公开(公告)号：US20060194866A1

公开(公告)日：2006-08-31

申请号：US11431056

申请日：2006-05-09

申请人： Glenn Friedman ,  Jeffrey McKie ,  Jonathan Wright ,  Sophie Perrin-Ninkovic ,  Bernd Stein

发明人： Glenn Friedman ,  Jeffrey McKie ,  Jonathan Wright ,  Sophie Perrin-Ninkovic ,  Bernd Stein

IPC分类号： A61K31/4025

CPC分类号： C07D311/16 ,  A61K31/40

摘要： This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neoplastic cell comprising administering an effective amount of a Benzopyranone Compound. The Benzopyranone Compounds have the formula: or a pharmaceutically acceptable salt thereof, wherein R1 is halogen, trifluoromethyl or C1-6 alkyl.

摘要翻译： 本发明涉及苯并吡喃酮化合物，包含苯并吡喃酮化合物的组合物和用于治疗或预防癌症或抑制癌细胞或肿瘤细胞生长的方法，包括给予有效量的苯并吡喃酮化合物。 苯并吡喃酮化合物具有下式：或其药学上可接受的盐，其中R 1是卤素，三氟甲基或C 1-6烷基。

公开(公告)号：US20050255094A1

公开(公告)日：2005-11-17

申请号：US11004789

申请日：2004-12-03

申请人： Bernd Stein ,  Maria Yang

发明人： Bernd Stein ,  Maria Yang

IPC分类号： A61K38/00 ,  A61K38/48 ,  C07H21/04 ,  C12N9/12 ,  C12N15/54 ,  C12P21/06

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

摘要翻译： 提供组合物和方法来增强丝裂原活化蛋白激酶p38的活性。 特别地提供了刺激磷酸化p38的丝裂原活化蛋白激酶激酶MEK6及其变体​​。 这样的化合物可用于例如治疗与p38级联相关的疾病，并鉴定通过p38抑制或激活信号转导的抗体和其它试剂。

公开(公告)号：US20050146200A1

公开(公告)日：2005-07-07

申请号：US11074049

申请日：2005-03-07

申请人： Bernd Stein ,  Mark McConnell ,  Joseph Depuydt ,  Michael Vankov ,  Ahmet Firatli

发明人： Bernd Stein ,  Mark McConnell ,  Joseph Depuydt ,  Michael Vankov ,  Ahmet Firatli

IPC分类号： A46D3/04 ,  A46D3/00 ,  A46D5/00 ,  B29C45/14 ,  B29L31/42

CPC分类号： A46D3/005 ,  B29C45/14385

摘要： A method is provided for manufacturing a function element carrier with function elements, for example, individual tufts made up of bristles and/or massage elements, interproximal cleaning elements, or other elements designed to be fastened to a toothbrush and also perform special functions. The function elements are equipped at their ends intended for anchoring in a toothbrush with an anchor, retainer or axle element. The method includes: (a) inserting several function elements in corresponding recesses of an injection mold, said injection mold being connected via grid or bar shaped channels formed in a die to recesses in the areas of the anchoring ends of the function elements; (b) filling the grid or bar shaped channels with liquefied plastic material and injecting said material at the anchoring ends of the function elements or embedding them therein; and (c) allowing the plastic material to cool and removing a function element carrier made up of a grid or bar shaped plastic frame and the function elements. Function element carriers and toothbrushes are also provided.

摘要翻译： 提供了一种用于制造功能元件载体的方法，功能元件载体具有功能元件，例如由刷毛和/或按摩元件，邻间清洁元件或设计为固定到牙刷的其它元件构成的单个簇，并且还执行特殊功能。 功能元件在其端部装备，用于锚固在具有锚定器，保持器或轴元件的牙刷中。 该方法包括：（a）将多个功能元件插入到注射模具的相应凹槽中，所述注射模具通过形成在模具中的格栅或条形通道连接到功能元件的锚定端部区域中的凹部; （b）用液化塑料材料填充格子或条形通道，并在功能元件的锚定端注入所述材料或将其嵌入其中; 和（c）允许塑料材料冷却并去除由格栅或条形塑料框架和功能元件构成的功能元件载体。 还提供功能元件载体和牙刷。

公开(公告)号：US20050064462A1

公开(公告)日：2005-03-24

申请号：US10870387

申请日：2004-06-16

申请人： Bernd Stein ,  Helen Brady ,  Dan Zhu

发明人： Bernd Stein ,  Helen Brady ,  Dan Zhu

IPC分类号： A61K31/138 ,  A61K31/445 ,  A61K31/56 ,  C12N20060101 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention provides methods, compositions, and kits, for determining the effects of one or more candidate compounds on hot flash symptoms. In certain aspects, the methods, compositions, and kits can be used to identify compounds that decrease the incidence of hot flash symptoms. In other aspects, the methods, compositions, and kits can be used to determine whether candidate compounds increase the incidence of undesirable hot flash symptoms when administered to a subject.

