Novel human protein kinase, phosphatase, and protease family members and uses thereof
    51.
    发明申请
    Novel human protein kinase, phosphatase, and protease family members and uses thereof 失效
    新型人蛋白激酶,磷酸酶和蛋白酶家族成员及其用途

    公开(公告)号:US20070099274A1

    公开(公告)日:2007-05-03

    申请号:US11636948

    申请日:2006-12-11

    摘要: The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供分离的核酸分子,命名为53070,15985,26583,21953,m32404,14089和23436核酸分子,其编码新的人蛋白激酶家族成员,丝氨酸/苏氨酸蛋白激酶家族成员,丝氨酸/苏氨酸磷酸酶家族成员 ,脯氨酰寡肽酶家族成员,胰蛋白酶家族成员,胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子,含有53070,15985,26583,21953,m32404,14089或23436核酸分子的重组表达载体,已经引入表达载体的宿主细胞,以及非人类转基因动物,其中53070 ,15985,26583,21953,m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953,m32404,14089或23436蛋白,融合蛋白,抗原肽和抗-53070,15985,26583,21953,m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

    Novel human hydrolase family members and uses thereof
    52.
    发明申请
    Novel human hydrolase family members and uses thereof 审中-公开
    新型人类水解酶家族成员及其用途

    公开(公告)号:US20070048784A1

    公开(公告)日:2007-03-01

    申请号:US11591659

    申请日:2006-11-01

    摘要: The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26443 and 46873 gene has been introduced or disrupted. The invention still further provides isolated 26443 and 46873 proteins, fusion proteins, antigenic peptides and anti-26443 or 46873 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新的人水解酶家族成员的分离的核酸分子,命名为26443和46873核酸分子。 本发明还提供了反义核酸分子,含有26443和46873核酸分子的重组表达载体,已经引入表达载体的宿主细胞,以及引入或破坏了26443和46873基因的非人类转基因动物。 本发明还进一步提供分离的26443和46873蛋白,融合蛋白,抗原肽和抗26443或46873抗体。 还提供了利用本发明组合物的诊断方法。

    80090, human fucosyltransferase nucleic acid molecules and uses thereof
    54.
    发明授权
    80090, human fucosyltransferase nucleic acid molecules and uses thereof 失效
    80090,人岩藻糖基转移酶核酸分子及其用途

    公开(公告)号:US06979564B2

    公开(公告)日:2005-12-27

    申请号:US10080960

    申请日:2001-10-19

    CPC分类号: C12N9/10 C07K14/705 C12N9/16

    摘要: The invention provides isolated nucleic acids molecules, designated 80090, 52874, 52880, 63497, or 33425 nucleic acid molecules, which encode novel fucosyltransferase, seven transmembrane receptor, or RhoGAP family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 80090, 52874, 52880, 63497, or 33425 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an 80090, 52874, 52880, 63497, or 33425 gene has been introduced or disrupted. The invention still further provides isolated 80090, 52874, 52880, 63497, or 33425 proteins, fusion proteins, antigenic peptides and anti-80090, 52874, 52880, 63497, or 33425 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供分离的核酸分子,命名为80090,52874,52880,63497或33425核酸分子,其编码新的岩藻糖基转移酶,七个跨膜受体或RhoGAP家族成员。 本发明还提供反义核酸分子,含有80090,52874,52880,63497或33425核酸分子的重组表达载体,已经引入表达载体的宿主细胞和非人类转基因动物,其中80090,528744,52880 ,63497或33425基因已被引入或破坏。 本发明还进一步提供分离的80090,52874,52880,63497或33425蛋白质,融合蛋白质,抗原肽和抗-80090,52874,52880,63497或33425抗体。 还提供了利用本发明组合物的诊断方法。

    Novel human genes and methods of use thereof
    55.
    发明申请
    Novel human genes and methods of use thereof 审中-公开
    新型人类基因及其使用方法

