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95 条记录 (耗时 0.057 秒)

    Amino heterocyclic modulators of chemokine receptor activity
    52.
    发明授权
    Amino heterocyclic modulators of chemokine receptor activity 失效
    趋化因子受体活性的氨基杂环调节剂

    公开(公告)号：US07700772B2

    公开(公告)日：2010-04-20

    申请号：US10589406

    申请日：2005-02-08

    申请人： Lihu Yang ,  Alexander Pasternak ,  Sander G. Mills

    发明人： Lihu Yang ,  Alexander Pasternak ,  Sander G. Mills

    IPC分类号： C07D401/04 ,  C07D407/04 ,  A61K31/445 ,  A61K31/438

    CPC分类号： C07D307/24 ,  C07D207/16 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04

    摘要： Compounds of Formula I and Formula II: (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R33, R34, R35, R36, R37, R38, A, j, k, m, n, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

    摘要翻译： 式I和式II化合物（其中n，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R15，R16，R17，R18，R19，R24，R25，R26， R28，R29，R30，R33，R34，R35，R36，R37，R38，A，j，k，m，n，X，Y和Z如本文所定义），其是趋化因子受体活性的调节剂， 预防或治疗某些炎性和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫性病态如类风湿性关节炎和动脉粥样硬化。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及趋化因子受体的疾病中的用途。

    Hydroisoindoline tachykinin receptor antagonists
    54.
    发明授权
    Hydroisoindoline tachykinin receptor antagonists 有权
    羟基异吲哚啉速激肽受体拮抗剂

    公开(公告)号：US07645790B2

    公开(公告)日：2010-01-12

    申请号：US10586727

    申请日：2005-01-26

    申请人： Jaime Lynn Bunda ,  Robert J. DeVita ,  Jinlong Jiang ,  Sander G. Mills

    发明人： Jaime Lynn Bunda ,  Robert J. DeVita ,  Jinlong Jiang ,  Sander G. Mills

    IPC分类号： A61K31/4035 ,  C07D209/44

    CPC分类号： C07D209/44

    摘要： The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂和速激肽抑制剂，特别是物质P的式I的加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性的药物制剂 成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。

    3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
    55.
    发明授权
    3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity 失效
    趋化因子受体活性的3,3-二取代四氢吡喃基环戊基酰胺调节剂

    公开(公告)号：US07566726B2

    公开(公告)日：2009-07-28

    申请号：US11587448

    申请日：2005-04-22

    申请人： Lihu Yang ,  Sander G. Mills ,  Kothandaraman Shankaran

    发明人： Lihu Yang ,  Sander G. Mills ,  Kothandaraman Shankaran

    IPC分类号： C07D217/02 ,  C07D471/02 ,  A61K31/4375

    CPC分类号： C07D471/04

    摘要： (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, Y and Z are defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

    摘要翻译： （其中n，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 15，R 16，R 17，R 18，Y和Z在本文中定义），其是趋化因子受体活性的调节剂， 预防或治疗某些炎性和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫病态如类风湿性关节炎和动脉粥样硬化。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及趋化因子受体的疾病中的用途。

    Hydroisoindoline Tachykinin Receptor Antagonists
    57.
    发明申请
    Hydroisoindoline Tachykinin Receptor Antagonists 有权
    羟基异吲哚啉速激肽受体拮抗剂

    公开(公告)号：US20080280966A1

    公开(公告)日：2008-11-13

    申请号：US10586727

    申请日：2005-01-26

    申请人： Jaime Lynn Bunda ,  Robert J. DeVita ,  Jinlong Jiang ,  Sander G. Mills

    发明人： Jaime Lynn Bunda ,  Robert J. DeVita ,  Jinlong Jiang ,  Sander G. Mills

    IPC分类号： A61K31/403 ,  C07D209/44

    CPC分类号： C07D209/44

    摘要： The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂和速激肽抑制剂，特别是物质P的式I的加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性的药物制剂 成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。