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公开(公告)号：US09320738B2
公开(公告)日：2016-04-26
申请号：US13001516
申请日：2009-06-30
申请人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
发明人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
IPC分类号： A61K9/20 , A61K31/513 , A61K31/4196 , A61K31/496 , A61K31/505 , A61K31/7048 , A61K38/51
CPC分类号： A61K31/513 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4196 , A61K31/496 , A61K31/505 , A61K31/7048 , A61K38/50 , A61K38/51 , C12Y305/04001 , A61K2300/00
摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorouracil in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.
摘要翻译： 本公开提供5-氟胞嘧啶的延长释放制剂。 另一方面，提供了一种治疗真菌病的方法。 该方法包括向有需要的受试者施用真菌治疗有效量的包含5-氟胞嘧啶的组合物。 另一方面，提供了治疗癌症的方法。 所述方法包括向有需要的受试者施用足够量的表达载体以诱导能够将5-氟胞嘧啶转化成癌症细胞中5-氟尿嘧啶的胞嘧啶脱氨酶和癌症治疗有效量的组合物 包含5-氟胞嘧啶。
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42.发明申请公开(公告)号：US20140178854A1
公开(公告)日：2014-06-26
申请号：US13882713
申请日：2011-10-28
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N2333/15
摘要： The disclosure provide cell lines and methods for the production of vectors and viral particles useful in diagnostics and therapeutics.
摘要翻译： 本公开提供用于生产用于诊断和治疗的载体和病毒颗粒的细胞系和方法。
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公开(公告)号：US20130323301A1
公开(公告)日：2013-12-05
申请号：US13882487
申请日：2011-10-31
申请人： Harry E. Gruber , Douglas J. Jolly , Derek G. Ostertag , Ryan S. Burnett , Amy H. Lin , Tiffany Huang , Joan M. Robbins
发明人： Harry E. Gruber , Douglas J. Jolly , Derek G. Ostertag , Ryan S. Burnett , Amy H. Lin , Tiffany Huang , Joan M. Robbins
IPC分类号： A61K31/7088 , A61K31/573 , A61N5/10 , A61K9/127 , A61K31/713 , A61K39/395 , A61K31/58
CPC分类号： A61K31/7088 , A61K9/127 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/713 , A61K35/768 , A61K39/21 , A61K39/3955 , A61K39/39558 , A61N5/10 , C12N15/867 , C12N2740/13032 , A61K2300/00
摘要： This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.
摘要翻译： 本公开涉及用于治疗细胞增殖性疾病的复制有效的病毒载体。 本公开还涉及这种复制感受态病毒载体在正常和患病组织中递送和表达异源核酸的用途以及促进体内和体外对组织的这种递送和表达的方法和组合物。 本公开还涉及用于这些用途的复制有效的逆转录病毒载体，以及促进体内治疗的方法和组合物。
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公开(公告)号：US20130130986A1
公开(公告)日：2013-05-23
申请号：US13638490
申请日：2011-03-29
CPC分类号： C12N7/00 , A61K31/513 , A61K38/2292 , A61K48/00 , C12N9/78 , C12N15/86 , C12N2740/13043 , C12N2760/16021 , C12N2760/16032 , C12N2760/16043
摘要： This disclosure provides modified cytosine deaminases(CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. It further provides use of such modified CDs with a thymosin-alpha-1 polypeptide in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。 它进一步提供这种修饰的CD与胸腺素-α-1多肽在治疗疾病和病症中的用途。
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公开(公告)号：US20110287020A1
公开(公告)日：2011-11-24
申请号：US13072704
申请日：2011-03-26
IPC分类号： A61K39/395 , A61P35/00 , A61K35/48 , C12N7/01 , C07H21/02
CPC分类号： C12N7/00 , A61K31/513 , A61K38/2292 , A61K48/00 , C12N9/78 , C12N15/86 , C12N2740/13043 , C12N2760/16021 , C12N2760/16032 , C12N2760/16043
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用此类修饰的CD的方法。
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46.发明授权公开(公告)号：US06531307B1
公开(公告)日：2003-03-11
申请号：US08455014
申请日：1995-05-31
IPC分类号： C12N15861
