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    1,2,3,4-TETRAHYDROQUINOXALINE COMPOUNDS HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY
    42.
    发明申请
    1,2,3,4-TETRAHYDROQUINOXALINE COMPOUNDS HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY 有权
    具有GLUCOCORTICOID受体结合活性的1,2,3,4-四氢喹啉化合物

    公开(公告)号：US20130303537A1

    公开(公告)日：2013-11-14

    申请号：US13937447

    申请日：2013-07-09

    申请人： SANTEN PHARMACEUTICAL CO., LTD.

    发明人： Mamoru MATSUDA ,  Toshiyuki MORI ,  Kenji KAWASHIMA ,  Minoru YAMAMOTO ,  Masatomo KATO ,  Miwa TAKAI ,  Masato NAGATSUKA ,  Sachiko KOBAYASHI

    IPC分类号： C07D241/46 ,  C07D409/14 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12

    CPC分类号： C07D241/46 ,  C07D241/44 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    摘要： A 1,2,3,4-tetrahydroquinoxaline compound represented by the following formula: In the formula (1), R1 represents substituents such as a halogen, an alkyl, a cycloalkyl, an aryl or a heterocyclic group; p represents 0 to 5; R2 represents substituents such as a halogen, an alkyl, a hydroxyl or an alkoxy group; q represents 0 to 2; R3 represents substituents such as hydrogen, an alkyl, an alkenyl, an alkylcarbonyl or an arylcarbonyl group; R4 and R5 independently represent substituents such as hydrogen, a halogen, an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an aryl or a heterocyclic group; R6 represents substituents such as hydrogen, an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an aryl or a heterocyclic group; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; R8 and R9 independently represent substituents such as hydrogen, an alkyl or an alkenyl; and X represents O or S.

    摘要翻译： 由下式表示的1,2,3,4-四氢喹喔啉化合物：式（1）中，R 1表示卤素，烷基，环烷基，芳基或杂环基等取代基。 p表示0〜5; R 2表示取代基，例如卤素，烷基，羟基或烷氧基; q表示0〜2; R3表示取代基，例如氢，烷基，烯基，烷基羰基或芳基羰基; R4和R5独立地表示取代基，例如氢，卤素，烷基，烯基，炔基，环烷基，芳基或杂环基; R6表示取代基，例如氢，烷基，烯基，炔基，环烷基，芳基或杂环基; A表示亚烷基; R 7表示OR 8，NR 8 R 9，SR 8，S（O）R 8，S（O） R8和R9独立地表示取代基，例如氢，烷基或烯基; X表示O或S.

    Quinoxaline derivative, light-emitting element, light-emitting device, and electronic appliance
    44.
    发明授权
    Quinoxaline derivative, light-emitting element, light-emitting device, and electronic appliance 有权
    喹喔啉衍生物，发光元件，发光装置和电子器具

    公开(公告)号：US08283052B2

    公开(公告)日：2012-10-09

    申请号：US11860190

    申请日：2007-09-24

    申请人： Masakazu Egawa ,  Atsushi Tokuda ,  Satoko Shitagaki

    发明人： Masakazu Egawa ,  Atsushi Tokuda ,  Satoko Shitagaki

    IPC分类号： H01L51/54 ,  C09K11/06

    CPC分类号： C07D241/36 ,  C07D241/42 ,  C07D241/46

    摘要： It is an object to provide a new substance excellent in electron-transporting property, and a light-emitting element and a light-emitting device using the substance. A quinoxaline derivative represented by the general formula (G1) is provided. In the general formula (G1), each of R1 to R4 represents hydrogen, an alkyl group having 1 to 4 carbon atoms, or an aryl group having 6 to 25 carbon atoms; and each of Ar1 and Ar2 represents an aryl group having 6 to 25 carbon atoms. Such a quinoxaline derivative is excellent in electron-transporting property and very effective as an electron-transporting material in a light-emitting element and the like.

