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公开(公告)号：US20220288822A1
公开(公告)日：2022-09-15
申请号：US17752275
申请日：2022-05-24
Inventor： Jennifer N. Rodriguez , Duncan J. Maitland , Thomas S. Wilson
IPC: B29C44/56 , C08J9/38 , A61L31/06 , A61L31/14 , C08G18/73 , B32B5/18 , B32B5/32 , C08G18/32 , C08L75/04
Abstract: Polymeric based closed cell foams, such as shape memory polymer foams, contain bubbles. Making these bubbles continuous is called reticulation. Disclosed are embodiments of a device and method to controllably reticulate polymer-based closed cell foams by puncturing the membranes of these polymer-based closed cell foams.
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公开(公告)号：US20220273852A1
公开(公告)日：2022-09-01
申请号：US17749270
申请日：2022-05-20
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM , SHAPE MEMORY MEDICAL, INC
Inventor： Duncan J. Maitland , Todd L. Landsman , John Horn , Landon Nash , Chung Yeh
Abstract: An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.
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公开(公告)号：US11338070B2
公开(公告)日：2022-05-24
申请号：US16690612
申请日：2019-11-21
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM , SHAPE MEMORY MEDICAL, INC
Inventor： Duncan J. Maitland , Todd L. Landsman , John Horn , Landon Nash , Chung Yeh
IPC: A61F2/945 , A61B17/12 , A61L31/14 , A61F2/954 , A61F2/07 , A61L31/06 , A61L31/18 , A61F2/82 , A61B90/00 , A61B17/00 , A61F2/89
Abstract: An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.
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公开(公告)号：US10781294B2
公开(公告)日：2020-09-22
申请号：US15746471
申请日：2016-07-22
Inventor： Landon D. Nash , Duncan J. Maitland , Nicole Docherty , Thomas S. Wilson , Ward Small, IV , Jason Ortega , Pooja Singhal
IPC: C08J9/36 , A61L24/00 , A61L24/04 , B05D1/00 , B05D3/14 , B05D7/02 , B29C59/14 , B32B27/06 , B32B5/18 , A61L31/14 , A61L31/06 , B29K33/04 , B29C44/56 , B29K69/00 , B29K75/00 , B29K77/00
Abstract: An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein.
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45.发明申请公开(公告)号：US20200253616A1
公开(公告)日：2020-08-13
申请号：US16776638
申请日：2020-01-30
Inventor： Anthony Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arteriovenous malformations, tissue engineering, and wound healing.
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Patent Agency Ranking
公开(公告)号：US10647037B2
公开(公告)日：2020-05-12
申请号：US15232619
申请日：2016-08-09
Inventor： Jennifer N. Rodriguez , Duncan J. Maitland , Thomas S. Wilson
IPC: B29C44/56 , C08J9/38 , A61L31/06 , A61L31/14 , C08G18/73 , B32B5/18 , B32B5/32 , C08G18/32 , B29K105/04 , B29K75/00 , C08G101/00
Abstract: Polymeric based closed cell foams, such as shape memory polymer foams, contain bubbles. Making these bubbles continuous is called reticulation. Disclosed are embodiments of a device and method to controllably reticulate polymer-based closed cell foams by puncturing the membranes of these polymer-based closed cell foams.
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公开(公告)号：US20190192743A1
公开(公告)日：2019-06-27
申请号：US16228082
申请日：2018-12-20
Applicant: The Texas A&M University System , Shape Memory Medical, Inc
Inventor： Duncan J. Maitland , Todd L. Landsman , John Horn , Landon Nash , Chung Yeh
CPC classification number: A61L31/146 , A61B17/12113 , A61F2/07 , A61F2/945 , A61F2/954 , A61F2002/826 , A61F2210/0023 , A61F2250/0098 , A61L31/06 , A61L31/18 , A61L2400/04 , A61L2400/06 , A61L2400/16
Abstract: An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.
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公开(公告)号：US20180140304A1
公开(公告)日：2018-05-24
申请号：US15575896
申请日：2016-05-25
Inventor： Sayyeda Marziya Hasan , Jennifer Nicole Rodriguez , Pooja Singhal , Thomas Stephen Wilson , Duncan J. Maitland
CPC classification number: A61B17/12113 , A61B17/12131 , A61B17/1219 , A61B2017/00526 , A61B2017/00871 , A61B2090/3966 , A61L31/128 , A61L31/14 , A61L31/146 , A61L31/18 , A61L2400/12 , A61L2400/16 , A61M31/002 , C08L2201/12
Abstract: The invention relates to radiopaque shape memory foam compositions and methods of using the compositions. In certain embodiments, the compositions are used in neurovascular occlusion applications.
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公开(公告)号：US20180009932A1
公开(公告)日：2018-01-11
申请号：US15548212
申请日：2016-02-02
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
IPC: C08G18/32 , C08G18/67 , C08G18/75 , B29K105/04
CPC classification number: C08G18/3206 , B29K2105/04 , C08G18/3212 , C08G18/6715 , C08G18/675 , C08G18/73 , C08G18/758 , C08L75/04 , C08L75/16 , C08L81/02
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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50.发明申请ULTRA LOW DENSITY BIODEGRADABLE SHAPE MEMORY POLYMER FOAMS WITH TUNABLE PHYSICAL PROPERTIES 有权超低密度可生物降解形状记忆聚合物具有可调物理特性公开(公告)号：US20170002130A1
公开(公告)日：2017-01-05
申请号：US15269516
申请日：2016-09-19
Inventor： Pooja Singhal , Thomas S. Wilson , Elizabeth Cosgriff-Hernandez , Duncan J. Maitland
CPC classification number: C08G18/6622 , A61B17/0057 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , C08G18/10 , C08G18/14 , C08G18/165 , C08G18/73 , C08G63/00 , C08G63/6852 , C08G71/04 , C08G2101/005 , C08G2101/0083 , C08G2230/00 , C08G2280/00 , C08J9/00 , C08J2375/06
Abstract: Compositions and/or structures of degradable shape memory polymers (SMPs) ranging in form from neat/unfoamed to ultra low density materials of down to 0.005 g/cc density. These materials show controllable degradation rate, actuation temperature and breadth of transitions along with high modulus and excellent shape memory behavior. A method of making extremely low density foams (up to 0.005 g/cc) via use of combined chemical and physical blowing agents, where the physical blowing agents may be a single compound or mixtures of two or more compounds, and other related methods, including of using multiple co-blowing agents of successively higher boiling points in order to achieve a large range of densities for a fixed net chemical composition. Methods of optimization of the physical properties of the foams such as porosity, cell size and distribution, cell openness etc. of these materials, to further expand their uses and improve their performance.
Abstract translation: 范围从纯/未发泡到超低密度材料形式的可降解形状记忆聚合物（SMP）的组合物和/或结构，其浓度低至0.005g / cc。 这些材料显示可控的降解速率，致动温度和转变幅度以及高模量和优异的形状记忆行为。 通过使用组合的化学和物理发泡剂制造极低密度泡沫（高达0.005g / cc）的方法，其中物理发泡剂可以是单一化合物或两种或更多种化合物的混合物，以及其它相关方法，包括 使用多个连续较高沸点的共发泡剂，以实现固定净化学成分的大范围密度。 优化泡沫物理性能的方法，如孔隙度，孔径，分布，细胞开放度等，进一步扩大使用范围，提高其性能。
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