公开(公告)号：US20070015690A1

公开(公告)日：2007-01-18

申请号：US11181178

申请日：2005-07-13

申请人： James Chang ,  Orest Olejnik ,  Bruce Firestone

发明人： James Chang ,  Orest Olejnik ,  Bruce Firestone

IPC分类号： A61K38/13 ,  A61K36/23 ,  A61K36/63 ,  A61K36/534 ,  A61K36/899 ,  A61K36/31 ,  A61K36/48 ,  A61K36/28

CPC分类号： A61K47/44 ,  A61K9/0048 ,  A61K9/107 ,  A61K38/13 ,  Y10S514/912 ,  Y10S514/975

摘要： A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.

公开(公告)号：US20060262360A1

公开(公告)日：2006-11-23

申请号：US11134798

申请日：2005-05-20

申请人： John Dalrymple ,  James Chang

发明人： John Dalrymple ,  James Chang

IPC分类号： H04N1/46

CPC分类号： H04N1/6033

摘要： Systems and methods for utilizing metadata embedded in a color measurement target to uniquely identify the target through color measurement. A color measurement target is used for color calibration, color characterization, color adjustment and/or color correction of a color output device and includes a collection of color patches imaged by the output device, wherein metadata is embedded directly into the color patches of the color measurement target to uniquely identify the target through color measurement. The metadata-bearing patches in the target are used to communicate information through color measurement, and can contribute to the color characterization.

公开(公告)号：US20060173060A1

公开(公告)日：2006-08-03

申请号：US11395019

申请日：2006-03-31

申请人： James Chang ,  Patrick Hughes

发明人： James Chang ,  Patrick Hughes

IPC分类号： A61K31/4166 ,  A61K9/50 ,  A61K9/16

CPC分类号： A61K31/4166

摘要： Biocompatible microparticles include an ophthalmically active alpha-2 adrenergic receptor agonist and a biodegradable polymer. The microparticles include oil-in-water emulsified microparticles which can be used to treat an ocular condition, such as glaucoma.

公开(公告)号：US20050244473A1

公开(公告)日：2005-11-03

申请号：US11117879

申请日：2005-04-29

申请人： Patrick Hughes ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang

发明人： Patrick Hughes ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang

IPC分类号： A61K9/00 ,  A61K31/13 ,  A61F2/00

CPC分类号： A61K9/0051

摘要： Biocompatible intraocular implants include an anti-excitotoxic agent and a biodegradable polymer that is effective to facilitate release of the anti-excitotoxic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

摘要翻译： 生物相容性眼内植入物包括抗兴奋性毒性剂和可生物降解的聚合物，其有效促进抗兴奋性毒性剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

公开(公告)号：US20050156700A1

公开(公告)日：2005-07-21

申请号：US11079717

申请日：2005-03-15

申请人： James Chang

发明人： James Chang

IPC分类号： H01F17/00 ,  H01L23/522 ,  H01L27/02 ,  H01L27/08 ,  H03B5/12 ,  H03B5/36 ,  H03D7/16 ,  H03D7/18 ,  H03G1/00 ,  H03H11/12 ,  H03J1/00 ,  H03J3/04 ,  H03J3/08 ,  H03J3/18 ,  H03L7/10 ,  H03L7/23 ,  H04B1/26

CPC分类号： H03L7/23 ,  H01F17/0006 ,  H01F17/0013 ,  H01F2017/0053 ,  H01F2021/125 ,  H01L23/5227 ,  H01L27/0248 ,  H01L27/08 ,  H01L2924/0002 ,  H01L2924/3011 ,  H03B5/364 ,  H03D7/161 ,  H03D7/18 ,  H03G1/0029 ,  H03H11/1291 ,  H03J1/0075 ,  H03J3/04 ,  H03J3/08 ,  H03J3/185 ,  H03J2200/10 ,  H03L7/10 ,  H01L2924/00

摘要： An integrated receiver with channel selection and image rejection substantially implemented on a single CMOS integrated circuit is described. A receiver front end provides programable attenuation and a programable gain low noise amplifier. Frequency conversion circuitry advantageously uses LC filters integrated onto the substrate in conjunction with image reject mixers to provide sufficient image frequency rejection. Filter tuning and inductor Q compensation over temperature are performed on chip. The filters utilize multi track spiral inductors with shields to increase circuit Q. The filters are tuned using local oscillators to tune a substitute filter, and frequency scaling during filter component values to those of the filter being tuned. In conjunction with filtering, frequency planning provides additional image rejection. The advantageous choice of local oscillator signal generation methods on chip is by PLL out of band local oscillation and by direct synthesis for in band local oscillator. The VCOs in the PLLs are centered using a control circuit to center the tuning capacitance range. A differential crystal oscillator is advantageously used as a frequency reference. Differential signal transmission is advantageously used throughout the receiver. ESD protection is provided by a pad ring and ESD clamping structure that maintains signal integrity. Also provided are shunts at each pin to discharge ESD build up. The shunts utilize a gate boosting structure to provide sufficient small signal RF performance, and minimal parasitic loading.

