公开(公告)号：US20250155446A1

公开(公告)日：2025-05-15

申请号：US19020590

申请日：2025-01-14

Applicant: 10x Genomics, Inc.

Inventor： Cedric Uytingco ,  James Michael Chell ,  Marlon Stoeckius ,  Albert Dale Kim ,  Dulce Ovando Morales ,  Andrej Hartnett ,  Yifeng Yin ,  Jennifer Chew

IPC: G01N33/68 ,  C12N15/10 ,  C12Q1/6804 ,  C12Q1/6874 ,  G01N1/30 ,  G01N21/64 ,  G01N33/58

Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.

公开(公告)号：US12209280B1

公开(公告)日：2025-01-28

申请号：US17368243

申请日：2021-07-06

Applicant: 10x Genomics, Inc.

Inventor： Marco Mignardi ,  Marlon Stoeckius

IPC: C12Q1/6874

Abstract: Provided herein are methods of identifying abundance and location of an RNA in a biological sample using an adaptor sequence and a primer. Also disclosed herein are kits, compositions, and systems that are used to perform the methods.

公开(公告)号：US20250019749A1

公开(公告)日：2025-01-16

申请号：US18788820

申请日：2024-07-30

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Michael Schnall-Levin ,  Christina Galonska ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876

Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

公开(公告)号：US20250019689A1

公开(公告)日：2025-01-16

申请号：US18683075

申请日：2022-08-10

Applicant: 10x Genomics, Inc.

Inventor： Christina Galonska ,  Marlon Stoeckius

IPC: C12N15/10

Abstract: Provided herein are methods, compositions, and kits including single-chain antibody nucleic acid libraries and methods of displaying single-chain antibodies and screening single-chain antibodies on a spatial array.

公开(公告)号：US20250002982A1

公开(公告)日：2025-01-02

申请号：US18344339

申请日：2023-06-29

Applicant: 10x Genomics, Inc.

Inventor： Marlon Stoeckius ,  James Michael Chell ,  Cedric Uytingco ,  Jennifer Chew ,  Felice Alessio Bava

IPC: C12Q1/6841 ,  C12Q1/6874

Abstract: The present disclosure relates to determining the location of analytes in fixed biological samples.

公开(公告)号：US20240301489A1

公开(公告)日：2024-09-12

申请号：US18605260

申请日：2024-03-14

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  Joseph Francis Shuga ,  Patrick Roelli ,  Denise Cheung ,  Alexander Hermes ,  Yifeng Yin ,  Naishitha Anaparthy ,  Ryo Hatori ,  Marlon Stoeckius ,  Rapolas Spalinskas ,  Anna-Maria Katsori ,  Cedric Uytingco ,  Mesruh Turkekul ,  David Sukovich ,  Christina Galonska ,  Aleksandra Jurek ,  Octavian Marian Bloju

IPC: C12Q1/6874 ,  C12N15/10 ,  C12Q1/6837

CPC classification number: C12Q1/6874 ,  C12N15/1065 ,  C12Q1/6837

Abstract: Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.

公开(公告)号：US20240271190A1

公开(公告)日：2024-08-15

申请号：US18165226

申请日：2023-02-06

Applicant: 10x Genomics, Inc.

Inventor： Marlon Stoeckius ,  James Michael Chell ,  Cedric Uytingco ,  Jennifer Chew ,  Felice Alessio Bava

IPC: C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6869

CPC classification number: C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6869 ,  C12Q2600/16

Abstract: The present disclosure relates to determining the location of analytes in fixed biological samples.

公开(公告)号：US11981965B2

公开(公告)日：2024-05-14

申请号：US18100133

申请日：2023-01-23

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

CPC classification number: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US20240124933A1

公开(公告)日：2024-04-18

申请号：US18483280

申请日：2023-10-09

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

CPC classification number: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US20230392204A1

公开(公告)日：2023-12-07

申请号：US18233606

申请日：2023-08-14

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/6811 ,  C12Q1/25 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

CPC classification number: C12Q1/6876 ,  C12Q1/6811 ,  C12Q1/25 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.