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    Metal Stent with Surface Layer of Noble Metal Oxide and Method of Fabrication
    42.
    发明申请
    Metal Stent with Surface Layer of Noble Metal Oxide and Method of Fabrication 失效
    金属支架与贵金属氧化物表面层及其制作方法

    公开(公告)号：US20080147167A1

    公开(公告)日：2008-06-19

    申请号：US11952624

    申请日：2007-12-07

    Applicant: Torsten Scheuermann ,  Lutz Stehling

    Inventor： Torsten Scheuermann ,  Lutz Stehling

    IPC: A61F2/06 ,  A61L33/02

    CPC classification number: A61L31/022 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2310/00598 ,  A61L31/088 ,  A61L31/18

    Abstract: In a process for producing a biocompatible stent, a tubular substrate of the stent adapted for diametric expansion has a layer of a noble metal oxide formed over at least the outer surface of greater diameter of the substrate, the substrate being composed of a metal or an alloy thereof that is non-noble or less-noble than the layer's noble metal. An interface region adapted to prevent corrosion and to provide a firm bond between the surface of the substrate and the noble metal oxide layer is established, at least in part, by forming the noble metal oxide layer with a progressively varying concentration of noble metal-to-oxide with depth of the layer such that a surface of pure noble metal and negligible oxide of the layer is in closest proximity to the surface of the substrate. In one embodiment of the process, the interface region is established by forming the surface of pure noble metal and negligible oxide thereof in direct contact with the metal or alloy of the substrate surface. In another, the interface region is established by first creating an oxide of the substrate metal or alloy thereof at the substrate surface, and then forming the noble metal oxide layer as above, but in contact with the substrate metal or alloy oxide. Alternatively, the noble metal oxide layer has no progressively varying concentration but simply overlies an oxide of the substrate metal or alloy.

    Abstract translation: 在制造生物相容性支架的方法中，适用于直径膨胀的支架的管状基底具有至少在基底的较大直径的外表面上形成的贵金属氧化物层，该基底由金属或 它的合金是非贵重的或比贵金属低贵的贵金属。 至少部分地通过以逐渐变化的贵金属浓度形成贵金属氧化物层，从而建立适于防止腐蚀并提供衬底的表面与贵金属氧化物层之间牢固结合的界面区域 - 至少 氧化物，其层的深度使得纯贵金属的表面和该层的可忽略的氧化物最接近衬底的表面。 在该方法的一个实施方案中，通过形成纯金属的表面和与基底表面的金属或合金直接接触的可忽略的氧化物的表面来建立界面区域。 另一方面，通过首先在基板表面产生基板金属或其合金的氧化物，然后如上所述形成贵金属氧化物层，但与基板金属或合金氧化物接触来建立界面区域。 或者，贵金属氧化物层的浓度没有逐渐变化，而是简单地覆盖基板金属或合金的氧化物。

    Medical devices and methods of making the same
    43.
    发明申请
    Medical devices and methods of making the same 失效
    医疗器械和制造方法

    公开(公告)号：US20060251794A1

    公开(公告)日：2006-11-09

    申请号：US11122583

    申请日：2005-05-05

    Applicant: Torsten Scheuermann

    Inventor： Torsten Scheuermann

    IPC: A61L33/00

    CPC classification number: C03C8/00 ,  A61L31/082

    Abstract: Medical devices, such as stents, and methods of making the devices are disclosed. In some embodiments, a method includes diffusing a first element into a first portion of the medical device. The first element includes carbon, hydrogen, nitrogen, oxygen, or combinations thereof. The first portion includes a refractory material.

    Abstract translation: 公开了诸如支架的医疗装置和制造装置的方法。 在一些实施例中，一种方法包括将第一元件扩散到医疗装置的第一部分中。 第一元素包括碳，氢，氮，氧或它们的组合。 第一部分包括耐火材料。

    Medical devices having a coating of inorganic material
    44.
    发明授权
    Medical devices having a coating of inorganic material 有权
    具有无机材料涂层的医疗器械

    公开(公告)号：US08920491B2

    公开(公告)日：2014-12-30

    申请号：US12425791

    申请日：2009-04-17

    Applicant: Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    Inventor： Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    IPC: A61F2/06 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

    CPC classification number: A61L29/10 ,  A61L29/16 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/61

    Abstract: In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.

