公开(公告)号：US08569726B2

公开(公告)日：2013-10-29

申请号：US13662214

申请日：2012-10-26

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Bin Huang ,  Abigail Freeman ,  Daniel Castro ,  David C. Gale

IPC: G21C11/00 ,  G21F1/00 ,  G21F3/00 ,  G21F7/00 ,  G02B5/00 ,  G21K1/00 ,  H01J1/52 ,  H01J3/00 ,  H01J5/18 ,  H01J29/46 ,  B01J19/00 ,  B01J19/08

CPC classification number: A61L2/08 ,  A61L2/081 ,  A61L2/082 ,  A61L2/085 ,  A61L2/087 ,  A61L2/10 ,  A61L2202/23 ,  A61L2202/24 ,  B65B55/00 ,  B65B55/16

Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.

Abstract translation: 公开了用于降低放射线灭菌的支架的方法和系统。

公开(公告)号：US20130269168A1

公开(公告)日：2013-10-17

申请号：US13779636

申请日：2013-02-27

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Bin Huang ,  David C. Gale ,  Daniel Castro

IPC: A61F2/958

CPC classification number: A61F2/958 ,  A61F2002/9505 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2002/9586 ,  B23P11/005 ,  Y10T29/49863 ,  Y10T29/49913 ,  Y10T29/49925 ,  Y10T29/49927 ,  Y10T29/53065 ,  Y10T29/53987

Abstract: A method of crimping a stent on a balloon of a catheter assembly is provided. A polymeric stent is disposed over a balloon in an inflated configuration. The stent is crimped over the inflated balloon to a reduced crimped configuration so that the stent is secured onto the balloon. The balloon wall membrane is wedged or pinched between the strut elements of the stent for increasing the retention of the stent on the balloon.

Abstract translation: 提供了一种将支架卷曲在导管组件的球囊上的方法。 将聚合物支架设置在膨胀构型的气球上。 将支架卷曲在膨胀的气囊上以减小卷曲构造，使得支架固定在气球上。 球囊壁膜被楔入或夹在支架的支柱元件之间，以增加支架在气囊上的保留。

公开(公告)号：US20130266619A1

公开(公告)日：2013-10-10

申请号：US13911547

申请日：2013-06-06

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Syed F.A. Hossainy

IPC: A61L31/16

CPC classification number: A61L31/16 ,  A61K31/445 ,  A61K31/74 ,  A61L31/10 ,  C08L33/06

Abstract: A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety is disclosed. A medical article comprising the composition in the coating thereof and a method of fabricating the medical article are also disclosed.

Abstract translation: 公开了包含包含线型丙烯酸均聚物或线性丙烯酸共聚物的结构组分和包含具有丙烯酸酯部分和生物有益部分的共聚物的生物有益成分的组合物。 还公开了包含其涂层中的组合物的医疗制品和制造医疗制品的方法。

公开(公告)号：US20130259911A1

公开(公告)日：2013-10-03

申请号：US13905423

申请日：2013-05-30

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Stephen D. Pacetti

IPC: A61K9/28

CPC classification number: A61K9/284 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  C08L53/02

Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.

Abstract translation: 提供了一种用于涂覆可植入装置的生物有益涂层组合物，例如药物洗脱支架，用该组合物涂覆该装置的方法，涂有该组合物的可植入装置以及一种治疗病症的方法。

公开(公告)号：US20130186327A1

公开(公告)日：2013-07-25

申请号：US13791368

申请日：2013-03-08

Applicant: Advanced Cardiovascular Systems, Inc,

Inventor： Grayson Morris ,  Svava Maria Atladottir ,  Carla Pienknagura

IPC: B05C1/02

CPC classification number: B05C1/022 ,  A46B9/00 ,  A46B9/028 ,  A46B11/063 ,  A61F2310/00389 ,  A61L27/28 ,  A61L31/08 ,  B05C11/1005 ,  B05C13/025

Abstract: A stent coating apparatus for coating a stent includes a brush assembly, a stent support, and a dispensing mechanism. The brush assembly includes a plurality of fibers, and the stent support carries a stent at a position in which the stent is in contact with the fibers. The dispensing mechanism dispenses a coating composition to the plurality of fibers.