    公开(公告)号:US20050214893A1

    公开(公告)日:2005-09-29

    申请号:US10968812

    申请日:2004-10-19

    摘要: The invention provides isolated nucleic acids molecules, designated 47476, 67210, 49875,46842,33201, 83378,84233,64708, 85041,84234,21617, 55562,23566,33489, and 57779 nucleic acid molecules, which encode novel human genes. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 gene has been introduced or disrupted. The invention still further provides isolated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 proteins, fusion proteins, antigenic peptides and anti-47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新的人基因的分离的核酸分子,命名为47476,67210,49875,46842,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489和57779核酸分子。 本发明还提供反义核酸分子,包含47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,161617,55562,23566,33489或57779核酸分子的重组表达载体,宿主细胞 已经引入了表达载体的非人类转基因动物,以及引入了47476,67210,49875,4642,43708,85041,84234,16617,55562,23566,33489或57779基因的非人类转基因动物,或 中断了 本发明还进一步提供分离的47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489或57779号蛋白,融合蛋白,抗原肽和抗-47476,67210, 49875,4462,33201,83378,84233,66708,85041,84234,21617,55562,253566,33489或57779抗体。 还提供了利用本发明组合物的诊断方法。

    14815, a human kinase family member and uses therefor
    57.
    发明申请
    14815, a human kinase family member and uses therefor 失效
    14815,一种人激酶家族成员,并用于此

    公开(公告)号:US20050118608A1

    公开(公告)日:2005-06-02

    申请号:US10831011

    申请日:2004-04-23

    申请人: Rachel Meyers

    发明人: Rachel Meyers

    IPC分类号: C12N9/12 C12Q1/68 C07H21/04

    CPC分类号: C12N9/1205

    摘要: The invention provides isolated nucleic acids molecules, designated 14815 nucleic acid molecules, which encode novel kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14815 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14815 gene has been introduced or disrupted. The invention still further provides isolated 14815 proteins, fusion proteins, antigenic peptides and anti-14815 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新型激酶家族成员的分离的核酸分子,命名为14815个核酸分子。 本发明还提供了反义核酸分子,含有14815个核酸分子的重组表达载体,已经引入了表达载体的宿主细胞,以及引入或破坏14815基因的非人转基因动物。 本发明还进一步提供了分离的14815蛋白,融合蛋白,抗原肽和抗14815抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    32142,21481,25964,21686, novel human dehydrogenase molecules and uses therefor
    58.
    发明授权
    32142,21481,25964,21686, novel human dehydrogenase molecules and uses therefor 有权
    32142,21481,25964,21686,新型人脱氢酶分子及其用途

    公开(公告)号:US06511834B1

    公开(公告)日:2003-01-28

    申请号:US09634955

    申请日:2000-08-08

    IPC分类号: C12N904

    CPC分类号: C12N9/0004 C07K2319/00

    摘要: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新型DHDR相关脱氢酶分子的分离的核酸分子,命名为DHDR核酸分子。 本发明还提供了反义核酸分子,含有DHDR核酸分子的重组表达载体,其中引入了表达载体的宿主细胞,以及DHDR基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的DHDR蛋白,融合蛋白,抗原肽和抗DHDR抗体。 还提供了利用本发明组合物的诊断方法。

    RNAi modulation of RSV and therapeutic uses thereof
    60.
    发明授权
    RNAi modulation of RSV and therapeutic uses thereof 有权
    RSV的RNAi调节及其治疗用途

    公开(公告)号:US07981869B2

    公开(公告)日:2011-07-19

    申请号:US12326867

    申请日:2008-12-02

    申请人: Rachel Meyers

    发明人: Rachel Meyers

    IPC分类号: C12N15/11 C07H21/02 C07H21/04

    摘要: The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.

    摘要翻译: 本发明基于体内证据,可以通过鼻内施用iRNA试剂以及通过肠胃外给药这种试剂来抑制RSV。 此外,显示可以同时治疗多于一种的病毒来实现有效的病毒降低。 基于这些发现,本发明提供了可用于减少受试者例如哺乳动物(例如人)中的RSV mRNA水平,RSV蛋白水平和病毒滴度的一般和特定组合物和方法。 这些发现可以应用于其他呼吸道病毒。