HIGH MOLECULAR WEIGHT ESTHETIC COMPOSITIONS
    42.
    发明公开

    公开(公告)号:US20230346680A1

    公开(公告)日:2023-11-02

    申请号:US18348736

    申请日:2023-07-07

    CPC classification number: A61K8/735 A61K8/042 A61Q19/00

    Abstract: Described are high molecular weight glycosaminoglycan (GAG) hydrogel compositions comprising GAGs covalently crosslinked with a carbohydrate crosslinker, and methods of making the high molecular weight GAG hydrogel compositions. Further described are methods of using the high molecular weight glycosaminoglycan (GAG) hydrogel compositions for reparative or plastic surgery, esthetic dermatology, facial contouring, body contouring, and gingival augmentation.

    METHOD OF SOFT TISSUE AUGMENTATION
    45.
    发明公开

    公开(公告)号:US20230211051A1

    公开(公告)日:2023-07-06

    申请号:US17941713

    申请日:2022-09-09

    Inventor: Bengt Agerup

    CPC classification number: A61L27/50 A61L27/20 A61L15/20 A61L15/58 A61L15/52

    Abstract: Particles made of a viscoelastic medium, are injectable gel particles, and have a size, when subjected to a physiological salt solution, in the range of from 1 to 5 mm. The particles are useful in a soft tissue augmentation implant. The implant includes particles of a viscoelastic medium, wherein a major volume of the particles are injectable gel particles The implant is useful in a method of soft tissue augmentation in a mammal, including man, comprising subepidermal administration at a site in said mammal where soft tissue augmentation is desirable, of an implant.

    METHOD OF PURIFYING BOTUFINUM TOXIN

    公开(公告)号:US20230029456A1

    公开(公告)日:2023-02-02

    申请号:US17757734

    申请日:2020-12-19

    Abstract: The present technology relates to commercial-scale methods for purifying botulinum toxin compositions obtained from cell cultures. Purification methods according to the present disclosure are based on a series of filtration and chromatographic separation steps that produce a high-purity botulinum toxin composition, which comprises botulinum toxin protein molecules (˜150 kDa) in solution, which is free, essentially free, or substantially free of botulinum toxin complexes and animal products, and without precipitating or lyophilizing botulinum toxin protein molecules. The purification method according to the present disclosure uses no precipitation, lyophilization, or centrifugation steps, permitting production of highly pure, highly active, free botulinum toxin protein molecules (˜150 kDa) in solution, without the need for reconstitution by the end user.

    Method of soft tissue augmentation
    48.
    发明授权

    公开(公告)号:US11458226B2

    公开(公告)日:2022-10-04

    申请号:US16593941

    申请日:2019-10-04

    Inventor: Bengt Ågerup

    Abstract: Particles made of a viscoelastic medium, are injectable gel particles, and have a size, when subjected to a physiological salt solution, in the range of from 1 to 5 mm. The particles are useful in a soft tissue augmentation implant. The implant includes particles of a viscoelastic medium, wherein a major volume of the particles are injectable gel particles The implant is useful in a method of soft tissue augmentation in a mammal, including man, comprising subepidermal administration at a site in said mammal where soft tissue augmentation is desirable, of an implant.

    Syringe
    49.
    发明授权
    Syringe 有权

    公开(公告)号:US11376369B2

    公开(公告)日:2022-07-05

    申请号:US16066900

    申请日:2016-12-21

    Abstract: A syringe including a barrel, a plunger moveably arranged within said barrel, and a plunger rod for driving said plunger. A first engagement member is arranged at the plunger rod, such that a longitudinal movement of the plunger rod yields a rotational movement of said first engagement member. The first engagement member includes a grooved surface. A second engagement member is arranged at the barrel to engage with said grooved surface of the first engagement member, wherein the first engagement member is arranged to move relative to the second engagement member, such that feedback is given to a user as the plunger rod is moved relative to the barrel for driving said plunger. The first engagement member is arranged at said plunger rod with a predetermined play there between.

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