    摘要翻译： 本发明的目的是提供一种电子传输性优异的新物质，以及使用该物质的发光元件和发光装置。 提供由通式（G1）表示的喹喔啉衍生物。 通式（G1）中，R 1〜R 4各自表示氢，碳原子数1〜4的烷基或碳原子数6〜25的芳基。 Ar 1和Ar 2分别表示碳原子数6〜25的芳基。 这种喹喔啉衍生物在电子传输性方面是优异的，并且作为发光元件等中的电子传输材料是非常有效的。

    Method of Producing Polymeric Phenazonium Compounds
    45.
    发明申请
    Method of Producing Polymeric Phenazonium Compounds 有权
    聚合苯胺化合物的制备方法

    公开(公告)号：US20120077956A1

    公开(公告)日：2012-03-29

    申请号：US12890013

    申请日：2010-09-24

    申请人： Andrew M. Krol ,  Ernest Long ,  Lev Taytsas

    发明人： Andrew M. Krol ,  Ernest Long ,  Lev Taytsas

    IPC分类号： C08G73/06

    CPC分类号： C08G73/0633 ,  C07D241/46 ,  C08G73/0694 ,  C25D3/38

    摘要： A process of making a polymeric phenazonium compound having the general formula: wherein R1, R2, R4, R5, R6, R8 and R9 are the same or different, and represent hydrogen, a low alkyl or a substituted aryl, R3 starts with NH2 and is diazotized followed by polymerization, R5 and R8 may alternatively represent monomeric or polymeric phenazonium radicals, R7 with its substituent group is a substituted amine, with RX and RY representing any combination of CH3, C2H5, and hydrogen, except that RX and RY cannot both be hydrogen, A is an acid radical, and n is an integer from 2 to 100, preferably from 2 to 20 is described. The polymeric phenazonium compound is usable in as an additive in a metal plating bath. The method includes the steps of: a) dissolving an effective amount of an amino compound in a formic acid solution; b) adding a nitrite salt to diazotize the amino compound; and c) adding sulfamic acid to neutralize any excess nitrous acid that may be formed in step b), whereby a polymeric phenazonium compound is produced.

    摘要翻译： 制备具有以下通式的聚合物苯扎嗪化合物的方法：其中R 1，R 2，R 4，R 5，R 6，R 8和R 9相同或不同，并且表示氢，低级烷基或取代的芳基，R 3从NH 2开始， 被重氮化，随后聚合，R 5和R 8可以代表单体或聚合物苯扎嗪基团，其取代基的R7是取代的胺，其中RX和RY表示CH 3，C 2 H 5和氢的任何组合，不同之处在于RX和RY不能同时 为氢，A为酸基，n为2〜100，优选为2〜20的整数。 聚合物苯扎嗪化合物可用作金属电镀浴中的添加剂。 该方法包括以下步骤：a）将有效量的氨基化合物溶于甲酸溶液中; b）加入亚硝酸盐以重氮化氨基化合物; 和c）加入氨基磺酸以中和步骤b）中可能形成的任何过量的亚硝酸，由此产生聚合的苯扎嗪化合物。

    NOVEL sEH INHIBITORS AND THEIR USE
    50.
    发明申请
    NOVEL sEH INHIBITORS AND THEIR USE 有权
    新型抑制剂及其用途

    公开(公告)号：US20100210656A1

    公开(公告)日：2010-08-19

    申请号：US12682073

    申请日：2008-10-10

    申请人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, JR.

    发明人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, JR.

    IPC分类号： A61K31/53 ,  C07D401/04 ,  C07D251/18 ,  C07D409/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D251/52 ,  A61P9/10 ,  A61P9/00 ,  A61P9/04 ,  A61P11/06 ,  A61P11/00 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07D241/46 ,  C07D251/18 ,  C07D251/52 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/04

    摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

    摘要翻译： 本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。 具体地，本发明涉及式I化合物：其中R1，R2，R4，R5，R6，A，B，Y，Z，n和m定义如下，及其药学上可接受的盐。 本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。