CPC分类号： C07K14/005 , A01K2217/05 , A01K2217/30 , A01K2267/0337 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K48/00 , C12N15/8509 , C12N15/86 , C12N2710/16622 , C12N2740/16043 , C12N2740/16052 , C12N2740/16322 , C12N2830/00 , C12N2830/001 , C12N2830/60 , C12N2840/20 , Y02A50/472
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (eg. HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译： 本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或没有细胞毒性的化合物的基因产物（例如HSVTK）的表达。 还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。
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公开(公告)号：US5888502A
公开(公告)日：1999-03-30
申请号：US463122
申请日：1995-06-05
IPC分类号： A01K67/027 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/155 , C07K14/16 , C07K14/73 , C12N7/04 , C12N9/12 , C12N15/867 , C12N5/10 , C12N15/86
CPC分类号： A01K67/0275 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C12N2740/13022 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16134 , C12N2740/16222
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
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公开(公告)号：US5817491A
公开(公告)日：1998-10-06
申请号：US361839
申请日：1994-12-22
IPC分类号： A01K67/027 , A01K67/033 , A61K38/20 , A61K38/21 , A61K39/00 , A61K48/00 , C07K14/15 , C07K14/73 , C12N5/10 , C12N7/04 , C12N15/85 , C12N15/867 , C12N15/87 , C12N15/86 , C12N5/08
CPC分类号： A01K67/0275 , A01K67/033 , A61K38/2013 , A61K38/217 , A61K39/0005 , A61K48/00 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N15/87 , C12N7/00 , A01K2217/05 , A01K2217/075 , A61K35/13 , C07K2319/00 , C12N2740/13022 , C12N2740/13043 , C12N2740/13052 , C12N2740/13062 , C12N2740/15022 , C12N2740/16222
摘要： An enveloped vector particle contains gag and pol proteins from a retrovirus, a nucleic acid sequence and an envelope that includes VSV G envelope glycoprotein. The vector particle can be used to introduce nucleic acids into cells.
摘要翻译： 包膜载体颗粒含有来自逆转录病毒，核酸序列和包含VSV G包膜糖蛋白的包膜的gag和pol蛋白。 载体颗粒可用于将核酸引入细胞。
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公开(公告)号：US5716613A
公开(公告)日：1998-02-10
申请号：US474736
申请日：1995-06-07
IPC分类号： A01K67/027 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/155 , C07K14/16 , C07K14/73 , C12N7/04 , C12N9/12 , C12N15/867 , C12N15/86
CPC分类号： A01K67/0275 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C12N2740/13022 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16134 , C12N2740/16222
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
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公开(公告)号：US5591624A
公开(公告)日：1997-01-07
申请号：US156789
申请日：1993-11-23
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K48/00 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N15/85 , C12N15/867 , C12N5/08
CPC分类号： A01K67/0275 , A01K67/033 , A61K39/0011 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C07K2319/00 , C12N2740/11043 , C12N2740/11052 , C12N2740/13022 , C12N2740/13023 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16222 , C12N2830/008
摘要： The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.
摘要翻译： 本文所述的本发明允许从生产细胞产生重组逆转录病毒（逆转录病毒载体颗粒），其比较常规更安全并且效价更高。 此外，提供了制备辅助细胞的方法，当引入重组逆转录病毒基因组以制备生产线时，产生靶向特定细胞类型的颗粒。 还提供了通过结合特定细胞类型的逆转录病毒或重组逆转录病毒来制备适于感染特定细胞类型（例如肿瘤）的重组逆转录病毒系统的方法。 还提供了用于产生重组逆转录病毒的方法，所述重组逆转录病毒整合在宿主基因组的特定少量位置中，并用于从转基因动物产生重组逆转录病毒。
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