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    Viral particle-like structure in physiological conditions, and method of forming it
    1.
    发明授权
    Viral particle-like structure in physiological conditions, and method of forming it 有权
    生理条件下的病毒颗粒状结构及其形成方法

    公开(公告)号：US09139816B2

    公开(公告)日：2015-09-22

    申请号：US12849437

    申请日：2010-08-03

    申请人： Hiroshi Handa ,  Akira Nakanishi ,  Masaaki Kawano

    发明人： Hiroshi Handa ,  Akira Nakanishi ,  Masaaki Kawano

    IPC分类号： C12Q1/70 ,  A61K6/00 ,  A61K39/12 ,  C12N7/00 ,  C07K14/005 ,  A61K39/00

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2710/22022 ,  C12N2710/22023 ,  Y02A50/467

    摘要： There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.

    摘要翻译： 提供了一种在生理条件下形成均匀病毒颗粒的新方法。 形成由病毒蛋白组成的均匀尺寸的病毒颗粒聚集体的方法的特征在于在室温下，在130mM至170mM氯化钠和1.5mM的存在下，将病毒蛋白如SV40病毒VP1在pH 5.0至7.0温度下孵育至 2.5mM二价阳离子，并且在存在颗粒形成加速因子如SV40 VP2的情况下。 为了封装待包封在病毒颗粒中的物质，在孵育期间包括待包被的物质。

    Viral Particle-Like Construct and Method of Forming the Same Under Physiological Conditions
    2.
    发明申请
    Viral Particle-Like Construct and Method of Forming the Same Under Physiological Conditions 审中-公开
    病毒颗粒状构造及其在生理条件下形成的方法

    公开(公告)号：US20080131928A1

    公开(公告)日：2008-06-05

    申请号：US11630954

    申请日：2005-06-30

    申请人： Hiroshi Handa ,  Akira Nakanishi ,  Masaaki Kawano

    发明人： Hiroshi Handa ,  Akira Nakanishi ,  Masaaki Kawano

    IPC分类号： C12P21/04 ,  C12N7/00 ,  C12N15/87

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2710/22022 ,  C12N2710/22023 ,  Y02A50/467

    摘要： There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.

    摘要翻译： 提供了一种在生理条件下形成均匀病毒颗粒的新方法。 形成由病毒蛋白组成的均匀尺寸的病毒颗粒聚集体的方法的特征在于，在室温下，在130mM至170mM氯化钠和1.5mM的存在下，在pH 5.0至7.0的温度下孵育病毒蛋白如SV40病毒VP1 至2.5mM二价阳离子，并且在存在颗粒形成加速因子如SV40 VP2的情况下。 为了封装待包封在病毒颗粒中的物质，在孵育期间包括待包被的物质。

    Seal configuration for suppressing developer leakage in a developing device
    5.
    发明授权
    Seal configuration for suppressing developer leakage in a developing device 有权
    用于抑制显影装置中的显影剂泄漏的密封构造

    公开(公告)号：US09116463B2

    公开(公告)日：2015-08-25

    申请号：US14091941

    申请日：2013-11-27

    申请人： Hiroshi Handa ,  Soun Kanada

    发明人： Hiroshi Handa ,  Soun Kanada

    IPC分类号： G03G15/08

    CPC分类号： G03G15/0817

    摘要： A developing device including: a first seal member arranged between a housing and a layer thickness regulation blade, and a second seal member arranged between the housing and a developing roller, wherein the first seal member is arranged adjacent to the second seal member in a rotating direction of the developing roller, wherein the second seal member includes a first member contacting a circumferential surface of the developing roller and a second member arranged between the housing and the first member, wherein the second member includes a protruding portion that, in the rotating direction of the developing roller, protrudes more towards the first seal member than the first member, and wherein end portions of the first and second members in the rotating direction of the developing roller are respectively configured to contact with the first seal member.

    摘要翻译： 一种显影装置，包括：布置在壳体和层厚度调节刀片之间的第一密封构件和布置在壳体和显影辊之间的第二密封构件，其中第一密封构件以旋转的方式布置成与第二密封构件相邻 显影辊的方向，其中所述第二密封构件包括接触所述显影辊的圆周表面的第一构件和布置在所述壳体和所述第一构件之间的第二构件，其中所述第二构件包括突出部分，所述突出部分沿所述旋转方向 显影辊的第一和第二构件的端部分别构造成与第一密封构件接触。

    Developing cartridge and process cartridge for stably rotating developing roller
    6.
    发明授权
    Developing cartridge and process cartridge for stably rotating developing roller 有权
    显影墨盒和处理盒，用于稳定旋转显影辊

    公开(公告)号：US08682216B2

    公开(公告)日：2014-03-25

    申请号：US13052907

    申请日：2011-03-21

    申请人： Hiroshi Handa ,  Hiroki Mori

    发明人： Hiroshi Handa ,  Hiroki Mori

    IPC分类号： G03G15/08

    CPC分类号： G03G21/1676 ,  G03G15/0806 ,  G03G15/0808 ,  G03G15/0865 ,  G03G21/1821 ,  G03G2221/163

    摘要： A developing cartridge includes: a developing roller main body; a developing roller shaft, which is arranged along a central axis line of the developing roller main body, and which protrudes from both end portions of the developing roller main body along the central axis line, wherein the developing roller shaft includes a small diameter part located at a first end portion in the axis line direction, the small diameter part having an outer diameter smaller than an outer diameter of a second end portion opposite to the first end portion; and a developing gear that is fixed to the first end portion of the developing roller shaft.

