公开(公告)号：US20120309106A1

公开(公告)日：2012-12-06

申请号：US13197294

申请日：2011-08-03

Applicant: Yoav Eichen ,  Uri Sivan ,  Erez Braun

Inventor： Yoav Eichen ,  Uri Sivan ,  Erez Braun

IPC: G01N27/26

CPC classification number: C12Q1/6825 ,  C12Q1/6816 ,  C12Q1/6834 ,  G01N33/5438

Abstract: The invention concerns a system, device, kit and method for detecting the presence, or concentration of a target in a sample. An assay set comprising at least two spaced apart electrodes is used, comprising a recognition moiety, capable of specific binding to the target, which is attached to at least one of the electrodes or the substrate therein between. If the recognition moiety binds the target then a conductive bridge can be formed between the electrodes, based on the complex between the recognition moiety and the target. The conductive bridge is formed by using nucleation-center forming entities attached to the complexes or to the targets from which a conductive substance is substantially grown. Alternatively the conducting bridge forms a conductive polymer between the electrodes.

Abstract translation: 本发明涉及一种用于检测样品中靶的存在或浓度的系统，装置，试剂盒和方法。 使用包含至少两个间隔开的电极的测定组，其包含能够特异性结合靶的识别部分，其连接到其中的至少一个电极或其中的基底。 如果识别部分结合靶，则可以基于识别部分和靶之间的复合物在电极之间形成导电桥。 导电桥是通过使用连接到复合物或基本上生长导电物质的靶的成核中心形成实体形成的。 或者，导电桥在电极之间形成导电聚合物。

公开(公告)号：US20120245434A1

公开(公告)日：2012-09-27

申请号：US13424685

申请日：2012-03-20

Applicant: Hossam Haick ,  Abraham Marmur ,  Urike Tisch

Inventor： Hossam Haick ,  Abraham Marmur ,  Urike Tisch

IPC: A61B5/00 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61B5/082 ,  A61B5/4082 ,  A61B5/4842 ,  B82Y15/00 ,  G06F19/707

Abstract: The present invention provides a system and method for diagnosing, monitoring, prognosing or staging Parkinson's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof or metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.

Abstract translation: 本发明提供了一种用于使用至少一个传感器诊断，监测，预后或分期帕金森病的系统和方法，所述传感器包括涂覆有环糊精或其衍生物的碳纳米管，或结合学习和模式识别算法涂覆有各种有机涂层的金属纳米颗粒。

公开(公告)号：US20120208863A1

公开(公告)日：2012-08-16

申请号：US13442918

申请日：2012-04-10

Applicant: EDDY KARNIELI ,  DAFNA BEN-YOSEF

Inventor： EDDY KARNIELI ,  DAFNA BEN-YOSEF

IPC: A61K31/713 ,  A61P3/08 ,  C07H21/02

CPC classification number: A61K31/713 ,  A61K38/1709 ,  C12N15/113 ,  C12N2310/14 ,  G01N33/5023

Abstract: Agents capable of alleviating AHNAK phosphoprotein-mediated repression of GLUT4 gene expression are useful for prevention, treatment, and/or alleviation of insulin resistance associated with obesity, lipotoxicity, hypertension, metabolic syndrome and type 2 diabetes. Preferred agents are double-stranded siRNAs.

Abstract translation: 能够减轻AHNAK磷蛋白介导的GLUT4基因表达抑制的试剂可用于预防，治疗和/或减轻与肥胖，脂毒性，高血压，代谢综合征和2型糖尿病相关的胰岛素抵抗。 优选的试剂是双链siRNA。

公开(公告)号：US20120171755A1

公开(公告)日：2012-07-05

申请号：US13338831

申请日：2011-12-28

Applicant: Elad Peer ,  Uri Sivan

Inventor： Elad Peer ,  Uri Sivan

IPC: C12M1/00

CPC classification number: C12M35/00

Abstract: The present invention provides a method of fabricating a device having hollow nanoneedles which extend through a supporting membrane. The device can be used as a molecular delivery system.5

Abstract translation: 本发明提供一种制造延伸穿过支撑膜的中空纳米针的装置的方法。 该装置可用作分子递送系统。 5

公开(公告)号：US08186589B2

公开(公告)日：2012-05-29

申请号：US12160779

申请日：2007-01-10

Applicant: Yosef Ben Asher ,  Sharoni Feldman ,  Pinchas Gurfil

Inventor： Yosef Ben Asher ,  Sharoni Feldman ,  Pinchas Gurfil

IPC: G06F19/00

CPC classification number: G05D1/104 ,  G05D1/0088

Abstract: The present invention relates to a hierarchical system and method for task assignment (TA), coordination and communication of multiple Unmanned Aerial Vehicles (DAV's) engaging multiple attack targets and conceives an ad-hoc routing algorithm for synchronization of target lists utilizing a distributed computing topology. Assuming limited communication bandwidth and range, coordination of UAV motion is achieved by implementing a simple behavioral flocking algorithm utilizing a tree topology for target list routing. The TA algorithm is based on a graph-theoretic approach, in which a node locates all the detectable targets, identifies them and computes its distance to each target. The node then produces an attack plan that minimizes the sum of distances of the UAV's in the subtree of a given node to the targets.

