公开(公告)号：US20060089503A1

公开(公告)日：2006-04-27

申请号：US10540023

申请日：2003-12-10

申请人： Takahiro Ohishi ,  Kohei Mori ,  Koichi Kinoshita ,  Katsuji Maehara ,  Hiroaki Kawasaki ,  Nobuo Nagashima ,  Yoshihide Fuse

发明人： Takahiro Ohishi ,  Kohei Mori ,  Koichi Kinoshita ,  Katsuji Maehara ,  Hiroaki Kawasaki ,  Nobuo Nagashima ,  Yoshihide Fuse

IPC分类号： C07D305/12 ,  C07D405/02

CPC分类号： C07D305/12 ,  C07C319/14 ,  C07D317/60 ,  C07D407/06 ,  C07C323/56

摘要： The present invention provides a process for simply producing an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines from inexpensive raw materials. An optically active 2-hydroxymethyl-3-phenylpropionic acid ester derivative which can be relatively easily obtained by asymmetric reduction reaction with an enzyme is cyclized to an optically active P-lactone derivative which is then reacted with a sulfur compound to produce an optically active 2-thiomethyl-3-phenylpropionic acid derivative in high yield.

摘要翻译： 本发明提供简单地生产用作廉价原料的药物中间体的光学活性2-硫代甲基-3-苯基丙酸衍生物的方法。 可以通过与酶的不对称还原反应相对容易地获得的光学活性的2-羟甲基-3-苯基丙酸酯衍生物环化成光学活性的P-内酯衍生物，然后与硫化合物反应以产生光学活性2 硫代甲基-3-苯基丙酸衍生物。

公开(公告)号：US20060045873A1

公开(公告)日：2006-03-02

申请号：US11209044

申请日：2005-08-23

申请人： Kazunari Taira ,  Hiroaki Kawasaki

发明人： Kazunari Taira ,  Hiroaki Kawasaki

IPC分类号： C12N15/87 ,  A61K48/00

CPC分类号： C12N15/85 ,  A01K2217/05 ,  A01K2267/0381 ,  A61K31/7088 ,  C12N15/111 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2830/008 ,  C12N2830/42 ,  C12N2830/46

摘要： The present inventors found that in human cells, synthetic small interfering RNAs (siRNAs) targeted to a region containing the CpG islands on gene promoters will specifically induce the methylation of CpG sequences within the target region or adjacent regions. Methylation of the promoters results in suppression at a transcriptional level of expression of genes downstream of the promoters. The present invention provides methods for inducing DNA methylation using the siRNAs, and methods for suppressing gene expression based on siRNA-directed methylation of promoters. The present invention also provides DNA methylation-inducing agents or gene expression-suppressing agents that comprise siRNAs or expression vectors for the siRNAs or dsRNAs.

摘要翻译： 本发明人发现，在人类细胞中，靶向包含基因启动子上的CpG岛的区域的合成小干扰RNA（siRNA）将特异性诱导靶区域或相邻区域内的CpG序列的甲基化。 启动子的甲基化导致抑制启动子下游基因表达的转录水平。 本发明提供使用siRNA诱导DNA甲基化的方法，以及基于siRNA引导的启动子甲基化抑制基因表达的方法。 本发明还提供了包含用于siRNA或dsRNA的siRNA或表达载体的DNA甲基化诱导剂或基因表达抑制剂。

公开(公告)号：US07002288B2

公开(公告)日：2006-02-21

申请号：US10076516

申请日：2002-02-19

申请人： Yoshihisa Yonezawa ,  Yukio Ogawa ,  Hiroaki Kawasaki ,  Yasuhiro Nohara ,  Yoshikazu Iidaka

发明人： Yoshihisa Yonezawa ,  Yukio Ogawa ,  Hiroaki Kawasaki ,  Yasuhiro Nohara ,  Yoshikazu Iidaka

IPC分类号： H01J1/88

CPC分类号： H01J31/126

摘要： An electron tube includes at least one metal film formed on a base, at least one linear member provided above the base, and at least one additional member for connecting said at least one linear member to said at least one metal film. The at least one linear member is connected to the at least one metal film by welding the at least one additional member to the at least one metal film.

