公开(公告)号：US20090054648A1

公开(公告)日：2009-02-26

申请号：US11914952

申请日：2006-05-19

申请人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

发明人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

IPC分类号： C07F5/00 ,  C07C61/04 ,  C07D209/54 ,  C07D401/02

CPC分类号： C07C255/31 ,  C07B53/00 ,  C07C271/22 ,  C07D209/54 ,  C07D401/04

摘要： The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.The invention provides a method for producing a compound represented by formula (2): (wherein n is an integer of 2 to 5; R1 represents a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group), which includes treating a compound represented by formula (1): (wherein n, R1, and R2 are the same as defined above; and R3 represents a hydrogen atom, a (substituted) alkyl group, or a (substituted) aralkyl group) under a hydrogen gas atmosphere in the presence of a metallic catalyst.

摘要翻译： 本发明提供一种生产螺环氨基吡咯烷酮衍生物的工业方法，其是用于生产喹诺酮抗菌剂的中间体。 本发明提供一种制备由式（2）表示的化合物的方法：（其中n为2至5的整数; R 1表示（取代的）烷基或（取代的）芳基; R 2表示（取代的） 烷氧基羰基，（取代的）芳烷氧基羰基，（取代的）脂族酰基或（取代的）芳族酰基），其包括处理由式（1）表示的化合物：其中n，R1和R2是 在氢气气氛下，在金属催化剂的存在下，R 3表示氢原子，（取代的）烷基或（取代的）芳烷基）。

公开(公告)号：US20090012120A1

公开(公告)日：2009-01-08

申请号：US11801395

申请日：2007-05-09

申请人： Babak Borhan ,  Jennifer M. Schomaker ,  Somnath Bhattacharjee ,  Keith Korthals

发明人： Babak Borhan ,  Jennifer M. Schomaker ,  Somnath Bhattacharjee ,  Keith Korthals

IPC分类号： A61K31/4015 ,  C07D207/12 ,  C07D209/32 ,  C07D209/54 ,  C07C211/00 ,  C07D211/00 ,  A61P35/00 ,  A61K31/13 ,  A61K31/403 ,  A61K31/445

CPC分类号： C07D207/12 ,  C07D209/32 ,  C07D209/54

摘要： An ylide-based aza-Payne rearrangement of 2,3-aziridin-1-ols leads to an efficient process for the preparation of pyrrolidines. The aza-Payne rearrangement under the basic reaction conditions favors the formation of epoxy amines. Subsequent nucleophilic attack of the epoxide by the ylide yields a bis-anion, which upon a 5-exo-tet ring closure yields the desired pyrrolidine, thus completing the relay of the 3-membered the 5-membered nitrogen containing ring system. This process takes place with complete transfer of stereochemical fidelity, and can be applied to sterically hindered aziridinols.

摘要翻译： 2,3-氮杂环丁烷-1-基的叶立德碱氮杂 - 佩恩重排导致制备吡咯烷的有效方法。 在碱性反应条件下的氮杂重复排列有利于环氧胺的形成。 随后的内鎓盐对环氧化物的亲核攻击产生双阴离子，其在5-外 - 闭环闭合时产生所需的吡咯烷，从而完成3元5元含氮环系统的中继。 该过程完全转移立体化学保真度，并且可以应用于空间位阻的氮丙啶醇。

公开(公告)号：US20080318776A1

公开(公告)日：2008-12-25

申请号：US11666870

申请日：2005-10-21

申请人： Reiner Fischer ,  Stefan Lehr ,  Mark Wilhelm Drewes ,  Dieter Feucht ,  Olga Malsam ,  Guido Bojack ,  Christian Arnold ,  Thomas Auler ,  Marin Jeffrey Hills ,  Heinz Kehne ,  Chris Rosinger

发明人： Reiner Fischer ,  Stefan Lehr ,  Mark Wilhelm Drewes ,  Dieter Feucht ,  Olga Malsam ,  Guido Bojack ,  Christian Arnold ,  Thomas Auler ,  Marin Jeffrey Hills ,  Heinz Kehne ,  Chris Rosinger

IPC分类号： A01N25/32 ,  C07D209/54 ,  A01N43/38 ,  A01P13/00 ,  C07C51/06 ,  A01P15/00 ,  A01N57/16 ,  C07F9/572

CPC分类号： C07D207/408 ,  C07D207/36 ,  C07D207/38 ,  C07D209/54

摘要： The invention relates to novel 2,6-diethyl-4-methylphenyl-substituted tetramic acid derivatives of the formula (I) in which A, B, D and G are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selectively herbicidal compositions comprising, firstly, the 2,6-diethyl-4-methylphenyl-substituted tetramic acid derivatives of the formula (I) and, secondly, at least one crop plant tolerance promoter compound.

