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    Hydrolysis of acylamino acids
    41.
    发明授权
    Hydrolysis of acylamino acids 有权
    酰氨基酸的水解

    公开(公告)号：US06552222B2

    公开(公告)日：2003-04-22

    申请号：US09927776

    申请日：2001-08-13

    申请人： Klaus Huthmacher ,  Christoph Weckbecker ,  Horst Weigel

    发明人： Klaus Huthmacher ,  Christoph Weckbecker ,  Horst Weigel

    IPC分类号： C07C32300

    CPC分类号： C07C227/20 ,  C07C319/20 ,  C07C229/08 ,  C07C323/58

    摘要： A process for the preparation of racemic amino acids, characterized in that an acylamino acid of the formula R1—CH(NH—CO—R2)COOH wherein R1 is hydrogen, a linear, branched or cyclic alkyl that has from 1 to 7 carbon atoms and that may contain substituents such as a hydroxyl, alkyloxy or alkylthio group; and R2 is a hydrogen atom or an alkyl having from 1 to 3 carbon atoms; is heated in the presence of water, in a pressure-resistant vessel, to a temperature in the range from 110° C. to 220° C. and is hydrolyzed.

    摘要翻译： 一种制备外消旋氨基酸的方法，其特征在于式R 1的酰基氨基酸是氢，具有1至7个碳原子并且可以含有取代基的直链，支链或环状烷基，例如羟基，烷氧基或 烷硫基 并且R 2是氢原子或具有1至3个碳原子的烷基; 在水的存在下，在耐压容器中加热至110℃至220℃的温度，并水解。

    PREPARATION OF 5-AMINOSALICYLIC ACID BY GAS PHASE CATALYTIC CARBOXYLATION
    50.
    发明申请
    PREPARATION OF 5-AMINOSALICYLIC ACID BY GAS PHASE CATALYTIC CARBOXYLATION 有权
    通过气相催化羰氧化制备5-氨基苯甲酸

    公开(公告)号：US20130281730A1

    公开(公告)日：2013-10-24

    申请号：US13997303

    申请日：2011-10-20

    申请人： Guangxing Li ,  Jinjin Li ,  Dajian Zhu ,  Qiang Jiang ,  Lingli Cai ,  Yong Xie ,  Lixin Gan

    发明人： Guangxing Li ,  Jinjin Li ,  Dajian Zhu ,  Qiang Jiang ,  Lingli Cai ,  Yong Xie ,  Lixin Gan

    IPC分类号： C07C229/64

    CPC分类号： C07C229/64 ,  C07C227/20 ,  C07C231/12 ,  C07C233/54

    摘要： Disclosed is a process for preparing 5-aminosalicylic acid by gas phase catalytic carboxylation, characterized in that carbon dioxide is introduced into a system of p-acetaminophenol and a basic compound at a temperature of 150° C.˜220° C. and a pressure of 0.5˜5.0 MPa in the presence of a catalyst, so as to carry out a gas phase catalytic carboxylation reaction to form a 5-aminosalicylate, and the crude product 5-aminosalicylate is separated, and then acidified to prepare 5-aminosalicylic acid (5-ASA). Since the gas phase catalytic reaction replaces a solid phase thermo-chemical reaction, the reaction is significantly improved in terms of the process flow, reaction conditions, product quality and energy consumption. In addition, the reaction has a short reaction time, good selectivity, high yield and no formation of wastes during the reaction, and is suitable for industrial production.

    摘要翻译： 公开了通过气相催化羧化制备5-氨基水杨酸的方法，其特征在于在150℃〜220℃的温度下将二氧化碳引入对乙酰氨基苯酚和碱性化合物的体系中， 在催化剂存在下为0.5〜5.0MPa，进行气相催化羧化反应以形成5-氨基水杨酸盐​​，并将5-氨基水杨酸粗产物分离，然后酸化以制备5-氨基水杨酸（ 5-ASA）。 由于气相催化反应代替了固相热化学反应，反应在工艺流程，反应条件，产品质量和能耗方面都得到了显着改善。 此外，反应时间短，选择性好，产率高，反应时不产生废物，适用于工业生产。