摘要翻译： 电子管包括形成在基底上的至少一个金属膜，设置在基底上方的至少一个直线构件和用于将所述至少一个线性构件连接到所述至少一个金属膜的至少一个附加构件。 所述至少一个线性构件通过将所述至少一个附加构件焊接到所述至少一个金属膜而连接到所述至少一个金属膜。

公开(公告)号：US20050179528A1

公开(公告)日：2005-08-18

申请号：US11043977

申请日：2005-01-28

申请人： Hiroaki Kawasaki

发明人： Hiroaki Kawasaki

IPC分类号： G01L17/00 ,  B60C23/02 ,  B60C23/06 ,  B60C23/00

CPC分类号： B60C23/061

摘要： A method for warning deflation of tires which can detect the deflation of 2 wheels at the same axle including a following axle, the simultaneous deflation of 4 wheels or the abrasion of tires only by the information of wheel speeds is provided. The method comprises the steps of: detecting the rotational information of each of tires; calculating and storing wheel speeds, vehicle accelerations, slip ratios of front and rear wheels, traveling distances and radius of traveling circle from the rotational information of said respective tires; calculating moving average of the vehicle accelerations and the slip ratios of front and rear wheels; accumulating the traveling distances and storing the moving averages of the vehicle accelerations and the slip ratios of front and rear wheels; determining regression coefficient and correlation coefficient of the slip ratio of front and rear wheels on the vehicle acceleration; determining the slip ratio of front and rear wheels when the vehicle acceleration is zero; determining whether the pressures of at least 2 wheels at the same axle or 4 wheels are simultaneously reduced or not, based on the regression coefficients and the slip ratio of front and rear wheels while the vehicle acceleration is zero; and warning deflation of tires.

摘要翻译： 提供了一种用于警告轮胎放气的方法，其可以检测到包括后轮的同一轴上的两个车轮的放气，仅通过车轮速度的信息同时放气4个车轮或轮胎的磨损。 该方法包括以下步骤：检测轮胎中的每一个的旋转信息; 计算和存储车轮速度，车辆加速度，前轮和后轮的滑移率，行进距离和行进圈半径与所述各个轮胎的旋转信息; 计算车辆加速度的移动平均值和前轮和后轮的滑移率; 累积行驶距离并存储车辆加速度的移动平均值和前轮和后轮的滑移率; 确定前轮和后轮的滑移率对车辆加速度的回归系数和相关系数; 确定当车辆加速度为零时前轮和后轮的滑移率; 基于车辆加速度为零时前轮和后轮的回归系数和滑移比，确定同一轴或四个车轮中至少两个车轮的压力是否同时减小; 并警告轮胎通货紧缩。

公开(公告)号：US06738704B2

公开(公告)日：2004-05-18

申请号：US10174939

申请日：2002-06-20

申请人： Hiroaki Kawasaki

发明人： Hiroaki Kawasaki

IPC分类号： B60T858

CPC分类号： G01C9/00 ,  F16H59/48 ,  F16H59/66 ,  F16H2059/405 ,  F16H2059/506 ,  F16H2059/663

摘要： An apparatus for judging road surface gradients including a speed detector for periodically detecting wheel speeds of four wheels of a vehicle, a vehicle body speed calculator for obtaining a vehicle body speed of the vehicle, a slip rate calculator for obtaining a slip rate, a vehicle body acceleration calculator for obtaining an acceleration of the vehicle body of the vehicle, a determining device for determining whether the acceleration of the vehicle body is within a specified range proximate to zero, and a gradient judging device for judging a gradient of a road surface depending on the determination of the determining device. The gradients of road surfaces might be judged without using various sensors but only on the basis of information which can be obtained from a speed detector for detecting wheel speeds.

摘要翻译： 一种用于判断路面梯度的装置，包括用于周期性地检测车辆四轮的车轮速度的速度检测器，用于获得车辆的车身速度的车身速度计算器，用于获得滑移率的滑移率计算器，车辆 车体加速度计算器，用于获得车辆的车体的加速度;确定装置，用于确定车身的加速度是否在接近于零的指定范围内;以及坡度判定装置，用于判断路面倾斜度的梯度 对确定装置的确定。 可以在不使用各种传感器的情况下判断路面的坡度，而只能基于可以从用于检测车轮速度的速度检测器获得的信息。

公开(公告)号：US06530271B2

公开(公告)日：2003-03-11

申请号：US10174966

申请日：2002-06-20

申请人： Hiroaki Kawasaki ,  Yukio Nakao

发明人： Hiroaki Kawasaki ,  Yukio Nakao

IPC分类号： B60C2302

CPC分类号： B60C23/006 ,  B60C23/061

摘要： An apparatus for detecting decrease in air-pressure for use in a two-wheeled vehicle including: a wheel speed detecting means for detecting wheel speeds; an acceleration calculating means for obtaining accelerations of a vehicle body of the two-wheeled vehicle; a slip rate calculating means for calculating slip rates when the acceleration of the vehicle body is in a specified range which is proximate to zero; an average value calculating means for obtaining average values of the slip rates and average vehicle body speeds; a difference calculating means for obtaining differences between the average values of the slip rates and a reference value which is based on an average vehicle body speed as preliminarily set when an internal pressure is normal; and a means for judging decrease in internal pressure. A decrease in air-pressure in a two-wheeled vehicle can be judged so as to enable safe driving.