摘要翻译： 本发明涉及其中A，B，D和G如上定义的式（I）的新的2,6-二乙基-4-甲基苯基取代的四
甲酸衍生物与多种制备方法和中间体以及 用作农药和/或除草剂，以及选择性除草组合物，其首先包含式（I）的2,6-二乙基-4-甲基苯基取代的四元酸衍生物，其次是至少一种作物植物 耐受启动子化合物。

公开(公告)号：US20080274893A1

公开(公告)日：2008-11-06

申请号：US12217742

申请日：2008-07-08

申请人： Reiner Fischer ,  Astrid Ullmann ,  Thomas Bretschneider ,  Mark Wilhelm Drewes ,  Christoph Erdelen ,  Angelika Lubos-Erdelen ,  Dieter Feucht ,  Udo Reckmann

发明人： Reiner Fischer ,  Astrid Ullmann ,  Thomas Bretschneider ,  Mark Wilhelm Drewes ,  Christoph Erdelen ,  Angelika Lubos-Erdelen ,  Dieter Feucht ,  Udo Reckmann

IPC分类号： A01N43/36 ,  C07D209/54 ,  C07D491/10 ,  A01P3/00 ,  A01P13/00 ,  A01P7/04 ,  A01N43/16 ,  C07D307/00

CPC分类号： C07D491/10 ,  A01N43/12 ,  A01N43/38 ,  A01N43/90 ,  C07D209/54 ,  C07D307/94 ,  C07D493/10

摘要： The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y, Z and R3 are as defined above, to processes and intermediates for their preparation and to their use as pesticides, microbicides and herbicides.

摘要翻译： 本发明涉及新的苯基取代的4-酮基内酰胺和式（I）的内酯，其中A，B，Q，G，W，X，Y，Z和R 3为 如上所述，涉及其制备方法和中间体以及作为杀虫剂，杀微生物剂和除草剂的用途。

公开(公告)号：US20070298969A1

公开(公告)日：2007-12-27

申请号：US10578900

申请日：2004-11-09

申请人： Reiner Fischer ,  Stefan Lehr ,  Mark Drewes ,  Christoph Erdelen ,  Angelika Lubos-Erdelen ,  Dieter Feucht ,  Jorg Konze ,  Peter Losel ,  Olga Malsam ,  Guido Bojack ,  Christian Arnold ,  Thomas Auler ,  Martin Hills ,  Heinz Kehne ,  Christopher Rosinger

发明人： Reiner Fischer ,  Stefan Lehr ,  Mark Drewes ,  Christoph Erdelen ,  Angelika Lubos-Erdelen ,  Dieter Feucht ,  Jorg Konze ,  Peter Losel ,  Olga Malsam ,  Guido Bojack ,  Christian Arnold ,  Thomas Auler ,  Martin Hills ,  Heinz Kehne ,  Christopher Rosinger

IPC分类号： A01N43/38 ,  A01N43/42 ,  A01N43/56 ,  A01N43/80 ,  A01N43/84 ,  A01P17/00 ,  A01P21/00 ,  C07D207/24 ,  C07D209/54

CPC分类号： C07D209/54 ,  A01N43/38 ,  A01N43/90 ,  A01N47/06 ,  A01N53/00 ,  C07D491/10 ,  C07D495/10 ,  A01N25/32 ,  A01N2300/00

摘要： The invention relates to novel 2-ethyl-4,6-dimethylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) in which A, B and G are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly the 2-ethyl-4,6-dimethylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) (where G may also be hydrogen) and secondly at least one crop plant compatibility-improving compound.

摘要翻译： 本发明涉及式（I）的新型2-乙基-4,6-二甲基苯基取代的螺环四酸衍生物，其中A，B和G如上定义，与多种制备方法和中间体相关， 它们用作农药和/或除草剂，以及选择性除草组合物，首先将式（I）的2-乙基-4,6-二甲基苯基取代的螺环四酸衍生物（其中G也可以是氢），其次是 至少一种作物植物相容性改善化合物。

公开(公告)号：US20070262703A1

公开(公告)日：2007-11-15

申请号：US11749131

申请日：2007-05-15

申请人： Ming-Han Tsai ,  Hao-Wu Lin ,  Hai-Ching Su ,  Chung-Chih Wu ,  Fu-Chuan Fang ,  Yuan-Li Liao ,  Ken-Tsung Wong ,  Chih-I Wu ,  Chi-Yen Lin ,  Wen-Yi Hung ,  Tei-Hung Hou ,  Wei-Jiun Chen

发明人： Ming-Han Tsai ,  Hao-Wu Lin ,  Hai-Ching Su ,  Chung-Chih Wu ,  Fu-Chuan Fang ,  Yuan-Li Liao ,  Ken-Tsung Wong ,  Chih-I Wu ,  Chi-Yen Lin ,  Wen-Yi Hung ,  Tei-Hung Hou ,  Wei-Jiun Chen

