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262 条记录 (耗时 0.034 秒)

    CRYSTAL STRUCTURE OF THE NanR AND ManNAc-6P COMPLEX, AND USES THEREOF
    51.
    发明申请
    CRYSTAL STRUCTURE OF THE NanR AND ManNAc-6P COMPLEX, AND USES THEREOF 有权
    NanR和ManNAC-6P复合物的晶体结构及其用途

    公开(公告)号：US20150010915A1

    公开(公告)日：2015-01-08

    申请号：US14310879

    申请日：2014-06-20

    申请人： SNU R&DB FOUNDATION ,  Korea Research Institute Of Bioscience And Biotechnology

    发明人： Sang Ho Choi ,  Byoung Sik Kim ,  Myung Hee Kim ,  Jung Won Hwang

    IPC分类号： G01N33/569 ,  C07K14/28

    CPC分类号： G01N33/56911 ,  C07K14/28 ,  G01N2400/00 ,  G01N2500/04

    摘要： The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of NanR which is a key pathogenic regulatory protein of Vibrio vulnificus and ManNA6P which is a NanR regulator. Further, the present invention relates to a modified NanR protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector. Furthermore, the present invention relates to a method for screening a substance regulating interaction between NanR and the transcriptional control region of nan operon which is a gene cluster regulated by NanR, or a substance regulating interaction between NanR and ManNAc-6P, by designing three-dimensional structure of the complex, and to an antibacterial composition including the screened substance.

    摘要翻译： 本发明涉及通过结晶作为创伤弧菌的关键致病性调节蛋白NanR的复合物和作为NanR调节剂的ManNA6P而研究的复合物的三维结构。 此外，本发明涉及修饰的NanR蛋白，编码该蛋白的多核苷酸，包含该多核苷酸的载体和包含该载体的转化体。 此外，本发明涉及一种用于筛选调节NanR与NanR调控的基因簇的Nan操纵子的转录控制区之间的相互作用的物质或调节NanR与ManNAc-6P之间的相互作用的物质的方法， 复合物的三维结构，以及包含筛选物质的抗菌组合物。

    METHOD FOR MANUFACTURING MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE USING TWO KINDS OF PARTICLE, AND MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE MANUFACTURED BY MEANS OF SAME
    52.
    发明申请
    METHOD FOR MANUFACTURING MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE USING TWO KINDS OF PARTICLE, AND MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE MANUFACTURED BY MEANS OF SAME 有权
    使用两种颗粒制造多功能生物材料共混物的方法和由其制造的多功能生物材料共混物

    公开(公告)号：US20140272945A1

    公开(公告)日：2014-09-18

    申请号：US14351291

    申请日：2012-10-12

    申请人： GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

    发明人： Min-Gon Kim ,  Yun Ju Sung ,  Ju Young Byun ,  Young-Kyoung Oh ,  Hyou-Arm Joung

    IPC分类号： G01N33/543 ,  G01N33/58

    CPC分类号： G01N33/54346 ,  B82Y15/00 ,  B82Y40/00 ,  G01N33/54333 ,  G01N33/569 ,  G01N33/587 ,  Y10S977/774

    摘要： Disclosed herein are a method for manufacturing a multi-functional bio-material conjugate used as a biosensor for detecting microorganisms, and the like, and a multi-functional bio-material conjugate manufactured by means of the same. The method for manufacturing a multi-functional bio-material conjugate includes: (a) coating a first nanoparticle having magnetic or fluorescent characteristics with protein; (b) manufacturing a conjugate by adsorbing a second nanoparticle having metallic characteristics onto the first nanoparticle coated with protein; and (c) manufacturing the multi-functional bio-material conjugate by adsorbing a bio-material onto the conjugate. The method for manufacturing a multi-functional bio-material conjugate according to the present invention may prevent precipitation of the nanoparticles, easily immobilize the bio-material, and manufacture a bio-material conjugate having multiple functions, by using two kinds of the particles. In addition, the multi-functional bio-material conjugate manufactured by the present method may be used to detect microorganisms at up to a concentration of 101 cfu.

    摘要翻译： 本文公开了一种制造用于检测微生物的生物传感器等的多功能生物材料结合体的方法和利用其制造的多功能生物材料共轭体。 制造多功能生物材料缀合物的方法包括：（a）用蛋白质涂覆具有磁性或荧光特性的第一纳米颗粒; （b）通过将具有金属特性的第二纳米颗粒吸附到涂覆有蛋白质的第一纳米颗粒上来制备缀合物; 和（c）通过将生物材料吸附到缀合物上制备多功能生物材料缀合物。 根据本发明的制备多功能生物材料结合物的方法可以通过使用两种颗粒来防止纳米颗粒的沉淀，容易地使生物材料固定，并制造具有多种功能的生物材料共轭物。 此外，通过本方法制造的多功能生物材料缀合物可以用于以高达101cfu的浓度检测微生物。

    Immunochromatography Detection Sensor Comprising Optical Waveguide and a Detection Method Using the Same
    54.
    发明申请
    Immunochromatography Detection Sensor Comprising Optical Waveguide and a Detection Method Using the Same 有权
    包含光波导的免检色谱检测传感器及使用其的检测方法

    公开(公告)号：US20140206103A1

    公开(公告)日：2014-07-24

    申请号：US14222291

    申请日：2014-03-21

    申请人： Infopia Co., Ltd ,  Korea Research Institute of Bioscience and Biotechnology

    发明人： Yong Beom SHIN ,  Min Gon Kim ,  Byeong Woo Bae

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54373 ,  G01N21/7703 ,  G01N30/95 ,  G01N33/558 ,  G01N2021/7766

    摘要： The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of the optical waveguide and the colored conjugate in the band formed on the membrane, resulting in the absorbance signal from the colored conjugate being greatly amplified to improve the sample detection sensitivity, and to a detection method using the same.

    摘要翻译： 本发明涉及包含光波导的免疫色谱检测传感器和使用其的检测方法，更具体地，涉及包括光波导的免疫色谱检测传感器，其中光波导设置在膜下方，透射通过光学的探测光束 波导使在光波导表面上产生的ev逝波与形成在膜上的带中的着色共轭之间的相互作用频率最大化，导致来自着色共轭的吸收信号被大大地放大以提高样品检测灵敏度， 检测方法使用相同。