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公开(公告)号：US07187344B2
公开(公告)日：2007-03-06
申请号：US10267083
申请日：2002-10-08
申请人： Bokke Johannes Feenstra , Menno Willem Jose Prins , Gerjan Franciscus Arthur Van De Walle , Henricus Franciscus Johannus Jacobus Van Tongeren
发明人： Bokke Johannes Feenstra , Menno Willem Jose Prins , Gerjan Franciscus Arthur Van De Walle , Henricus Franciscus Johannus Jacobus Van Tongeren
CPC分类号： G02B26/005 , G02B27/2214 , H04N13/305 , H04N13/359
摘要： Switching between 2D and 3D visualization is achieved by an optical-index matching fluid (9) which can be brought between a lenticular sheet (6, 7) and a top plate (10). The fluid may contain two immiscible fluids while switching is based on (re)distribution of the fluids due to electrostatic forces.
摘要翻译： 通过光学折射率匹配流体（9）实现2D和3D可视化之间的切换，光学折射率匹配流体（9）可以被带入透镜片（6,7）和顶板（10）之间。 流体可以包含两种不混溶的流体，而切换是基于由静电力引起的流体的分布（重新）。
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公开(公告)号：US06961167B2
公开(公告)日：2005-11-01
申请号：US10479360
申请日：2002-06-04
CPC分类号： G02B26/005 , G02B26/0816 , G02F1/167 , G02F1/195 , G09F9/372
摘要： Pixels of a display device include a reservoir containing two immiscible fluids. Switching of a pixel state is based on redistribution of the fluids within the reservoir due to electrostatic forced applied onto electrodes, and a potential applied to one of the fluids which is electrically conducting.
摘要翻译： 显示装置的像素包括含有两种不混溶流体的储存器。 像素状态的切换是基于由于静电强制施加到电极上的储存器内的流体的再分配，以及施加到导电的流体之一的电位。
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公开(公告)号：US10092903B2
公开(公告)日：2018-10-09
申请号：US12809208
申请日：2008-12-16
申请人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
发明人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
IPC分类号： B01L3/00
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
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公开(公告)号：US09272290B2
公开(公告)日：2016-03-01
申请号：US13384251
申请日：2010-07-12
摘要： The invention relates to a method and an apparatus (100) for the enrichment of magnetic particles (1) in a sample fluid. The sample fluid is provided in a sample cartridge (2) between a first pole (111) and a second pole (112) of an actuator magnet (110). A minimal magnetic flux as well as a minimal magnetic gradient are then established inside the sample fluid, wherein their values depend on the particular magnetic particles (1) and the sample fluid under consideration. In a preferred embodiment, the first pole (111) has a single tip (T).
摘要翻译： 本发明涉及一种用于在样品流体中富集磁性颗粒（1）的方法和装置（100）。 样品流体设置在致动器磁体（110）的第一极（111）和第二极（112）之间的样品盒（2）中。 然后在样品流体内建立最小的磁通量以及最小的磁梯度，其中它们的值取决于具体的磁性颗粒（1）和所考虑的样品流体。 在优选实施例中，第一极（111）具有单个尖端（T）。
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公开(公告)号：US08440150B2
公开(公告)日：2013-05-14
申请号：US13139459
申请日：2009-06-17
IPC分类号： B01L99/00
CPC分类号： B01F13/0809 , B01L3/502738 , B01L3/502792 , B01L2200/027 , B01L2200/0647 , B01L2300/0816 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/043 , B01L2400/0633 , B01L2400/0688 , B01L2400/088 , F16K99/0001 , F16K99/0021 , F16K99/0046 , F16K2099/0074 , Y10T137/0324 , Y10T436/2575
摘要： The present invention relates to a hydrophobic valve for liquids having an appreciable surface tension comprising magnetic particles, said device comprising at least two planar solid substrates with a functionalized surface each, wherein at least a first solid substrate has a patterned surface comprising at least two hydrophilic areas separated from one another by at least one hydrophobic area, wherein the said two planar substrates are disposed with a distance to one another in a sandwiched, parallel fashion, in such way that said functionalized surfaces are facing one another, said valve further comprising a magnetic actuator.
摘要翻译： 本发明涉及一种具有包含磁性颗粒的明显表面张力的液体疏水阀，所述装置包括至少两个具有功能化表面的平面固体基质，其中至少第一固体基质具有包含至少两个亲水性的图案化表面 通过至少一个疏水区域彼此分离的区域，其中所述两个平面基板以夹着平行的方式彼此间隔开设置，使得所述功能化表面彼此面对，所述阀还包括一个 磁力驱动器。
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公开(公告)号：US08217647B2
公开(公告)日：2012-07-10
申请号：US12518895
申请日：2007-12-18
申请人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van Ijzendoorn , Xander Jozef Antoine Janssen
发明人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van Ijzendoorn , Xander Jozef Antoine Janssen
IPC分类号： G01R33/00 , G01N33/553
CPC分类号： G01N15/0266 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N2015/0092 , G01R33/093 , G01R33/1269 , Y10S436/806
摘要： A method and system for measuring agglutination in a target-induced agglutination assay with one or more magnetic particles is performed in a reaction chamber. After the magnetic particles, which are capable of binding to a target are provided in the assay, an agglutination process is performed resulting in agglutinated particles. Further an alternating current magnetic field (HAC) is applied to the assay. The method further includes measuring an effect of the HAC on the one or more magnetic particles unattached to any surface. The measured effect is indicative of one or more agglutination parameters.