    摘要翻译： 显影盒包括：显影辊主体; 显影辊轴，其沿着显影辊主体的中心轴线布置，并且沿着中心轴线从显影辊主体的两个端部突出，其中显影辊轴包括位于 在所述轴线方向的第一端部，所述小直径部的外径小于与所述第一端部相反的第二端部的外径; 以及固定到显影辊轴的第一端部的显影齿轮。

    PHARMACEUTICAL COMPOSITION UTILIZING PANCREATIC BETA CELL PROLIFERATION FACTOR
    7.
    发明申请
    PHARMACEUTICAL COMPOSITION UTILIZING PANCREATIC BETA CELL PROLIFERATION FACTOR 审中-公开
    利用胰腺癌细胞增殖因子的药物组合物

    公开(公告)号：US20130086704A1

    公开(公告)日：2013-04-04

    申请号：US13702208

    申请日：2011-06-13

    申请人： Takeshi Imai ,  Hiroshi Handa

    发明人： Takeshi Imai ,  Hiroshi Handa

    IPC分类号： C12N15/85

    CPC分类号： C12N15/85 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0362 ,  A61K38/45 ,  A61K48/005 ,  C12N9/1051 ,  G01N33/507 ,  G01N2333/91102

    摘要： Disclosed are a pharmaceutical composition, a screening method, and the like which use UDP-glucose glycoprotein glycosyl transferase 1 (UGGT1) or a gene encoding the same. UGGT1 has an extremely high proliferative activity compared to known pancreatic β-cell proliferation factors; thus, UGGT1 can act as a useful therapeutic agent for diabetes without any modification and is also useful as a target substance for the development of a new therapeutic agent for diabetes.

    摘要翻译： 公开了使用UDP-葡萄糖糖蛋白糖基转移酶1（UGGT1）或其编码基因的药物组合物，筛选方法等。 与已知的胰腺细胞增殖因子相比，UGGT1具有极高的增殖活性; 因此，UGGT1可以作为糖尿病的有用治疗剂而没有任何修饰，也可用作开发新的糖尿病治疗剂的目标物质。

    SCREENING METHOD UTILIZING THALIDOMIDE-TARGETING FACTOR
    8.
    发明申请
    SCREENING METHOD UTILIZING THALIDOMIDE-TARGETING FACTOR 有权
    筛选方法利用半胱氨酸靶向因子

    公开(公告)号：US20120192297A1

    公开(公告)日：2012-07-26

    申请号：US13498067

    申请日：2010-10-18

    申请人： Hiroshi Handa ,  Hideki Ando ,  Takumi Itoh ,  Kentaro Hotta

    发明人： Hiroshi Handa ,  Hideki Ando ,  Takumi Itoh ,  Kentaro Hotta

    IPC分类号： G01N33/68 ,  C12N15/12 ,  A01K67/027 ,  C07K14/435

    CPC分类号： G01N33/566 ,  G01N2500/04

    摘要： With an aim to provide means for developing a compound devoid of teratogenicity but retaining beneficial actions, a screening method for a non-teratogenic substance comprising bringing a test substance into contact with cereblon or a fragment of cereblon, evaluating the bindability of the test substance with cereblon or the fragment of cereblon, and selecting a test substance that does not bind to cereblon or the fragment of cereblon or a test substance exhibiting lower bindability with cereblon or the fragment of cereblon than does thalidomide is provided.

    摘要翻译： 目的是提供开发不具有致畸性但保留有益作用的化合物的方法，用于非致畸物质的筛选方法，包括使测试物质与大脑或脑片的片段接触，评估测试物质与 提供了与沙门氏菌相比，不能结合到脑部或与本发明的化合物相比较的表现出与巧克力片或巧克力片相比具有较低粘合性的测试物质的测试物质。

    Microsphere containing glycidyl methacrylate covered polymer and spacer coupled compound for isolating substances
    10.
    发明授权
    Microsphere containing glycidyl methacrylate covered polymer and spacer coupled compound for isolating substances 有权
    含有甲基丙烯酸缩水甘油酯覆盖聚合物的微球和用于分离物质的间隔物偶联化合物

    公开(公告)号：US06545132B1

    公开(公告)日：2003-04-08

    申请号：US09440597

    申请日：1999-11-15

    申请人： Hiroshi Handa ,  Haruma Kawaguchi

    发明人： Hiroshi Handa ,  Haruma Kawaguchi

    IPC分类号： C07K122

    CPC分类号： C07K14/705 ,  G01N33/54313 ,  G01N33/54353 ,  G01N33/94 ,  Y10S435/803 ,  Y10S435/815 ,  Y10S530/815 ,  Y10S530/816

    摘要： A microsphere is prepared containing a compound possessing physiological activity coupled to a styrene-glycidyl methacrylate polymer through a spacer. Compounds that may be used include receptors such as proteins, and 3-[(5-(2,3-dimethoxy-6-methyl-benzoquinonyl)]-2-nonyl-2-propionic acid. A preferred spacer is an ethylene glycol diglycidyl ether derivative. Preferably, the whole surface of the styrene-glycidyl methacrylate polymer is covered with glycidyl methacrylate. The microsphere may be used for isolating and detecting substances such as proteins that bind to the coupled compound.

    摘要翻译： 制备含有通过间隔物与苯乙烯 - 甲基丙烯酸缩水甘油酯聚合物偶联的生理活性的化合物的微球。 可以使用的化合物包括蛋白质和3 - [（5-（2,3-二甲氧基-6-甲基 - 苯醌基）] -2-壬基-2-丙酸等受体，优选的间隔基是乙二醇二缩水甘油基 醚衍生物，苯乙烯 - 甲基丙烯酸缩水甘油酯聚合物的整个表面优选被甲基丙烯酸缩水甘油酯覆盖，微球可用于分离和检测结合偶联化合物的蛋白质等物质。