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    Metalens for light field imaging
    513.
    发明授权
    Metalens for light field imaging 有权

    公开(公告)号：US11686885B2

    公开(公告)日：2023-06-27

    申请号：US16721343

    申请日：2019-12-19

    Applicant: ACADEMIA SINICA

    Inventor： Din-Ping Tsai ,  Cheng-Hung Chu ,  Ren-Jie Lin ,  Mu-Ku Chen ,  Pin-Chieh Wu

    IPC: G02B3/00 ,  G02B1/00 ,  H04N23/55

    CPC classification number: G02B3/0068 ,  G02B1/002 ,  G02B3/0087 ,  H04N23/55

    Abstract: Compound eyes of insects are great optical system for imaging and sensing by the nature creator, which is an unsurpassed challenge due to its precision and small size. Here, we use meta-lens consisting of GaN nano-antenna to open the fascinating doorway to full-color achromatic light field imaging and sensing. A 60×60 multi-channels meta-lens array is used for effectively capturing multi-dimensional optical information including image and depth. Based on this, the multi-dimensional light field imaging and sensing of a moving object is capable to be experimentally implemented. Our system presents a diffraction-limit resolution of 1.95 micrometer via observing the standard resolution test chart under white light illumination. This is the first mimic optical light field imaging and sensing system of insect compound eye, which has potential applications in micro robotic vision, non-men vehicle sensing, virtual and augmented reality, etc.

    4(1H)-quinolone derivatives and uses thereof
    517.
    发明授权
    4(1H)-quinolone derivatives and uses thereof 有权

    公开(公告)号：US11638705B2

    公开(公告)日：2023-05-02

    申请号：US16831346

    申请日：2020-03-26

    Applicant: Academia Sinica

    Inventor： Rong-Jie Chein ,  Pan-Chyr Yang ,  Chi-Huey Wong ,  Ming-Shiu Lin ,  Ting-Jen Cheng ,  Ting-Hung Chou

    IPC: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

    Abstract: Compounds of Formula (I) and methods for treating, delaying, and/or preventing the adverse effects of proliferative diseases, such as cancers including, for example, lung cancer, breast cancer, ovarian cancer, prostate cancer, head cancer, neck cancer, head and neck cancer, or leukemia (e.g., cancer resistant to treatment by one or more microtubule-targeting agents, e.g., cancer resistant to multiple drugs associated with P-glycoprotein (P-gp) overexpression). Methods of inhibiting polymerization of a cancer cell microtubule in a subject in need thereof or a cell, tissue, or biological sample, binding β-tubulin, inhibiting microtubule assembly and, inducing apoptosis in a cancer cell resistant to multiple drugs in a tissue, biological sample, or subject. Pharmaceutical compositions, kits, and methods of using the compounds for treating any of the target diseases described herein.

    RECOMBINANT ANTIBODY AND USES THEREOF
    519.
    发明申请
    RECOMBINANT ANTIBODY AND USES THEREOF 有权

    公开(公告)号：US20230037864A1

    公开(公告)日：2023-02-09

    申请号：US17851277

    申请日：2022-06-28

    Applicant: Academia Sinica

    Inventor： Shang-Te Danny HSU ,  Hui-Wen CHANG ,  Chia-Yu CHANG

    IPC: C07K16/10 ,  G01N33/569

    Abstract: Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.

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