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    Method and apparatus for continuous particle production using supercritical fluid
    42.
    发明申请
    Method and apparatus for continuous particle production using supercritical fluid 有权
    使用超临界流体连续生产粒子的方法和装置

    公开(公告)号：US20040156911A1

    公开(公告)日：2004-08-12

    申请号：US10434426

    申请日：2003-05-08

    申请人： Ferro Corporation

    发明人： Pratibhash Chattopadhyay ,  Boris Y. Shekunov ,  Jeffrey S. Seitzinger

    IPC分类号： A61K009/14 ,  B01J013/04

    CPC分类号： B01J13/02 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0411 ,  B01D11/0484

    摘要： A method and an apparatus for continuously producing particles from an emulsion by supercritical fluid extraction. The emulsion includes a solute suspended or dissolved in the supercritical fluid soluble first phase. The supercritical fluid and the emulsion contact each other such that the first phase dissolves from the emulsion into the supercritical fluid and the solute precipitates to form a suspension in a non supercritical fluid soluble second phase of the emulsion. The supercritical fluid carries away the dissolved first phase. The solvent bearing supercritical fluid, together with the solute suspended in the second phase, is removed from an extraction chamber at a rate that is about the same as a rate that the emulsion and the supercritical fluid flow into the extraction chamber. Thus, a constant mass and pressure is maintained in the extraction chamber and the particles are produced continuously.

    摘要翻译： 一种通过超临界流体萃取从乳液中连续生产颗粒的方法和装置。 乳液包括悬浮或溶解在超临界流体可溶的第一相中的溶质。 超临界流体和乳液彼此接触，使得第一相从乳液溶解到超临界流体中，并且溶质沉淀以在乳液的非超临界流体溶解的第二相中形成悬浮液。 超临界流体带走溶解的第一相。 溶剂轴承超临界流体与悬浮在第二相中的溶质一起以与乳液和超临界流体流入萃取室的速率大致相同的速率从萃取室中除去。 因此，在提取室中保持恒定的质量和压力，并且连续地产生颗粒。

    Composite particles and method for preparing
    43.
    发明申请
    Composite particles and method for preparing 有权
    复合颗粒及其制备方法

    公开(公告)号：US20040071781A1

    公开(公告)日：2004-04-15

    申请号：US10441137

    申请日：2003-05-19

    申请人： Ferro Corporation

    发明人： Pratibhash Chattopadhyay ,  Boris Y. Shekunov ,  Jeffrey S. Seitzinger ,  Robert W. Huff

    IPC分类号： A61K009/14 ,  B01J013/02 ,  B01J013/04

    CPC分类号： B01D11/0411 ,  B01J13/02

    摘要： A method for producing composite particles using a supercritical fluid extraction technique on an emulsion. First and second materials (for example, a polymer and a biologically active material) are dissolved or suspended in a preferably solvent to form a solution or dispersion. The solution or dispersion is emulsified in a polar solvent to form an oil-in-water or water-in-oil-in-water emulsion. The emulsion is contacted with a supercritical fluid to extract the solvent. Removal of the solvent by the supercritical fluid from the emulsion supersaturates at least the first material in the solution causing the first material to precipitate out of the solution as composite particles that include both the first and second materials.

    摘要翻译： 一种使用超临界流体萃取技术在乳液上制备复合颗粒的方法。 将第一和第二材料（例如，聚合物和生物活性材料）溶解或悬浮在优选溶剂中以形成溶液或分散体。 将溶液或分散体在极性溶剂中乳化以形成水包油或水包油包水乳液。 将乳液与超临界流体接触以萃取溶剂。 由超临界流体从乳液中除去溶剂至少使溶液中的第一种材料过饱和，导致第一种材料沉淀出溶液，作为包括第一和第二种材料的复合颗粒。

    Method and device for forming particles
    45.
    发明授权
    Method and device for forming particles 失效
    用于形成颗粒的方法和装置

    公开(公告)号：US06551532B1

    公开(公告)日：2003-04-22

    申请号：US09600068

    申请日：2000-07-10

    申请人： Catherine Boissier ,  Håkan Glad

    发明人： Catherine Boissier ,  Håkan Glad

    IPC分类号： B29B910

    CPC分类号： B01J19/26 ,  A61K9/1688 ,  A61K9/1694 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0411 ,  B01D11/0488 ,  B01F5/0662 ,  B01F2215/0032 ,  B01J2/04 ,  B01J3/008 ,  B01J2219/00051 ,  B01J2219/00162

