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    Pacemaker lead for sensing a physiologic parameter of the body
    51.
    发明授权
    Pacemaker lead for sensing a physiologic parameter of the body 失效
    起搏器导线用于感测身体的生理参数

    公开(公告)号：US5267564A

    公开(公告)日：1993-12-07

    申请号：US716032

    申请日：1991-06-14

    Applicant: James E. Barcel ,  Alvin H. Weinberg ,  Shahram Moaddeb ,  James R. Thacker

    Inventor： James E. Barcel ,  Alvin H. Weinberg ,  Shahram Moaddeb ,  James R. Thacker

    IPC: A61B5/145 ,  A61B5/1459 ,  A61N1/05 ,  A61N1/365 ,  A61N1/37 ,  H01R43/00 ,  A61B5/0205

    CPC classification number: A61N1/056 ,  A61N1/36557 ,  A61N1/3702 ,  Y10T29/49117

    Abstract: The present invention includes a body implantable lead having a multi-polar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having glass frit sealing rings are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the glass frit such that the glass frit reflows between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.

    Travenously placed defibrillation leads
    52.
    发明授权
    Travenously placed defibrillation leads 失效
    静脉放置除颤线

    公开(公告)号：US4998975A

    公开(公告)日：1991-03-12

    申请号：US429440

    申请日：1989-10-30

    Applicant: Donald M. Cohen ,  James R. Thacker

    Inventor： Donald M. Cohen ,  James R. Thacker

    IPC: A61N1/04 ,  A61N1/05 ,  A61N1/39

    CPC classification number: A61N1/3918 ,  A61N1/0563 ,  A61N1/0587

    Abstract: A cardiac defibrillation system and method includes an epicardial electrode for making electrical contact with the epicardium from a position within the pericardial space, an endocardial electrode for making electrical contact with the endocardium of the heart, and means for making electrical contact with the epicardial and endocardial electrodes. The endocardial electrode is inserted transvenously into the heart in conventional manner. The epicardial electrode is also inserted transvenously into the heart, through the heart wall, and into the pericardial space. No open chest surgery is required.

    Physiologically responsive pacemaker and method of adjusting the pacing interval thereof
    53.
    发明授权
    Physiologically responsive pacemaker and method of adjusting the pacing interval thereof 失效
    生理反应起搏器和调整其起搏间隔的方法

    公开(公告)号：US4712555A

    公开(公告)日：1987-12-15

    申请号：US716831

    申请日：1985-03-27

    Applicant: Hans T. Thornander ,  John W. Poore ,  Jason A. Sholder ,  James R. Thacker ,  David C. Amundson

    Inventor： Hans T. Thornander ,  John W. Poore ,  Jason A. Sholder ,  James R. Thacker ,  David C. Amundson

    IPC: A61N1/08 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37 ,  A61N1/36

    CPC classification number: A61N1/365 ,  A61N1/368 ,  A61N1/3712 ,  A61N1/3714 ,  A61N1/3716

    Abstract: A pacemaker and physiological sensor for use therewith that allows the rate at which the pacemaker delivers electrical stimulation pulses to the heart, or the escape interval during which a natural heart event must occur before an electrical stimulation pulse is delivered, to be adjusted as needed in order to satisfy the body's physiological needs. The sensor measures the depolarization time interval between an atrial stimulation pulse, A, and the responsive atrial or ventricle depolarization, P or R respectively, as an indication of the physiological demands placed on the heart. The time interval between a ventricular stimulation pulse, V, and the responsive ventricular depolarization, R, may also be measured and used as an indication of physiological need, and hence as an alternative criteria for rate control. Atrial depolarization is sensed by detecting a P-wave, and ventricular depolarization is preferably sensed by detecting an R-wave. A method of measuring A-P, A-R, or V-R intervals is used to ascertain if these intervals are increasing or decreasing. If, over several heart cycles or beats, an increase or decrease in these measurements is detected, the pacing interval set by the pacemaker is adjusted in an appropriate direction in order to adjust the heart stimulation rate accordingly.

    Abstract translation: 用于其的起搏器和生理传感器允许起搏器向心脏传递电刺激脉冲的速率，或者在传送电刺激脉冲之前必须发生自然心脏事件的逃逸间隔，以根据需要进行调整 为了满足身体的生理需要。 传感器测量心房刺激脉冲A与反应性心房或心室去极化P或R之间的去极化时间间隔，作为对心脏的生理需求的指示。 也可以测量心室刺激脉冲V与响应性心室去极化R之间的时间间隔，并将其用作生理需要的指示，并因此用作速率控制的替代标准。 通过检测P波来感测心房去极化，并且优选通过检测R波来感测心室去极化。 使用测量A-P，A-R或V-R间隔的方法来确定这些间隔是否增加或减少。 如果在几个心脏周期或节拍中检测到这些测量值的增加或减少，起搏器设定的起搏间隔将在适当的方向进行调节，以便相应地调整心脏刺激速率。

    Systems and methods for positioning implanted devices in a patient
    54.
    发明授权
    Systems and methods for positioning implanted devices in a patient 有权
    用于将植入的装置定位在患者体内的系统和方法

    公开(公告)号：US08965482B2

    公开(公告)日：2015-02-24

    申请号：US12895403

    申请日：2010-09-30

    Applicant: James R. Thacker ,  Jon Parker ,  Yougandh Chitre

    Inventor： James R. Thacker ,  Jon Parker ,  Yougandh Chitre

    IPC: A61B5/06 ,  A61N1/36 ,  A61B19/00 ,  A61B5/00 ,  A61N1/372

    CPC classification number: A61B5/065 ,  A61B5/063 ,  A61B5/066 ,  A61B5/407 ,  A61B34/20 ,  A61B90/06 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2090/062 ,  A61B2560/045 ,  A61N1/36071 ,  A61N1/36128 ,  A61N1/36185 ,  A61N1/37217 ,  A61N1/37241