摘要翻译： 一种用于检测用于两轮车辆的气压降低的装置，包括：用于检测车轮速度的车轮速度检测装置; 用于获得所述两轮车辆的车体的加速度的加速度计算装置; 滑行率计算装置，用于当车体的加速度处于接近于零的指定范围时计算滑移率; 平均值计算装置，用于获得滑移率和平均车体速度的平均值; 差分计算装置，用于当内部压力正常时获得预先设定的滑移率的平均值和基于平均车辆速度的参考值之间的差; 以及判断内压下降的手段。 可以判断两轮车辆中的空气压力的降低，以便能够安全驾驶。

公开(公告)号：US06522062B2

公开(公告)日：2003-02-18

申请号：US09776689

申请日：2001-02-06

申请人： Yukio Ogawa ,  Kazuyoshi Ishikawa ,  Katsutoshi Kougo ,  Hiroaki Kawasaki

发明人： Yukio Ogawa ,  Kazuyoshi Ishikawa ,  Katsutoshi Kougo ,  Hiroaki Kawasaki

IPC分类号： H01J162

CPC分类号： H01J31/126 ,  G09G3/06

摘要： A fluorescent display device of the plane grid type capable of reducing accumulation of charges on an insulating layer, to thereby prevent an electron shading phenomenon and permit electrons emitted from a filament toward anode electrodes to be uniformly spread in a plane-like manner on both sides of the filament. A first substrate is formed thereon with stripe-like thin-film anode electrodes and stripe-like thin-film grids in a matrix-like manner through a thin-film insulating layer. The insulating layer and grids are formed with openings. Phosphors are deposited on portions of the anode electrodes exposed through the openings. The grids are formed into a height equal to or smaller than that of the phosphors. A second substrate is formed thereon with back electrodes for controlling emission of electrons from filaments. Control voltages applied to the back electrodes have a potential gradient given thereto so that a potential difference occurs between a position near the filaments and a position apart therefrom.

摘要翻译： 平面栅型的荧光显示装置，其能够减少绝缘层上的电荷堆积，从而防止电子阴影现象，并允许从灯丝向阳极发射的电子均匀地均匀地分布在两面 的长丝。 在其上通过薄膜绝缘层以矩阵状的方式在其上形成有条状薄膜阳极电极和条状薄膜栅极的第一衬底。 绝缘层和栅格形成有开口。 荧光体沉积在通过开口暴露的阳极电极的部分上。 栅格形成为等于或小于荧光体的高度。 在其上形成有用于控制从细丝发射电子的背电极的第二基板。 施加到背电极的控制电压具有给定的电位梯度，使得在细丝附近的位置和与其分开的位置之间产生电位差。

公开(公告)号：US06354560B1

公开(公告)日：2002-03-12

申请号：US09453488

申请日：1999-12-03

申请人： Hiroaki Kawasaki ,  Hiroaki Maru ,  Nobuo Akiba

发明人： Hiroaki Kawasaki ,  Hiroaki Maru ,  Nobuo Akiba

IPC分类号： B29C3300

CPC分类号： B22D17/2236 ,  B22D17/20 ,  B22D45/00 ,  B29C45/374

摘要： A marking device is provided that can confirm a mark imprinted on a molded piece from outside a molding tool and can inscribe a plurality of marks with a sole marker. The marking device consists of a reference sleeve, a top imprint portion, a sleeve, a top imprint portion, and a pin. The reference sleeve is fixedly assembled and has the top reference imprint surface confronting a molding area, a reference imprint mark being formed on the stamp surface. The top imprint portion is rotatably journaled within the reference sleeve and has the top display imprint surface being flush with the top reference imprint surface, on which data imprint marks to be pointed by a reference imprint mark are formed. The sleeve has a base end actuator, on which data display are indicated, formed at a protrusion protruded from a molding area outward. The top imprint member is rotatably journaled within the sleeve and has a top display imprint surface being flush with the top reference imprint surface, on which a data imprint mark to be pointed a reference imprint mark is formed. The pin has a base end actuator having a protrusion protruded from a molding area outward, on which data display indicators respectively corresponding to data imprint marks are indicated.