Abstract translation: 用于涂覆支架的支架涂覆装置包括刷组件，支架支架和分配机构。 刷组件包括多根纤维，并且支架支架在支架与纤维接触的位置处承载支架。 分配机构将涂料组合物分配给多个纤维。

公开(公告)号：US20130123422A1

公开(公告)日：2013-05-16

申请号：US13686380

申请日：2012-11-27

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Stephen Dirk Pacetti ,  Thierry Glauser

IPC: A61L27/34

CPC classification number: A61L31/10 ,  A61L27/34 ,  C08G63/66 ,  C09D167/00

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings include block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.

Abstract translation: 公开了用于植入式医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的至少一种生物相容性聚合物的至少一个嵌段 一种类型的连接部分。

公开(公告)号：US20130116380A1

公开(公告)日：2013-05-09

申请号：US13686392

申请日：2012-11-27

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.

Inventor： Stephen Dirk Pacetti ,  Thierry Glauser

IPC: C09D167/00

CPC classification number: A61L31/10 ,  A61L27/34 ,  C08G63/66 ,  C09D167/00

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.

Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的嵌段聚合物，至少一个生物相容性聚合物的嵌段和至少 一种类型的连接部分。

公开(公告)号：US20040234737A1

公开(公告)日：2004-11-25

申请号：US10760132

申请日：2004-01-15

Applicant: Advanced Cardiovascular Systems Inc.

Inventor： Stephen Pacetti

IPC: B05D001/36

CPC classification number: A61L27/34 ,  A61F2/82 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02 ,  B05D7/586 ,  C08L53/02 ,  C08L53/025 ,  C09D129/04 ,  C09D153/02 ,  C09D153/025 ,  Y10T428/1355 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/24942 ,  Y10T428/31504 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31678 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T428/31935 ,  Y10T428/31938 ,  C08L2666/02

Abstract: A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.

Abstract translation: 公开了一种降低治疗物质从可植入医疗装置（例如支架）释放的速率的膜。

公开(公告)号：US20040176793A1

公开(公告)日：2004-09-09

申请号：US10737704

申请日：2003-12-16

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Barry L. Kramer

IPC: A61M029/00

CPC classification number: A61M25/104 ,  A61M2025/0183 ,  A61M2025/107 ,  A61M2025/1079

Abstract: An intravascular catheter system, such as a dilatation catheter system for angioplasty procedures, which provides for the replacement of the catheter or the guidewire during the procedure. The intravascular catheter has a guidewire-receiving inner lumen extending along its length. A first guidewire port is provided in the catheter body at or near the proximal end of the catheter. A second guidewire port is provided in the catheter body at a location spaced distally from the first guidewire port and proximally from a diagnostic or therapeutic tool, such as a dilatation balloon, on a distal portion of the catheter. A third guidewire port is provided in the distal end of the catheter. The guidewire ports are in communication with the guidewire-receiving inner lumen.

公开(公告)号：US20040059259A1

公开(公告)日：2004-03-25

申请号：US10659930

申请日：2003-09-11

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Wayne E. Cornish ,  John Schreiner ,  James Jacobs ,  Marc M. Jalisi ,  Mark T. Richardson ,  Kent C. Stalker ,  Olin J. Palmer

IPC: A61B005/00

CPC classification number: A61B5/6851 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

Abstract translation: 本发明涉及一种具有多个具有至少两个相邻的远端锥形芯段的多个远端锥形芯部段的远端部分，其中最远端锥形芯部段优选地具有比近端相邻的锥形芯部分更大的锥度。 本发明还涉及一种细长的体内装置，优选的导丝或其一部分，其具有芯构件或类似物，多个相邻的锥形段具有锥形角，该锥形角构造成在纵向截面上产生刚度线性变化 的设备。 该装置还可以具有连续变化的锥角的芯部分，以产生曲线轮廓，该轮廓优选被配置成在装置的纵向部分上产生芯的刚度的线性变化。