , Jurgen Blumbach , Michael Limbert , Hans-Ulrich Schorlemmer , Gerhard Dickneite , Hans-Harald Sedlacek
IPC分类号： A61K31/33 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/455 , A61K31/465 , A61K31/53 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07D211/54 , C07D211/84 , C07D213/80 , C07D231/18 , C07D235/28 , C07D237/18 , C07D239/38 , C07D241/18 , C07D249/12 , C07D253/06 , C07D253/07 , C07D277/20 , C07D277/32 , C07D277/36 , C07D277/46 , C07D277/56 , C07D277/70 , C07D277/74 , C07D285/12 , C07D285/125 , C07D521/00 , A61K31/38 , C07D213/62 , C07D277/34
CPC分类号： C07D213/80 , C07D235/28 , C07D249/12 , C07D253/07 , C07D277/36 , C07D277/46 , C07D277/56 , C07D277/74 , C07D285/125
摘要： Heterocyclic sulfides of the general formula heterocycle-S-R, a process for their preparation and, in particular, their use for immunostimulation, immunorestoration and cytostatic treatment, and pharmaceutical agents, which contain a sulfide of this type, for these indications.
摘要翻译： 用于这些适应症的通式杂环-S-R的杂环硫化物，其制备方法，特别是其用于免疫刺激，免疫测定和细胞抑制处理的药物和含有这种硫化物的药剂。
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公开(公告)号：US4510129A
公开(公告)日：1985-04-09
申请号：US406531
申请日：1982-08-09
IPC分类号： A61K38/46 , A61K38/47 , A61K39/39 , A61P37/04 , C12N9/24 , A61K39/42 , A61K39/02 , A61K39/12 , A61K39/40
CPC分类号： A61K38/47 , A61K39/39 , A61K2039/55516
摘要： The invention relates to an agent for stimulating the immunologic reactivity, comprising a mixture of an antigen and neuraminidase.
摘要翻译： 本发明涉及用于刺激免疫反应性的试剂，其包含抗原和神经氨酸酶的混合物。
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公开(公告)号：US4479934A
公开(公告)日：1984-10-30
申请号：US101645
申请日：1979-12-10
摘要： What is disclosed is a method for the therapy of immunocomplex diseases with an agent which contains Fc-reagents that react with the Fc-part of the antibody contained in the immunocomplex, but which themselves do not posses an immunologically active Fc-part or an Fc-part capable of being activated.
摘要翻译： 所公开的是使用含有与免疫复合物中所含的抗体的Fc部分反应但与本发明不具有免疫活性Fc部分或Fc的Fc试剂反应的试剂来治疗免疫复合物疾病的方法 - 能够被激活。
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公开(公告)号：US4332783A
公开(公告)日：1982-06-01
申请号：US66793
申请日：1979-08-15
IPC分类号： G01N33/564 , G01N33/54 , G01N33/58 , G01N33/60
CPC分类号： G01N33/564 , Y10S436/80 , Y10S436/804 , Y10S436/828
摘要： What is disclosed is a method for the immunological determination of an immuno-complex, comprising an antigen and an antibody, in a liquid containing said immuno-complex, which method comprises(a) incubating said liquid containing said immumo-complex with a first reagent bound to a carrier, said first reagent being specific for an antigenic determinant of the antigen in said immuno-complex and being present in an amount sufficient to fix said immuno-complex;(b) separating the carrier from said liquid containing said immuno-complex and incubating it in a solution of a second reagent, said second reagent being specific for an antigenic determinant of the antibody in said immuno-complex and being present in an amount sufficient to fix said immuno-complex; and(c) separating the carrier from said solution of the second reagent and determining the amount of bound or unbound second reagent.
摘要翻译： 所公开的是在含有所述免疫复合物的液体中免疫测定包含抗原和抗体的方法，该方法包括（a）将含有所述免疫复合物的液体与第一试剂 所述第一试剂对所述免疫复合物中的抗原的抗原决定簇是特异性的，并且以足以固定所述免疫复合物的量存在; （b）将载体从含有所述免疫复合物的液体中分离并将其孵育在第二试剂的溶液中，所述第二试剂对所述免疫复合物中的抗体的抗原决定簇是特异性的，并且以足以 修复免疫复合物; 和（c）从第二试剂的溶液中分离载体并确定结合或未结合的第二试剂的量。
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公开(公告)号：US4166106A
公开(公告)日：1979-08-28
申请号：US835789
申请日：1977-09-22
IPC分类号： A61K39/00 , G01N33/563 , G01N33/16
CPC分类号： G01N33/563 , Y10S435/96 , Y10S435/962 , Y10S436/80 , Y10S436/805
摘要： A method for determininng a reagent capable of immunologic reaction by direct or indirect test methods, wherein an antigen is contacted with the Fc fragment of an immune globulin prior to contacting it with an antibody having no specificity to said Fc fragment, whereby unspecific linkages arre decreased.
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公开(公告)号：US4157383A
公开(公告)日：1979-06-05
申请号：US732134
申请日：1976-10-13
IPC分类号： G01N33/49 , A61K35/14 , A61K38/16 , G01N33/53 , G01N33/554 , A01N1/02 , G01N1/00 , G01N31/00 , G01N33/16
CPC分类号： G01N33/554 , A61K35/19 , Y10S436/80
摘要： The invention provides tanned thrombocytes, a process for preparing them and a diagnostic agent containing them to make evident antibodies of thrombocytes.
摘要翻译： 本发明提供了鞣制的凝血细胞，其制备方法和含有它们的诊断剂以制备明显的凝血细胞抗体。
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