    摘要： The present invention relates to a method for forming particles of a substance, comprising the step of introducing into a mixing chamber (8), in which the temperature and pressure are controlled, a fluid gas (4) and at least one vehicle system (1) comprising at least one substance in solution or suspension such that droplet formation and extraction of the vehicle occur substantially simultaneously by the action of the fluid gas (4). Turbulence is induced in at least one of said fluid gas (4) and said vehicle system (1) so as to create a controlled disorder in the flow of the at least one of the fluid gas (4) or the vehicle system (1) in order to control the particle formation in said mixing chamber (8), said controlled disorder being created by at least one flow perturbation means (11). The invention also relates to a mixing chamber having at least one flow perturbation means (11) that is disposed for interacting with at least one of a fluid gas (4) or vehicle system (1) supplied by the at least one supply member (4, 5) so as to induce turbulence or limited disorder in the at least one of the fluid gas (4) or vehicle system (1).

    摘要翻译： 本发明涉及一种形成物质颗粒的方法，包括将控制温度和压力的流体气体（4）和至少一个车辆系统（1）引入混合室（8）的步骤， ）包括溶液或悬浮液中的至少一种物质，使得液滴形成和提取车辆基本上同时通过流体气体（4）的作用发生。 在所述流体气体（4）和所述车辆系统（1）中的至少一个中引起湍流，以便在至少一个流体气体（4）或车辆系统（1）的流动中产生受控的紊乱， 为了控制所述混合室（8）中的颗粒形成，所述受控紊乱由至少一个流动扰动装置（11）产生。 本发明还涉及一种具有至少一个流动扰动装置（11）的混合室，所述流动扰动装置（11）设置成与由至少一个供应构件（4）提供的流体气体（4）或车辆系统（1）中的至少一个相互作用 ，5），以便在流体气体（4）或车辆系统（1）中的至少一个中引起湍流或有限的紊乱。

    Method and apparatus for the formation of particles
    46.
    发明申请
    Method and apparatus for the formation of particles 审中-公开
    用于形成颗粒的方法和装置

    公开(公告)号：US20020073511A1

    公开(公告)日：2002-06-20

    申请号：US09996020

    申请日：2001-11-27

    发明人： Mazen H. Hanna ,  Peter York

    IPC分类号： B01J002/04 ,  B01D009/02

    CPC分类号： A61K9/1688 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0411 ,  B01D11/0488 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  Y02P20/544

    摘要： The invention provides a method for forming particles of a substance, by co-introducing into a particle formation vessel, in which the temperature and pressure are controlled, of a supercritical fluid; a solution or suspension of the substance in a first vehicle; and a second vehicle which is both substantially miscible with the first vehicle and substantially soluble in the supercritical fluid in such a way that dispersion of the solution or suspension and the second vehicle, and extraction of the vehicles, occur substantially simultaneously and substantially immediately on introduction of the fluids into the vessel, by the action of the supercritical fluid. Preferably the solution suspension of the substance is introduced separately from the second vehicle, in such a way that contact between the solution/suspension and the second vehicle occurs either substantially simultaneously with, or immediately before, their dispersion by the supercritical fluid and extraction of the vehicles by the supercritical fluid. The method allows a high degree of control over the size, shape, crystalline form and other physico-chemical properties of the particulate product. The invention also provides apparatus for carrying out such a method, using a coaxial nozzle to introduce the fluids into the particle formation vessel, and a particulate product made using the method or the apparatus.

    摘要翻译： 本发明提供了通过将超临界流体共同引入其中控制温度和压力的颗粒形成容器中来形成物质颗粒的方法; 该物质在第一种载体中的溶液或悬浮液; 以及第二种车辆，其基本上与第一辆车混合并且基本上溶解在超临界流体中，使得溶液或悬浮液和第二车辆的分散和车辆的提取基本上同时且基本上立即在引入时发生 的流体通过超临界流体的作用进入容器。 优选地，物质的溶液悬浮液与第二种载体分离地引入，使得溶液/悬浮液和第二载体之间的接触基本上与超临界流体分散或同时或之前由超临界流体分散出来， 车辆由超临界流体。 该方法允许高度控制颗粒产品的尺寸，形状，结晶形式和其他物理化学性质。 本发明还提供了一种使用同轴喷嘴将流体引入颗粒形成容器中的这种方法的装置，以及使用该方法或装置制成的颗粒状产品。

