公开(公告)号：US20090196659A1

公开(公告)日：2009-08-06

申请号：US12362777

申请日：2009-01-30

申请人： Hiroshi Handa

发明人： Hiroshi Handa

IPC分类号： G03G15/08

CPC分类号： G03G15/0877 ,  G03G15/0875 ,  G03G2215/085

摘要： A casing of a developing apparatus defines a developing chamber and a developer accommodating chamber, that accommodates developer, therein. The developing chamber and the developer accommodating chamber are arranged side by side. The casing is formed with a replenishing port for supplying new developer from a developer replenishing unit into the developing chamber. The supply roller is disposed in the developing chamber. The replenishing port is located right above the supply roller when the developing apparatus is disposed in an orientation in which the developing apparatus is intended to be placed in a main casing of an image forming apparatus. The control unit controls the supply roller to rotate when the developing apparatus is mounted in the main casing. The supply roller stirs old developer that have already been located in the developing chamber and the new developer, and transports the old developer and the new developer from the developing chamber into the developer accommodating chamber.

摘要翻译： 显影装置的壳体限定了容纳显影剂的显影室和显影剂容纳室。 显影室和显影剂容纳室并排布置。 壳体形成有用于将新显影剂从显影剂补充单元供应到显影室中的补充口。 供给辊设置在显影室中。 当显影装置设置在显影装置将被放置在图像形成装置的主壳体中的方向上时，补充口位于供给辊的正上方。 当显影装置安装在主壳体中时，控制单元控制供给辊旋转。 供应辊搅拌已经位于显影室和新显影剂中的旧显影剂，并将旧显影剂和新显影剂从显影室输送到显影剂容纳室中。

公开(公告)号：US5122600A

公开(公告)日：1992-06-16

申请号：US411127

申请日：1989-09-22

申请人： Haruma Kawaguchi ,  Akira Asai ,  Yasuji Ohtsuka ,  Hiroshi Handa

发明人： Haruma Kawaguchi ,  Akira Asai ,  Yasuji Ohtsuka ,  Hiroshi Handa

IPC分类号： C12N15/09 ,  C07K1/14 ,  C07K1/16 ,  C07K1/22 ,  C07K14/47 ,  C12N15/00 ,  C12P21/00

CPC分类号： C07K14/47

摘要： There are disclosed a DNA-immobilized microsphere comprising DNA chains having base sequences which bind a specific protein specifically, and a carrier having a particle size of not more than 50 .mu.m and not less than 0.01 .mu.m which does not adsorb any protein, said carrier and said DNA chains being bound to each other by a chemical bond, and a process for purifying a protein using said microsphere.

摘要翻译： 公开了包含具有特异性结合特定蛋白质的碱基序列的DNA链的DNA固定化微球和不吸附任何蛋白质的粒径不大于50μm且不小于0.01μm的载体，所述 载体和所述DNA链通过化学键彼此结合，以及使用所述微球纯化蛋白质的方法。

公开(公告)号：US10994007B2

公开(公告)日：2021-05-04

申请号：US15363748

申请日：2016-11-29

申请人： Hiroshi Handa ,  Saitama Medical University ,  SYSMEX CORPORATION

发明人： Hiroshi Handa ,  Masaaki Kawano ,  Masahiko Kato

IPC分类号： A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  C07K14/005 ,  A61K39/00

摘要： Disclosed is an immunity inducer. The immunity inducer comprises virus like particles; the virus like particles comprise a virus-derived outer coat protein and an antigen-bound protein comprising an exogenous antigen; the outer coat protein constitutes an outer coat of the virus like particles, and the antigen-bound protein is comprised in the outer coat; and the virus like particles induce an immune effect of a living body on the antigen.

公开(公告)号：US20170151326A1

公开(公告)日：2017-06-01

申请号：US15363748

申请日：2016-11-29

申请人： Hiroshi HANDA ,  Saitama Medical University ,  SYSMEX CORPORATION

发明人： Hiroshi HANDA ,  Masaaki KAWANO ,  Masahiko KATO

IPC分类号： A61K39/39 ,  C07K14/005

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/572 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/43 ,  C12N7/00 ,  C12N2710/22023 ,  C12N2710/22034 ,  C12N2760/16134

摘要： Disclosed is an immunity inducer. The immunity inducer comprises virus like particles; the virus like particles comprise a virus-derived outer coat protein and an antigen-bound protein comprising an exogenous antigen; the outer coat protein constitutes an outer coat of the virus like particles, and the antigen-bound protein is comprised in the outer coat; and the virus like particles induce an immune effect of a living body on the antigen.

