公开(公告)号：US08795595B2

公开(公告)日：2014-08-05

申请号：US12772050

申请日：2010-04-30

申请人： Rajiv Shah

发明人： Rajiv Shah

IPC分类号： G01N21/64 ,  G01N33/48 ,  G01N33/66

CPC分类号： G01N21/6428 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/14865

摘要： A sensing apparatus may include a substrate having a first side for a sensing element and a second side for electronics, the substrate may have a at least one via from the first side of the substrate to the second side of the substrate, the at least one via may be hermetically sealed with an optically transmissive material.

摘要翻译： 感测装置可以包括具有用于感测元件的第一侧和用于电子器件的第二侧的衬底，衬底可以具有从衬底的第一侧到衬底的第二侧的至少一个通孔，至少一个 通孔可以用光学透射材料气密密封。

公开(公告)号：US08795224B2

公开(公告)日：2014-08-05

申请号：US13009531

申请日：2011-01-19

申请人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

发明人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H50/30

摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

公开(公告)号：US08777896B2

公开(公告)日：2014-07-15

申请号：US13009519

申请日：2011-01-19

申请人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

发明人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H50/30

摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

摘要翻译： 一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。 该算法计算具有比例，导数和基础速率分量的传送量。 可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。 交付量的安全限制可能包含在算法中。 该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。 生物状态由感测装置感测到，该感测装置向控制器提供信号。 所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

公开(公告)号：US20140012115A1

公开(公告)日：2014-01-09

申请号：US13541262

申请日：2012-07-03

申请人： Yiwen Li ,  Jenn-Hann Larry Wang ,  Rajiv Shah

发明人： Yiwen Li ,  Jenn-Hann Larry Wang ,  Rajiv Shah

IPC分类号： A61B5/1473 ,  C23C16/50

CPC分类号： C12Q1/54 ,  C12Q1/006 ,  G01N27/307

摘要： Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of adhesion promoting compositions useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.

摘要翻译： 本发明的实施方案提供了用于制备分析物传感器的方法和材料，所述分析物传感器具有多个分层元件，例如由糖尿病个体用于监测血糖浓度的电流葡萄糖传感器。 本发明的实施方案利用等离子体沉积技术形成用于这种传感器的粘合促进组合物的薄膜。 结合由这些方法形成的薄膜组合物的传感器表现出许多期望的特性。

公开(公告)号：US08608924B2

公开(公告)日：2013-12-17

申请号：US13328472

申请日：2011-12-16

申请人： Kenneth W. Cooper ,  David Y. Choy ,  Rajiv Shah ,  Gopikrishnan Soundararajan ,  Ratnakar Vejella

发明人： Kenneth W. Cooper ,  David Y. Choy ,  Rajiv Shah ,  Gopikrishnan Soundararajan ,  Ratnakar Vejella

IPC分类号： G01N27/327 ,  G01N27/416

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/6849 ,  A61B17/3468 ,  A61B2560/0223 ,  G01N27/3271

摘要： According to an embodiment of the invention, a method of determining hydration of a sensor having a plurality of electrodes is disclosed. In particular embodiments, the method couples a sensor electronics device to the sensor and measures the open circuit potential between at least two of the plurality of electrodes. Then, the open circuit potential measurement is compared to a predetermined value. In some embodiments, the plurality of electrodes includes a working electrode, a reference electrode, and a counter electrode. In still further embodiments, the open circuit potential between the working electrode and the reference electrode is measured. In other embodiments, the open circuit potential between the working electrode and the counter electrode is measured. In still other embodiments, the open circuit potential between the counter electrode and the reference electrode is measured.

摘要翻译： 根据本发明的实施例，公开了一种确定具有多个电极的传感器的水化的方法。 在具体实施例中，该方法将传感器电子设备耦合到传感器并且测量多个电极中的至少两个之间的开路电位。 然后，将开路电位测量与预定值进行比较。 在一些实施例中，多个电极包括工作电极，参考电极和对电极。 在另外的实施例中，测量工作电极和参考电极之间的开路电位。 在其他实施例中，测量工作电极和对电极之间的开路电位。 在其他实施例中，测量对电极和参考电极之间的开路电位。

公开(公告)号：US08602992B2

公开(公告)日：2013-12-10

申请号：US12887465

申请日：2010-09-21

申请人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

发明人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

摘要翻译： 传感器系统包括传感器和传感器电子设备。 传感器包括多个电极。 传感器电子设备包括连接检测装置，电源和延迟电路。 连接检测装置确定传感器电子设备是否连接到传感器并发送连接信号。 延迟电路接收连接信号，等待预设的水合时间，并且在经过预设水合时间之后将调节的电压从电源耦合到传感器中的电极。 或者，传感器电子设备可以包括电检测电路和微控制器。 电检测电路确定多个电极是否水合，并且如果电极是水合的则产生中断。 微控制器接收中断，并将代表电压的信号传送到多个电极的电极。

公开(公告)号：US08532732B2

公开(公告)日：2013-09-10

申请号：US12887449

申请日：2010-09-21

申请人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

发明人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC分类号： A61B5/05

CPC分类号： G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US08352011B2

公开(公告)日：2013-01-08

申请号：US12264810

申请日：2008-11-04

申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Larry Wang ,  Kent L. Clark

发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Larry Wang ,  Kent L. Clark

IPC分类号： A61B5/05

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

公开(公告)号：US20120227737A1

公开(公告)日：2012-09-13

申请号：US13472117

申请日：2012-05-15

申请人： JOHN J. MASTROTOTARO ,  Rajiv Shah ,  Partha Ray ,  Kenny J. Long ,  Andrew C. Hayes ,  Nandita Patel ,  Cary D. Talbot ,  Bahar Reghabi

发明人： JOHN J. MASTROTOTARO ,  Rajiv Shah ,  Partha Ray ,  Kenny J. Long ,  Andrew C. Hayes ,  Nandita Patel ,  Cary D. Talbot ,  Bahar Reghabi

IPC分类号： A61M5/31 ,  A61M5/307 ,  A61M15/00

CPC分类号： G06F19/3456 ,  G16H40/63

摘要： An analyte sensor and systems for determining analyte levels in a user's body. The analyte sensor and systems are adapted to be used with single dose medication devices and include a communication system to transmit the communications from the analyte sensor to the user to notify the user of an estimated amount of fluid to deliver to the user's body. More particularly, these apparatuses and methods for use are for providing convenient monitoring of blood glucose levels in determining the appropriate amount of insulin to deliver.

摘要翻译： 分析物传感器和用于确定用户身体中的分析物水平的系统。 分析物传感器和系统适于与单剂量药物装置一起使用，并且包括通信系统，用于将来自分析物传感器的通信传输给用户，以向使用者通报估计量的流体以递送给使用者的身体。 更具体地，这些使用的装置和方法用于在确定适当量的胰岛素输送时提供对血糖水平的便利监测。

公开(公告)号：US08187851B2

公开(公告)日：2012-05-29

申请号：US12179502

申请日：2008-07-24

申请人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

发明人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

IPC分类号： C12N11/02 ,  C12Q1/54 ,  C12Q1/26 ,  C12M1/34

CPC分类号： C07K1/1077 ,  C12Q1/54 ,  Y10S435/817

摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。