IPC分类号： C07F7/02 ,  C07D209/54 ,  H01J1/62

CPC分类号： C07F7/0812 ,  C07C211/61 ,  C07C2603/18 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  H01L51/006 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0094 ,  H05B33/14 ,  Y10S428/917

摘要： The present invention discloses synthesis of 2,2′-disubstituted 9,9′-spirobifluorene-based triaryldiamine. First, 2,2′-diamino-9,9′-spirobifluorene, a Pd-catalyst as auxiliary and aryl halide BX are provided, wherein X is selected from the group consisting of: Cl, Br and I, B comprises one of the following group: aryl moiety, hetero cycle, multiple fused ring, multiple fused ring with hetero atom(s). Next, a substitution reaction is performed to react the 2,2′-diamino-9,9′-spirobifluorene with the aryl halide BX to produce the 2,2′-disubstituted 9,9′-spirobifluorene-based triaryldiamines. In addition, the present invention discloses organic light emitting devices comprising hole transporting material comprising 2,2′-bis(N,N-disubstituted amino)-9,9′-spirobifluorenes.

摘要翻译： 本发明公开了2,2'-二取代的9,9'-螺二芴基的三芳基二胺的合成。 首先，提供2,2'-二氨基-9,9'-螺二芴，Pd-催化剂作为辅助和芳基卤化物BX，其中X选自：Cl，Br和I，B包括 以下组：芳基部分，杂环，多稠环，多杂稠环与杂原子。 接着，进行取代反应，使2,2'-二氨基-9,9'-螺二芴与芳基卤化物BX反应，生成2,2'-二取代的9,9'-螺二芴基的三芳基二胺。 另外本发明还公开了包含2,2'-双（N，N-二取代氨基）-9,9'-螺二芴的空穴传输材料的有机发光器件。

公开(公告)号：US20070244007A1

公开(公告)日：2007-10-18

申请号：US10585195

申请日：2004-12-29

申请人： Reiner Fischer ,  Stefan Lehr ,  Dieter Feucht ,  Peter Losel ,  Olga Malsam ,  Guido Bojack ,  Thomas Auler ,  Martin Hills ,  Heinz Kehne ,  Christopher Rosinger

发明人： Reiner Fischer ,  Stefan Lehr ,  Dieter Feucht ,  Peter Losel ,  Olga Malsam ,  Guido Bojack ,  Thomas Auler ,  Martin Hills ,  Heinz Kehne ,  Christopher Rosinger

IPC分类号： A01N25/32 ,  A01N43/38 ,  C07D209/54

CPC分类号： C07C233/52 ,  A01N43/38 ,  A01N47/06 ,  C07C2601/14 ,  C07D209/54

摘要： The invention relates to novel cis-alkoxyspiro-substituted tetramic acid derivatives of the formula (I), in which A, G, X, Y and Z are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly cis-alkoxyspiro-substituted tetramic acid derivatives and secondly a crop plant compatibility-improving compound.

摘要翻译： 本发明涉及其中A，G，X，Y和Z如上所定义的式（I）的新型顺式 - 烷氧基硅烷取代的四酸衍生物与多种制备方法和中间体及其用途 作为农药和/或除草剂，以及选择性除草组合物，其包含首先顺式 - 烷氧基螺
吡喃酮取代的四聚酸衍生物，其次是作物植物相容性改善化合物。

公开(公告)号：US20070085074A1

公开(公告)日：2007-04-19

申请号：US11549563

申请日：2006-10-13

申请人： Fu-Shing Wang ,  Kuang-Mei Hsu

发明人： Fu-Shing Wang ,  Kuang-Mei Hsu

IPC分类号： H01L51/00 ,  C07D405/02 ,  C07D403/02 ,  C07D209/54 ,  C07D209/96

CPC分类号： C07D209/58 ,  C07D215/12 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C09B23/10 ,  C09B23/105 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1044 ,  H01L51/0064

摘要： The present invention provides a blue laser light-absorbent substance, which is suitably used in organic photo conductor, laser optical data carrier or organic light-emitting diodes. The blue laser light-absorbent substance includes a merocyanine compound of the general formula (1) wherein n is an integer of from 0 to 3; R1 is unsubstituted or phenyl-, halogen-, ester-, siliy-substituted linear or branched alkyl group having 1 to 6 carbon atoms; R2 is unsubstituted or substituted phenyl, benzyl or naphthyl; N and R1R2 together represent aromatic-fused N-containing heterocyclic group (NR1R2); Y1 is unsubstituted or substituted alkoxy group having 1 to 8 carbon atoms; Y2 is cyano, nitro, halogen or carboxylate; or O and Y1Y2 together represent epoxy or N-containing heterocyclic hydrocarbonyl ketone (OY1Y2).

