公开(公告)号：US5204472A

公开(公告)日：1993-04-20

申请号：US807523

申请日：1991-12-13

Applicant: Jurgen Stoltefuss ,  Horst Boshagen ,  Siegfried Goldmann ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

Inventor： Jurgen Stoltefuss ,  Horst Boshagen ,  Siegfried Goldmann ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

IPC: C07D211/90 ,  C07D215/14 ,  C07D217/04 ,  C07D401/04 ,  C07D409/04 ,  C07D409/14 ,  C07D491/04

CPC classification number: C07D401/04 ,  C07D211/90 ,  C07D215/14 ,  C07D217/04 ,  C07D409/04 ,  C07D409/14 ,  C07D491/04

Abstract: Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## in which R.sup.6 -denotes hydrogen, halogen or straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms,R.sup.7 denotes aryl, thienyl or pyridyl, andR.sup.4 represents hydrogen, or optionally substituted alkyl, alkenyl, alkadienyl or alkynyl,and their physiologically acceptable salts.

Abstract translation: 式（I）的正性正向活性4-喹啉基 - 二氢吡啶，其中R 1和R 5相同或不同并且表示具有至多8个碳原子的直链或支链烷基，R 2表示硝基或氰基，或R 1和 R2一起形成下式的内酯环：R 3表示下式的基团：其中R 6表示氢，卤素或直链或支链烷基或烷氧基，每种情况都具有 至8个碳原子，R7表示芳基，噻吩基或吡啶基，R4表示氢或任选取代的烷基，烯基，链二烯基或炔基，及其生理上可接受的盐。

公开(公告)号：US09150580B2

公开(公告)日：2015-10-06

申请号：US14115871

申请日：2012-05-02

Applicant: Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Alexander Straub ,  Jens Ackerstaff ,  Nils Griebenow ,  Andreas Knorr ,  Frank Wunder ,  Volkhart Min-Jian Li

Inventor： Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Alexander Straub ,  Jens Ackerstaff ,  Nils Griebenow ,  Andreas Knorr ,  Frank Wunder ,  Volkhart Min-Jian Li

IPC: C07D487/04 ,  A61K31/5025 ,  A61K31/53 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/5025 ,  A61K31/53 ,  A61K45/06

Abstract: The present application relates to novel substituted imidazopyridazines having the following formula (I): to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.

Abstract translation: 本申请涉及具有下式（I）的新型取代的咪唑并哒嗪：其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于生产药物的用途 治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。

公开(公告)号：US20100063043A1

公开(公告)日：2010-03-11

申请号：US12551487

申请日：2009-08-31

Applicant: Alexander Straub ,  Thomas Lampe ,  Josef Pernerstorfer ,  Elisabeth Perzborn ,  Jens Pohlmann ,  Susanne Röhrig ,  Karl-Heinz Schlemmer

Inventor： Alexander Straub ,  Thomas Lampe ,  Josef Pernerstorfer ,  Elisabeth Perzborn ,  Jens Pohlmann ,  Susanne Röhrig ,  Karl-Heinz Schlemmer

IPC: A61K31/421 ,  C07D413/10 ,  C07D413/14 ,  A61K31/5377 ,  A61P9/00 ,  A61P9/10 ,  A61P25/28 ,  A61P35/00 ,  C12N5/00

CPC classification number: C07D413/10 ,  C07D413/14

Abstract: The invention relates to the field of blood coagulation, more particularly, to novel compounds of general formula (I), to a method for producing said compounds and to their use as active ingredients in medicaments for the prevention and/or the treatment of diseases.

Abstract translation: 本发明涉及血液凝固领域，更具体地说，涉及通式（I）的新型化合物，涉及用于制备所述化合物的方法及其作为用于预防和/或治疗疾病的药物中的活性成分的用途。

公开(公告)号：US07592339B2

公开(公告)日：2009-09-22

申请号：US11460529

申请日：2006-07-27

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: A61K31/5377 ,  C07D409/14

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

公开(公告)号：US07482472B2

公开(公告)日：2009-01-27

申请号：US11717414

申请日：2007-03-12

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer

IPC: C07D209/44 ,  C07D207/00 ,  C07D409/00 ,  A61K31/33 ,  A61K31/40 ,  A61K31/38

CPC classification number: C07D209/48 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D495/04

Abstract: The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and methods of using them for the prevention and/or treatment of various diseases.

Abstract translation: 本发明涉及血液凝固。 公开了式（I）的新型化合物，这些化合物的制备方法，含有它们的药物组合物及其用于预防和/或治疗各种疾病的方法。

公开(公告)号：US07439408B2

公开(公告)日：2008-10-21

申请号：US11403743

申请日：2006-04-13

Applicant: Alexander Straub

Inventor： Alexander Straub

IPC: C07C21/18

CPC classification number: A01N43/78 ,  C07C331/04 ,  C07C333/20 ,  C07D277/36

Abstract: The present invention relates to a process for preparing a compound of formula (V) where R is H or F, by reacting a compound of formula (IV) where R is H or F, with hydrogen sulphide or salts thereof, optionally in the presence of a reaction auxiliary and optionally in the presence of a diluent.