摘要翻译： 本发明提供了用于确定一种或多种候选化合物对热闪光症状的影响的方法，组合物和试剂盒。 在某些方面，方法，组合物和试剂盒可用于鉴定降低热闪症状发生率的化合物。 在其他方面，方法，组合物和试剂盒可用于确定候选化合物是否在施用于受试者时增加不期望的热闪光症状的发生率。

公开(公告)号：US06444455B1

公开(公告)日：2002-09-03

申请号：US09295029

申请日：1999-04-20

申请人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

发明人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

IPC分类号： C12N900

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

摘要翻译： 提供组合物和方法用于治疗与丝裂原活化蛋白激酶级联相关的疾病。 特别地，提供了刺激磷酸化和激活底物如ATF2的丝裂原活化蛋白激酶p38-2及其多肽变体。 多肽可用于例如鉴定通过p38-2激酶级联抑制或激活信号转导的抗体和其它试剂。 此类多肽和试剂也可用于治疗与丝裂原活化蛋白激酶级联相关的疾病。

公开(公告)号：US06348607B1

公开(公告)日：2002-02-19

申请号：US09806514

申请日：2001-04-16

申请人： Ulrich Müller ,  Georg Heinrich Grosch ,  Bernd Stein ,  Norbert Rieber

发明人： Ulrich Müller ,  Georg Heinrich Grosch ,  Bernd Stein ,  Norbert Rieber

IPC分类号： C07D30108

CPC分类号： C07D301/10 ,  C07D301/08 ,  Y02P20/125

摘要： In a process for oxidizing an organic compound containing at least one C—C double bond, or a mixture of two or more thereof, which comprises the step (II) below: (II) reaction of the organic compound or the mixture of two or more thereof with a medium comprising molecular oxygen in the presence of a heterogeneous catalyst, the medium further comprises carbon monoxide (CO).

摘要翻译： 在含有至少一种CC双键的有机化合物或其两种或更多种的混合物的方法中，所述方法包括以下步骤（II）：（II）有机化合物或其两种或多种的混合物的反应 在非均相催化剂存在下，使用包含分子氧的介质，所述介质还包含一氧化碳（CO）。

公开(公告)号：US06253589B1

公开(公告)日：2001-07-03

申请号：US09424744

申请日：2000-03-31

申请人： Karl Heinz Putz ,  Bernd Stein ,  Heinz Steinhauer ,  Wilhelm Zimmermann

发明人： Karl Heinz Putz ,  Bernd Stein ,  Heinz Steinhauer ,  Wilhelm Zimmermann

IPC分类号： B21D2216

CPC分类号： B21H7/187 ,  B21D22/16 ,  B21H1/04 ,  B21H3/08 ,  B21H5/025 ,  Y10T29/49471

摘要： The invention relates to a flowturning device (1; 101) for producing an internal geared wheel (17) with inner toothing, one set of which is slanted. The workpiece (9) is held by a retaining member (16; 116) during shaping of the first inner toothing. The workpiece (9) is held by the first toothing on the first shaping toot (2; 102) during shaping of the second inner toothing. Once the internal geared wheel (17) has been finished, the rotational coupling between both shaping tools (2, 4; 102, 104) is detached. The internal geared wheel (17) is detached from the slanted toothing(s) by means of a stripping member (18).

摘要翻译： 本发明涉及一种用于制造具有内齿轮的内齿轮（17）的一个流动翻转装置（1; 101），其中一组倾斜。 在第一内齿轮成形期间，工件（9）由保持构件（16; 116）保持。 在第二内齿齿形成期间，工件（9）由第一齿形件保持在第一成形齿轮（2; 102）上。 一旦内部齿轮（17）已经完成，两个成型工具（2,4; 102,104）之间的旋转联接被分离。 内部齿轮轮（17）通过剥离部件（18）与倾斜的齿部分离。

