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公开(公告)号:US10092903B2
公开(公告)日:2018-10-09
申请号:US12809208
申请日:2008-12-16
申请人: Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
发明人: Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
IPC分类号: B01L3/00
摘要: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
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公开(公告)号:US20100273142A1
公开(公告)日:2010-10-28
申请号:US12809208
申请日:2008-12-16
申请人: Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J.M. Bruyninckx , Thea Van Der Wijk , Marius losif Boamfa , Remco Den Dulk
发明人: Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J.M. Bruyninckx , Thea Van Der Wijk , Marius losif Boamfa , Remco Den Dulk
IPC分类号: C12Q1/00 , G01N33/553 , G01N33/53
CPC分类号: B01L3/502738 , B01L2200/0647 , B01L2300/089 , B01L2300/161 , B01L2400/043 , B01L2400/0688 , B01L2400/088
摘要: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
摘要翻译: 本发明公开了具有阀状结构(3)的微流体装置,通过该微流体装置可以以最少的流体输送运输磁性颗粒。 这允许顺序处理磁性颗粒。
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公开(公告)号:US20110206560A1
公开(公告)日:2011-08-25
申请号:US13126000
申请日:2009-10-27
申请人: Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
发明人: Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
IPC分类号: G01N30/00
CPC分类号: G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要: The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译: 本发明提供了一种生物传感器,其包括用于容纳流体样品的盒,所述盒包括至少两个室,其中每个室包括具有一个或多个结合位点的传感器表面。 生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。 生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。 其中,结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。
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公开(公告)号:US08211456B2
公开(公告)日:2012-07-03
申请号:US11990544
申请日:2006-08-16
IPC分类号: B05D3/10
CPC分类号: C08F293/00 , C08F265/00 , C08F287/00 , C08F291/00 , Y10T428/31504 , Y10T428/31855
摘要: The present invention relates to “grafting to” methods of modifying materials surfaces with high-density polymer brushes. A method of the present invention comprises contacting in succession or simultaneously an activated material surface, a solution of a polymeric material having a polymeric backbone with pendant reactive moieties, and a melt of brush-forming terminally-functionalized polymer chains, in order to allow a covalent bonding reaction to occur between surface and polymers, wherein upon completion of the reaction, the polymeric material forms a layer between the material surface and the brush polymer chains.
摘要翻译: 本发明涉及用高密度聚合物刷改性材料表面的“接枝”方法。 本发明的方法包括连续地或同时地将活化的材料表面,具有聚合物主链的聚合物材料的溶液与侧链反应性部分接触,以及刷成型的末端官能化的聚合物链的熔体,以便允许 在表面和聚合物之间发生共价键合反应,其中在反应完成时,聚合物材料在材料表面和刷子聚合物链之间形成一层。
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公开(公告)号:US20090280157A1
公开(公告)日:2009-11-12
申请号:US11990544
申请日:2006-08-16
CPC分类号: C08F293/00 , C08F265/00 , C08F287/00 , C08F291/00 , Y10T428/31504 , Y10T428/31855
摘要: The present invention relates to “grafting to” methods of modifying materials surfaces with high-density polymer brushes. A method of the present invention comprises contacting in succession or simultaneously an activated material surface, a solution of a polymeric material having a polymeric backbone with pendant reactive moieties, and a melt of brush-forming terminally-functionalized polymer chains, in order to allow a covalent bonding reaction to occur between surface and polymers, wherein upon completion of the reaction, the polymeric material forms a layer between the material surface and the brush polymer chains.
摘要翻译: 本发明涉及用高密度聚合物刷改性材料表面的“接枝”方法。 本发明的方法包括连续地或同时地将活化的材料表面,具有聚合物主链的聚合物材料的溶液与侧链反应性部分接触,以及刷成型的末端官能化的聚合物链的熔体,以便允许 在表面和聚合物之间发生共价键合反应,其中在反应完成时,聚合物材料在材料表面和刷子聚合物链之间形成一层。
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公开(公告)号:US20110203700A1
公开(公告)日:2011-08-25
申请号:US13127167
申请日:2009-11-10
申请人: Monica Scholten , Joost Hubert Maas , Godefridus Johannes Verhoeckx , Maurice Hubert Elisabeth Van Der Beek
发明人: Monica Scholten , Joost Hubert Maas , Godefridus Johannes Verhoeckx , Maurice Hubert Elisabeth Van Der Beek
CPC分类号: B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2200/0621 , B01L2300/0681 , B01L2300/0816 , B01L2300/0877 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688
摘要: The invention relates to microfluidic systems, and more specifically to a microfluidic system comprising a capillary channel (14) and an inlet (12) for receiving a fluid, as well as a method of filling a capillary channel (14). Provided is a microfluidic system, having an inlet (12) for receiving a fluid, a capillary channel (14), an outlet (20) for letting excess fluid out, and a reservoir (10) for interfacing the inlet (12) to the capillary channel (14). The reservoir (10) forms a first passage from the inlet (12) to the outlet (20), and a second passage from the inlet (12) to an entrance (22) of the capillary channel (14). A hydraulic resistance of the first passage is sufficiently low in order to effect a pressure reduction at the entrance (22) of the capillary channel (14) when a fluid is received under pressure at the inlet (12).