摘要翻译： 描述了基本上在单个CMOS集成电路上实现的具有信道选择和图像抑制的集成接收机。 接收机前端提供可编程衰减和可编程增益低噪声放大器。 频率转换电路有利地使用集成到衬底上的LC滤波器与图像抑制混合器结合，以提供足够的图像频率抑制。 过滤器调谐和电感Q补偿温度在芯片上执行。 滤波器利用具有屏蔽的多轨螺旋电感器来增加电路Q.使用本地振荡器调谐滤波器以调整替代滤波器，以及在滤波器组件值期间频率缩放至正被调谐的滤波器的滤波器。 结合滤波，频率规划提供了额外的镜像抑制。 片上本地振荡器信号产生方法的有利选择是通过PLL带外本地振荡和通过频带本地振荡器的直接合成。 PLL中的VCO使用控制电路居中，使调谐电容范围居中。 差分晶体振荡器有利地用作频率参考。 差分信号传输有利地用于整个接收机。 ESD保护由保护信号完整性的焊盘环和ESD钳位结构提供。 还提供每个引脚上的分流器，以放电ESD积聚。 分流器利用栅极升压结构来提供足够的小信号RF性能和最小的寄生负载。

公开(公告)号：US5013908A

公开(公告)日：1991-05-07

申请号：US276629

申请日：1988-11-28

申请人： James Chang

发明人： James Chang

IPC分类号： G01M11/08 ,  G08B13/12

CPC分类号： G01M11/083 ,  G08B13/124 ,  G08B13/186

摘要： A fiber optic detection system comprising an array of fiber optic elements is presented. Each fiber optic element is uniquely encoded using a plurality of discrete ferquencies, digital codes or other encoding techniques. When a break occurs in one or more fiber optic elements, the missing light frequencies or digital codes are sensed, thereby indicating the break. Preferably, the fiber optic elements are arranged in a grid pattern so that precise location of the break can be made.

摘要翻译： 提出了一种包括光纤元件阵列的光纤检测系统。 每个光纤元件使用多个离散傅里叶变换，数字代码或其他编码技术进行唯一编码。 当在一个或多个光纤元件中发生中断时，感测到丢失的光频率或数字码，从而指示断开。 优选地，光纤元件以网格图案布置，使得可以进行断裂的精确位置。

公开(公告)号：US07942654B2

公开(公告)日：2011-05-17

申请号：US11833493

申请日：2007-08-03

申请人： James Chang

发明人： James Chang

IPC分类号： F04B43/08 ,  F04B43/12 ,  F04B45/06

CPC分类号： F04B43/1292 ,  F04B43/0072 ,  F04B43/0081

摘要： The present invention provides an addressable multi-channel peristaltic pump. According to the invention, this pump design allows for selection and operation of one or more pump heads on a drive shaft, while locking other non-selected pump heads in a stationary position. It is possible to operate the multi-channel pump using a limited number of motors, preferably two motors: a selector motor and a dispense motor. Thus, the pump provides for pumping or dispensing of one or more fluids without the need for multiple pumps. Likewise, compared with typical single motor multi-channel systems, where all pump heads on the drive shaft must rotate at the same time, the present invention provides for selective dispensing of one or more fluids. The pumps of the present invention are suitable for any multiple fluid transfer application, including in automated multi-channel reagent dispensing systems, such as nucleic acid purification systems.

摘要翻译： 本发明提供一种可寻址的多通道蠕动泵。 根据本发明，该泵设计允许在驱动轴上选择和操作一个或多个泵头，同时将其它未选择的泵头锁定在静止位置。 可以使用有限数量的电动机，优选两个电动机来操作多通道泵：选择器电动机和分配电动机。 因此，泵提供一个或多个流体的泵送或分配，而不需要多个泵。 同样，与典型的单电动机多通道系统相比，驱动轴上的所有泵头必须同时旋转，本发明提供了一种或多种流体的选择性分配。 本发明的泵适用于任何多种流体转移应用，包括在自动多通道试剂分配系统中，例如核酸纯化系统。

公开(公告)号：US20070299004A1

公开(公告)日：2007-12-27

申请号：US11897177

申请日：2007-08-28

申请人： Andrew Acheampong ,  Diane Tang-Liu ,  James Chang ,  David Power

发明人： Andrew Acheampong ,  Diane Tang-Liu ,  James Chang ,  David Power

IPC分类号： A61K38/13 ,  A61P27/02

CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K9/107 ,  A61K47/02 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32 ,  A61K47/44

摘要： Methods of treating an eye of a human or animal include administering to an eye of a human or animal a composition in the form of an emulsion including water, a hydrophobic component and a cyclosporin component in a therapeutically effective amount of less than 0.1% by weight of the composition. The weight ratio of the cyclosporin component to the hydrophobic component is less than 0.8.