    Method and apparatus for the formation of particles
    47.
    发明授权
    Method and apparatus for the formation of particles 失效
    用于形成颗粒的方法和装置

    公开(公告)号：US5851453A

    公开(公告)日：1998-12-22

    申请号：US578700

    申请日：1996-01-31

    申请人： Mazen Hanna ,  Peter York

    发明人： Mazen Hanna ,  Peter York

    IPC分类号： A61K9/14 ,  A61K9/16 ,  B01D11/00 ,  B01F5/06 ,  B01J2/00 ,  B01J2/04 ,  B01J3/00 ,  B01J19/00 ,  B05B7/06 ,  B29B9/10

    CPC分类号： B01F5/0659 ,  A61K9/1688 ,  A61K9/1694 ,  B01D11/0411 ,  B01J2/04 ,  B05B7/06 ,  B05D2401/90

    摘要： A method for the dewatering of a material layer of paper fibers in a double-screen former, where the sheet weight (oven-dried sheet weight (otro)) is more than 100 g/m.sup.2 and/or the screen circulates with a speed of at least 100 m/min. Two screens are guided at two guide surfaces that, for example, belong to open forming cylinders. In this arrangement forming cylinders of this kind are so dimensioned and positioned that no dewatering elements that contact one of the screens are present between the run-out line of the screens from the first guide surface and the run-in line at the second guide surface.

    摘要翻译： PCT No.PCT / GB94 / 01426 Sec。 371日期1996年1月31日 102（e）日期1996年1月31日PCT提交1994年6月30日PCT公布。 第WO95 / 01221号公报 日期1995年1月12日，一种双层筛网中纸纤维材料层脱水的方法，其中片材重量（烘干片材重量（otro））大于100g / m2和/或筛网 以至少100米/分钟的速度循环。 在两个引导表面上引导两个屏幕，例如属于打开的成型滚筒。 在这种布置中，形成这种类型的圆柱体的尺寸和定位使得在第一引导表面和第二引导表面的引入线之间不存在接触屏幕之一的脱水元件 。

    Equipment assembly for and method of processing particles
    50.
    发明授权
    Equipment assembly for and method of processing particles 有权
    设备组装和加工颗粒的方法

    公开(公告)号：US09233348B2

    公开(公告)日：2016-01-12

    申请号：US14306938

    申请日：2014-06-17

    申请人： CRITITECH, INC.

    发明人： Greg S Johnson ,  Bala Subramaniam ,  Fenhui Niu

    IPC分类号： B01D11/04 ,  B01J3/00 ,  B01D46/48 ,  A61J3/02 ,  B01J8/00 ,  B01J4/00 ,  B01D9/00 ,  B01D46/00

    CPC分类号： B01J8/006 ,  A61J3/02 ,  B01D9/0013 ,  B01D9/0054 ,  B01D11/0411 ,  B01D46/0068 ,  B01J3/008 ,  B01J4/002 ,  Y02P20/544

    摘要： An equipment assembly for preparing, harvesting and collecting particles is disclosed. The assembly comprises a tandem filter system with one or more high pressure filters, one or more low pressure filters and one or more collection vessel. Particles can be prepared, harvested and collected continuously, semi-continuously or in a batch-type operation. A tandem filter system and its method of use are also disclosed. Particles made with the assembly and according the instant methods are also disclosed. The assembly provides improved particle harvesting and collection over other systems and permits continuous particle formation, in particular by dispersion of a solute-containing process fluid within a supercritical anti-solvent.

    摘要翻译： 公开了一种用于制备，收集和收集颗粒的设备组件。 组件包括具有一个或多个高压过滤器，一个或多个低压过滤器和一个或多个收集容器的串联过滤器系统。 可以连续，半连续或间歇式操作来制备，收获和收集颗粒。 还公开了一种串联过滤系统及其使用方法。 还公开了使用组装制成的颗粒和根据即时方法制备的颗粒。 该组件在其它系统上提供改进的颗粒收获和收集，并允许连续的颗粒形成，特别是通过在超临界反溶剂中分散含溶质的工艺流体。