Abstract translation: 本发明涉及一种用于任务分配（TA）的分层系统和方法，涉及多个攻击目标的多个无人驾驶飞行器（DAV）的协调和通信，并且构思了利用分布式计算拓扑来同步目标列表的自组织路由算法 。 假设有限的通信带宽和范围，UAV运动的协调是通过使用用于目标列表路由的树形拓扑的简单行为植入算法来实现的。 TA算法基于图理论方法，其中节点定位所有可检测的目标，识别它们并计算其到每个目标的距离。 该节点然后产生一个攻击计划，最小化给定节点的子任务中的UAV在目标上的距离之和。

公开(公告)号：US20120077696A1

公开(公告)日：2012-03-29

申请号：US13256712

申请日：2010-03-14

Applicant: Arie Admon ,  Michal Bassani-Sternberg

Inventor： Arie Admon ,  Michal Bassani-Sternberg

IPC: C40B30/04 ,  C40B40/10

CPC classification number: G01N33/56977 ,  G01N33/57484

Abstract: The invention relates to diagnostic kits, methods of diagnosing, prognosing and staging diseases, and immunogenic compositions. The invention is based on the detection of peptides associated with circulating soluble HLA complexes in particular disease states, including malignant diseases.

Abstract translation: 本发明涉及诊断试剂盒，诊断，预后和分期疾病的方法以及免疫原性组合物。 本发明基于与循环可溶性HLA复合物，特别是疾病状态（包括恶性疾病）相关的肽的检测。

公开(公告)号：US20120058945A1

公开(公告)日：2012-03-08

申请号：US13296061

申请日：2011-11-14

Applicant: MOUSSA YOUDIM ,  Matitiyahu Fridkin ,  Hailin Zheng ,  Abraham Warshawsky ,  Rivka Warshawsky

Inventor： MOUSSA YOUDIM ,  Matitiyahu Fridkin ,  Hailin Zheng ,  Abraham Warshawsky ,  Rivka Warshawsky

IPC: A61K38/09 ,  A61K38/00 ,  A61P25/28 ,  A61K31/497 ,  A61P25/00 ,  A61K31/4412 ,  C07K5/10 ,  C07K7/06 ,  A61P25/16 ,  A61K38/22 ,  A61K31/47

CPC classification number: C07D295/15 ,  A61K38/00 ,  A61K45/06 ,  A61K47/547 ,  C07D213/69 ,  C07D215/26 ,  C07D295/205 ,  C07K7/06 ,  C07K7/22 ,  C07K7/23 ,  C07K14/57563 ,  C07K14/70 ,  Y02A50/411

Abstract: Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, e.g., a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, an inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding aging, and prevention and/or treatment of skin aging and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety. The neuroprotective function is imparted to the compound, e.g., by a neuroprotective peptide. A combined antiapoptotic and neuroprotective function is provided by a propargyl group.

Abstract translation: 表现出神经保护和良好转运性质的新型铁螯合剂可用于铁螯合治疗用于治疗与铁超载和氧化应激相关的疾病，病症或病状，例如神经变性或脑血管疾病或病症，肿瘤性疾病，血色素沉着症，地中海贫血症， 心血管疾病，糖尿病，炎性疾病，蒽环类心脏毒性，病毒感染，原生动物感染，酵母感染，延迟衰老，以及防止和/或治疗针对阳光和/或紫外光的皮肤老化和皮肤保护。 铁螯合剂功能由8-羟基喹啉，羟基吡啶酮或异羟肟基部分提供。 神经保护功能被赋予化合物，例如通过神经保护肽。 由炔丙基提供组合的抗细胞凋亡和神经保护功能。