公开(公告)号：US09268261B2

公开(公告)日：2016-02-23

申请号：US14091361

申请日：2013-11-27

申请人： Hiroshi Handa ,  Hiroki Mori

发明人： Hiroshi Handa ,  Hiroki Mori

IPC分类号： G03G15/08

CPC分类号： G03G15/0898 ,  G03G15/0817

摘要： A developing device includes a frame, a developing roller, a blade unit, and a first seal member. A blade unit extends in an axial direction of the developing roller and in contact with the peripheral surface thereof. The first seal member is configured to seal a boundary between the frame and the axial end portions of the developing roller. The frame has a fixing portion to which end portions of the blade is fixed. The fixing portion has a support surface having an outer edge and an inner edge in the axial direction. The outer edge is positioned outward of an inner edge of the first seal member in the axial direction, and the inner edge of the support surface is positioned inward of the inner edge of the first seal member in the axial direction.

摘要翻译： 显影装置包括框架，显影辊，叶片单元和第一密封构件。 刀片单元沿显影辊的轴向延伸并与其外周表面接触。 第一密封构件被构造成密封框架和显影辊的轴向端部之间的边界。 框架具有固定部分，叶片的端部固定到该固定部分。 固定部具有轴向的外缘和内缘的支撑面。 外缘沿轴向位于第一密封部件的内缘的外侧，支承面的内缘沿轴向位于第一密封部件的内缘的内侧。

公开(公告)号：US09139816B2

公开(公告)日：2015-09-22

申请号：US12849437

申请日：2010-08-03

申请人： Hiroshi Handa ,  Akira Nakanishi ,  Masaaki Kawano

发明人： Hiroshi Handa ,  Akira Nakanishi ,  Masaaki Kawano

IPC分类号： C12Q1/70 ,  A61K6/00 ,  A61K39/12 ,  C12N7/00 ,  C07K14/005 ,  A61K39/00

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2710/22022 ,  C12N2710/22023 ,  Y02A50/467

摘要： There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.

摘要翻译： 提供了一种在生理条件下形成均匀病毒颗粒的新方法。 形成由病毒蛋白组成的均匀尺寸的病毒颗粒聚集体的方法的特征在于在室温下，在130mM至170mM氯化钠和1.5mM的存在下，将病毒蛋白如SV40病毒VP1在pH 5.0至7.0温度下孵育至 2.5mM二价阳离子，并且在存在颗粒形成加速因子如SV40 VP2的情况下。 为了封装待包封在病毒颗粒中的物质，在孵育期间包括待包被的物质。

公开(公告)号：US09109043B2

公开(公告)日：2015-08-18

申请号：US13819809

申请日：2011-09-02

申请人： Takeshi Imai ,  Hiroshi Handa

发明人： Takeshi Imai ,  Hiroshi Handa

IPC分类号： C07K14/47 ,  A61K38/45 ,  A61K38/16 ,  A01K67/027

CPC分类号： C07K14/4703 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0362 ,  A61K38/16 ,  A61K38/45 ,  G01N2500/00 ,  G01N2800/042

摘要： It is an object of the present invention to provide a newly identified insulin secretion regulation factor that can control blood sugar in the normal range, and a method for screening an antidiabetic drug using said factor.In accordance with the present invention, there is provided a composition which is (i) a protein comprising an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4; or (ii) a protein comprising an amino acid sequence in which one or several amino acids are deleted, substituted or added in an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4 and negatively regulating insulin secretion, as well as a method for screening antidiabetic drug using said protein or a nucleic acid encoding the same.

摘要翻译： 本发明的目的是提供一种能够控制正常范围内的血糖的新鉴定的胰岛素分泌调节因子，以及使用该因子筛选抗糖尿病药物的方法。 根据本发明，提供了一种组合物，其是（i）包含SEQ ID NO：2或SEQ ID NO：4所示的氨基酸序列的蛋白质; 或（ii）包含氨基酸序列的蛋白质，其中一个或几个氨基酸被缺失，取代或添加在由SEQ ID NO：2或SEQ ID NO：4表示的氨基酸序列中并负调节胰岛素分泌 作为使用所述蛋白质或编码该蛋白质的核酸筛选抗糖尿病药物的方法。

