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公开(公告)号：US20140243929A1
公开(公告)日：2014-08-28
申请号：US14268770
申请日：2014-05-02
CPC分类号： A61N1/3727 , A61B5/02405 , A61B5/4035 , A61B5/4839 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/362 , A61N1/37264
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
摘要翻译： 本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。 因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。
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52.发明授权Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权使用一个或多个可植入装置监测疾病和药物管理的计时生理节律公开(公告)号：US08805493B2
公开(公告)日：2014-08-12
申请号：US13847362
申请日：2013-03-19
发明人： Yi Zhang , John D. Hatlestad , Gerard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/36
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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公开(公告)号：US20140094875A1
公开(公告)日：2014-04-03
申请号：US14097286
申请日：2013-12-05
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate information using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译： 一个实施例使用加速度计来感测心脏声音，并且使用感测到的心脏声音来确定心率信息。 一个实施例使用加速计来感测呼吸活动。 实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，随后是刺激关闭部分。 电连接到植入的神经刺激装置的电极用于远程检测心脏活动。 远程检测到的心脏活动用于在刺激ON部分期间检测心率信息，并在刺激OFF部分期间检测心率信息。 检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激器装置执行的神经刺激治疗和/或用于提供患者状况的诊断信息。
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公开(公告)号：US20140005742A1
公开(公告)日：2014-01-02
申请号：US13925427
申请日：2013-06-24
发明人： Deepa Mahajan , Yanting Dong , Sunipa Saha , Holly Rockweiler , Kenneth N. Hayes , Krzysztof Z. Siejko , Clayton S. Foster
IPC分类号： A61N1/37
CPC分类号： A61N1/3686 , A61B5/0031 , A61B5/04001 , A61B5/0452 , A61N1/36514 , A61N1/3684 , A61N1/3702 , A61N1/371 , A61N1/37247
摘要： Various techniques are disclosed for quickly and efficiently determining cardiac pacing vectors that minimize phrenic nerve stimulation.
摘要翻译： 公开了各种技术，用于快速有效地确定最小化膈神经刺激的心脏起搏载体。
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55.发明授权公开(公告)号：US11950915B2
公开(公告)日：2024-04-09
申请号：US17116819
申请日：2020-12-09
发明人： Venugopal Allavatam , Stephen J. Hahn , Keith L. Herrmann , Mitchell D. Lanz , Krzysztof Z. Siejko , Benjamin Speakman
IPC分类号： A61B5/316 , A61B5/00 , A61B5/287 , A61B5/30 , A61B5/304 , A61B5/349 , A61B5/352 , A61N1/362 , A61N1/37 , A61N1/39
CPC分类号： A61B5/316 , A61B5/287 , A61B5/30 , A61B5/304 , A61B5/349 , A61B5/352 , A61B5/725 , A61N1/3627 , A61N1/3702 , A61N1/3925 , A61N1/3956 , A61B5/7282
摘要： Methods and/or device facilitating and selecting among multiple modes of filtering a cardiac electrical signal, in which one filtering mode includes additional high pass filtering of low frequency signals, relative to the other filtering mode. The selection filtering modes may include comparing sensed signal amplitude to one or more thresholds, using the multiple modes of filtering. In another example, an additional high pass filter is enabled, over and above a default or baseline filtering mode, and the detected cardiac signal is monitored for indications of possible undersensing, and/or for drops in amplitude toward a threshold, and the additional high pass filter may be disabled upon finding of possible undersensing or drop in signal amplitude.
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公开(公告)号：US11850087B2
公开(公告)日：2023-12-26
申请号：US16386611
申请日：2019-04-17
发明人： Jonathan Bennett Shute , Rezwan Ahmed , Bin Mi , Krzysztof Z. Siejko , Pramodsingh Hirasingh Thakur , Qi An
IPC分类号： A61B7/02 , A61B5/00 , A61B7/04 , A61B5/349 , A61B5/0205 , A61N1/362 , A61B5/1455
CPC分类号： A61B7/026 , A61B5/0051 , A61B5/349 , A61B5/6803 , A61B5/6817 , A61B7/04 , A61B5/02055 , A61B5/1455 , A61B5/486 , A61B2562/0204 , A61N1/362
摘要： Systems and methods for detecting heart sound information from a subject's head are described. A system embodiment includes a headgear to be worn on the subject's head, and first and second sensors to sense respectively first and second physiologic signals each representing vibration, motion, or displacement conducted through patient body tissue. The sensed physiologic signals contain heart sound information. At least one of the first or the second sensor is included in the headgear, and placed at a head location to sense a physiologic signal indicative of heart sounds. The system includes a processor to generate a composite signal using the sensed first and second physiologic signals. The system may generate a heart sound metric using the composite signal, and detect a cardiac event such as an arrhythmia or worsening heart failure.
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公开(公告)号：US11311731B2
公开(公告)日：2022-04-26
申请号：US16845730
申请日：2020-04-10
发明人： Yinghong Yu , Krzysztof Z. Siejko , Qi An
摘要： This document discusses, among other things, systems and methods to determine a response curve between received cardiac electrical information from a subject, such as a time of a P wave, and received cardiac acceleration information of the subject, such as a time of a first heart sound (S1) or a second heart sound (S2), to a set of stimulation signals provided to the subject at different AVD intervals. In certain examples, one or more cardiac resynchronization therapy (CRT) parameters can be determined for the subject using the determined response curve.
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公开(公告)号：US11260216B2
公开(公告)日：2022-03-01
申请号：US16201678
申请日：2018-11-27
发明人： Jeffrey E. Stahmann , Keith R. Maile , Krzysztof Z. Siejko , Allan Charles Shuros , William J. Linder , Benjamin J. Haasl , Michael J. Kane , Brendan Early Koop
摘要： A ventricularly implantable medical device that includes a sensing module that is configured to detect an artifact during ventricular filling and to identify an atrial event based at least on part on the detected artifact. Control circuitry of the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified atrial event.
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公开(公告)号：US11198010B2
公开(公告)日：2021-12-14
申请号：US16366823
申请日：2019-03-27
发明人： Stephen J. Hahn , Pramodsingh Hirasingh Thakur , Qi An , Viktoria A. Averina , Krzysztof Z. Siejko , Ramesh Wariar
摘要： This document discusses, among other things, systems and methods to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, and alternate the first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay. Physiologic information can be received from the patient, and one of the first or second pacing period for delivery to the patient can be determined using the received physiologic information.
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60.发明授权公开(公告)号：US10888238B2
公开(公告)日：2021-01-12
申请号：US16177884
申请日：2018-11-01
发明人： Venugopal Allavatam , Stephen J. Hahn , Keith L. Herrmann , Mitchell D. Lanz , Krzysztof Z. Siejko , Benjamin Speakman
IPC分类号： A61B5/0402 , A61B5/0452 , A61N1/39 , A61N1/37 , A61N1/362 , A61B5/00 , A61B5/0456 , A61B5/0428 , A61B5/042 , A61B5/04
摘要： Methods and/or device facilitating and selecting among multiple modes of filtering a cardiac electrical signal, in which one filtering mode includes additional high pass filtering of low frequency signals, relative to the other filtering mode. The selection filtering modes may include comparing sensed signal amplitude to one or more thresholds, using the multiple modes of filtering. In another example, an additional high pass filter is enabled, over and above a default or baseline filtering mode, and the detected cardiac signal is monitored for indications of possible undersensing, and/or for drops in amplitude toward a threshold, and the additional high pass filter may be disabled upon finding of possible undersensing or drop in signal amplitude.
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