摘要翻译： 治疗人或动物眼睛的方法包括向人或动物眼睛施用包含水，疏水组分和环孢菌素组分的乳液形式的组合物，其治疗有效量小于0.1重量％ 的组成。 环孢菌素组分与疏水组分的重量比小于0.8。

公开(公告)号：US20070087962A1

公开(公告)日：2007-04-19

申请号：US11470923

申请日：2006-09-07

申请人： Walter Tien ,  Richard Graham ,  James Chang

发明人： Walter Tien ,  Richard Graham ,  James Chang

IPC分类号： A61K38/13 ,  A61K31/355

CPC分类号： A61K38/13 ,  A61K31/355

摘要： A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an emulsion. is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.

摘要翻译： 包含治疗有效浓度的环孢菌素和维生素E生育酚聚乙二醇琥珀酸酯的液体，其中所述液体是乳液。 在此公开。 使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

公开(公告)号：US20070077908A1

公开(公告)日：2007-04-05

申请号：US11393899

申请日：2006-03-31

申请人： Pieter Vorenkamp ,  Klaas Bult ,  Frank Carr ,  Christopher Ward ,  Ralph Duncan ,  Tom Kwan ,  James Chang ,  Haideh Khorramabadi

发明人： Pieter Vorenkamp ,  Klaas Bult ,  Frank Carr ,  Christopher Ward ,  Ralph Duncan ,  Tom Kwan ,  James Chang ,  Haideh Khorramabadi

IPC分类号： H04B1/10 ,  H04B1/26 ,  H04N5/455

CPC分类号： H03D3/18 ,  H01F17/0006 ,  H01F17/0013 ,  H01F27/34 ,  H01F27/40 ,  H01F27/42 ,  H01F2017/0053 ,  H01F2021/125 ,  H01L23/5227 ,  H01L27/0248 ,  H01L27/0251 ,  H01L27/08 ,  H01L2924/0002 ,  H01L2924/3011 ,  H03B5/04 ,  H03B5/364 ,  H03D7/161 ,  H03D7/18 ,  H03F1/26 ,  H03F1/3211 ,  H03F3/195 ,  H03F3/45183 ,  H03F3/45188 ,  H03F3/68 ,  H03F3/72 ,  H03F2200/111 ,  H03F2200/294 ,  H03F2200/372 ,  H03F2200/447 ,  H03F2200/63 ,  H03F2203/45264 ,  H03F2203/45286 ,  H03G1/0023 ,  H03G1/0029 ,  H03G3/3052 ,  H03H7/25 ,  H03H11/04 ,  H03H11/1291 ,  H03H11/53 ,  H03H11/54 ,  H03H19/004 ,  H03J1/0075 ,  H03J3/04 ,  H03J3/08 ,  H03J3/185 ,  H03J2200/10 ,  H03L7/10 ,  H03L7/183 ,  H03L7/23 ,  H03L2207/06 ,  H01L2924/00

摘要： An integrated receiver with channel selection and image rejection substantially implemented on a single CMOS integrated circuit is described. A receiver front end provides programable attenuation and a programable gain low noise amplifier. Frequency conversion circuitry advantageously uses LC filters integrated onto the substrate in conjunction with image reject mixers to provide sufficient image frequency rejection. Filter tuning and inductor Q compensation over temperature are performed on chip. The filters utilize multi track spiral inductors. The filters are tuned using local oscillators to tune a substitute filter, and frequency scaling during filter component values to those of the filter being tuned. In conjunction with filtering, frequency planning provides additional image rejection. The advantageous choice of local oscillator signal generation methods on chip is by PLL out of band local oscillation and by direct synthesis for in band local oscillator. The VCOs in the PLLs are centered using a control circuit to center the tuning capacitance range. A differential crystal oscillator is advantageously used as a frequency reference. Differential signal transmission is advantageously used throughout the receiver.

摘要翻译： 描述了基本上在单个CMOS集成电路上实现的具有信道选择和图像抑制的集成接收机。 接收机前端提供可编程衰减和可编程增益低噪声放大器。 频率转换电路有利地使用集成到衬底上的LC滤波器与图像抑制混合器结合，以提供足够的图像频率抑制。 过滤器调谐和电感Q补偿温度在芯片上执行。 滤波器采用多轨螺旋电感。 使用本地振荡器调整滤波器以调整替代滤波器，以及滤波器组件值期间的频率缩放与被调谐的滤波器的频率缩放。 结合滤波，频率规划提供了额外的镜像抑制。 片上本地振荡器信号产生方法的有利选择是通过PLL带外本地振荡和通过频带本地振荡器的直接合成。 PLL中的VCO使用控制电路居中，使调谐电容范围居中。 差分晶体振荡器有利地用作频率参考。 差分信号传输有利地用于整个接收机。