公开(公告)号：US06592877B1

公开(公告)日：2003-07-15

申请号：US09072967

申请日：1998-05-05

Applicant: Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik ,  Michael J. Lodes ,  Ronald C. Hendrickson

Inventor： Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik ,  Michael J. Lodes ,  Ronald C. Hendrickson

IPC: A61K3904

CPC classification number: C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

公开(公告)号：US06509448B2

公开(公告)日：2003-01-21

申请号：US09736457

申请日：2000-12-13

Applicant: Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan ,  Aijun Wang

Inventor： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan ,  Aijun Wang

IPC: C07K1618

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S977/911 ,  Y10S977/912 ,  Y10S977/916

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US06458366B1

公开(公告)日：2002-10-01

申请号：US09072596

申请日：1998-05-05

Applicant: Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik ,  Michael J. Lodes ,  Ronald C. Hendrickson

Inventor： Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik ,  Michael J. Lodes ,  Ronald C. Hendrickson

IPC: A61K3904

CPC classification number: C12Q1/6883 ,  A61K39/00 ,  C07K14/35 ,  C07K16/1289 ,  C07K2319/00 ,  C12Q1/689 ,  G01N33/5695

Abstract: Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

Abstract translation: 公开了用于诊断结核病的化合物和方法。 提供的化合物包括含有一种或多种结核分枝杆菌蛋白质的至少一个抗原部分的多肽和编码这种多肽的DNA序列。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的结核分枝杆菌感染。 还提供了针对这种多肽的抗体。

公开(公告)号：US5763276A

公开(公告)日：1998-06-09

申请号：US619916

申请日：1996-03-20

Applicant: William S. Craig ,  John R. Harper ,  Sam D. Hernandez ,  Paul J. Kostel ,  Jonathan R. Parker ,  Thomas S. Vedvick

Inventor： William S. Craig ,  John R. Harper ,  Sam D. Hernandez ,  Paul J. Kostel ,  Jonathan R. Parker ,  Thomas S. Vedvick

IPC: G01N30/02 ,  A61K38/00 ,  A61P35/00 ,  A61P43/00 ,  B01D41/04 ,  C07K14/00 ,  C07K14/47 ,  C07K14/78 ,  C12N15/09 ,  C12Q1/00 ,  G01N30/06 ,  G01N30/26 ,  G01N30/46 ,  G01N30/88 ,  G01N30/96 ,  G01N33/53 ,  G01N33/68 ,  G01N33/00 ,  C07K1/20 ,  G01N27/00

CPC classification number: G01N33/5308 ,  C07K14/4725 ,  G01N33/68 ,  Y10T436/173845

Abstract: The invention provides a process for detecting the presence of guanidinium ions in a sample solution. The detection process involves contacting a sample solution suspected of containing guanidinium ions with a cation exchange resin and eluting the guanidinium ions present in the sample solution with an aqueous buffer solution having a pH of about 1.5 to about 2. This is followed by contacting the eluant with a cation suppressor column and simultaneously flowing a suppressor regenerate solution in the opposite direction on the opposite side of the permeable membrane of the column, and finally, detecting the presence of guanidinium ions in the eluant from the ion exchange column which was contacted with the suppressor column by use of a conductivity detector.

Abstract translation: 本发明提供了检测样品溶液中胍离子的存在的方法。 检测过程包括将怀疑含有胍离子的样品溶液与阳离子交换树脂接触，并用pH为约1.5至约2的pH缓冲溶液洗脱存在于样品溶液中的胍离子。然后将洗脱液 用阳离子抑制柱，同时在柱的可渗透膜的相对侧沿相反方向流动抑制剂再生溶液，最后，检测离离子交换柱的洗脱液中胍基离子的存在，该离子交换柱与 抑制柱通过使用电导率检测器。