公开(公告)号：US09091960B2

公开(公告)日：2015-07-28

申请号：US14091362

申请日：2013-11-27

申请人： Hiroshi Handa ,  Hiroki Mori

发明人： Hiroshi Handa ,  Hiroki Mori

IPC分类号： G03G15/08

CPC分类号： G03G15/0817

摘要： A cartridge is configured to supply developing agent to a peripheral surface of a photosensitive drum. The cartridge includes a frame, a developing roller and first and second side seal members. The developing roller defines an axial direction, and is configured to supply developing agent in the frame to the photosensitive drum. The first side seal member is configured to seal a boundary between the frame and one end portion of the developing roller in the axial direction. The second side seal member is configured to seal a boundary between the frame and another end portion of the developing roller. The first and second side seal members define a gap therebetween in the axial direction, and the gap has a gap length smaller than a width in the axial direction of a maximum width sheet conveyed to the photosensitive drum.

摘要翻译： 墨盒构造成将显影剂供应到感光鼓的外围表面。 盒包括框架，显影辊以及第一和第二侧面密封件。 显影辊限定轴向，并且构造成将框架中的显影剂供应到感光鼓。 第一侧密封构件被构造成沿着轴向密封框架和显影辊的一个端部之间的边界。 第二侧密封构件被构造成密封框架和显影辊的另一端部之间的边界。 第一侧密封构件和第二侧面密封构件在轴向上限定了间隙，间隙具有小于传送到感光鼓的最大宽度片材的轴向宽度的间隙长度。

公开(公告)号：US20140153960A1

公开(公告)日：2014-06-05

申请号：US14091362

申请日：2013-11-27

申请人： Hiroshi Handa ,  Hiroki Mori

发明人： Hiroshi Handa ,  Hiroki Mori

IPC分类号： G03G15/08

CPC分类号： G03G15/0817

摘要： A cartridge is configured to supply developing agent to a peripheral surface of a photosensitive drum. The cartridge includes a frame, a developing roller and first and second side seal members. The developing roller defines an axial direction, and is configured to supply developing agent in the frame to the photosensitive drum. The first side seal member is configured to seal a boundary between the frame and one end portion of the developing roller in the axial direction. The second side seal member is configured to seal a boundary between the frame and another end portion of the developing roller. The first and second side seal members define a gap therebetween in the axial direction, and the gap has a gap length smaller than a width in the axial direction of a maximum width sheet conveyed to the photosensitive drum.

摘要翻译： 墨盒构造成将显影剂供应到感光鼓的外围表面。 盒包括框架，显影辊以及第一和第二侧面密封件。 显影辊限定轴向，并且构造成将框架中的显影剂供应到感光鼓。 第一侧密封构件被构造成沿着轴向密封框架和显影辊的一个端部之间的边界。 第二侧密封构件被构造成密封框架和显影辊的另一端部之间的边界。 第一侧密封构件和第二侧面密封构件在轴向上限定了间隙，间隙具有小于传送到感光鼓的最大宽度片材的轴向宽度的间隙长度。

公开(公告)号：US20140153959A1

公开(公告)日：2014-06-05

申请号：US14091361

申请日：2013-11-27

申请人： Hiroshi Handa ,  Hiroki Mori

发明人： Hiroshi Handa ,  Hiroki Mori

IPC分类号： G03G15/08

CPC分类号： G03G15/0898 ,  G03G15/0817

摘要： A developing device includes a frame, a developing roller, a blade unit, and a first seal member. A blade unit extends in an axial direction of the developing roller and in contact with the peripheral surface thereof. The first seal member is configured to seal a boundary between the frame and the axial end portions of the developing roller. The frame has a fixing portion to which end portions of the blade is fixed. The fixing portion has a support surface having an outer edge and an inner edge in the axial direction. The outer edge is positioned outward of an inner edge of the first seal member in the axial direction, and the inner edge of the support surface is positioned inward of the inner edge of the first seal member in the axial direction.

摘要翻译： 显影装置包括框架，显影辊，叶片单元和第一密封构件。 刀片单元沿显影辊的轴向延伸并与其外周表面接触。 第一密封构件被构造成密封框架和显影辊的轴向端部之间的边界。 框架具有固定部分，叶片的端部固定到该固定部分。 固定部具有轴向的外缘和内缘的支撑面。 外缘沿轴向位于第一密封部件的内缘的外侧，支承面的内缘沿轴向位于第一密封部件的内缘的内侧。