公开(公告)号：US20240132471A1

公开(公告)日：2024-04-25

申请号：US18524678

申请日：2023-11-30

申请人： Hoffmann-La Roche Inc.

发明人： Lea Aurelie BOUCHE ,  Wolfgang GUBA ,  Georg JAESCHKE ,  Stefanie Katharina MESCH ,  Angélique PATINY-ADAM ,  Christian SCHNIDER ,  Sandra STEINER ,  Andreas Michael TOSSTORFF

IPC分类号： C07D401/12 ,  C07D253/07 ,  C07D405/14 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D253/07 ,  C07D405/14 ,  C07D471/04

摘要： The invention relates to novel compounds having the general formula Ib






wherein R1, R2, R1, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.

公开(公告)号：US20240122469A1

公开(公告)日：2024-04-18

申请号：US18542893

申请日：2023-12-18

申请人： HOFFMANN-LA ROCHE INC.

发明人： Geraint Iwan DAVIES ,  Jonas Franz DORN ,  Bernhard FEHLMANN ,  Noémie HURST-FISCHER ,  Angelos KARATSIDIS ,  Joerg SPRENGEL

IPC分类号： A61B3/113 ,  A61B3/00 ,  A61B5/00 ,  A61B5/11 ,  G06F3/01

CPC分类号： A61B3/113 ,  A61B3/0025 ,  A61B3/005 ,  A61B5/1114 ,  A61B5/6803 ,  G06F3/012 ,  G06F3/013

摘要： A virtual reality system for quantifying functional visual capabilities of a user at varying assessment conditions (e.g., varying light, contrast, color conditions), using a head-mountable display. In addition to the high relevance to users with optical conditions, the present embodiments can lead to rapid and simple measurements within the controlled and reproducible testing conditions that virtual reality can offer. The virtual environment system can obtain a selection of a task to be performed. During execution of the task, a virtual environment optical setting (e.g., a modified lighting setting in the virtual environment display) can be dynamically modified. The user can interact with the objects during execution of the task, which can provide an insight into functional visual capabilities of the user. After completion of the task, an output can be generated that quantifies a functional visual capability of the user during execution of the task.

公开(公告)号：US11952155B2

公开(公告)日：2024-04-09

申请号：US17296770

申请日：2019-11-25

申请人： HOFFMANN-LA ROCHE INC.

发明人： Carmen Lema Martinez ,  Joerg Luemkemann ,  Tobias Werk ,  Thomas Zumstein ,  Daniel Kullmann

IPC分类号： B65B3/00 ,  A61J1/10 ,  A61J1/14 ,  A61J1/20 ,  B65B3/02 ,  B65B29/10

CPC分类号： B65B3/003 ,  A61J1/10 ,  A61J1/1475 ,  A61J1/2024 ,  A61J1/2093 ,  B65B3/022 ,  B65B29/10

摘要： A method of manufacturing a flexible container housing a drug substance is disclosed that includes forming a first compartment from a flexible sheet-like material, filling a liquid into the first compartment, sealing the first compartment, forming a second compartment from the flexible sheet-like material, filling a dry drug formulation into the second compartment, and sealing the second compartment. The method further involves lyophilizing the drug formulation inside a tubular cartridge, filling the second compartment by introducing the tubular cartridge through an opening of the second compartment such that an open end of the tubular cartridge is positioned distant from the opening of the second compartment, providing the drug formulation from the open end of the tubular cartridge into the second compartment, and withdrawing the tubular cartridge from the second compartment. The first and second compartments are separated by a frangible seal which opens when the first compartment is compressed.

公开(公告)号：US20240100063A1

公开(公告)日：2024-03-28

申请号：US18303802

申请日：2023-04-20

申请人： Hoffmann-La Roche Inc.

发明人： Denise Corti ,  Stephan Gasser ,  Gabor Gyulveszi ,  Claudio Murgia ,  Tobias Schmidt ,  Martha Liliana Serrano Serrano ,  Pablo Umaña

IPC分类号： A61K31/551 ,  A61K31/506 ,  A61K31/5377 ,  C07K16/28

CPC分类号： A61K31/551 ,  A61K31/506 ,  A61K31/5377 ,  C07K16/2827 ,  A61K2039/505

摘要： The present invention relates to combination therapies employing PD-1 axis binding antagonists and LRRK2 inhibitors and, and the use of these combination therapies for the treatment of cancer.

公开(公告)号：US20240087726A1

公开(公告)日：2024-03-14

申请号：US18506905

申请日：2023-11-10

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc. ,  Ventana Medical Systems, Inc.