摘要翻译： 在反应室中进行用于测定靶诱导的凝集测定中的一种或多种磁性颗粒的凝集的方法和系统。 在测定中提供能够结合到靶的磁性颗粒之后，进行凝集过程，导致凝集的颗粒。 此外，将交流磁场（HAC）应用于测定。 该方法还包括测量HAC对未附着到任何表面的一个或多个磁性颗粒的影响。 测量的效果表示一个或多个凝集参数。
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公开(公告)号：US20120161754A1
公开(公告)日：2012-06-28
申请号：US13384251
申请日：2010-07-12
IPC分类号： G01N27/74
摘要： The invention relates to a method and an apparatus (100) for the enrichment of magnetic particles (1) in a sample fluid. The sample fluid is provided in a sample cartridge (2) between a first pole (111) and a second pole (112) of an actuator magnet (110). A minimal magnetic flux as well as a minimal magnetic gradient are then established inside the sample fluid, wherein their values depend on the particular magnetic particles (1) and the sample fluid under consideration. In a preferred embodiment, the first pole (111) has a single tip (T).
摘要翻译： 本发明涉及一种用于在样品流体中富集磁性颗粒（1）的方法和装置（100）。 样品流体设置在致动器磁体（110）的第一极（111）和第二极（112）之间的样品盒（2）中。 然后在样品流体内建立最小的磁通量以及最小的磁梯度，其中它们的值取决于具体的磁性颗粒（1）和所考虑的样品流体。 在优选实施例中，第一极（111）具有单个尖端（T）。
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公开(公告)号：US20120119727A1
公开(公告)日：2012-05-17
申请号：US12678502
申请日：2008-09-16
申请人： Menno Willem Jose Prins , Leonardus Josephus Ijzendoorn , Xander Jozef Antoine Janssen , Mykhaylo Ovsyanko
发明人： Menno Willem Jose Prins , Leonardus Josephus Ijzendoorn , Xander Jozef Antoine Janssen , Mykhaylo Ovsyanko
CPC分类号： G01N27/745 , G01N35/0098 , G01R33/1269
摘要： A sensor device for detecting one or more magnetic particles (102) in a sample fluid is described. The sensor device (100) uses at least one rotating magnetic field generator (108) for applying a rotating magnetic field to the sample and more particularly the one or more magnetic particles (102) incorporated therein. The sensor device also comprises a controller for controlling the magnetic field generator such that the rotating frequency of the applied magnetic field is substantially larger than the critical slipping frequency for the magnetic particle. The effect of the induced rotation is sensed using a sensor element (112). Presence, amount and binding properties of the magnetic particles (102) may be derived from the measured effect. Alternatively or additionally the viscosity of the sample fluid may be determined.
摘要翻译： 描述了用于检测样品流体中的一个或多个磁性颗粒（102）的传感器装置。 传感器装置（100）使用至少一个旋转磁场发生器（108），用于向样品施加旋转磁场，更具体地，其中结合有一个或多个磁性颗粒（102）。 传感器装置还包括用于控制磁场发生器的控制器，使得施加的磁场的旋转频率基本上大于磁性颗粒的临界滑移频率。 使用传感器元件（112）感测感应旋转的影响。 磁性颗粒（102）的存在，量和结合性质可以从测量的效果导出。 或者或另外，可以确定样品流体的粘度。
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公开(公告)号：US20110240130A1
公开(公告)日：2011-10-06
申请号：US13139459
申请日：2009-06-17
CPC分类号： B01F13/0809 , B01L3/502738 , B01L3/502792 , B01L2200/027 , B01L2200/0647 , B01L2300/0816 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/043 , B01L2400/0633 , B01L2400/0688 , B01L2400/088 , F16K99/0001 , F16K99/0021 , F16K99/0046 , F16K2099/0074 , Y10T137/0324 , Y10T436/2575
摘要： The present invention relates to a hydrophobic valve for liquids having an appreciable surface tension comprising magnetic particles, said device comprising at least two planar solid substrates with a functionalized surface each, wherein at least a first solid substrate has a patterned surface comprising at least two hydrophilic areas separated from one another by at least one hydrophobic area, wherein the said two planar substrates are disposed with a distance to one another in a sandwiched, parallel fashion, in such way that said functionalized surfaces are facing one another, said valve further comprising a magnetic actuator.
摘要翻译： 本发明涉及一种具有包含磁性颗粒的明显表面张力的液体疏水阀，所述装置包括至少两个具有功能化表面的平面固体基质，其中至少第一固体基质具有包含至少两个亲水性的图案化表面 通过至少一个疏水区域彼此分离的区域，其中所述两个平面基板以夹着平行的方式彼此间隔开设置，使得所述功能化表面彼此面对，所述阀还包括一个 磁力驱动器。
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公开(公告)号：US20100289483A1
公开(公告)日：2010-11-18
申请号：US12669218
申请日：2008-07-16
申请人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
发明人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/74
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译： 本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。 传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。 第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，并且第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b） 的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。 本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。
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