    Abstract: Systems and methods for positioning implanted devices in a patient are disclosed. A method in accordance with a particular embodiment includes, for each of a plurality of patients, receiving a target location from which to deliver a modulation signal to the patient's spinal cord. The method further includes implanting a signal delivery device within a vertebral foramen of each patient, and positioning an electrical contact carried by the signal delivery device to be within ±5 mm. of the target location, without the use of fluoroscopy. The method can still further include, for each of the plurality of patients, activating the electrical contact to modulate neural activity at the spinal cord. In further particular embodiments, RF signals, ultrasound, magnetic fields, and/or other techniques are used to locate the signal delivery device.

    Abstract translation: 公开了将植入装置定位在患者体内的系统和方法。 根据特定实施例的方法包括对于多个患者中的每一个，接收目​​标位置，从所述目标位置向所述患者的脊髓传送调制信号。 该方法还包括将信号传送装置植入每个患者的椎骨孔内，并将由信号传送装置承载的电接触定位在±5mm以内。 的目标位置，无需使用荧光透视。 该方法还可以包括对于多个患者中的每一个，激活电接触以调节脊髓的神经活动。 在另外的特定实施例中，使用RF信号，超声波，磁场和/或其它技术来定位信号传递装置。

    METHOD FOR PROGRAMMING IMPLANTABALE DEVICE
    58.
    发明申请
    METHOD FOR PROGRAMMING IMPLANTABALE DEVICE 审中-公开
    编写IMPLANTABALE设备的方法

    公开(公告)号：US20130006325A1

    公开(公告)日：2013-01-03

    申请号：US13538022

    申请日：2012-06-29

    Applicant: Carla M. Woods ,  James R. Thacker ,  David K. Peterson ,  Holly A. Segel ,  Susan E. Ford ,  Margaret E. Theriot ,  Kerry Bradley

    Inventor： Carla M. Woods ,  James R. Thacker ,  David K. Peterson ,  Holly A. Segel ,  Susan E. Ford ,  Margaret E. Theriot ,  Kerry Bradley

    IPC: A61N1/36

    CPC classification number: A61N1/36071 ,  A61N1/08 ,  A61N1/36185 ,  A61N1/37241 ,  A61N1/37247

    Abstract: A programming system for selecting an electrode configuration for use in a medical electrical stimulator coupled to an electrode array. A programmer is configured for providing a set of electrode configurations for the electrode array, automatically testing a first portion of the set of electrode configurations in a first order, allowing the selection of one or more of the tested electrode configurations, determining whether a suitable number of electrode configurations from among the first portion have been selected within a predefined interval, and automatically testing a second portion of the set of electrode configurations in a second order if the suitable number of electrode configurations from among the first portion are not selected within the predefined interval. The programmer may further allow the selection of the tested electrode configurations, and adjusting parameters during the testing, wherein the adjusting is controllably shared in parallel between a clinician and a patient.

    Abstract translation: 一种用于选择用于耦合到电极阵列的医用电刺激器中的电极配置的编程系统。 编程器被配置为提供用于电极阵列的一组电极配置，以一级自动测试该组电极配置的第一部分，允许选择一个或多个测试电极配置，确定是否合适数量 已经在预定义的间隔内选择了第一部分中的电极配置，并且如果来自第一部分中的适当数量的电极配置未被选择在预定义的范围内，则以二次自动测试该组电极配置的第二部分 间隔。 编程者可以进一步允许选择所测试的电极配置，并且在测试期间调整参数，其中调整在临床医生和患者之间可并行共享。

    SYSTEMS AND METHODS FOR SELECTING NEURAL MODULATION CONTACTS FROM AMONG MULTIPLE CONTACTS
    59.
    发明申请
    SYSTEMS AND METHODS FOR SELECTING NEURAL MODULATION CONTACTS FROM AMONG MULTIPLE CONTACTS 审中-公开
    从多个联系人中选择神经调制联系的系统和方法

    公开(公告)号：US20120253422A1

    公开(公告)日：2012-10-04

    申请号：US13076197

    申请日：2011-03-30

    Applicant: James R. Thacker ,  Jon Parker

    Inventor： James R. Thacker ,  Jon Parker

    IPC: A61N1/36

    CPC classification number: A61N1/37247 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/36185

    Abstract: The present technology is directed generally to systems and methods for selecting neural modulation contacts from among multiple contacts. A system in accordance with a particular embodiment includes a patient implantable signal delivery system having (n) contacts positioned to deliver therapy signals to a patient, where (n) is greater than three, and an external signal generator coupled to the signal delivery device and having a computer-readable medium containing instructions that, when executed, perform the operations of (a) identifying a contact pair, (b) delivering neural modulation signals to the contact pair, (c) changing one or more of the contacts of the contact pair, and (d) repeating operations (b)-(c) for each of at most (n−1) unique contact pairs.

    Abstract translation: 本技术一般涉及用于从多个接触中选择神经调制接触的系统和方法。 根据特定实施例的系统包括患者可植入信号传递系统，其具有定位成将治疗信号传递给患者的（n）触点，其中（n）大于3，以及外部信号发生器，其耦合到所述信号传送装置和 具有包含指令的计算机可读介质，所述指令在被执行时执行（a）识别联系人对的操作，（b）将神经调制信号传递到所述联系对，（c）改变所述联系人中的一个或多个触点 对，以及（d）对于最多（n-1）个独特的接触对中的每一个重复操作（b） - （c）。

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