发明人： Paolo Santiago Syjuco OCAMPO ,  Bernhard STIMPEL ,  Yao NIE ,  Fahime SHEIKHZADEH ,  Xiao LI ,  Przemyslaw SZOSTAK ,  Prasanna PORWAL ,  Faranak AGHAEI

IPC分类号： G16H30/40 ,  G06T7/00 ,  G16H20/00 ,  G16H50/20

CPC分类号： G16H30/40 ,  G06T7/0012 ,  G16H20/00 ,  G16H50/20

摘要： A method includes accessing a digital pathology image that depicts tumor cells sampled from a subject. A plurality of patches may be selected from the digital pathology image, wherein each of the patches depicts tumor cells. A mutation prediction may be generated for each of the patches, wherein the mutation prediction represents a prediction of a likelihood that an actionable mutation appears in the patch. Based on the plurality of mutation predictions, a prognostic prediction related to one or more treatment regimens for the subject may be generated. The prognostic prediction may be based on determining one or more mutational contexts of the digital pathology image as an unknown driver or a tumor suppressor, an oncogene driver mutation, or a gene fusion.

公开(公告)号：US20240084295A1

公开(公告)日：2024-03-14

申请号：US18331536

申请日：2023-08-29

申请人： Hoffmann-La Roche Inc.

发明人： Martin Bollmark ,  Walter Fernando Sehgelmeble Torrejon ,  Filippo Sladojevich ,  Ulf Tedebark

IPC分类号： C12N15/11 ,  C07H19/10 ,  C07H19/20

CPC分类号： C12N15/111 ,  C07H19/10 ,  C07H19/20 ,  C12N2310/313 ,  C12N2310/3231 ,  C12N2330/30

摘要： The invention provides the use of a compound of formula (I), as defined, for the preparation of an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage. Various synthesis methods using compounds of formula (I) are provided.

公开(公告)号：US20240079138A1

公开(公告)日：2024-03-07

申请号：US18139873

申请日：2023-04-26

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc. ,  Ventana Medical Systems, Inc.

发明人： Yao NIE ,  Xiao LI ,  Trung Kien NGUYEN ,  Fabien GAIRE ,  Eldad KLAIMAN ,  Ido BEN-SHAUL ,  Jacob GILDENBLAT ,  Ofir Etz HADAR

IPC分类号： G16H50/20 ,  G06T7/00 ,  G16H30/40

CPC分类号： G16H50/20 ,  G06T7/0012 ,  G16H30/40 ,  G06T2207/20084

摘要： Systems and methods relate to predicting disease progression by processing digital pathology images using neural networks. A digital pathology image that depicts a specimen stained with one or more stains is accessed. The specimen may have been collected from a subject. A set of patches are defined for the digital pathology image. Each patch of the set of patches depicts a portion of the digital pathology image. For each patch of the set of patches and using an attention-score neural network, an attention score is generated. The attention-score neural network may have been trained using a loss function that penalized attention-score variability across patches in training digital pathology images labeled to indicate no or low subsequent disease progression. Using a result-prediction neural network and the attention scores, a result is generated that represents a prediction of whether or an extent to which a disease of the subject will progress.

公开(公告)号：US20240076302A1

公开(公告)日：2024-03-07

申请号：US18496034

申请日：2023-10-27

申请人： Hoffmann-La Roche Inc. ,  PTC Therapeutics, Inc.

发明人： Hasane RATNI ,  Luke GREEN ,  Marla L. WEETALL ,  Nikolai A. NARYSHKIN

IPC分类号： C07D519/00

CPC分类号： C07D519/00

摘要： The present invention provides compounds of formula (I)






wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

公开(公告)号：US20240059692A1

公开(公告)日：2024-02-22

申请号：US18255085

申请日：2021-11-29

申请人： Hoffmann-La Roche Inc.

发明人： Cosimo DOLENTE ,  Annick GOERGLER ,  David Stephen HEWINGS ,  Georg JAESCHKE ,  Ulrike OBST SANDER ,  Antonio RICCI

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The invention provides novel compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as described herein. The compound of formula (I) can be used as a medicament.

公开(公告)号：US11901077B2

公开(公告)日：2024-02-13

申请号：US17376796

申请日：2021-07-15

申请人： HOFFMANN-LA ROCHE INC.

发明人： Eldad Klaiman ,  Jacob Gildenblat

IPC分类号： G16H15/00 ,  G16H50/20 ,  G16H30/40 ,  G06F3/0482 ,  G06V20/69 ,  G06F18/214 ,  G06F18/22 ,  G06F18/40 ,  G06F18/21 ,  G06V10/762 ,  G06V10/774 ,  G06V10/80 ,  G06V10/44

CPC分类号： G16H50/20 ,  G06F3/0482 ,  G06F18/214 ,  G06F18/217 ,  G06F18/2163 ,  G06F18/22 ,  G06F18/40 ,  G06V10/454 ,  G06V10/763 ,  G06V10/774 ,  G06V10/809 ,  G06V20/695 ,  G06V20/698 ,  G16H30/40 ,  G06V2201/03

摘要： The method includes receiving digital images of tissue samples of patients, the images having assigned a label indicating a patient-related attribute value; splitting each received image into a set of image tiles; computing a feature vector for each tile; training a Multiple-Instance-Learning program on all the tiles and respective feature vectors for computing for each of the tiles a numerical value being indicative of the predictive power of the feature vector associated with the tile in respect to the label of the tile's respective image; and outputting a report gallery including tiles sorted in accordance with their respectively computed numerical value and/or including a graphical representation of the numerical value.