摘要翻译： 本发明提供了适用于有机光导体，激光光数据载体或有机发光二极管的蓝色激光吸收物质。 蓝色激光吸收物质包括通式（1）的部花青化合物，其中n为0-3的整数; R 1是未取代的或具有1至6个碳原子的苯基，卤素，酯，硅烷基取代的直链或支链烷基; R 2是未取代或取代的苯基，苄基或萘基; N和R 1 R 2 2一起代表芳香族稠合的含N杂环基团（NR 1 R 2 R 2） ; Y 1是未取代或取代的碳原子数为1〜8的烷氧基; Y 2是氰基，硝基，卤素或羧酸酯; 或O和Y 1 Y 2 2一起代表环氧或含氮杂环烃基酮（OY 1 Y 2） ）。

公开(公告)号：US07122678B2

公开(公告)日：2006-10-17

申请号：US11078961

申请日：2005-03-11

申请人： Justin Stephen Bryans ,  David Christopher Horwell ,  Andrew John Thorpe ,  David Juergen Wustrow ,  Po-Wai Yuen

发明人： Justin Stephen Bryans ,  David Christopher Horwell ,  Andrew John Thorpe ,  David Juergen Wustrow ,  Po-Wai Yuen

IPC分类号： C07D209/54 ,  C07C69/74 ,  C07C61/06

CPC分类号： C07D221/20 ,  C07C49/417 ,  C07C69/608 ,  C07C69/612 ,  C07C205/51 ,  C07C205/53 ,  C07C229/28 ,  C07C229/34 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2602/50 ,  C07D209/96 ,  C07D307/94 ,  C07D311/96

摘要： The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.

公开(公告)号：US20050256308A1

公开(公告)日：2005-11-17

申请号：US10529601

申请日：2003-04-17

申请人： Nobuhide Watanabe ,  Hiroshi Nakagawa ,  Jun-ichi Tsuji ,  Hisao Minato ,  Akihisa Ikeno ,  Chie Kohayakawa

发明人： Nobuhide Watanabe ,  Hiroshi Nakagawa ,  Jun-ichi Tsuji ,  Hisao Minato ,  Akihisa Ikeno ,  Chie Kohayakawa

IPC分类号： A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/451 ,  A61K31/495 ,  A61K31/55 ,  A61P15/12 ,  A61P19/10 ,  A61P35/00 ,  A61P43/00 ,  C07C217/20 ,  C07C217/24 ,  C07D211/14 ,  C07D295/092 ,  C07D209/54 ,  C07D209/96

CPC分类号： C07D295/088 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/451 ,  A61K31/495 ,  A61K31/55 ,  C07C217/20 ,  C07C217/24 ,  C07C2603/97 ,  C07D211/14

摘要： A spiro compound represented by the following formula (I) wherein R1 and R2 are the same or different and each is a hydrogen atom, a chlorine atom and the like, n is 1, 2 or 3, a bond containing a broken line is a single bond or a double bond, A is —X—(CH2)q—N(R3)(R4); a group represented by the following formula (a) and the like, wherein X is an oxygen atom or a sulfur atom, q is 2 or 3, R3 and R4 are the same or different and each is a C1-6 alkyl group and the like, or R3 and R4 optionally form, together with the adjacent nitrogen atom, a piperidine ring and the like optionally substituted by one or two C1-6 alkyl and the like, R5 is a C1-6 alkyl group and the like, R6 is a hydrogen atom and the like, and r and t are each independently one or two, or a pharmaceutically acceptable acid addition salt thereof. The compound is useful as a selective estrogen receptor modulator having a climacteric syndrome-ameliorating effect, and can be expected to be a drug for the prophylaxis and/or treatment of osteoporosis, climacteric syndrome and breast cancer.

摘要翻译： 由下式（I）表示的其中R 1和R 2相同或不同并且各自为氢原子，氯原子等的螺环化合物， n为1,2或3，含有虚线的键为单键或双键，A为-X-（CH 2 CH 2）q -N（ R 4）（R 4）; 由下式（a）表示的基团等，其中X为氧原子或硫原子，q为2或3，R 3和R 4为 相同或不同，并且各自为C 1-6烷基等，或R 3和R 4任选地形成，一起 与相邻的氮原子一起，任选被一个或两个C 1-6烷基等取代的哌啶环等，R 5是C 1 -6个烷基等，R 6是氢原子等，r和t各自独立地为一个或两个，或其药学上可接受的酸加成盐。 该化合物可用作具有更年期综合征 - 改善作用的选择性雌激素受体调节剂，并且可以预期是用于预防和/或治疗骨质疏松症，更年期综合征和乳腺癌的药物。