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    Antisecretory imidazole amidine compounds, composition and method of use
    41.
    发明授权
    Antisecretory imidazole amidine compounds, composition and method of use 失效
    咪唑咪唑类化合物，组成及使用方法

    公开(公告)号：US4379158A

    公开(公告)日：1983-04-05

    申请号：US193742

    申请日：1980-10-03

    Applicant: Yasufumi Hirata ,  Isao Yanagisawa ,  Toshinari Tamura ,  Masaaki Takeda

    Inventor： Yasufumi Hirata ,  Isao Yanagisawa ,  Toshinari Tamura ,  Masaaki Takeda

    IPC: C07D213/32 ,  C07D213/68 ,  C07D213/86 ,  C07D233/54 ,  C07D233/64 ,  C07D277/26 ,  C07D277/30 ,  C07D307/52 ,  A61K31/615 ,  C07D401/12

    CPC classification number: C07D213/86 ,  C07D213/32 ,  C07D213/68 ,  C07D233/64 ,  C07D277/26 ,  C07D307/52

    Abstract: Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N--R.sub.1 (wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s), an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N--R.sub.1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmacologically acceptable acid addition salts thereof.The compounds of this invention are useful as gastric acid secretion inhibitors.

    Abstract translation: 式中，Het表示可具有取代基的5元或6元杂环基的新型杂环化合物。 Z表示硫原子或氧原子; X表示氧原子或由N-R 1表示的未取代或取代的亚氨基（其中R 1为氢原子，低级烷基，氰基，未取代或烷基取代的氨基甲酰基，未取代或低级烷基取代的硫代氨基甲酰基 ，或低级烷酰氨基）; Y表示氢原子，可具有取代基的低级烷基，3-6个碳原子的环烷基，低级烯基，低级炔基，可具有取代基的芳基， 可以具有取代基的芳烷基，羟基，氰基，氨基甲酰基，脒基，可被卤素原子取代的烷酰基，烷酰基氨基，芳基羰基氨基， 烷基氨基，芳基氨基，芳基氨磺酰基，低级烷氧基氨基甲酰基或氨甲酰基氨基; m和n表示1-3的整数; 当X是N-R1时，所述X和Y可以彼此结合形成含有2-3个可具有取代基的氮原子的5元或6元杂环，其药理学上可接受的酸加成盐 。 本发明的化合物可用作胃酸分泌抑制剂。

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