    Abstract translation: 在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。 在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中 可膨胀材料是暴露于含水环境时膨胀的材料。 在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。 在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中， 阻挡层具有多个不连续性。 还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

    Medical devices having metal coatings for controlled drug release
    46.
    发明授权
    Medical devices having metal coatings for controlled drug release 有权
    具有用于受控药物释放的金属涂层的医疗装置

    公开(公告)号：US08361139B2

    公开(公告)日：2013-01-29

    申请号：US12498829

    申请日：2009-07-07

    Applicant: Aiden Flanagan ,  Barry O'Brien ,  Torsten Scheuermann

    Inventor： Aiden Flanagan ,  Barry O'Brien ,  Torsten Scheuermann

    IPC: A61F2/06 ,  A61F2/00

    CPC classification number: A61L31/088 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/624

    Abstract: Medical devices having a plurality of nanoparticles disposed over a surface of the medical device. The nanoparticles have a core comprising a therapeutic agent and a shell surrounding the core, wherein the shell comprises a metal. A barrier layer is disposed over the nanoparticles. The barrier layer is water-permeable and comprises a metal that may be different from the metal used in the nanoparticle shells. In certain embodiments, the metal in the barrier layer undergoes galvanic corrosion. Also disclosed are medical device having a reservoir containing a therapeutic agent, with nanoparticles and a barrier layer being disposed over the reservoir; and medical devices having multiple barrier layers and multiple reservoirs containing therapeutic agents.

    Abstract translation: 具有设置在医疗装置的表面上的多个纳米颗粒的医疗装置。 纳米颗粒具有包含治疗剂的核心和围绕核心的壳体，其中壳体包含金属。 阻挡层设置在纳米粒子上。 阻挡层是透水性的并且包含可以与纳米颗粒壳中使用的金属不同的金属。 在某些实施例中，阻挡层中的金属经历电偶腐蚀。 还公开了具有包含治疗剂的储存器的医疗装置，其中纳米颗粒和阻挡层设置在储存器上方; 以及具有多个阻隔层的医疗装置和含有治疗剂的多个储存器。

    Resonator with adjustable capacitance for medical device
    47.
    发明授权
    Resonator with adjustable capacitance for medical device 失效
    用于医疗设备的可调电容谐振器

    公开(公告)号：US08046048B2

    公开(公告)日：2011-10-25

    申请号：US12220819

    申请日：2008-07-29

    Applicant: Torsten Scheuermann

    Inventor： Torsten Scheuermann

    IPC: A61B5/05

    CPC classification number: G01R33/286 ,  G01R33/3628

    Abstract: Systems and methods for a resonator with an adjustable capacitance for a medical device. In one embodiment, a resonator system includes a resonator device with an LC resonator circuit that has an adjustable capacitance, an inductor coil in series with the adjustable capacitance, and an adjustable capacitance control that can control the adjustable capacitance to obtain different particular capacitance values. This embodiment also includes a medical device, positioned with the resonator device, so that at least a portion of the inductor coil surrounds a space that is surrounded by at least a portion of the medical device.

    Abstract translation: 用于医疗设备具有可调电容的谐振器的系统和方法。 在一个实施例中，谐振器系统包括具有可调电容的LC谐振器电路的谐振器装置，与可调电容串联的电感线圈，以及可调节的电容控制，其可以控制可调电容以获得不同的特定电容值。 该实施例还包括与谐振器装置一起定位的医疗装置，使得电感线圈的至少一部分围绕由医疗装置的至少一部分包围的空间。

    Bioerodible Endoprosthesis
    48.
    发明申请
    Bioerodible Endoprosthesis 审中-公开
    生物蚀刻内置假体

    公开(公告)号：US20100292776A1

    公开(公告)日：2010-11-18

    申请号：US12466110

    申请日：2009-05-14

    Applicant: Jan Weber ,  Torsten Scheuermann

    Inventor： Jan Weber ,  Torsten Scheuermann

    IPC: A61F2/06

    CPC classification number: A61F2/91 ,  A61F2/852 ,  A61F2210/0004 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2250/003 ,  A61F2250/0063

    Abstract: A stent includes a first tubular element formed of a first bioerodible metal composition and second tubular element formed of a second biodegradable metal composition. The first and second tubular elements are concentrically arranged; and the first and second bioerodible metal compositions are different.

    Abstract translation: 支架包括由第一生物腐蚀性金属组合物形成的第一管状元件和由第二生物可降解金属组合物形成的第二管状元件。 第一和第二管状元件同心地布置; 并且第一和第二生物腐蚀性金属组合物是不同的。

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