摘要翻译: 本发明涉及微流体系统,更具体地涉及一种微流体系统,该微流体系统包括用于接收流体的毛细通道(14)和入口(12),以及填充毛细通道(14)的方法。 提供了一种微流体系统,其具有用于接收流体的入口(12),用于使过量流体排出的毛细通道(14),出口(20),以及用于将入口(12)与 毛细管通道(14)。 储存器(10)形成从入口(12)到出口(20)的第一通道和从入口(12)到毛细通道(14)的入口(22)的第二通道。 当在入口(12)的压力下接收流体时,第一通道的液压阻力足够低,以便在毛细通道(14)的入口(22)处实现减压。
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公开(公告)号:US20100132986A1
公开(公告)日:2010-06-03
申请号:US12382006
申请日:2009-03-05
申请人: Jurgen Hackert , Paul Tranter , Joost Hubert Maas
发明人: Jurgen Hackert , Paul Tranter , Joost Hubert Maas
CPC分类号: H05K3/182 , C25D5/02 , H05K3/125 , H05K3/246 , H05K3/381 , H05K2201/0347 , H05K2203/013 , H05K2203/0709 , H05K2203/107 , H05K2203/121
摘要: The invention provides method for preparing a conductive device comprising the steps of: (a) providing a non-conductive substrate layer; (b) modifying the surface of the non-conductive substrate layer by means of a laser beam treatment; (c) applying a pattern of an ink on a surface of the substrate layer, which ink comprises a first metal; (d) depositing a second metal on the ink pattern obtained in step (c); and (e) applying a third metal on the second metal by means of electrodeposition. The invention further provides a conductive device obtainable by said method.
摘要翻译: 本发明提供了一种制备导电器件的方法,包括以下步骤:(a)提供非导电衬底层; (b)通过激光束处理改性非导电基底层的表面; (c)在基材层的表面上施加油墨图案,该油墨包括第一金属; (d)在步骤(c)中获得的油墨图案上沉积第二金属; 和(e)通过电沉积在第二金属上施加第三金属。 本发明还提供可通过所述方法获得的导电装置。
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公开(公告)号:US20120156765A1
公开(公告)日:2012-06-21
申请号:US13393097
申请日:2010-08-25
CPC分类号: B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , Y10T29/4998
摘要: The invention relates to a fluid filtering device comprising a filter (2) for filtering a fluid and a substrate (3) comprising a collecting structure (4) for collecting the filtered fluid from the filter (2). An adhesive (5) holds the filter (2) in place with respect to the collecting structure (4). The filter (2), the substrate (3) with the collecting structure (4) and the adhesive (5) are arranged such that the collecting structure (4) contacts the filter (2) and the filter (2) is attached to the substrate (3) by the adhesive (5). The collecting structure is very close to the filter and the adhesive ensures that the collecting structure remains very close to the filter. The filtered fluid can therefore be collected very efficiently and very fast. The fluid filtering device is preferentially used for filtering blood in a biosensing device.
摘要翻译: 本发明涉及一种流体过滤装置,其包括用于过滤流体的过滤器(2)和包括用于从过滤器(2)收集过滤流体的收集结构(4)的基底(3)。 粘合剂(5)将过滤器(2)相对于收集结构(4)保持在适当的位置。 过滤器(2),具有收集结构(4)的基板(3)和粘合剂(5)被布置成使得收集结构(4)接触过滤器(2),并且过滤器(2)附接到 基材(3)由粘合剂(5)。 收集结构非常接近过滤器,并且粘合剂确保收集结构保持非常接近过滤器。 因此,可以非常有效和非常快地收集过滤的流体。 流体过滤装置优选用于过滤生物传感装置中的血液。
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公开(公告)号:US20110294677A1
公开(公告)日:2011-12-01
申请号:US13148070
申请日:2010-02-18
CPC分类号: C08G77/392 , B01L3/502707 , B01L2300/123 , B01L2300/161 , B01L2400/0406 , B01L2400/088 , C08G77/12
摘要: The invention relates to a novel microfluidic system having a substrate based on rubber material having polar side groups which are linked to the rubber polymer backbone via a spacer. By doing so, a transport of water-based fluids such as blood, saliva etc. will occur by capillary forces.
摘要翻译: 本发明涉及一种新颖的微流体系统,其具有基于具有极性侧基的橡胶材料的基底,其通过间隔物连接到橡胶聚合物主链上。 通过这样做,通过毛细血管力将发生诸如血液,唾液等水基流体的运输。
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