公开(公告)号：US20120040993A1

公开(公告)日：2012-02-16

申请号：US13146975

申请日：2010-01-31

Applicant: Moussa B. H. Youdim ,  Mati Fridkin ,  Hailin Zheng

Inventor： Moussa B. H. Youdim ,  Mati Fridkin ,  Hailin Zheng

IPC: A61K31/496 ,  C07D401/12 ,  C07D401/10 ,  C07D401/14 ,  C07C259/10 ,  C07C271/40 ,  C07C211/41 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/166 ,  A61K31/27 ,  A61K31/13 ,  A61P39/04 ,  A61P25/00 ,  A61P39/02 ,  A61P9/00 ,  A61P25/16 ,  A61P25/28 ,  A61P25/08 ,  A61P35/00 ,  A61P25/24 ,  A61P3/10 ,  A61P29/00 ,  A61P19/02 ,  A61P17/06 ,  A61P33/02 ,  A61P31/10 ,  A61P31/12 ,  A61P31/18 ,  A61P33/06 ,  C07D215/34

CPC classification number: C07C259/10 ,  C07C211/38 ,  C07C271/40 ,  C07C2602/08 ,  C07C2603/74 ,  C07D215/34 ,  C07D401/06 ,  C07D401/12

Abstract: Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition. The present invention encompasses compounds of the formulas I to VI.

Abstract translation: 提供多官能化合物，其包含两个或多个选自以下的官能部分：（i）赋予铁螯合剂功能的部分; （ii）赋予神经保护功能的部分; （iii）赋予组合的抗细胞凋亡，神经保护和/或神经恢复功能的部分; （iv）赋予脑MAO抑制的部分，优选在肝脏和小肠中几乎没有MAO抑制作用; （v）赋予胆碱酯酶抑制功能的部分; 和（vi）赋予N-甲基-D-天冬氨酸受体（NMDAR）抑制的部分及其药学上可接受的盐和旋光异构体。 多官能化合物可用于治疗或预防可通过铁螯合治疗和/或神经保护和/或神经恢复，和/或凋亡抑制和/或MAO抑制和/或MAO抑制和/或治疗的/ 或胆碱酯酶抑制和/或NMADR抑制。 本发明包括式I至VI的化合物。

公开(公告)号：US08045830B2

公开(公告)日：2011-10-25

申请号：US12438754

申请日：2007-08-28

Applicant: Erez Hasman

Inventor： Erez Hasman

IPC: G02F1/01 ,  G02B6/26

CPC classification number: G02B6/102 ,  G02B6/4204

Abstract: A wave-guiding system and method for mode-selective transmission of a spatially coherent light beam is disclosed. The system comprises a wave-guide with an inlet and an outlet for transmitting one or more modes; a first mode-shaping optical element for shaping the spatially coherent light beam before it enters through the inlet of the wave-guide to a desired mode of the wave-guide; and a second mode-shaping optical element for shaping light beam after it exits from the outlet of the wave-guide for obtaining a desired vectorial field.

Abstract translation: 公开了一种用于空间相干光束的模式选择性传输的波导系统和方法。 该系统包括具有用于传输一种或多种模式的入口和出口的波导; 第一模式整形光学元件，用于在空间相干光束通过波导的入口进入波导的所需模式之前成形; 以及用于在光束从波导的出口离开之后成形光束以获得期望的矢量场的第二模式整形光学元件。

公开(公告)号：US20110238000A1

公开(公告)日：2011-09-29

申请号：US13133241

申请日：2009-12-07

Applicant: Dror Seliktar ,  Liat Oss-Ronen

Inventor： Dror Seliktar ,  Liat Oss-Ronen

IPC: A61M37/00 ,  A61K47/42 ,  A61K38/43 ,  A61K31/785 ,  A61K38/38 ,  A61P7/04 ,  A61P3/02 ,  A61P31/00 ,  A61P31/12 ,  A61P23/00 ,  A61P29/00 ,  A61P35/00

CPC classification number: A61K9/0024 ,  A61K31/37 ,  A61K47/42 ,  A61K47/6903

Abstract: A hydrogel system comprising polymer-conjugated albumin molecules is provided for controlled release delivery of therapeutic agents. The polymer is a functionalized synthetic polymer, preferably PEG-diacrylate. The polymer-conjugated albumin is preferably mono-PEGylated albumin. The hydrogel system may comprise a matrix to which the polymer-conjugated albumin molecules are linked via a functional group of the polymer. The matrix may be formed from the same polymer of the polymer-albumin conjugate.

Abstract translation: 提供包含聚合物共轭白蛋白分子的水凝胶体系用于治疗剂的控制释放递送。 聚合物是官能化的合成聚合物，优选PEG-二丙烯酸酯。 聚合物结合的白蛋白优选是单PEG化的白蛋白。 所述水凝胶体系可以包含基质，所述聚合物结合的白蛋白分子通过所述聚合物的官能团连接到基质上。 基质可以由聚合物 - 白蛋白缀合物的相同聚合物形成。