公开(公告)号：US5771902A

公开(公告)日：1998-06-30

申请号：US533426

申请日：1995-09-25

Applicant: Abraham P. Lee ,  Peter A. Krulevitch ,  M. Allen Northrup ,  Jimmy C. Trevino

Inventor： Abraham P. Lee ,  Peter A. Krulevitch ,  M. Allen Northrup ,  Jimmy C. Trevino

IPC: A61B17/00 ,  A61B17/12 ,  A61B17/28 ,  A61B19/00

CPC classification number: A61B17/12022 ,  G01L1/18 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00318 ,  A61B2017/00345 ,  A61B2017/1205 ,  A61B2017/2926

Abstract: Micromachined thin film cantilever actuators having means for individually controlling the deflection of the cantilevers, valve members, and rudders for steering same through blood vessels, or positioning same within a blood vessel, for example. Such cantilever actuators include tactile sensor arrays mounted on a catheter or guide wire tip for navigation and tissues identification, shape-memory alloy film based catheter/guide wire steering mechanisms, and rudder-based steering devices that allow the selective actuation of rudders that use the flowing blood itself to help direct the catheter direction through the blood vessel. While particularly adapted for medical applications, these cantilever actuators can be used for steering through piping and tubing systems.

Abstract translation: 微加工薄膜悬臂致动器具有用于单独控制悬臂，阀构件和用于通过血管转向其的方向舵的偏转的装置，或者例如将其定位在血管内。 这种悬臂致动器包括安装在用于导航和组织识别的导管或导丝尖端的触觉传感器阵列，基于形状记忆合金膜的导管/导丝线转向机构和基于方向舵的转向装置，其允许选择性地致动使用 流血本身帮助导管导管通过血管。 虽然这些悬臂式致动器特别适用于医疗应用，但可用于通过管道和管道系统进行转向。

公开(公告)号：US5639423A

公开(公告)日：1997-06-17

申请号：US938106

申请日：1992-08-31

Applicant: M. Allen Northrup ,  Richard M. White

Inventor： M. Allen Northrup ,  Richard M. White

IPC: C12N15/09 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  C12Q1/68 ,  G01N1/00 ,  G01N29/02 ,  G01N35/00 ,  G01N37/00 ,  G01N33/48

CPC classification number: B01L7/52 ,  B01F11/0266 ,  B01F13/0059 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/50273 ,  B01L7/525 ,  G01N29/022 ,  G01N35/00 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0093 ,  B01J2219/00932 ,  B01J2219/00934 ,  B01J2219/00952 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0436 ,  B01L9/527 ,  G01N2035/00237 ,  G01N2035/00554 ,  G01N2291/02466 ,  G01N2291/0256 ,  G01N2291/0421 ,  G01N35/1079 ,  Y10S73/04

Abstract: An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of the instrument provides accurate, contamination-free processing. The instrument may include reagent reservoirs, agitators and mixers, heaters, pumps, and optical or electromechanical sensors. Ultrasonic Lamb-wave devices may be used as sensors, pumps and agitators.