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453 条记录 (耗时 0.025 秒)

    Boron-Enhanced Shape Memory Endoprostheses
    51.
    发明申请
    Boron-Enhanced Shape Memory Endoprostheses 审中-公开
    硼增强型形状记忆内假体

    公开(公告)号：US20090018644A1

    公开(公告)日：2009-01-15

    申请号：US11777729

    申请日：2007-07-13

    申请人： Jan Weber ,  Barry O'Brien

    发明人： Jan Weber ,  Barry O'Brien

    IPC分类号： A61F2/82

    CPC分类号： A61L31/022 ,  A61L31/084 ,  A61L31/088 ,  A61L31/128 ,  A61L31/14 ,  A61L2400/16

    摘要： An endoprosthesis comprises a member capable of supporting a body passageway. The member has a surface region overlying a bulk region, and comprises a shape memory alloy and boron. The concentration of boron in the surface region is greater than the concentration of boron in the bulk region.

    摘要翻译： 内假体包括能够支撑身体通道的构件。 该构件具有覆盖体区域的表面区域，并且包括形状记忆合金和硼。 表面区域中硼的浓度大于体积区域中的硼浓度。

    Hardened polymeric lumen surfaces
    52.
    发明申请
    Hardened polymeric lumen surfaces 审中-公开
    硬化的聚合物管腔表面

    公开(公告)号：US20080312639A1

    公开(公告)日：2008-12-18

    申请号：US11818021

    申请日：2007-06-13

    申请人： Jan Weber

    发明人： Jan Weber

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0045 ,  A61L29/04 ,  A61L29/14 ,  A61L2400/18 ,  A61M25/0009 ,  A61M25/0023 ,  A61M25/0054 ,  A61M2025/0062

    摘要： Apparatuses, systems, and methods for surface modification of catheters. The surface modification can be localized to a lumen surface of the catheter. The surface modification to the lumen surface extends radially into the catheter body a predetermined distance to provide a hardened zone having a hardness that is greater than a hardness of an exterior surface of the catheter body.

    摘要翻译： 导管表面改性的装置，系统和方法。 表面改性可以定位于导管的内腔表面。 对内腔表面的表面改性径向延伸到导管主体预定距离以提供具有大于导管主体外表面的硬度的硬度的硬化区域。

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    54.
    发明申请
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
    用于与电力源一起递送治疗剂的内部医疗装置

    公开(公告)号：US20080262412A1

    公开(公告)日：2008-10-23

    申请号：US12077603

    申请日：2008-03-20

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30 ,  A61M25/10

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

    STENTS WITH CERAMIC DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME
    55.
    发明申请
    STENTS WITH CERAMIC DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME 失效
    具有陶瓷药物储存层的方法及其制造和使用方法

    公开(公告)号：US20080249615A1

    公开(公告)日：2008-10-09

    申请号：US11697079

    申请日：2007-04-05

    申请人： Jan Weber

    发明人： Jan Weber

    IPC分类号： A61F2/06

    CPC分类号： A61L33/00 ,  A61F2/915 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08

    摘要： A method of making a drug eluting stent comprises forming a porous stent body surface layer by ion implantation, applying a layer of ceramic particles on the porous layer and compressing the layer of ceramic particles. The layer of ceramic particles can be compressed to successively higher densities. Drugs can be loaded into the layer of ceramic materials at a relatively low density before the layer of ceramic materials is compressed to a higher density to achieve a desired low drug release rate.

    摘要翻译： 制备药物洗脱支架的方法包括通过离子注入形成多孔支架体表面层，在多孔层上施加陶瓷颗粒层并压缩陶瓷颗粒层。 可以将陶瓷颗粒层压缩成连续较高的密度。 在将陶瓷材料层压缩到更高密度以获得期望的低药物释放速率之前，药物可以以相对较低的密度装载到陶瓷材料层中。