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1.发明授权Method for making reflection defective retroviral vectors for infecting human cells 失效复制用于感染人细胞的有缺陷的逆转录病毒载体的方法
公开(公告)号：US5856185A
公开(公告)日：1999-01-05
申请号：US472109
申请日：1995-06-07
申请人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
发明人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/85 , C12N15/867 , C07H21/04 , C12N15/48
CPC分类号： A01K67/033 , A61K38/2013 , A61K38/217 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
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公开(公告)号：US5591624A
公开(公告)日：1997-01-07
申请号：US156789
申请日：1993-11-23
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K48/00 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N15/85 , C12N15/867 , C12N5/08
CPC分类号： A01K67/0275 , A01K67/033 , A61K39/0011 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C07K2319/00 , C12N2740/11043 , C12N2740/11052 , C12N2740/13022 , C12N2740/13023 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16222 , C12N2830/008
摘要： The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.
摘要翻译： 本文所述的本发明允许从生产细胞产生重组逆转录病毒（逆转录病毒载体颗粒），其比较常规更安全并且效价更高。 此外，提供了制备辅助细胞的方法，当引入重组逆转录病毒基因组以制备生产线时，产生靶向特定细胞类型的颗粒。 还提供了通过结合特定细胞类型的逆转录病毒或重组逆转录病毒来制备适于感染特定细胞类型（例如肿瘤）的重组逆转录病毒系统的方法。 还提供了用于产生重组逆转录病毒的方法，所述重组逆转录病毒整合在宿主基因组的特定少量位置中，并用于从转基因动物产生重组逆转录病毒。
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公开(公告)号：US5716832A
公开(公告)日：1998-02-10
申请号：US462492
申请日：1995-06-05
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K48/00 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N15/85 , C12N15/867 , C12N15/00
CPC分类号： A01K67/0275 , A01K67/033 , A61K39/0011 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C07K2319/00 , C12N2740/11043 , C12N2740/11052 , C12N2740/13022 , C12N2740/13023 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16222 , C12N2830/008
摘要： The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titre than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.
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公开(公告)号：US07070994B2
公开(公告)日：2006-07-04
申请号：US10205179
申请日：2002-07-24
IPC分类号： C12N5/10 , C12N5/08 , C12N5/00 , C12N15/867 , C12N15/48
CPC分类号： C12N15/8509 , A01K67/033 , A01K2217/05 , A01K2267/01 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C07K2319/32 , C12N7/00 , C12N9/1211 , C12N15/86 , C12N2740/13022 , C12N2740/13023 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16222
摘要： The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.
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公开(公告)号：US06410326B1
公开(公告)日：2002-06-25
申请号：US08486683
申请日：1995-06-07
申请人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
发明人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
IPC分类号： C12N1563
CPC分类号： A01K67/033 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N15/86 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
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公开(公告)号：US06310045B1
公开(公告)日：2001-10-30
申请号：US08474636
申请日：1995-06-06
IPC分类号： A01N4304
CPC分类号： C12N15/86 , A01K67/0271 , A01K67/0275 , A01K67/033 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/55 , C07K14/57 , C07K14/70514 , C07K14/70535 , C07K2319/00 , C07K2319/02 , C07K2319/75 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N2740/13022 , C12N2740/13043 , C12N2740/13052 , C12N2740/13062 , C12N2740/15022 , C12N2760/16122 , Y02A50/472
摘要： The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting the growth of a selected tumor is provided comprising the step of directly administering to a warm-blooded animal a vector construct which directs the expression of at least one anti-tumor agent, such that the growth of said tumor is inhibited. Representative examples of anti-tumor agents include immune activators and tumor proliferation inhibitors.
摘要翻译： 本发明提供了利用重组病毒载体抑制所选择的肿瘤生长的方法。 简言之，在本发明的一个方面，提供了抑制所选择的肿瘤生长的方法，其包括直接向温血动物施用指导至少一种抗肿瘤剂表达的载体构建体的步骤， 使得所述肿瘤的生长被抑制。 抗肿瘤剂的代表性实例包括免疫激活剂和肿瘤增殖抑制剂。
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公开(公告)号：US5662896A
公开(公告)日：1997-09-02
申请号：US32846
申请日：1993-03-17
IPC分类号： C12N15/09 , A01K67/027 , A01K67/033 , A61K35/13 , A61K35/76 , A61K38/00 , A61K38/16 , A61K38/20 , A61K38/21 , A61K38/46 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/55 , C07K14/57 , C07K14/73 , C07K14/735 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/23 , C12N15/85 , C12N15/867 , C12N15/86 , C12N15/26
CPC分类号： C12N15/86 , A01K67/0271 , A01K67/0275 , A01K67/033 , A61K38/2013 , A61K38/217 , A61K39/0011 , C07K14/005 , C07K14/55 , C07K14/57 , C07K14/70514 , C07K14/70535 , C12N15/8509 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C07K2319/02 , C07K2319/75 , C12N2740/13022 , C12N2740/13043 , C12N2740/13052 , C12N2740/13062 , C12N2740/15022 , C12N2760/16122
摘要： The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting the growth of a selected tumor is provided comprising the step of directly administering to a warm-blooded animal a vector construct which directs the expression of at least one anti-tumor agent, such that the growth of said tumor is inhibited. Representative examples of anti-tumor agents include immune activators and tumor proliferation inhibitors.
摘要翻译： 本发明提供了利用重组病毒载体抑制所选择的肿瘤生长的方法。 简言之，在本发明的一个方面，提供了抑制所选择的肿瘤生长的方法，其包括直接向温血动物施用指导至少一种抗肿瘤剂表达的载体构建体的步骤， 使得所述肿瘤的生长被抑制。 抗肿瘤剂的代表性实例包括免疫激活剂和肿瘤增殖抑制剂。
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公开(公告)号：US06241982B1
公开(公告)日：2001-06-05
申请号：US08468646
申请日：1995-06-06
IPC分类号： A61K4800
CPC分类号： A01K67/033 , A01K67/0275 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/03 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N15/86 , C12N2710/16622 , C12N2740/13022 , C12N2740/15022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译： 本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。 还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。
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9.发明授权Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene 失效生成编码细胞因子和条件致死基因的腺病毒载体的细胞公开(公告)号：US06569679B1
公开(公告)日：2003-05-27
申请号：US08471645
申请日：1995-06-06
IPC分类号： C12N1586
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C12N7/00 , C12N9/1211 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2710/16622 , C12N2740/13043 , C12N2740/15022 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译： 本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。 还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。
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10.发明授权
公开(公告)号：US5997859A
公开(公告)日：1999-12-07
申请号：US467034
申请日：1995-06-06
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/20 , A61K38/21 , A61K39/00 , A61K48/00 , A61P35/00 , A61P35/04 , C07K14/035 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/85 , C12N15/867 , A61K31/70
CPC分类号： A01K67/033 , A01K67/0275 , A61K38/2013 , A61K38/217 , A61K39/0011 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/03 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2710/16622 , C12N2740/13022 , C12N2740/15022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译： 本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。 还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。
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