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1.发明申请公开(公告)号：US20140012115A1
公开(公告)日：2014-01-09
申请号：US13541262
申请日：2012-07-03
申请人： Yiwen Li , Jenn-Hann Larry Wang , Rajiv Shah
发明人： Yiwen Li , Jenn-Hann Larry Wang , Rajiv Shah
IPC分类号： A61B5/1473 , C23C16/50
CPC分类号： C12Q1/54 , C12Q1/006 , G01N27/307
摘要： Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of adhesion promoting compositions useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.
摘要翻译： 本发明的实施方案提供了用于制备分析物传感器的方法和材料，所述分析物传感器具有多个分层元件，例如由糖尿病个体用于监测血糖浓度的电流葡萄糖传感器。 本发明的实施方案利用等离子体沉积技术形成用于这种传感器的粘合促进组合物的薄膜。 结合由这些方法形成的薄膜组合物的传感器表现出许多期望的特性。
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公开(公告)号：US20080026473A1
公开(公告)日：2008-01-31
申请号：US11492273
申请日：2006-07-25
申请人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。
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公开(公告)号：US08352011B2
公开(公告)日：2013-01-08
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
IPC分类号： A61B5/05
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US09237865B2
公开(公告)日：2016-01-19
申请号：US11492273
申请日：2006-07-25
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
IPC分类号： G01N33/48 , A61B5/05 , A61B5/1486 , A61B5/145 , C12Q1/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。
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5.发明申请ANALYTE SENSORS COMPRISING BLENDED MEMBRANE COMPOSITIONS AND METHODS FOR MAKING AND USING THEM 有权包含混合膜组合物的分析仪传感器及其制备和使用方法公开(公告)号：US20110152654A1
公开(公告)日：2011-06-23
申请号：US12643790
申请日：2009-12-21
IPC分类号： A61B5/1473 , G01N27/26 , C12Q1/26 , B05D1/36
CPC分类号： G01N33/5438 , G01N27/307 , G01N33/54393
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物和支化丙烯酸酯聚合物的共混混合物。
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6.发明授权Analyte sensors comprising blended membrane compositions and methods for making and using them 有权分析物传感器包括混合膜组合物和制备和使用它们的方法公开(公告)号：US08660628B2
公开(公告)日：2014-02-25
申请号：US12643790
申请日：2009-12-21
IPC分类号： A61B5/05
CPC分类号： G01N33/5438 , G01N27/307 , G01N33/54393
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物和支化丙烯酸酯聚合物的共混混合物。
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7.发明申请STABILIZED POLYMERS FOR USE WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开用于分析传感器的稳定聚合物及其制备和使用方法公开(公告)号：US20130178726A1
公开(公告)日：2013-07-11
申请号：US13344343
申请日：2012-01-05
IPC分类号： A61B5/1477 , C08G77/388 , A61K49/00
CPC分类号： C08G77/458 , C08K5/13 , C12Q1/002 , C08L75/00
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物，其包含一种或多种选自其稳定聚合物抵抗热和/或氧化降解的能力的试剂。
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公开(公告)号：US08808532B2
公开(公告)日：2014-08-19
申请号：US13010636
申请日：2011-01-20
申请人： Qingling Yang , Rajiv Shah , Xiaolong Li , Barry Phong Pham , Yiwen Li
发明人： Qingling Yang , Rajiv Shah , Xiaolong Li , Barry Phong Pham , Yiwen Li
IPC分类号： G01N27/327
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译： 本发明的实施例提供具有优化元件的电流分析传感器，例如由溅射的铂组合物形成的电极以及被选择用于优化各种传感器元件和传感器的特性的材料层。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。
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公开(公告)号：US08608921B2
公开(公告)日：2013-12-17
申请号：US13010640
申请日：2011-01-20
申请人： Xiaolong Li , Rajiv Shah , Qingling Yang , Yiwen Li , Barry Phong Pham
发明人： Xiaolong Li , Rajiv Shah , Qingling Yang , Yiwen Li , Barry Phong Pham
IPC分类号： G01N27/327 , G01N27/416
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译： 本发明的实施例提供具有优化元件的电流分析传感器，例如由溅射的铂组合物形成的电极以及被选择用于优化各种传感器元件和传感器的特性的材料层。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。
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公开(公告)号：US20120190950A1
公开(公告)日：2012-07-26
申请号：US13010636
申请日：2011-01-20
申请人： Qingling Yang , Rajiv Shah , Xiaolong Li , Barry Phong Pham , Yiwen Li
发明人： Qingling Yang , Rajiv Shah , Xiaolong Li , Barry Phong Pham , Yiwen Li
IPC分类号： A61B5/1468 , G01N27/333 , B05D1/36 , B05D5/12 , C23C16/50 , H01B1/22 , G01N33/50
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译： 本发明的实施例提供具有优化元件的电流分析传感器，例如由溅射的铂组合物形成的电极以及被选择用于优化各种传感器元件和传感器的特性的材料层。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。
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