公开(公告)号：US5948885A

公开(公告)日：1999-09-07

申请号：US651940

申请日：1996-05-20

申请人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

发明人： Bernd Stein ,  Maria X. H. Yang ,  David B. Young

IPC分类号： A61K38/00 ,  C12N1/21 ,  C12N9/12 ,  A61K38/16 ,  C07H21/04 ,  G01N33/53

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

公开(公告)号：US09192227B2

公开(公告)日：2015-11-24

申请号：US13641152

申请日：2011-03-18

申请人： Bernd Stein ,  Bernhard Rees ,  Ingo Kumpf ,  Florian Kiefer

发明人： Bernd Stein ,  Bernhard Rees ,  Ingo Kumpf ,  Florian Kiefer

IPC分类号： A46D3/04 ,  A46D1/08

CPC分类号： A46D3/045 ,  A46D1/08 ,  A46D3/04

摘要： An apparatus (1) for producing bristle arrangements for brushes, in particular toothbrushes, having a bristle supply (2) and an apparatus (3) for extracting individual bundles (4) of bristles from the bristle supply (2), and also having a transporting apparatus for transporting the bundles (4) of bristles by way of at least one hollow line (8) by means of a stream of gas or air in perforations in a bundle-retaining plate, is characterized in that the apparatus (3) for extracting the bundles (4) of bristles from the bristle supply (2) has at least one bundle holder (6), and in that the bundle holder(s) (6) of the extraction means (3), the inner contour (10) of the hollow line(s) (8) and the perforations in the bundle-retaining plate are each contoured in a manner corresponding to the bundle contour which is desired in the bristle arrangement.

摘要翻译： 一种用于制造用于刷子的刷毛装置的设备（1），特别是具有刷毛供应装置（2）的刷子和用于从刷毛供应装置（2）提取单个束（4）的刷毛的装置（3），并且还具有 用于通过至少一个空心线（8）通过束保持板中的穿孔中的气体或空气流输送刷毛束（4）的输送装置的特征在于，用于 从刷毛供应装置（2）提取刷毛束（4）具有至少一个捆扎架（6），并且提取装置（3）的束夹持器（6），内轮廓（10） ）和中空线（8）中的穿孔和束保持板中的穿孔各自以对应于刷毛布置中期望的束轮廓的方式进行轮廓。

公开(公告)号：US09174201B2

公开(公告)日：2015-11-03

申请号：US13119948

申请日：2009-09-09

申请人： Martin Ernst ,  Bernd Stein ,  Steffen Maas ,  Jörg Pastre ,  Thorsten Johann ,  Johann-Peter Melder

发明人： Martin Ernst ,  Bernd Stein ,  Steffen Maas ,  Jörg Pastre ,  Thorsten Johann ,  Johann-Peter Melder

IPC分类号： C07C211/14 ,  C07C211/35 ,  C07C209/26 ,  B01J23/72 ,  B01J35/02 ,  B01J37/00 ,  C07C209/16 ,  B01J21/04 ,  B01J37/02 ,  B01J37/18

CPC分类号： B01J23/72 ,  B01J21/04 ,  B01J35/023 ,  B01J37/0009 ,  B01J37/0201 ,  B01J37/18 ,  C07C209/16 ,  C07C209/26 ,  C07C2601/14 ,  Y02P20/582 ,  C07C211/08 ,  C07C211/10 ,  C07C211/12 ,  C07C211/14 ,  C07C211/35

摘要： Process for the continuous preparation of an amine by reaction of a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary and secondary amines at a temperature in the range from 60 to 300° C. in the presence of a catalyst comprising copper oxide and aluminum oxide, wherein the reaction takes place in the gas phase and the catalytically active composition of the catalyst before reduction with hydrogen comprisesfrom 20 to 75% by weight of aluminum oxide (Al2O3),from 20 to 75% by weight of oxygen-comprising compounds of copper, calculated as CuO,from 0 to 2% by weight of oxygen-comprising compounds of sodium, calculated as Na2O, andless than 5% by weight of oxygen-comprising compounds of nickel, calculated as NiO, and the shaped catalyst body has a pellet shape having a diameter in the range from 1 to 4 mm and a height in the range from 1 to 4 mm.

摘要翻译： 通过伯醇或仲醇，醛和/或酮与氢和选自氨，伯胺和仲胺的氮化合物在60至300℃的温度下反应连续制备胺的方法 在包含氧化铜和氧化铝的催化剂存在下，其中反应在气相中进行，催化剂在用氢还原前的催化活性组合物包含20至75重量％的氧化铝（Al 2 O 3 ），20至75重量％的以氧化铜计的含氧化合物的铜（以CuO计）为0至2重量％的含氧化合物的钠（以Na 2 O计）和小于5重量％ 包括以NiO计算的镍化合物，并且成型催化剂体具有直径在1至4mm范围内且高度在1至4mm范围内的颗粒形状。