Abstract translation: 本发明涉及制备其中R为H或F的式（Ⅴ）化合物的方法，其中R为H或F的式（Ⅳ）化合物与其硫化氢或其盐， 的反应助剂，任选地在稀释剂的存在下。

公开(公告)号：US20080217960A1

公开(公告)日：2008-09-11

申请号：US11950527

申请日：2007-12-05

Applicant: Stefan Kochert ,  Jochen Becker ,  Ralph Dalhaeuser ,  Andres Stiller ,  Alexander Straub ,  Thomas Hogger ,  Mark Riess ,  Josef Reindl ,  Juergen Kempf ,  Niklas Eberle ,  Robert Schalausky

Inventor： Stefan Kochert ,  Jochen Becker ,  Ralph Dalhaeuser ,  Andres Stiller ,  Alexander Straub ,  Thomas Hogger ,  Mark Riess ,  Josef Reindl ,  Juergen Kempf ,  Niklas Eberle ,  Robert Schalausky

IPC: B62D25/04

CPC classification number: B62D29/002

Abstract: A lengthwise extended component contains of a support that possesses flow channels in the direction of its longitudinal axis. The support additionally possesses external surfaces that are offset to each other in the direction of the longitudinal axis as well as a lateral external surface. These external surfaces are provided with a layer of a thermally expansible and curable composition. Reinforcing components of this type are suitable for stiffening and/or reinforcing hollow supports, such as the A-, B- or C-pillars, the roof edges or the rocker panels of vehicles, especially passenger cars.

Abstract translation: 纵向延伸部件包含在其纵向轴线方向上具有流动通道的支撑件。 支撑件还具有在纵向轴线方向上彼此偏移的外表面以及侧向外表面。 这些外表面设置有可热膨胀和可固化组合物的层。 这种类型的加强部件适用于加强和/或加强中空支撑件，例如A-，B-或C-支柱，车辆的车顶边缘或摇摆板，特别是乘用车。

公开(公告)号：US07385093B2

公开(公告)日：2008-06-10

申请号：US11403514

申请日：2006-04-13

Applicant: Alexander Straub

Inventor： Alexander Straub

IPC: C07C21/18

CPC classification number: A01N43/78 ,  C07C331/04 ,  C07C333/20 ,  C07D277/36

Abstract: The present invention relates to a process for preparing compounds of formula (IV) where R is H or F, by reacting a compound of formula (II) where where R is H or F, and X is bromine, chlorine, mesylate, or tosylate, with a thiocyanate salt of formula (III) M+SCN−  (III) where M+ is hydrogen, an ammonium ion, a tetraalkylammonium ion, or an alkali metal or alkaline earth metal ion, optionally in the presence of a reaction auxiliary and optionally in the presence of a diluent.

Abstract translation: 本发明涉及制备其中R为H或F的式（Ⅳ）化合物的方法，其中R为H或F，X为溴，氯，甲磺酸酯或甲苯磺酸的式（Ⅱ）化合物 与式（III）的硫氰酸盐进行比较<？in-line-formula description =“In-line Formulas”end =“lead”→>> （III）<？in-line-formula description =“In-line formula”end =“tail”？>其中M +为氢，铵离子，四烷基铵离子或碱金属 或碱土金属离子，任选地在反应助剂存在下，任选地在稀释剂存在下。

公开(公告)号：US20080039446A1

公开(公告)日：2008-02-14

申请号：US11717414

申请日：2007-03-12

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer

IPC: A61K31/403 ,  A61K31/381 ,  A61K31/4178 ,  A61K31/445 ,  A61K31/5377 ,  C07D211/32 ,  C07D239/20 ,  C07D243/08 ,  C07D409/12 ,  C07D413/14 ,  C07D409/14 ,  C07D401/12 ,  C07D241/04 ,  C07D221/00 ,  A61K31/5513 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/4025

CPC classification number: C07D209/48 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D495/04

Abstract: The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and methods of using them for the prevention and/or treatment of various diseases.

Abstract translation: 本发明涉及血液凝固。 公开了式（I）的新型化合物，这些化合物的制备方法，含有它们的药物组合物及其用于预防和/或治疗各种疾病的方法。

公开(公告)号：US07291622B2

公开(公告)日：2007-11-06

申请号：US11192961

申请日：2005-07-29

Applicant: Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elizabeth Perzborn

Inventor： Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elizabeth Perzborn

IPC: A61K31/437 ,  C07D403/04

CPC classification number: C07D471/04

Abstract: This invention relates to methods for treating sexual dysfunction, by administering a compound of the formula wherein R1 is H or a di-C1-6-alkylaminocarbonyl radical, and R2 is a radical of the formula —O—C(X)—NR3R4 wherein X is O or S. The compound may also be administered in combination with at least one organic nitrate or NO donor, or in combination with at least one compound which inhibits the breakdown of cyclic guanosine monophosphate (cGMP).

Abstract translation: 本发明涉及治疗性功能障碍的方法，通过给予下式化合物其中R 1是H或二-C 1-6 - 烷基氨基羰基，R 其中X是O或S，式（II）化合物也可以是式（Ⅳ）的基团：其中X是O或S。 与至少一种有机硝酸盐或NO供体组合施用，或与至少一种抑制环磷酸鸟苷（cGMP）分解的化合物组合施用。