摘要翻译： 提供一种标记装置，其可以从模制工具的外侧确认压印在模制件上的标记，并且可以用唯一标记物刻上多个标记。 标记装置由参考套筒，顶部压印部分，套筒，顶部压印部分和销组成。 参考套筒被固定地组装并且具有面对成型区域的顶部参考压印表面，在印模表面上形成参考印记标记。 顶部压印部分可旋转地轴颈安装在参考套筒内，并且顶部显示器压印表面与顶部参考压印表面齐平，在其上形成要由参考压印标记指向的数据压印标记。 套筒具有基端致动器，在其上指示数据显示器，形成在从模制区域向外突出的突起处。 顶部压印构件可旋转地轴颈安装在套筒内，并且具有与顶部参考压印表面齐平的顶部显示器压印表面，在其上形成指向参考压印标记的数据压印标记。 该销具有一个基端致动器，该基端致动器具有从成型区域向外突出的突出部，其上分别对应于数据压印标记的数据显示指示器。

公开(公告)号：US09293954B2

公开(公告)日：2016-03-22

申请号：US13983895

申请日：2011-12-06

申请人： Hiroaki Kawasaki ,  Yuichi Yoshikawa

发明人： Hiroaki Kawasaki ,  Yuichi Yoshikawa

IPC分类号： H02K21/12 ,  H02K1/27 ,  H02K21/16

CPC分类号： H02K1/2706 ,  H02K1/276 ,  H02K21/16

摘要： Provided are a rotor of a motor capable of attaining a high-speed rotation by appropriately dispersing a stress exerted on a flux barrier portion while reducing a leakage of magnetic flux, and a fan driving motor including the rotor. A second inner wall surface is greater than a first inner wall surface in length in a cross-section perpendicular to a rotational axis (C). A side wall surface has a flux barrier wall surface extending from each of both ends of the second inner wall surface in the cross-section perpendicular to the rotational axis (C), the flux barrier wall surface extending outward relative to the second inner wall surface in an extending direction of the second inner wall surface and more distant from an outer edge of a rotor as it goes from the second inner wall surface toward the first inner wall surface in the cross-section perpendicular to the rotational axis (C).

摘要翻译： 提供一种能够通过适当地分散施加在磁通屏障部分上的应力来实现高速旋转的电动机的转子，同时减少磁通量的泄漏，以及包括转子的风扇驱动电动机。 在垂直于旋转轴线（C）的横截面中，第二内壁表面的长度大于第一内壁表面。 侧壁表面具有从垂直于旋转轴线（C）的横截面中从第二内壁表面的两端各自延伸的通量阻挡壁表面，阻挡壁表面相对于第二内壁表面向外延伸 在第二内壁表面的延伸方向上，在与第二内壁表面垂直于旋转轴线（C）的横截面中从第二内壁表面朝向第一内壁表面更远离转子的外边缘。

公开(公告)号：US09149794B2

公开(公告)日：2015-10-06

申请号：US13266773

申请日：2009-12-03

申请人： Yoshikazu Kawai ,  Hiroaki Kawasaki ,  Naomi Kawahara

发明人： Yoshikazu Kawai ,  Hiroaki Kawasaki ,  Naomi Kawahara

IPC分类号： C07K16/00 ,  B01J20/32 ,  B01J20/289

CPC分类号： C08B37/00 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3229 ,  B01J20/3244 ,  B01J20/3248

摘要： The present invention relates to a method for producing a formyl group-containing porous base matrix, comprising the steps of introducing a spacer in a formyl group-containing porous particle; and then oxidizing the spacer with periodic acid and/or a periodate, to transform the part of the spacer into a formyl group; wherein the formyl group content in the porous particle after introduction of the spacer is not more than 3 μmol per 1 mL of the porous particle. Also, the present invention relates to a method for producing an adsorbent, comprising the step of immobilizing an amino group-containing ligand on the formyl group-containing porous base matrix. According to the present invention, a formyl-group containing porous base matrix and an adsorbent produced from the porous base matrix of which adsorption amount is high and which is has high strength and of which ligand is difficult to be leaked are provided.

摘要翻译： 本发明涉及一种含有甲酰基的多孔基质基质的制造方法，包括以下步骤：在含甲酰基的多孔质粒子中引入间隔物; 然后用高碘酸和/或高碘酸盐氧化间隔物，以将部分间隔物转化成甲酰基; 其中间隔物引入后的多孔质粒中的甲酰基含量相对于1mL多孔质粒不超过3μmol。 此外，本发明涉及一种吸附剂的制造方法，其特征在于，含有含氨基的配位体固定在含甲酰基的多孔质基体上的工序。 根据本发明，提供了含有甲酰基的多孔基质基质和由吸附量高，强度高，配体难以泄漏的多孔基质基质生成的吸附剂。